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List of works by Jeffrey Schlom

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts: National Harbor, MD, USA. 9-13 November 2016.

scientific article published on 8 December 2016

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

4-1BB ligand enhances tumor-specific immunity of poxvirus vaccines

scientific article published on 31 March 2006

A Case Report of Sequential Use of a Yeast-CEA Therapeutic Cancer Vaccine and Anti-PD-L1 Inhibitor in Metastatic Medullary Thyroid Cancer

scientific article published on 07 August 2020

A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

scientific article published on 20 May 2019

A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based Immunotherapy Vaccine Regimen in Patients with Advanced Cancer

scientific article published on 08 October 2019

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer ⬇️

scientific article published on November 8, 2011

A Randomized, Double-blind, Phase II Trial of PSA-TRICOM (PROSTVAC) in Patients with Localized Prostate Cancer: The Immunotherapy to Prevent Progression on Active Surveillance Study

scientific article published on 07 September 2018

A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates.

scientific article

A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responses

scientific article published on 20 May 2016

A human cytotoxic T-lymphocyte epitope and its agonist epitope from the nonvariable number of tandem repeat sequence of MUC-1.

scientific article published on March 2004

A novel ELISPOT assay to enhance detection of antigen-specific T cells employing antigen-presenting cells expressing vector-driven human B7-1

scientific article published on 01 August 2003

A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

scientific article published on 13 July 2017

A phase I study of recombinant (r) vaccinia-CEA(6D)-TRICOM and rFowlpox-CEA(6D)-TRICOM vaccines with GM-CSF and IFN-α-2b in patients with CEA-expressing carcinomas

scientific article published on 31 August 2016

A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver ⬇️

scientific article published on August 28, 2011

A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy

article

A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab.

scientific article

A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer

scientific article

A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production

scientific article

A viral vaccine encoding prostate-specific antigen induces antigen spreading to a common set of self-proteins in prostate cancer patients

scientific article

ABO blood type correlates with survival on prostate cancer vaccine therapy

scientific article published on 18 August 2015

ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody

scientific article

Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody

scientific article published on March 2015

Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction

scientific article published in December 2002

Actinium-225 conjugates of MAb CC49 and humanized delta CH2CC49

scientific article published on 01 April 2002

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

scholarly article by Fatima Karzai et al published 4 December 2018 in Journal for Immunotherapy of Cancer

Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy

scientific article published on October 2004

An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression.

scientific article published in February 2018

An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele

scientific article

Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types

scientific article

Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy

scientific article published on 2 August 2016

Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824).

scientific article published on 8 September 2017

Analyses of recombinant vaccinia and fowlpox vaccine vectors expressing transgenes for two human tumor antigens and three human costimulatory molecules.

scientific article published on February 2005

Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody

scientific article published on 21 February 2017

Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination ⬇️

scientific article published on October 26, 2010

Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy

scientific article published on July 2008

Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis

scientific article published on 2 November 2017

Anti-tumor effects of anti-PD-L1 therapy in an orthotopic bladder tumor model

scientific article published on 6 November 2014

Antiandrogen, vaccine and combination therapy in patients with nonmetastatic hormone refractory prostate cancer

scientific article

Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells

scientific article published on 26 May 2015

Antigen-presenting cells containing multiple costimulatory molecules promote activation and expansion of human antigen-specific memory CD8+ T cells

scientific article published on 09 August 2008

Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial

scientific article published on 31 March 2017

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies

scientific article published on 01 December 2020

Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer

scientific article

Brachyury, a driver of tumor invasiveness and resistance to multiple therapies, is a novel immunotherapy target.

scientific article

Cancer vaccines: moving beyond current paradigms

scientific article published on July 2007

Cancer vaccines: preclinical studies and novel strategies

scientific article published on January 2006

Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancer

scientific article published on 01 September 2002

Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination

scientific article published on 4 December 2006

Chitosan solution enhances the immunoadjuvant properties of GM-CSF.

scientific article published on 5 November 2007

Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients ⬇️

scientific article

Clinical evaluation of TRICOM vector therapeutic cancer vaccines

scientific article

Clinical safety of a viral vector based prostate cancer vaccine strategy

scientific article published on 16 August 2007

Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

scientific article published on March 2006

Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice

scientific article

Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on immune enhancement

scientific article published on June 2008

Combination therapies utilizing neoepitope-targeted vaccines

scientific article published on 08 October 2020

Combination therapy of an orthotopic renal cell carcinoma model using intratumoral vector-mediated costimulation and systemic interleukin-2.

scientific article published in March 2007

Combination therapy with an OX40L fusion protein and a vaccine targeting the transcription factor twist inhibits metastasis in a murine model of breast cancer

scientific article published on 5 August 2017

Combining Vaccines with Conventional Therapies for Cancer

scientific article

Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer

scientific article

Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells

scientific article

Concurrent vaccination with two distinct vaccine platforms targeting the same antigen generates phenotypically and functionally distinct T-cell populations

scientific article

Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

scientific article published on 23 October 2019

Costimulatory molecules as adjuvants for immunotherapy

scientific article

Detection and Characterization of Circulating Tumour Cells from Frozen Peripheral Blood Mononuclear Cells

scientific article published in January 2015

Differential gene expression profiles in a human T-cell line stimulated with a tumor-associated self-peptide versus an enhancer agonist peptide ⬇️

scientific article published on May 1, 2003

Digital immunohistochemistry analysis of intratumoral immune infiltrates in prostate cancer patients treated with intraprostatic/systemic PSA-TRICOM vaccine

scientific article published on 7 November 2013

Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells

scientific article published on 01 February 2019

Distinct effects of saracatinib on memory CD8+ T cell differentiation

scientific article

Do Not Minimize the Impact of Cellular Immunity in the Development of Vaccines and Therapeutics for COVID-19

scientific article published on 11 July 2020

Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial.

scientific article published on 20 August 2015

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

scientific article published on 01 February 2020

EXTH-63. EFFICIENT ADCC-MEDIATED KILLING OF MALIGNANT MENINGIOMA CELLS USING AVELUMAB AND AN ENGINEERED HIGH AVIDITY NATURAL KILLER CELL LINE, haNK

Early changes in immune cell subsets with corticosteroids in patients with solid tumors: implications for COVID-19 management

scientific article published on 01 November 2020

Effect of Talactoferrin Alfa on the Immune System in Adults With Non-Small Cell Lung Cancer ⬇️

scientific article published on July 11, 2013

Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine

scientific article

Effect of age and cancer on peripheral immune cell subsets and their PD-1 and PD-L1 expression.

scientific article published on 4 November 2015

Effects of conventional therapeutic interventions on the number and function of regulatory T cells.

scientific article published on October 2013

Effects of tyrosine kinase inhibitors alone or in combination with vaccine on tumor-infiltrating myeloid cells

scientific article published on 7 November 2013

Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma

scientific article published on 21 October 2019

Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK

scientific article published on 17 October 2019

Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and Combinatorial Immunotherapy

scientific article published on 10 July 2019

Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role ⬇️

scientific article published on August 28, 2012

Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice

scientific article published on January 2008

Enhanced antitumor effects by combining an IL-12/anti-DNA fusion protein with avelumab, an anti-PD-L1 antibody

scientific article

Enhanced expression of lymphotactin by CD8+ T cells is selectively induced by enhancer agonist peptides of tumor-associated antigens ⬇️

scientific article published on November 21, 2003

Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer

scientific article

Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein

scientific article

Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab

scientific article published on 9 May 2016

Enhanced levels of costimulation lead to reduced effector/memory CD8+ T cell functionality

scientific article published on September 2007

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types

scholarly article by Kristin C Hicks et al published 2018 in OncoImmunology

Evaluation of immune cell subsets of cancer patients treated with Avelumab, a fully human IgG1 anti-PD-L1 MAb capable of mediating ADCC of human tumor cells.

scientific article published on 4 November 2015

Exercise enhances vaccine-induced antigen-specific T cell responses

scientific article

External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing

scientific article published on June 2004

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

scientific article published on 21 August 2018

Flow-cytometry phenotypic assessment of immune cell subsets reflecting function for the identification of breast cancer patients receiving vaccine plus docetaxel with longer progression-free survival

scientific article published on 7 November 2013

Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist

scientific article published on 01 April 2020

General keynote: vaccine strategies for the therapy of ovarian cancer

scientific article

Generation of human T cells directed against an agonist epitope of Brachyury, a transcription factor involved in human tumor cell epithelial to mesenchymal transition (EMT).

scientific article published on 7 November 2013

Harnessing the unique local immunostimulatory properties of modified vaccinia Ankara (MVA) virus to generate superior tumor-specific immune responses and antitumor activity in a diversified prime and boost vaccine regimen

scientific article

Human B cells that hyperexpress a triad of costimulatory molecules via avipox-vector infection: an alternative source of efficient antigen-presenting cells

scientific article published on 9 March 2004

Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen

scientific article

Humoral response to a viral glycan correlates with survival on PROSTVAC-VF

scientific article

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas

scientific article published on 18 February 2016

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

scientific article

IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells

scientific article published in April 2008

IL15N72D superagonist/IL15Rα-Fc fusion complex (ALT-803) exhibits anti-metastatic activity in murine breast tumor model.

scientific article published on 4 November 2015

Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis

scientific article

Identification and characterization of a human agonist cytotoxic T-lymphocyte epitope of human prostate-specific antigen.

scientific article published in January 2002

Identification and characterization of agonist epitopes of the MUC1-C oncoprotein

scientific article published on 7 November 2013

Identification and characterization of agonist epitopes of the MUC1-C oncoprotein.

scientific article published on 15 November 2013

Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7.

scientific article published on 4 April 2017

Identification by digital immunohistochemistry of intratumoral changes of immune infiltrates after vaccine in the absence of modifications of PBMC immune cell subsets.

scientific article published on 22 February 2014

Identification of an interferon-gamma-inducible carcinoembryonic antigen (CEA) CD8(+) T-cell epitope, which mediates tumor killing in CEA transgenic mice

scientific article published on September 2002

Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).

scientific article published on August 2007

Identification of novel human CTL epitopes and their agonist epitopes of mesothelin

scientific article

Identification of tumor associated immune responses against brachyury, a transcription factor and driver of EMT, in chordoma patients receiving a yeast-brachyury vaccine (gi-6301).

scientific article published on 6 November 2014

IgG Responses to Tissue‐Associated Antigens as Biomarkers of Immunological Treatment Efficacy ⬇️

scientific article published on December 19, 2010

Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa

scientific article published on 01 April 2022

Immune impact induced by PROSTVAC (PSA-TRICOM), a therapeutic vaccine for prostate cancer

scientific article

Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer

scientific article

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine ⬇️

scientific article published on October 1, 2013

Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine

scientific article published on 01 June 2020

Immunotherapy with Autologous, Human Dendritic Cells Transfected with Carcinoembryonic Antigen mRNA

scientific article published on 01 June 2003

Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer

scientific article published on 11 December 2012

Impact of age on antigen-specific T lymphocyte response in patients treated with PSA-TRICOM

article published in 2014

In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications

scientific article published in May 2002

In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines

scientific article

Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses

scientific article

Induction of higher-avidity human CTLs by vector-mediated enhanced costimulation of antigen-presenting cells

scientific article

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy

Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

scientific article published on 9 December 2004

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

scientific article published on 17 December 2019

Inhibition of TGF-β1 Signaling Promotes Central Memory T Cell Differentiation ⬇️

scientific article published on July 31, 2013

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

scientific article published on 21 June 2018

International meeting on cancer vaccines: how can we enhance efficacy of therapeutic vaccines?

scientific article published in September 2004

Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells

scientific article

Intratumoral delivery of vector mediated IL-2 in combination with vaccine results in enhanced T cell avidity and anti-tumor activity

scientific article published on 15 May 2007

Intratumoral immunotherapy of established solid tumors with chitosan/IL-12.

scientific article

Intratumoral vaccination and diversified subcutaneous/ intratumoral vaccination with recombinant poxviruses encoding a tumor antigen and multiple costimulatory molecules

scientific article published on February 2004

Intravesical immunotherapy of superficial bladder cancer with chitosan/interleukin-12.

scientific article published on 28 July 2009

Introduction: Therapeutic Cancer Vaccines ⬇️

scientific article published on June 1, 2012

Investigation of antibody dependent cellular cytotoxicity as a mechanism of action for a novel anti-PD-L1 monoclonal antibody

scientific article published on 6 November 2014

Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial ⬇️

scientific article published on February 10, 2012

Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice

scientific article published on 4 April 2010

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

scientific article published on 14 February 2018

Malignant Mesothelioma Effusions Are Infiltrated by CD3+ T Cells Highly Expressing PD-L1 and the PD-L1+ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab

scientific article published on 17 August 2016

Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells ⬇️

scientific article published on May 11, 2011

Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy

scientific article published on 21 March 2019

Minimizing the immunogenicity of antibodies for clinical application

scientific article

Modified vaccinia virus ankara recombinants are as potent as vaccinia recombinants in diversified prime and boost vaccine regimens to elicit therapeutic antitumor responses.

scientific article published in November 2003

Morphological changes induced by intraprostatic PSA-based vaccine in prostate cancer biopsies (phase I clinical trial)

scientific article published on 30 April 2018

Multiple costimulatory modalities enhance CTL avidity

scientific article published in May 2005

Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody

scientific article published on 03 October 2016

Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer

scientific article published on 01 March 2020

New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy

scientific article published on 04 June 2009

Nuclear Brachyury Expression Is Consistent in Chordoma, Common in Germ Cell Tumors and Small Cell Carcinomas, and Rare in Other Carcinomas and Sarcomas: An Immunohistochemical Study of 5229 Cases

scientific article published on 4 April 2015

Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer

scientific article

Overcoming hypoxia-induced functional suppression of NK cells

scientific article published on 01 April 2020

Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.

scientific article

PD-1 and PD-L1 expression on PBMC subsets in normal individuals and cancer patients

PD-L1 and MHC-I expression in 19 human tumor cell lines and modulation by interferon-gamma treatment

scientific article published on 6 November 2014

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations

scientific article published on 01 May 2020

Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy

scientific article

Paradigm shifts in cancer vaccine therapy.

scientific article published on 28 March 2008

Pharmacokinetics and tumor localization of (111)in-labeled HuCC49DeltaC(H)2 in BALB/c mice and athymic murine colon carcinoma xenograft

scientific article published on 01 April 2006

Phase 1 trial of M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in advanced solid tumors

scientific article published on 3 January 2018

Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury

scientific article

Phase I Trial of a Modified Vaccinia Ankara Priming Vaccine Followed by a Fowlpox Virus Boosting Vaccine Modified to Express Brachyury and Costimulatory Molecules in Advanced Solid Tumors

scientific article published on 26 December 2019

Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury

scientific article published on 30 June 2015

Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV-PSA) in patients with metastatic androgen-independent prostate cancer

scientific article

Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules

scientific article published on 01 April 2005

Phase I study of intraprostatic vaccine administration in men with locally recurrent or progressive prostate cancer ⬇️

scientific article published on July 9, 2013

Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcino

scientific article published on 21 December 2004

Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors

scientific article published on 05 September 2019

Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma.

scientific article published on 07 December 2013

Phase I trial of an enhanced prostate-specific antigen-based vaccine and anti-CTLA-4 antibody in patients with metastatic androgen-independent prostate cancer

article

Phase I, dose-escalation, clinical trial of MVA-Brachyury-TRICOM vaccine demonstrating safety and brachyury-specific T cell responses

scientific article published on 4 November 2015

Phase II randomized study of vaccine treatment of advanced prostate cancer (E7897): a trial of the Eastern Cooperative Oncology Group

scientific article published in June 2004

Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs

scientific article published on 06 January 2005

Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma

scientific article published on May 2008

Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules

scientific article published on 4 August 2005

Potential utility of the pan-Bcl-2 inhibitor GX15-070 (obatoclax) in cancer immunotherapy.

scientific article

Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1

scientific article published on 05 September 2018

Preclinical and clinical studies of recombinant poxvirus vaccines for carcinoma therapy

scientific article published on January 2007

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

scientific article published on 24 April 2006

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Radioimmunotherapy of human colon carcinoma xenografts using a 213Bi-labeled domain-deleted humanized monoclonal antibody

scientific article published in April 2004

Rationale for IL-15 superagonists in cancer immunotherapy

scientific article published on 11 March 2020

Re: interdisciplinary critique of sipuleucel-T as immunotherapy in castration-resistant prostate cancer

scientific article published on 01 July 2012

Recent Advances in Therapeutic Cancer Vaccines ⬇️

scientific article published on January 17, 2012

Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells

scientific article published on 03 December 2007

Recombinant cancer vaccines and new vaccine targets. Interview by Jenaid Rees.

scientific article published on 7 October 2013

SDR grafting--a new approach to antibody humanization

scientific article (publication date: May 2005)

Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

scholarly article by Clint T Allen et al published 3 May 2019 in Journal for Immunotherapy of Cancer

Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant

scientific article

Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial

scientific article published on 28 July 2016

Serum antibodies to blood group A predict survival on PROSTVAC-VF.

scientific article published on 29 January 2013

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

scientific article published on 01 March 2020

Soluble CD27-Pool in Humans May Contribute to T Cell Activation and Tumor Immunity ⬇️

scientific article published on May 15, 2013

Strategies for cancer vaccine development

scientific article

Strategies for the development of PSA-based vaccines for the treatment of advanced prostate cancer

scientific article published on August 2003

Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells ⬇️

scientific article published on March 22, 2011

Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes

scientific article

Synergistic antitumor activity of immune strategies combined with radiation.

scientific article published on September 2007

Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor

scientific article published on 26 February 2016

Systemic immunotherapy of superficial mouse bladder cancer with Avelumab (MSB0010718C), an anti-PD-L1 immune checkpoint inhibitor

scientific article published on 4 November 2015

TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression

scientific article

TRICOM vector based cancer vaccines.

scientific article

Targeted delivery of murine IFN-gamma using a recombinant fowlpox virus: NK cell recruitment to regional lymph nodes and priming of tumor-specific host immunity

scientific article published on February 2008

Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12.

scientific article published on 11 June 2019

The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring ⬇️

scientific article published on January 20, 2011

The Development of Next-generation PBMC Humanized Mice for Preclinical Investigation of Cancer Immunotherapeutic Agents

scientific article published on 01 October 2020

The Feasibility and Safety of Immunotherapy with Dendritic Cells Loaded with CEA mRNA Following Neoadjuvant Chemoradiotherapy and Resection of Pancreatic Cancer

scientific article published on 01 January 2002

The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells

scientific article

The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells

scientific article

The Use of a Humanized NSG-β2m-/- Model for Investigation of Immune and Anti-tumor Effects Mediated by the Bifunctional Immunotherapeutic Bintrafusp Alfa

scientific article published on 21 April 2020

The antitumor and immunoadjuvant effects of IFN-alpha in combination with recombinant poxvirus vaccines

scientific article

The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy

scientific article published on 19 May 2016

The combined activation of positive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses

scientific article published on 23 February 2007

The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic.

scientific article published on 7 September 2015

The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic.

scientific article published on 4 November 2015

The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy.

scientific article published on April 2007

The immunocytokine NHS-IL12 as a potential cancer therapeutic

scientific article

The impact of leukapheresis on immune-cell number and function in patients with advanced cancer

scientific article published on 5 August 2015

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

scientific article published on 27 November 2018

The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors

scientific article published on June 2005

The role of oncogenic MUC1-C in brachyury-induced immunotherapy resistance

scientific article published on 6 November 2014

The role of soluble CD40L in immunosuppression ⬇️

scientific article published on January 1, 2013

The use of chelated radionuclide (samarium-153-ethylenediaminetetramethylenephosphonate) to modulate phenotype of tumor cells and enhance T cell-mediated killing

scientific article

Therapeutic Cancer Vaccines: Current Status and Moving Forward ⬇️

scientific article published on March 6, 2012

Therapeutic Vaccines for HPV-Associated Malignancies

scientific article published on 07 October 2020

Therapeutic cancer vaccines

scientific article published in January 2014

Therapeutic vaccines in metastatic castration-resistant prostate cancer: principles in clinical trial design.

scientific article published on January 2010

Therapy of Established Tumors with Rationally Designed Multiple Agents Targeting Diverse Immune-Tumor Interactions: Engage, Expand, Enable

scientific article published on 22 December 2020

Translational Research Working Group developmental pathway for immune response modifiers.

scientific article published on September 2008

Treatment with the IDO inhibitor INCB024360 increased lysis of human tumor cell targets by peptide-specific CTL.

scientific article published on 4 November 2015

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

scientific article published on 07 July 2020

Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.

scientific article published on 12 February 2013

Upregulation of oncogenic MUC1 by the EMT transcription factor brachyury mediates immunotherapy-resistance in tumor cells.

scientific article published on 4 November 2015

Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects

scientific article published on 7 February 2008

Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses.

scientific article published on July 2008

Vaccine therapy of established tumors in the absence of autoimmunity ⬇️

scientific article published on May 1, 2003

Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity.

scientific article published in December 2002

Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process.

scientific article

Vaccines against human carcinomas: strategies to improve antitumor immune responses

scientific article

Vaccines as an Integral Component of Cancer Immunotherapy

scientific article published in December 2018

Vaccines as monotherapy and in combination therapy for prostate cancer

scientific article

Vaccines with enhanced costimulation maintain high avidity memory CTL.

scientific article

Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity

scientific article published on 01 January 2002

Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activity

scientific article published on 01 October 2002

Viral Vector-Based Therapeutic Cancer Vaccines ⬇️

scientific article published on September 1, 2011

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