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List of works by Sander R. Piersma

Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer.

scientific article published on 8 December 2014

Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector

scientific article

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

scientific article published on 14 June 2018

Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression.

scientific article

Cellular imaging using matrix-enhanced and metal-assisted SIMS.

scientific article published on January 2010

Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies

scientific article published on 30 July 2018

Colorectal cancer candidate biomarkers identified by tissue secretome proteome profiling

scientific article published on 10 January 2014

Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture

scientific article

Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach

scientific article published on 14 January 2020

Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas

scientific article

Comparison of the performance of two affinity depletion spin filters for quantitative proteomics of CSF: Evaluation of sensitivity and reproducibility of CSF analysis using GeLC-MS/MS and spectral counting

scientific article published on 29 March 2010

Composition of the type VII secretion system membrane complex.

scientific article published on 27 August 2012

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

scientific article published on 19 July 2019

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

scientific article published on 11 August 2020

Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach

scientific article published on 18 July 2014

Differential detergent extraction of mycobacterium marinum cell envelope proteins identifies an extensively modified threonine-rich outer membrane protein with channel activity.

scientific article published on March 2013

Direct molecular imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry.

scientific article

Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins

scientific article

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

scientific article published on 13 August 2018

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

scientific article published on 4 May 2015

Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer

scientific article published on 16 December 2016

Evaluation of different phospho-tyrosine antibodies for label-free phosphoproteomics

scientific article

Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients

scientific article published on 23 December 2013

Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes

scientific article published on 10 April 2015

Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis

scientific article

Exploration of the platelet proteome in patients with early-stage cancer.

scientific article published on 9 February 2018

Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.

scientific article published on April 2015

Feasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model

scientific article published on 08 December 2020

Feasibility of urinary extracellular vesicle proteome profiling using a robust and simple, clinically applicable isolation method

scientific article published on 28 April 2017

Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC.

scientific article

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry

scientific article published on February 2006

High-throughput and targeted in-depth mass spectrometry-based approaches for biofluid profiling and biomarker discovery

scientific article

Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer

scientific article published on 25 January 2019

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

scientific article published on 12 April 2019

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

scientific article published on 24 May 2019

Identification of differentially expressed splice variants by the proteogenomic pipeline Splicify

scientific article

Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

scientific article published on 18 June 2020

Imaging mass spectrometry at cellular length scales

scientific article

Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment

scientific article published on 21 September 2020

Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2

scientific article published on 09 October 2020

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

scientific article published on 15 May 2013

Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

scientific article published on 01 February 2020

Label-free mass spectrometry-based proteomics for biomarker discovery and validation

scientific article published on May 2012

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells

scientific article published on 24 July 2015

Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression

scientific article published on 30 August 2019

Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus

scientific article

Multidrug-resistant transporter expression does not always result in drug resistance

scientific article published on 08 September 2018

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

scientific article published on 15 January 2018

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

scientific article published on 18 October 2016

Novel Stool-Based Protein Biomarkers for Improved Colorectal Cancer Screening: A Case-Control Study.

scientific article published on 21 November 2017

Novel diagnostic cerebrospinal fluid biomarkers for pathologic subtypes of frontotemporal dementia identified by proteomics.

scientific article published on 19 January 2016

Omics Analysis of Educated Platelets in Cancer and Benign Disease of the Pancreas

scientific article published on 29 December 2020

On the beta-binomial model for analysis of spectral count data in label-free tandem mass spectrometry-based proteomics

scientific article

Optimized Combination of HDACI and TKI Efficiently Inhibits Metabolic Activity in Renal Cell Carcinoma and Overcomes Sunitinib Resistance

scientific article published on 28 October 2020

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

scientific article published on 05 October 2020

PPIB mutations cause severe osteogenesis imperfecta

scientific article published on 24 September 2009

Peptide-mediated ‘miniprep’ isolation of extracellular vesicles is suitable for high-throughput proteomics.

scientific article published on 22 February 2016

Phosphotyrosine-based phosphoproteomics for target identification and drug response prediction in AML cell lines

scientific article published on 26 February 2020

Phosphotyrosine-based-phosphoproteomics scaled-down to biopsy level for analysis of individual tumor biology and treatment selection

scientific article published on 22 April 2017

Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression

scientific article published on 13 January 2020

Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction

scientific article published on 30 January 2019

Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells

scientific article published on 19 September 2019

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

scientific article

Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

scientific article published on 10 May 2019

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

scientific article published on 12 January 2021

Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems

scientific article published on 23 January 2013

Proteomics of differential extraction fractions enriched for chromatin-binding proteins from colon adenoma and carcinoma tissues.

scientific article published on 17 December 2013

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance

scientific article published on 8 February 2013

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

scientific article

Proteomics of the TRAP-induced platelet releasate

scientific article

Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer.

scientific article

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article published on 16 January 2018

Quantitative analysis of CDX2 protein expression improves its clinical utility as a prognostic biomarker in stage II and III colon cancer

scientific article published on 17 December 2020

Re-assessment of the high-grade serous ovarian cancer phosphoproteome - Identification of kinase candidates in TCGA tumors for future clinical intervention

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer

scientific article published on 23 August 2016

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

scientific article published on 14 January 2016

Specific chaperones for the type VII protein secretion pathway.

scientific article

Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies

scientific article published on 16 October 2020

Strategies for kinome profiling in cancer and potential clinical applications: chemical proteomics and array-based methods

scientific article published on 08 June 2010

Subcellular imaging mass spectrometry of brain tissue.

scientific article published in February 2005

Subnuclear proteomics in colorectal cancer: identification of proteins enriched in the nuclear matrix fraction and regulation in adenoma to carcinoma progression.

scientific article published on 20 January 2010

Sunitinib activates Axl signaling in renal cell cancer.

scientific article published on 27 January 2016

The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer

scientific article published on 29 April 2020

The proteome of the locus ceruleus in Parkinson's disease: relevance to pathogenesis

scientific article published on 8 November 2011

The secretome of colon cancer stem cells contains drug-metabolizing enzymes

scientific article published on 5 July 2013

Tools and strategies for visualization of large image data sets in high-resolution imaging mass spectrometry.

scientific article

Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

scientific article published on 01 June 2019

Whole gel processing procedure for GeLC-MS/MS based proteomics ⬇️

scientific article published on April 23, 2013

Workflow comparison for label-free, quantitative secretome proteomics for cancer biomarker discovery: method evaluation, differential analysis, and verification in serum

scientific article

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