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List of works by Takeshi Kuwata

A case of a protruded lesion formed by a poorly differentiated intramucosal adenocarcinoma of the stomach: an immunohistochemical analysis

scientific article published on 11 December 2017

A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas

scientific article published on 29 April 2007

A novel gene-protein assay for evaluating HER2 status in gastric cancer: simultaneous analyses of HER2 protein overexpression and gene amplification reveal intratumoral heterogeneity

scientific article published on 11 June 2014

Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions

scientific article published on 20 November 2017

Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations

scientific article published on 15 November 2015

Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation

scientific article published in December 2013

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

scientific article published on 07 July 2020

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma

scientific article published on 01 July 2020

Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells

scientific article

Bronchogenic cyst at esophagogastric junction treated by laparoscopic full-thickness resection and hand-sewn closure: a case report

scientific article published on 27 April 2016

Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts

scientific article published on 15 September 2015

Case of pyloric gland adenoma accompanied by a component of foveolar epithelial-type adenoma within the lesion

scientific article published on 29 May 2018

Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma

scientific article published on 20 October 2016

Characterization of low active ghrelin ratio in patients with advanced pancreatic cancer

scientific article published on 18 May 2018

Characterization of the large‐scale Japanese patient‐derived xenograft (J‐PDX) library

scientific article published on 24 March 2021

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

scientific article published on 06 November 2018

Clinical and molecular factors for selection of nivolumab or irinotecan as third-line treatment for advanced gastric cancer

scientific article published on 17 July 2020

Clinical significance of lymphatic invasion in the esophageal region in patients with adenocarcinoma of the esophagogastric junction

scientific article published on 02 May 2020

Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

scholarly article by Saori Mishima et al published 31 January 2019 in Journal for Immunotherapy of Cancer

Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer

scientific article published on 14 February 2019

Clinicopathological features and endoscopic findings of HER2-positive gastric cancer

scientific article published on 02 March 2018

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

scientific article

Clinicopathological features of PD-L1 expression with MMR, EBV status and cancer genome alterations in MGC

scientific article published on 01 October 2017

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients

scientific article published on 14 September 2016

Clinicopathological features of stomach cancer with invasive micropapillary component ⬇️

scientific article published on October 12, 2011

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

scientific article published on 22 October 2016

Depressed gastric-type adenoma in nonatrophic gastric mucosa without Helicobacter pylori infection

scientific article published on 25 March 2019

Determination of the optimal cutoff percentage of residual tumors to define the pathological response rate for gastric cancer treated with preoperative therapy (JCOG1004-A)

scientific article published on 27 June 2014

Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line

scientific article published on 01 March 2019

Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line

scientific article published on 29 March 2019

Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas

scientific article published on 04 June 2018

Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging ⬇️

scientific article published on 14 December 2020

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

scientific article published on 7 April 2016

E-cadherin expression on human carcinoma cell affects trastuzumab-mediated antibody-dependent cellular cytotoxicity through killer cell lectin-like receptor G1 on natural killer cells

scientific article published on May 2011

Efficacy and safety of ramucirumab-containing chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma

scientific article published on 01 November 2018

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia

scientific article published on 20 February 2009

Erratum: Author's Affiliation Correction. Type II human epidermal growth factor receptor heterogeneity is a poor prognosticator for type II human epidermal growth factor receptor positive gastric cancer (<i>World J Clin Cases</i> 2019; Aug 6; 7 (15)

scientific article published on 01 November 2020

Establishment of Novel Gastric Cancer Patient-Derived Xenografts and Cell Lines: Pathological Comparison between Primary Tumor, Patient-Derived, and Cell-Line Derived Xenografts ⬇️

scientific article published on 14 June 2019

Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma

Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population

scientific article published on 22 February 2013

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

scientific article

Extra-perigastric Extranodal Metastasis is a Significant Prognostic Factor in Node-Positive Gastric Cancer

scientific article published on 01 October 2019

Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma

scientific article

Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.

scientific article published in June 2018

Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma

scientific article

Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts

scientific article published on August 2010

Gene copy number gain of EGFR is a poor prognostic biomarker in gastric cancer: evaluation of 855 patients with bright-field dual in situ hybridization (DISH) method

scientific article published on 9 December 2014

Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells

scientific article published on 21 May 2019

HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer

scientific article published on 01 August 2019

High Mobility Group Box1 (HMGB1) released from cancer cells induces the expression of pro-inflammatory cytokines in peritoneal fibroblasts

scientific article

Human epidermal growth factor receptor 2-, epidermal growth factor receptor-, and mesenchymal epithelial transition factor-positive sites of gastric cancer using surgical samples

scientific article published on 27 June 2018

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

scientific article

Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma

scientific article published on 28 July 2013

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia

scientific article published on 5 October 2017

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

scientific article published on 12 February 2018

Impact of DNA integrity on the success rate of tissue-based next-generation sequencing: Lessons from nationwide cancer genome screening project SCRUM-Japan GI-SCREEN

scientific article published on 08 October 2020

Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner: implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells

scientific article

Interpretation of HER2 tests in gastric cancer: confirmation of interobserver differences and validation of a QA/QC educational program

scientific article published on 15 March 2014

Interstitial growth as an aggressive growth pattern in primary lung cancer

scientific article

Intramucosal-lymphatic invasion has a slight impact on lymph node metastasis in patients with early gastric cancer

scientific article published on 18 November 2019

Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection

scientific article

Lenvatinib plus pembrolizumab in patients with advanced gastric cancer in the first-line or second-line setting (EPOC1706): an open-label, single-arm, phase 2 trial

scientific article published on 23 June 2020

Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma

scientific article published on 28 October 2018

Long-term oncological outcomes of laparoscopic versus open transhiatal resection for patients with Siewert type II adenocarcinoma of the esophagogastric junction

scientific article published on 05 February 2020

Machine learning-based histological classification that predicts recurrence of peripheral lung squamous cell carcinoma

scientific article published on 18 July 2020

Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung

scientific article published on 27 July 2016

Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis

scientific article published on 23 April 2012

Multicenter phase 1/2 Trial of napabucasin and pembrolizumab in patients with metastatic colorectal cancer (EPOC1503/SCOOP Trial)

scientific article published on 21 July 2020

Neural Invasion Spreads Macrophage-Related Allodynia via Neural Root in Pancreatic Cancer

scientific article published on 21 March 2018

PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma ⬇️

scientific article published on November 21, 2012

Pathological evaluation and grading for neoadjuvant therapy

scientific article published on 01 September 2012

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

scientific article published on 2 May 2017

Pin1 acts as a modulator of cell proliferation through alteration in NF‐κB but not β‐catenin/TCF4 signalling in a subset of endometrial carcinoma cells ⬇️

scientific article published on 01 December 2010

Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma

scientific article published on 20 February 2015

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma

scientific article published on 6 March 2018

Posttherapy topographical nodal status, ypN-site, predicts survival of patients who received neoadjuvant chemotherapy followed by curative surgical resection for non-type 4 locally advanced gastric cancer: supplementary analysis of JCOG1004-A

scientific article published on 22 June 2020

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer

scientific article published on 09 January 2019

Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients

scientific article published on 15 February 2015

Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung

scientific article published on 01 September 2019

Regorafenib Plus Nivolumab in Patients With Advanced Gastric or Colorectal Cancer: An Open-Label, Dose-Escalation, and Dose-Expansion Phase Ib Trial (REGONIVO, EPOC1603)

scientific article published on 28 April 2020

Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug

scientific article published on 23 April 2009

Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients

scientific article

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas ⬇️

scientific article published on January 9, 2012

Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma

scientific article published in October 2010

Surgical Specimens of Colorectal Cancer Fixed with PAXgene Tissue System Preserve High-Quality RNA.

scientific article published in October 2015

TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

scientific article

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 T cells in the tumor microenvironment

scholarly article by Yasuko Tada et al published 11 October 2018 in Journal for Immunotherapy of Cancer

Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment

scientific article

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced non-colorectal (Non-CRC) gastrointestinal cancer

The Nationwide Cancer Genome Screening Projects for Gastrointestinal Cancer in Japan (SCRUM-Japan GI-SCREEN): Efficient identification of actionable cancer genome alterations in advanced colorectal and non-colorectal gastrointestinal cancer (GI Scree

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

scientific article published on 31 August 2020

The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung

scientific article published on 22 December 2015

The difference in Ezrin-pAkt signaling axis between lepidic and papillary predominant invasive adenocarcinomas of the lung

scientific article published on 08 April 2016

The impact of molecular subtype on efficacy of chemotherapy and checkpoint inhibition in advanced gastric cancer

scientific article published on 10 March 2020

The nationwide cancer genome screening project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced gastric cancer (GC)

The potential application of PD-1 blockade therapy for early-stage biliary tract cancer

scientific article published on 01 April 2020

The ratio of cancer cells to stroma after induction therapy in the treatment of non-small cell lung cancer

scientific article published on 17 September 2016

The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma

scientific article published on 31 January 2018

The real-world data on microsatellite instability status in various unresectable or metastatic solid tumors

scientific article published on 06 January 2021

The report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan

scientific article published on 08 July 2020

Transcriptional Up-Regulation of Sox9 by NF-κB in Endometrial Carcinoma Cells, Modulating Cell Proliferation Through Alteration in the p14ARF/p53/p21WAF1 Pathway ⬇️

scientific article published on June 12, 2012

Transcriptional regulation of pro-apoptotic Par-4 by NF-kappaB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis

scientific article published in May 2010

Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor κB/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas ⬇️

scientific article published on April 22, 2013

Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells

scientific article published on 16 September 2013

Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis

scientific article published on 16 January 2007

Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity

scientific article published on 7 May 2012

Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma

scientific article published on 31 October 2015

Up-regulation and nuclear localization of beta-catenin in endometrial carcinoma in response to progesterone therapy

scientific article published in January 2003

Upregulation of TCF4 expression as a transcriptional target of beta-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells

scientific article

[Hairy cell leukemia complicated by bone marrow necrosis following cladribine administration]

scientific article published on 01 January 2019

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