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List of works by Jack R Harkema

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice

scientific article published on 16 September 2015

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

scientific article

A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling

scientific article published on 20 September 2005

A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia

scientific article

Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease

scientific article

Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation

scientific article

Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice

scientific article

Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location.

scientific article published on 26 November 2015

Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid

scientific article

Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity

journal article published in 2023

Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice

scientific article published on 22 October 2013

Airborne particulate matter from goat farm increases acute allergic airway responses in mice

scientific article published on 22 June 2020

Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice

scientific article published on 31 March 2004

Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan

scientific article

Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet

scientific article published on 22 August 2013

Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ⬇️

scientific article published on July 11, 2011

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress

scientific article published on 17 January 2008

Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares

scientific article

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha ⬇️

scientific article published on October 9, 2011

Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression

scientific article published on 18 February 2020

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis

scientific article published on 2 September 2011

Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ

scientific article published on 13 October 2020

Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice

scientific article published in April 2003

Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

scientific article

Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.

scientific article published on 23 December 2004

CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure.

scientific article

Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice ⬇️

scientific article published on November 23, 2012

Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan

scientific article published in May 2010

Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome

scientific article published on 29 October 2013

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

scientific article

Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan

scientific article published on January 2007

Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates

scientific article published on 27 January 2009

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice

scientific article published on 07 September 2006

Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice

scientific article published on 27 November 2007

Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats

scientific article published on 01 April 1989

Correction: Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

scientific article published on 6 February 2017

Correction: Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

scientific article published on 24 July 2019

DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS.

scientific article published on 3 October 2003

Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection ⬇️

scientific article published on August 26, 2011

Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection

scientific article published on 7 November 2006

Design-based sampling and quantitation of the respiratory airways

scientific article

Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features

scientific article

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans ⬇️

scientific article (publication date: November 2012)

Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse

article

Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats ⬇️

scientific article published on March 7, 2012

Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies

scientific article published on 6 July 2012

Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus

scientific article published on 13 December 2019

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

scientific article published on 25 August 2016

Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function

scientific article published on 11 July 2018

Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz

scientific article published on 01 June 1991

Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats.

scientific article

Effects of concentrated ambient particles on normal and hypersecretory airways in rats

scientific article

Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine

scientific article

Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations

scientific article

Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology

scientific article published on 21 September 2005

Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium

scientific article published on 01 April 2001

Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice

scientific article published on July 2013

Enhanced allergic airway disease in old mice is associated with a Th17 response

scientific article published on 01 October 2014

Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats

scientific article

Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene

scientific article published on 6 March 2007

Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus.

scientific article

Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan

scientific article

Expression of the Bcl-2 protein in nasal epithelia of F344/N rats during mucous cell metaplasia and remodeling.

scientific article published in June 1998

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

scientific article

Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats

scientific article published on 23 April 2009

Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma

scientific article published on 26 October 2007

HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice

scientific article published on 18 September 2008

Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.

scientific article

Imipramine blocks acute silicosis in a mouse model.

scientific article

Immune responses in the lung and local lymph node of A/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin

scientific article published in July 2003

In vitro culture of microdissected rat nasal airway tissues

scientific article published on June 1999

Influence of total western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice

scientific article published on 15 May 2020

Influx, Persistence, and Recall of Eosinophils and GATA-3+ Innate Lymphoid Cells in the Nasal Mucosa of Mice Exposed and Reexposed to the Gaseous Air Pollutant Ozone

scientific article published on 15 November 2019

Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats

scientific article published on 11 September 2015

Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone: A New Paradigm in Pathogenesis

scientific article published on 19 September 2019

Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.

scientific article published in January 2017

Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans

scientific article

Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium ⬇️

scientific article published on May 6, 2013

Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease

scientific article published on 03 April 2020

Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation.

scientific article

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

scientific article (publication date: 2015)

Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury

scientific article

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

scientific article published on 18 September 2017

Lupus, Silica, and Dietary Omega-3 Fatty Acid Interventions

scientific article published on 14 November 2019

Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

scientific article published on 29 March 2019

Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice

scientific article published on 28 August 2007

Nanotoxicology—A Pathologist’s Perspective ⬇️

scientific article published on December 14, 2010

National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health

scientific article published on 26 September 2016

Neighborhood air pollution and household environmental health as it relates to respiratory health and healthcare utilization among elderly persons with asthma

scientific article published on 27 February 2019

Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

scientific article published on 16 December 2011

Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States

scientific article published in 2021

Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury

scientific article published in April 2010

Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure

scientific article

Neutrophil-dependent and neutrophil-independent alterations in the nasal epithelium of ozone-exposed rats

scientific article published on 01 August 2000

No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function

scientific article

Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

scientific article

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

scientific article published on 09 September 2020

Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report

scientific article published on 01 April 2020

Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure

journal article published in 2021

Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol

scientific article published on 20 July 2007

Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.

scientific article published on 28 May 2003

Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.

scientific article published on 11 November 2015

Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice

scientific article published in March 2016

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands

scientific article published on 18 December 2009

PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions

scientific article

PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio ⬇️

scientific article published on June 1, 2011

Pathogenesis and Persistence of Increased Epithelial Mucosubstances in the Nasal Airways of Rats and Mice Episodically Exposed to Ethylene

scientific article published on 25 September 2020

Personal-level exposure to environmental temperature is a superior predictor of endothelial-dependent vasodilatation than outdoor-ambient level

scientific article

Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat

scientific article published on 01 February 2002

Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit

scientific article published on September 2004

Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum

scientific article

Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution.

scientific article

Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice

scientific article

Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains

scientific article published on 30 November 2020

Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring

scientific article published on 21 August 2020

Rodent models of allergic rhinitis: relevance to human pathophysiology

scientific article published on May 2007

Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice

scientific article published on 28 October 2019

Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation

scientific article

Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain

scientific article

Satratoxin-G from the Black Mold Stachybotrys chartarum Induces Rhinitis and Apoptosis of Olfactory Sensory Neurons in the Nasal Airways of Rhesus Monkeys ⬇️

scientific article published on May 2, 2012

Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation

scientific article published on 01 July 2020

Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats

scientific article published on 01 November 2018

Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations

scientific article published on 2 February 2018

Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse

scientific article

Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

scientific article

Source-to-receptor pathways of anthropogenic PM2.5 in Detroit, Michigan: Comparison of two inhalation exposure studies

Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma

scientific article

Strain Differences in a Murine Model of Air Pollutant-induced Nonatopic Asthma and Rhinitis

scientific article published on 15 November 2016

Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model

scientific article published on March 2016

Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.

scientific article published on 11 December 2013

T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis

scientific article published on 12 August 2006

Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of Delta9-tetrahydrocannabinol

scientific article published on 11 December 2007

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity

scientific article published on 30 March 2005

The Need for a Tighter Particulate-Matter Air-Quality Standard

scientific article published on 10 June 2020

The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential

scientific article (publication date: July 2009)

The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures

scientific article

The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide

scientific article published on 28 May 2003

The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study ⬇️

scientific article published on August 6, 2013

The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin

scientific article

The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium

scientific article

Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques

scientific article

Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice.

scientific article published in April 2007

Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure

scientific article published on 14 March 2008

Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.

scientific article published on 15 July 2004

Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice.

scientific article

Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice

scientific article published on 17 July 2013

Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

scientific article published on 15 December 2021

Two faces of vitamin e in the lung

scientific article published on October 2014

World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice.

scientific article

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