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List of works by Kathryn Z Guyton

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ⬇️

scientific article

A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants

scientific article

A review of the genotoxicity of 1,2-dichloroethane (EDC) ⬇️

scientific article published on January 19, 2011

A systematic approach for identifying and presenting mechanistic evidence in human health assessments

scientific article published on 16 August 2013

Addressing human variability in next-generation human health risk assessments of environmental chemicals

scientific article

Adverse effects in risk assessment: modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans

scientific article

Approaches to human health risk assessment based on the signal-to-noise crossover dose

scientific article published in July 2012

Carcinogenicity of drinking coffee, mate, and very hot beverages

scientific article

Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes

journal article published in 2014

Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate

scientific article published on 20 March 2015

Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure

scientific article

Classification schemes for carcinogenicity based on hazard identification serve science and society

scientific article published on 16 February 2017

Colorectal adenomas: a prototype for the use of surrogate end points in the development of cancer prevention drugs

scientific article published on June 2004

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

scientific article published on 12 November 2019

DNA repair during in utero development: A review of the current state of knowledge, research needs, and potential application in risk assessment ⬇️

scientific article published on 06 June 2011

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review

scientific article

Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity

scientific article published on January 2009

Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity

scientific article published on January 2009

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity

scientific article published on January 2009

Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment

scientific article published on August 2010

Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity

scientific article published on January 2009

Human health effects of tetrachloroethylene: key findings and scientific issues

scientific article

Human health effects of trichloroethylene: key findings and scientific issues

scientific article

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

scientific article

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

scientific article

Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making

journal article published in 2008

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

scientific article published on 11 September 2017

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse

scientific article

Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment

scientific article

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data ⬇️

scientific article (publication date: May 2012)

Prevention of liver cancer

scientific article

Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides

scientific article (publication date: December 2016)

Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

scientific article (publication date: 15 April 2005)

Prostate-specific antigen doubling time as a surrogate marker for evaluation of oncologic drugs to treat prostate cancer

scientific article published on June 2004

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments

scientific article

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

scientific article

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

scientific article published on 09 March 2020

The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes

scientific article published on January 2009

The next generation of risk assessment multi-year study - highlights of findings, applications to risk assessment, and future directions

journal article published in 2016

The progress and promise of molecular imaging probes in oncologic drug development

scientific article published in November 2005

Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity

scientific article

Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard

scientific article published on 23 August 2013

Upstream adverse effects in risk assessment: a model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans

scientific article published on 7 July 2012

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

scientific article

Vitamin D and vitamin D analogs as cancer chemopreventive agents

scientific article

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