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List of works by Luc Willems

A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat ⬇️

scientific article published on February 1, 1992

A life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds

article

A map of binary SARS-CoV-2 protein interactions implicates host immune regulation and ubiquitination

scientific article

A recombinant attenuated candidate vaccine that efficiently and persistently protects against bovine leukemia virus in herds.

scientific article published on 7 January 2014

APOBEC3 Interference during Replication of Viral Genomes

scientific article

Ablation of non-coding RNAs affects bovine leukemia virus B lymphocyte proliferation and abrogates oncogenesis

scientific article published on 14 May 2020

Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model ⬇️

scientific article published on July 23, 2013

An efficient vaccine against bovine leukemia virus.

scientific article published on 28 August 2015

BLV: lessons on vaccine development

scientific article published on 07 October 2019

Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo

scientific article (publication date: April 2016)

Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo

scientific article

Bovine leukemia virus becomes established in dairy herds before the first lactation.

scientific article published on 30 July 2016

Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B

scientific article published on 24 October 2019

Cell dynamics and immune response to BLV infection: a unifying model

scientific article published on January 2007

Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

scientific article

Conservative Mutations in the Immunosuppressive Region of the Bovine Leukemia Virus Transmembrane Protein Affect Fusion but Not Infectivity in Vivo ⬇️

scientific article published on May 22, 1998

Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis

scientific article

Earlier onset of delta-retrovirus-induced leukemia after splenectomy

scientific article

Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5'-LTR and Tax Gene on Viral Transcriptional Activity

scientific article published on 13 October 2020

Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease

scientific article published on 16 April 2008

Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep

scientific article

Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy

scientific article

Fusogenic segments of bovine leukemia virus and simian immunodeficiency virus are interchangeable and mediate fusion by means of oblique insertion in the lipid bilayer of their target cells ⬇️

scientific article published on May 1, 1992

Gene activation therapy: from the BLV model to HAM/TSP patients

scientific article published on June 2009

HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells

scientific article published on 26 April 2022

How HTLV-1 may subvert miRNAs for persistence and transformation

scientific article published on 12 November 2008

How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells ⬇️

scientific article published on January 5, 2012

Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling

scientific article published on 21 September 2006

In Vitro and In Vivo Oncogenic Potential of Bovine Leukemia Virus G4 Protein ⬇️

scientific article published on March 1, 1998

Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep

scientific article

Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism

scientific article published on 19 September 2019

Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program

scientific article published on 04 November 2011

Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program.

scientific article

Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression

scientific journal article

Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus

scientific article

Lack of mutation in the gene during bovine leukemia virus-induced leukemogenesis ⬇️

scientific article published on November 1, 1997

Lymphocyte kinetics: the interpretation of labelling data

scientific article

Massive depletion of BLV proviral clones located in genomic transcriptionally active sites during primary infection.

scientific article published on 7 January 2014

Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection

scientific article

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

scientific article

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

scientific article

Mutation of a Single Envelope N-Linked Glycosylation Site Enhances the Pathogenicity of Bovine Leukemia Virus

scientific article published on 17 June 2015

Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential ⬇️

scientific article published on May 1, 1992

Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells

scientific article published on 08 September 2020

ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms

scientific article published on 11 May 2020

Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase

scientific article

Overlapping CRE and E box motifs in the enhancer sequences of the bovine leukemia virus 5' long terminal repeat are critical for basal and acetylation-dependent transcriptional activity of the viral promoter: implications for viral latency

scientific article published on December 2004

Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep

scientific article

Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation ⬇️

scientific article published on April 30, 1998

Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV.

scientific article

Quantification of Cell Turnover in the Bovine Leukemia Virus Model

scientific article published on January 2017

Rates of CTL killing in persistent viral infection in vivo

scientific article

Recent Advances in BLV Research

scientific article

Reduced cell turnover in bovine leukemia virus-infected, persistently lymphocytotic cattle

scientific article

Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1.

scientific article

Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads

scientific article

Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants

scientific article

Reducing the global burden of HTLV-1 infection: An agenda for research and action

scientific article

Role of glycosylation in bovine leukemia virus infection

scientific article published on 6 June 2011

Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep

scientific article

Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B

scientific article

Subcellular localization of the bovine leukemia virus R3 and G4 accessory proteins

scientific article

Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1

scientific article

The HTLV-1 Tax interactome

scientific article published on 14 August 2008

The bovine leukemia virus microRNAs permit escape from innate immune response and contribute to viral replication in the natural host.

scientific article published on 28 August 2015

The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity.

scientific article published on 21 June 2005

VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study

scientific article

Vaccination against δ-retroviruses: the bovine leukemia virus paradigm

scientific article (publication date: 20 June 2014)

Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo

scientific article

Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models

scientific article

Viral expression directs the fate of B cells in BLV-infected sheep

scientific article

Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep

scientific article published on 26 October 2011

Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA

scientific article

bta-miR-23a Regulates the Myogenic Differentiation of Fetal Bovine Skeletal Muscle-Derived Progenitor Cells by Targeting MDFIC Gene

scientific article published on 20 October 2020

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