List of works by Koen J Dechering

A NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages

scientific article published on 16 April 2019

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

scientific article published on 3 May 2013

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A new P. falciparum gametocyte drug screening assay based on pLDH detection.

scientific article published on 15 October 2012

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

scientific article published on 5 September 2017

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase

scientific article

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

scientific article published on 21 December 2015

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds

scientific article published on 10 November 2015

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

scientific article published on 09 September 2016

Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate--Tackling the Cocktail Challenge

scientific article published on 6 July 2015

Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail

scientific article published on 17 May 2016

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and a

scholarly article by Alessandra Vallone et al published 25 April 2018 in European Journal of Medicinal Chemistry

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

scientific article published on 01 September 2019

Bioassay development

article

Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway

scientific article

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development

scientific article published on December 2002

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

DNA methylation restricts spontaneous multi-lineage differentiation of mesenchymal progenitor cells, but is stable during growth factor-induced terminal differentiation

scientific article published on 28 January 2011

Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization

scientific article

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells

scientific article

Epigenetics: DNA demethylation promotes skeletal myotube maturation.

scientific article

Functional antibodies against sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso

scientific article published on 01 January 2018

Gene array analysis of bone morphogenetic protein type I receptor-induced osteoblast differentiation.

scientific article published in July 2003

High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells

scientific article

Identification of novel bacterial M.SssI DNA methyltransferase inhibitors.

scientific article published on 25 October 2012

Identification of novel regulators associated with early-phase osteoblast differentiation

scientific article

MicroRNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells

scientific article published on 27 January 2014

Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation

scientific article published on 13 June 2006

Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts

scientific article published on 7 April 2005

Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission

scientific article published on 15 December 2017

Novel pantothenate derivatives for anti-malarial chemotherapy

scientific article

Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis

scientific article published on 24 October 2009

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

scientific article published on 20 April 2022

Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1

scientific article published on 26 March 2013

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity

scientific article published on 8 June 2015

Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators

scientific article

TSLP is differentially regulated by vitamin D3 and cytokines in human skin

scientific article

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells

scientific article published in July 2010

The role of collagen crosslinking in differentiation of human mesenchymal stem cells and MC3T3-E1 cells

scientific article

The transcriptome's drugable frequenters

scientific article

X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11 -Substituted Steroids

scientific article

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