List of works by Andrew B Ward

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

scientific article

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

scientific article

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

scientific article

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

scientific article published on July 2016

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

scientific article published on 01 May 2019

A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

scientific article published on 01 November 2020

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

scientific article published on 15 July 2020

A common solution to group 2 influenza virus neutralization

scientific article

A cross-neutralizing antibody between HIV-1 and influenza virus

scientific article published on 22 March 2021

A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris

scientific article

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

scientific article published on 31 October 2019

A helical processing pipeline for EM structure determination of membrane proteins

scientific article published on 20 September 2011

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.

scientific article published on 10 July 2018

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

scientific article

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

scientific article published on 21 September 2020

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

scientific article published on 04 December 2020

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

scientific article

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

scientific article

A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union

scientific article

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

scientific article published on 13 July 2020

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

scientific article published on December 2015

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

scientific article published on 29 September 2020

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

scientific article

An MPER antibody neutralizes HIV-1 using germline features shared among donors

scientific article published on 26 November 2019

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

scientific article published on 27 July 2020

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

scientific article published on 04 February 2020

Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface

scientific article published on 04 August 2020

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.

scientific article published on May 2017

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

scientific article

Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

scientific article

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site

scientific article

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

scientific article published on 4 May 2016

Antibody responses to viral infections: a structural perspective across three different enveloped viruses

scientific article published on 18 March 2019

Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics

scientific article published on 11 July 2019

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

scientific article published on 20 February 2013

Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 01 May 2020

Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

scientific article published on 17 March 2020

Biochemistry. Integrative structural biology

scientific article published on February 2013

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

scientific article

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

scientific article

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

scientific article published on 24 April 2014

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.

scientific article

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

scientific article published on 23 December 2021

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

scientific article published in Nature Communications

Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin

scientific article

Characterization of a stable HIV-1 B/C recombinant, soluble and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes

scientific article

Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens

scientific article

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

scientific article published on 21 October 2013

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies.

scientific article

Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

scientific article published on 16 April 2015

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

article

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.

scientific article published in June 2018

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

scientific article

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.

scientific article

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

scientific article published on 01 June 2019

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

scientific article published on April 2017

Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.

scientific article published on 9 October 2015

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

scientific article published on 20 January 2016

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

scientific article published on 03 August 2020

Cross-neutralization of influenza A viruses mediated by a single antibody loop

scientific article

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

scientific article published on 23 September 2020

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

scientific article

Cryo-EM structure of circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

scientific article published on 10 October 2018

Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

scientific article

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Deception through Mimicry: A Cellular Antiviral Strategy

scientific article published on 01 December 2018

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

scientific article

Designing Facial Amphiphiles for the Stabilization of Integral Membrane Proteins

scientific article published on 01 January 2007

Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

scientific article published on 15 February 2019

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

scientific article published on 02 July 2019

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers

scientific article published on 28 February 2017

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

scientific article

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

scientific article published in Nature Communications

Discoveries in structure and physiology of mechanically activated ion channels

scientific article published on 25 November 2020

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

scientific article published on 27 December 2019

Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells

scientific article published on 25 July 2020

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

scientific article published on 7 August 2017

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.

scientific article

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

article

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

scientific article published on October 2017

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

scientific article published on 28 January 2018

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

scientific article

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

scientific article published on 07 April 2021

Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 17 February 2020

Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.

scientific article

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

scientific article published on 19 September 2019

Envelope proteins of two HIV-1 clades induced different epitope-specific antibody response

scientific article published on 8 February 2018

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

scientific article published on 23 February 2018

Evolving spike-protein -glycosylation in SARS-CoV-2 variants

scientific article published on 18 December 2023

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

article

Flexibility in the ABC transporter MsbA: Alternating access with a twist

scientific article

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties

article

From structure to sequence: Antibody discovery using cryoEM

scientific article published on 19 January 2022

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

scientific article

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

scientific article

Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses.

scientific article published in April 2018

HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

scientific article published in November 2017

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

scientific article published on 07 September 2016

HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite

scientific article published on 05 June 2020

HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate

scientific article

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

scientific article published on 01 April 2020

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 vaccine design through minimizing envelope metastability

article

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

scientific article published on 16 June 2020

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

scientific article

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

scientific article published on 24 August 2017

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

scientific article published on 6 September 2017

Highly Conserved Protective Epitopes on Influenza B Viruses

scientific article

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

scientific article published on 17 August 2016

Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses

scientific article

Human antibodies that neutralize respiratory droplet transmissible H5N1influenza viruses.

scientific article published in November 2013

Human germinal centres engage memory and naive B cells after influenza vaccination

scientific article published on 31 August 2020

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins.

scientific article published on 7 November 2019

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.

scientific article published on May 2017

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

scientific article published in 2021

Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes

scientific article published on 15 April 2015

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

scientific article published on 14 August 2017

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.

scientific article

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

scientific article

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

scientific article published on 15 May 2017

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

scientific article published on 26 August 2015

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

scientific article published on 03 July 2013

Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice

scientific article published on 19 November 2019

Innovations in structure-based antigen design and immune monitoring for next generation vaccines

scientific article published on 22 April 2020

Insights into the trimeric HIV-1 envelope glycoprotein structure

scientific article

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages

scientific article

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

scientific article published on 18 February 2016

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor

scientific article published on 5 April 2016

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques

scientific article published on 01 September 2020

Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines

scientific article published on 01 March 2020

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

scientific article published on 31 August 2020

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Mechanism of human antibody-mediated neutralization of Marburg virus

scientific article

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy

scientific article published on 15 September 2015

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

scientific article published on 21 August 2018

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

scientific article

Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E

scientific article

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

scientific article published on 12 May 2020

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

scientific article published on 28 February 2020

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

scientific article published on 30 September 2020

Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA

scientific article published on 10 December 2008

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

scientific article published on 01 November 2018

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

scientific article published on 12 July 2017

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

scientific article

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

scientific article published on 17 October 2020

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

scientific article published on 04 February 2019

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

scientific article published on 13 May 2020

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

scientific article published on 15 June 2020

Pre-fusion structure of a human coronavirus spike protein.

scientific article

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

scientific article

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

scientific article published on 28 June 2016

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

scientific article published on 26 June 2015

Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

scientific article published in Scientific Reports

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

scientific article published on 20 November 2020

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

scientific article published on 20 July 2017

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

article

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

scientific article

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.

scientific article published on 28 February 2018

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

scientific article published on 31 March 2018

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies

article

Recognition of influenza H3N2 variant virus by human neutralizing antibodies

scientific article published on July 2016

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

scientific article

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

scientific article

Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens

article

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

scientific article published on 14 July 2020

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

scientific article published on 14 September 2020

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

scientific article published on 12 December 2019

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

scientific article

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

scientific article

Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles

scientific article published on 17 June 2008

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

scientific article published on 15 July 2019

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

scientific article published on 11 May 2021

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 09 May 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 01 January 2020

Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein

scientific article published on 10 March 2017

Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers

article

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

scientific article published on 8 December 2017

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

scientific article published in Scientific Reports

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

scientific article published on 25 April 2014

Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

scientific article

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

scientific article

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

scientific article published on 19 November 2019

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

scientific article published on 16 June 2015

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

scientific article published on 01 September 2019

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

scientific article published on 06 August 2020

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

scientific article published on 20 October 2020

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

scientific article published on 11 August 2020

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

scientific article

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

scientific article published on 14 November 2017

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

scientific article published on 27 May 2020

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

scientific article published on 03 July 2013

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

scientific article published on 11 April 2022

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

scientific article

Structural evolution of glycan recognition by a family of potent HIV antibodies

scientific article

Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen

scientific article published on 24 October 2016

Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

scientific article published on 12 May 2022

Structure and Immune Recognition of the HIV Glycan Shield.

scientific article published on 29 March 2018

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

scientific article

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

scientific article published on 22 December 2020

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

scientific article published on 29 May 2019

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

scientific article published on 09 March 2020

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

scientific article

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.

scientific article

Structure of the Ebola virus nucleoprotein - RNA complex

Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

scientific article published on 16 February 2019

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

scientific article published on 28 May 2019

Structure of the human volume regulated anion channel

scientific article published on 10 August 2018

Structure of the mechanically activated ion channel Piezo1.

scientific article published on 20 December 2017

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

scientific article published on 30 December 2015

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

scientific article published on 21 November 2017

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

scientific article published in 2022

Structures of Ebola virus GP and sGP in complex with therapeutic antibodies

scientific article published on 08 August 2016

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

scientific article

Structures of protective antibodies reveal sites of vulnerability on Ebola virus

scientific article

Structures of the otopetrin proton channels Otop1 and Otop3

scientific article published on 03 June 2019

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

scientific article

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

scientific article published on September 2016

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

scientific article published on 04 August 2020

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

scientific article published on 05 August 2020

The 2017 Keystone Symposium on HIV Vaccines

scientific article published on 8 August 2017

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

article

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization

article

The HIV-1 envelope glycoprotein structure: nailing down a moving target

scientific article published on January 2017

The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans

scientific article published on 17 April 2017

The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux

scientific article

Time-course, negative-stain electron microscopy-based analysis for investigating protein-protein interactions at the single-molecule level

scientific article published on 29 September 2017

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.

scientific article published on 28 June 2016

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

scientific article

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

scientific article

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

scientific article published on 12 November 2019

Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates

scientific article published in 2024

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

scholarly article by Matthias G Pauthner et al published 15 January 2019 in Immunity

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

scientific article

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

Visualization of the HIV-1 Env Glycan Shield Across Scales

scientific article published on 12 November 2019

Visualization of the HIV-1 Env glycan shield across scales

scientific article published on 22 October 2020

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

scientific article (preprint)

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

scientific article published on 27 May 2020

Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties

scientific article published on 8 January 2015

Windex: a toolset for indexing helices

scientific article

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate

scientific article

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