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List of works by Nigel W Bunnett

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

scientific article published on 28 January 2021

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

scientific article published on 04 November 2019

Actions of somatostatins on gastric smooth muscle cells

scientific article published on March 1, 1992

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

scientific article published on December 28, 2012

Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells

scientific article published on October 1, 1994

Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons

scientific article published on November 23, 2001

Antibodies to the rat substance P receptor: production and characterization

scientific article published on December 1, 1992

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

scientific article published on 16 September 2019

Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B 2 receptor subtype

scientific article published on May 1, 1998

Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase

scientific article published on May 1, 1991

Cellular sites of expression of the neurokinin‐1 receptor in the rat gastrointestinal tract

scientific article published on August 7, 1995

Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, Gαq/11, G-Protein Receptor Kinase-2/3, and β-Arrestin-1/2

scientific article published on August 1, 1998

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation

scientific article published on September 13, 1994

Effects of cholecystokinin and gastrin antagonists on pancreatic exocrine secretion stimulated by gastrin-releasing peptide

scientific article published on January 1, 1992

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

scientific article published on 16 June 2020

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

scientific article published on 30 October 2017

Endothelin-Converting Enzyme-1 Actions Determine Differential Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 at High Agonist Concentrations

scientific article published on February 9, 2012

Expression and Function of Proteinase-activated Receptor 2 in Human Bronchial Smooth Muscle

scientific article published on October 1, 2001

G Protein-Coupled Receptor Signaling: Implications for the Digestive System

scientific article published on July 1, 1997

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

scientific article

Immunochemical localization of aminopeptidase M in the alimentary tract of the guinea pig and rat

scientific article published on June 1, 1992

Inflammation-associated changes in DOR expression and function in the mouse colon

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

scientific article published on 2 July 2015

Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells

scientific article published on September 1, 1991

Interactions of the Skin and Nervous System

scientific article published on August 1, 1997

Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanisms in rats

scientific article published on January 1, 1992

Isolation of a neuropeptide-degrading carboxypeptidase from the human stomach

scientific article published on January 1, 1992

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon.

scientific article

Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice

scientific article published on May 27, 2011

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2

scientific article published on August 5, 1997

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2

scientific article published on September 15, 1997

Mechanisms Attenuating Cellular Responses to Neuropeptides: Extracellular Degradation of Ligands and Desensitization of Receptors

scientific article published on August 1, 1997

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

scientific article

Neural and hormonal mechanisms mediate the enterogastric reflex: A study in intestinal transplants in rats

scientific article published on September 1, 1991

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems

scientific article published on 01 April 1998

Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1

scientific article published on March 13, 2012

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

scientific article

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

scientific article published on 3 January 2013

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

Protease-activated receptors: how proteases signal to cells

scientific article published on December 1, 2001

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

scientific article published on 29 May 2019

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases

scientific article published on June 1, 1998

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

scientific article published on 22 April 2015

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

scientific article published on 03 February 2022

Selective release of somatostatin by calcitonin gene-related peptide and influence on pancreatic secretion

scientific article published on June 30, 1992

Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2

scientific article published on August 20, 2013

Serine proteases mediate inflammatory pain in acute pancreatitis

scientific article published on March 24, 2011

Somatostatin inhibits pancreatic exocrine secretion via a neural mechanism

scientific article published on September 1, 1990

Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats

scientific article published on October 15, 2003

Substance P Regulates Th1-Type Colitis in IL-10 Knockout Mice

scientific article published on October 1, 2003

Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors

scientific article published on October 1, 1993

Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system

scientific article published on 03 December 2020

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

scientific article published on January 2015

The Isolation and Sequence Analysis of Vasoactive Intestinal Peptide from a Ganglioneuroblastoma*

scientific article published on 01 December 1984

The control of microvascular permeability and blood pressure by neutral endopeptidase

scientific article published on August 1, 1997

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

scientific article published on 27 April 2020

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

scientific article

Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors

scientific article published on September 1, 1997