Search filters

List of works by Thomas Tuschl

A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways

scientific article published on December 2008

A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity ⬇️

scientific article published on April 27, 2012

A census of human RNA-binding proteins

A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells ⬇️

scientific article published on May 26, 2013

A genome-wide view of the expression and processing patterns of Thermus thermophilus HB8 CRISPR RNAs

scientific article published on 21 February 2012

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

A novel class of small RNAs bind to MILI protein in mouse testes

scientific journal article

A pancreatic islet-specific microRNA regulates insulin secretion

scientific article

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.

scientific article

A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation

scientific article

A selective microRNA-based strategy inhibits restenosis while preserving endothelial function

scientific article

A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements

scientific article

A uniform system for microRNA annotation

scientific article

AUF1 promotes let-7b loading on Argonaute 2.

scientific article

Absolute quantification of microRNAs by using a universal reference

scientific article published on 27 October 2009

Activity of hammerhead ribozymes containing non-nucleotidic linkers

scientific article published on December 1993

An Image-Based Biosensor Assay Strategy to Screen for Modulators of the microRNA 21 Biogenesis Pathway ⬇️

scientific article published on August 1, 2012

Analysis of gene function in somatic mammalian cells using small interfering RNAs

scientific article (publication date: February 2002)

Analysis of the miRNA targetome in EBV-infected B cells

scientific article published on 19 April 2012

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development

scientific article

Barcoded cDNA Libraries for miRNA Profiling by Next-Generation Sequencing

Barcoded cDNA library preparation for small RNA profiling by next-generation sequencing

scientific article

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

scientific article

Biochemical isolation of Argonaute protein complexes by Ago-APP

scientific article

Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing

scientific article

Cell and Microvesicle Urine microRNA Deep Sequencing Profiles from Healthy Individuals: Observations with Potential Impact on Biomarker Studies

scientific article published on 19 January 2016

Cellular cofactors affecting hepatitis C virus infection and replication

scientific article

Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

scientific article

Characterizing Expression and Processing of Precursor and Mature Human tRNAs by Hydro-tRNAseq and PAR-CLIP.

scientific article published in August 2017

Clustering and conservation patterns of human microRNAs

scientific article

Co-repressor CBFA2T2 regulates pluripotency and germline development

scientific journal article

Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells

scientific article

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

scientific article

Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations ⬇️

scientific article published on February 25, 2013

Correction: Human MicroRNA Targets

scientific article

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

scientific article

Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense

scientific article (publication date: December 2006)

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

scientific article

DGCR8-dependent microRNA biogenesis is essential for skin development

scholarly article

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs

scientific article published on 15 March 2017

Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis

scientific article

Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma

scientific article published on 28 August 2016

Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions

scientific article

Design of hammerhead ribozymes for the inhibition of gene expression ex vivo by exogenous application.

scientific article published in January 1993

Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo

scientific article published on February 2010

Discovery and Characterization of piRNAs in the Human Fetal Ovary

scientific article published on 14 October 2015

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

scientific article (publication date: 24 May 2001)

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

scientific article

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages

scientific article

Efficient differentiation of steroidogenic and germ-like cells from epigenetically-related iPSCs derived from ovarian granulosa cells

scientific article

Efficient solid-phase synthesis of pppRNA by using product-specific labeling

scientific article

Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype

scientific article

Empirical insights into the stochasticity of small RNA sequencing

scientific article published on 7 April 2016

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

scientific article

Eukaryote-specific insertion elements control human ARGONAUTE slicer activity

scientific article

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease

scientific article

FMRP targets distinct mRNA sequence elements to regulate protein expression

scientific journal article

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

scientific article

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate ⬇️

scientific article published on December 3, 2001

Genome-wide annotation and analysis of zebra finch microRNA repertoire reveal sex-biased expression

scientific article (publication date: 26 December 2012)

Genome-wide identification of miRNA targets by PAR-CLIP.

scientific article published on 19 August 2012

Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response

scientific article

Global target mRNA specification and regulation by the RNA-binding protein ZFP36.

scientific article

Hammerhead ribozymes: importance of stem-loop II for activity

scientific article

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

scientific article

Human MicroRNA targets

scientific article

Identification and characterization of small RNAs involved in RNA silencing

scientific article published on 18 August 2005

Identification of Novel Genes Coding for Small Expressed RNAs ⬇️

scientific article (publication date: 26 October 2001)

Identification of RNA-protein interaction networks using PAR-CLIP

scientific article

Identification of clustered microRNAs using an ab initio prediction method

scientific article

Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets

scientific article

Identification of essential genes in cultured mammalian cells using small interfering RNAs.

scientific article published on December 2001

Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition

scientific article published on 12 March 2013

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing

scientific article

Identification of novel argonaute-associated proteins

scientific article

Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets

scientific article

Identification of tissue-specific microRNAs from mouse

scientific article (publication date: 30 April 2002)

Identification of virus-encoded microRNAs

scientific article

Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity

scientific article

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

scientific article

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

scientific article published on 30 June 2011

Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism

scientific article published on 08 January 2014

Learning the language of post-transcriptional gene regulation

scientific article

Mammalian miRNA curation through next-generation sequencing

scientific article

Mechanisms of gene silencing by double-stranded RNA

scientific article

MicroRNA Sequence Profiles of Human Kidney Allografts With or Without Tubulointerstitial Fibrosis ⬇️

scientific article published on December 15, 2012

MicroRNA sequence and expression analysis in breast tumors by deep sequencing

scientific article

MicroRNA targets in Drosophila

scientific article

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase

scientific article

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

scientific journal article

MicroRNA-21 in glomerular injury

scientific article

MicroRNA-24 regulates vascularity after myocardial infarction

scientific article published on 25 July 2011

MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas

scientific article published on July 2008

MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC.

scientific article

MicroRNAs in Human Cancer ⬇️

scientific article published on January 1, 2013

MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood

scientific article

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

scientific article published on 31 October 2008

Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin

scientific article published on 02 October 2008

Multi-disciplinary methods to define RNA–protein interactions and regulatory networks ⬇️

scientific article published on February 28, 2013

Multicolor microRNA FISH effectively differentiates tumor types

scientific article

Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex

scientific article

Multiplexed miRNA fluorescence in situ hybridization for formalin-fixed paraffin-embedded tissues

scientific article

New insights in the mechanism of microRNA-mediated target repression

scientific article published on 4 November 2011

New microRNAs from mouse and human

scientific article

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors

scientific article published on 2 September 2013

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

scientific article

Oligonucleotide duplexes containing 2'-amino-2'-deoxycytidines: thermal stability and chemical reactivity

scientific article published on January 1994

On the art of identifying effective and specific siRNAs

scientific article published on September 2006

Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins

scientific article

PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins

scientific article

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

scientific article

PAR-CLIP for Discovering Target Sites of RNA-Binding Proteins

scientific article published in January 2018

PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins

scientific article

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin

scientific article published on 12 January 2018

Probing RNA tertiary structure: interhelical crosslinking of the hammerhead ribozyme

scientific article published on August 1995

Quantitative mass spectrometry and PAR-CLIP to identify RNA-protein interactions

scientific article

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

RISC is a 5' phosphomonoester-producing RNA endonuclease

scientific article

RNA cleavage by small catalytic RNAs ⬇️

scientific article published on June 1, 1995

RNA interference and small interfering RNAs

scientific article

RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells

scientific article published in July 2004

RNA interference is mediated by 21- and 22-nucleotide RNAs

scientific article (publication date: 15 January 2001)

RNA sets the standard

scientific article published in Nature

RNA targets of wild-type and mutant FET family proteins

scientific article published on 13 November 2011

RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries

scientific article

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

scientific article (publication date: 31 March 2000)

Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway® recombination cloning technology and Flp-In T-REx® lines

scientific article published on January 2013

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline

scientific article

Reprogramming of the microRNA transcriptome mediates resistance to rapamycin

scientific article published on 8 January 2013

Selection invitro of novel ribozymes from a partially randomized U2 and U6 snRNA library ⬇️

scientific article published on May 1, 1998

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

scientific article published on April 2003

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

scientific article

Silencing of microRNAs in vivo with 'antagomirs'

scientific article (publication date: December 2005)

Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF.

scientific article published on 21 September 2016

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

scientific article (publication date: 6 September 2002)

Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma

scientific article

Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy

scientific article published on June 2002

Specific RNAi mediated gene knockdown in zebrafish cell lines

scientific article published on 19 July 2005

Specificity, duplex degradation and subcellular localization of antagomirs

scientific article published on 16 April 2007

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

scientific article

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

scientific article

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

scientific article

Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS

scientific article

Structural biology of RNA silencing and its functional implications

scientific article

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

scientific article

Structure of the guide-strand-containing argonaute silencing complex

scientific article

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

scientific article

Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites

scientific article

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes

scientific article published on September 2017

Targeted mRNA degradation by double-stranded RNA in vitro

scientific article

The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

scientific article published on October 2017

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

scientific article published on 7 July 2017

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

scientific article

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

scientific article published on 26 September 2016

The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

scientific article published on 26 January 2018

The developmental miRNA profiles of zebrafish as determined by small RNA cloning

scientific article

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members

scientific article published on 20 February 2008

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome

scientific article

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

scientific article

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

scientific article published on 20 July 2009

The small RNA profile during Drosophila melanogaster development

scientific article (publication date: August 2003)

The viral and cellular microRNA targetome in lymphoblastoid cell lines

scientific article published in January 2012

Transcriptome-Wide Identification of Protein Binding Sites on RNA by PAR-CLIP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)

scientific article

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

scientific article

Unique microRNAs appear at different times during the course of a delayed-type hypersensitivity reaction in human skin

scientific article

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline

scientific article published on 29 January 2014

Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter

scientific article

Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines

scientific article

miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

scientific article

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

scientific article

miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

scientific article published on 11 January 2009

miRNAs in human cancer

scientific article

microRNAs are biomarkers of oncogenic human papillomavirus infections

scientific article published on 03 March 2014

siRNA Selection Server: an automated siRNA oligonucleotide prediction server

scientific article published on July 2004

siRNAs: applications in functional genomics and potential as therapeutics

scientific article

Paulina is supported by:

About Paulina

Help