List of works - Randy L Johnson

A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.

scientific article published on 22 November 2017

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

scientific article

ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients.

scientific article published on 28 October 2013

AMPK modulates Hippo pathway activity to regulate energy homeostasis

scientific article

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

scientific article

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

scientific article published on 19 March 2016

Bile acids activate YAP to promote liver carcinogenesis

scientific article

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

scientific article

Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

scientific article published in 2022

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin

scientific article

Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells

scientific article

Functional genetic analysis of mouse chromosome 11

scientific article (publication date: 4 September 2003)

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

scientific article published on 21 December 2017

Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors

scientific article

Hesr, a mediator of the Notch signaling, functions in heart and vessel development

scientific article

Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.

scientific article published on November 2011

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity

scientific article published on 26 November 2018

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

scientific article published on 6 June 2014

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration

scientific article

Hippo signaling impedes adult heart regeneration.

scientific article published on December 2013

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

scientific journal article

Hippo signaling: growth control and beyond

scientific article

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

scientific article published on 26 March 2019

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma

scientific article published on 12 October 2015

Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer

scientific article published on 06 August 2018

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

scientific article published on 17 August 2016

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

scientific article published on 02 April 2020

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice ⬇️

scientific article published on May 1, 2011

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

scientific article published on May 28, 2013

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer

scientific article

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

scientific article

Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

scientific article published on 06 June 2019

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

scientific article

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

scientific article published in February 2018

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

scientific journal article

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning

scientific journal article

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

scientific article published on 16 March 2020

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

scientific article

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

scientific article published on 25 October 2018

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

scientific article published in Journal of Biological Chemistry

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

scientific article

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

scientific article

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

scientific article

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma.

scientific article published on 11 August 2017

Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning.

scientific article published on April 2010

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

scientific article published on 01 December 2019

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

scientific article

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

scientific article published on 27 April 2020

YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer

scientific article published on 18 December 2018

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

scientific article published on 01 November 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

scientific article

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

scientific article published on 21 September 2015

List of works by Randy L Johnson

A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients.

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

Bile acids activate YAP to promote liver carcinogenesis

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin

Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells

Functional genetic analysis of mouse chromosome 11

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors

Hesr, a mediator of the Notch signaling, functions in heart and vessel development

Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration

Hippo signaling impedes adult heart regeneration.

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Hippo signaling: growth control and beyond

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma

Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice ⬇️

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma.

Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning.

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma