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List of works by Mariapia A Degli-Esposti

"Natural Regulators": NK Cells as Modulators of T Cell Immunity

scientific article

A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic cells but delays CD8+ T cell activation and impairs viral clearance.

scientific article published on 08 May 2013

A contribution of mouse dendritic cell-derived IL-2 for NK cell activation

scientific article

A natural genetic variant of granzyme B confers lethality to a common viral infection

scientific article (publication date: December 2014)

A new polymorphic and multicopy MHC gene family related to nonmammalian class I

scientific journal article

A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells

scientific article

A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment.

scientific article published on 11 December 2017

ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome

scientific article published on 22 May 2020

Activation of NK cell cytotoxicity

scientific article

Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells

scientific article

Activation of the lymphotoxin beta receptor by cross-linking induces chemokine production and growth arrest in A375 melanoma cells

scientific article published on 01 February 1997

Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice

scientific article

Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo

scientific article published on 4 February 2011

An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes

scientific article published on January 1, 1992

Ancestral haplotypes carry haplotypic and haplospecific polymorphisms of BAT1: possible relevance to autoimmune disease

scientific article published on 01 June 1992

Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM

scientific article published on January 1, 1992

Ancestral haplotypes: conserved population MHC haplotypes

scientific article published on 01 August 1992

Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family

scientific article published on 01 December 1996

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. ⬇️

scientific article

CIS is a potent checkpoint in NK cell-mediated tumor immunity

scientific article

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

scientific article published on 16 March 2012

Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.

scientific article published on 26 October 2010

Cell-based therapies for ocular inflammation.

scientific article published on 29 March 2013

Characterization of 4AOHW cell line panel including new data for the 10IHW panel.

scientific article published on September 1993

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

scientific article

Close encounters of different kinds: dendritic cells and NK cells take centre stage

scientific article

CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus

scientific article published on 14 May 2013

Cross-talk between dendritic cells and natural killer cells in viral infection

scientific article

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

scientific article

Cytomegalovirus MHC class I homologues and natural killer cells: an overview

scientific article

Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye.

scientific article published on 31 May 2018

Cytomegalovirus evasion of natural killer cell responses

scientific article

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

scientific article published on 26 June 2015

Differences in gene copy number carried by different MHC ancestral haplotypes. Quantitation after physical separation of haplotypes by pulsed field gel electrophoresis.

scientific article

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

scientific article published on 27 May 2020

Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

scientific article

Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD.

scientific article published on 24 January 2018

Function of CMV-encoded MHC class I homologues.

scientific article

Functional analysis of granzyme M and its role in immunity to infection

scientific article published in September 2005

Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN

scientific journal article

Functional interactions between dendritic cells and NK cells during viral infection

scientific article published on 23 December 2002

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.

scientific article published on 07 December 2016

Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial

scientific article published on 25 February 2017

Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial

scientific article published on 29 September 2015

Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis

scientific article

Genetics of diabetes. Studies of MHC haplotypes by pulsed field gel electrophoresis

scientific article published on June 1991

Genomic MHC haplotyping of mutant cell lines using a novel marker.

scientific article published on October 1993

Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells

scientific article published in January 2009

Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells

HLA and Singaporean Chinese myasthenia gravis

scientific article published on 01 January 1993

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

scientific article published on 01 October 2020

High Chlamydia Burden Promotes Tumor Necrosis Factor-Dependent Reactive Arthritis in SKG Mice.

scientific article published on June 2015

IL-2 mediates adjuvant effect of dendritic cells

scientific article published on 01 April 2002

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

scientific article

In vivo imaging of ocular MCMV infection

scientific article published on 13 August 2009

Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

scientific article published on 01 November 2001

Innate immunity defines the capacity of antiviral T cells to limit persistent infection

scientific article

Insights into the mechanisms of CMV-mediated interference with cellular apoptosis

scientific article

Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.

scientific article

Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection.

scientific article

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

Killers and beyond: NK-cell-mediated control of immune responses.

scientific article

Kinetics of ocular and systemic antigen-specific T-cell responses elicited during murine cytomegalovirus retinitis

scientific article published on 17 May 2011

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

scientific article published on 14 July 2015

Ly49C Impairs NK Cell Memory in Mouse Cytomegalovirus Infection.

scientific article published on 27 May 2016

Ly49C-dependent control of MCMV Infection by NK cells is cis-regulated by MHC Class I molecules

scientific article

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

scientific article

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

scientific article published on 18 September 2019

Modulation of innate and adaptive immunity by cytomegaloviruses

scientific article published on 30 October 2019

Murine cytomegalovirus homologues of cellular immunomodulatory genes

scientific article

Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease

scientific article published on 04 March 2020

Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells

scientific article

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation

scientific article

NK cells require IL-28R for optimal in vivo activity

scientific article published on 21 April 2015

NK1.1+ cells and murine cytomegalovirus infection: what happens in situ?

scientific article

NKT cells and viral immunity

scientific article published on June 2004

Natural killer cells in viral infection: more than just killers.

scientific article published on December 2006

Neuromuscular function and polymorphism of the acetylcholine receptor gamma gene

scientific article published on 01 May 1992

New major histocompatibility complex genes

scientific article published on 01 September 1993

Ocular antigen does not cause disease unless presented in the context of inflammation.

scientific article published on 27 October 2017

PCR SSCP reveals haplotype related polymorphism of PERB1: a new marker for MHC beta block typing

scientific article published on 01 December 1994

Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

scientific article published on 01 November 2006

Peripheral natural killer cell maturation depends on the transcription factor Aiolos

scientific article

Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration

scientific article published on 10 November 2016

Polymorphism in the human B144 gene in different MHC haplotypes

scientific article published on June 1, 1992

Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates.

scientific article published on 10 November 2011

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

scientific article published on 01 July 2019

Sequence differences between HLA-B and TNF distinguish different MHC ancestral haplotypes

scientific article published on 01 March 1992

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

scientific article

T cell responses in experimental viral retinitis: mechanisms, peculiarities and implications for gene therapy with viral vectors.

scientific article published on 27 April 2011

TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation

scientific article published on 12 November 2011

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

scientific article published on October 2014

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

scientific article

Targeting of a natural killer cell receptor family by a viral immunoevasin

scientific article

The Avidity Game: Selecting Natural-Born Killers

scientific article published on 01 June 2019

The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s.

scientific article published in March 2018

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

scientific article published on 24 August 2020

The early kinetics of cytomegalovirus-specific CD8+ T-cell responses are not affected by antigen load or the absence of perforin or gamma interferon

scientific article published on 12 March 2008

The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals

scientific article published on 16 December 2013

The interplay between host and viral factors in shaping the outcome of cytomegalovirus infection

scientific article published on 5 December 2006

The murine cytomegalovirus chemokine homolog, m131/129, is a determinant of viral pathogenicity

scientific article

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

scientific article

The roles of interferon-γ and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity

scientific article published on 30 June 2009

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

scientific article published on 27 August 2019

Three-Year Follow-Up of Phase 1 and 2a rAAV.sFLT-1 Subretinal Gene Therapy Trials for Exudative Age-Related Macular Degeneration

scientific article published on 13 March 2019

Typing of 4AOHW cells by allospecific natural killer cells

scientific article published on September 1993

Updated characterization of ancestral haplotypes using the Fourth Asia-Oceania Histocompatibility Workshop panel

scientific article

Virally mediated inhibition of Bax in leukocytes promotes dissemination of murine cytomegalovirus

scientific article published on 24 October 2008

m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection

scientific article

rAAV.sFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector.

scientific article

β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

article

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