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List of works by Yoram Vodovotz

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress

scientific article published on 22 December 2017

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

scientific article published on January 2004

A Biohybrid Device for the Systemic Control of Acute Inflammation

scientific article published on May 2012

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

scientific article published on 25 June 2015

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion

article

A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression

scientific article

A Role for Angiotensin II in the Activation of Extracellular Signal-Regulated Kinases in the Liver During Hemorrhagic Shock ⬇️

scientific article published on October 1, 2003

A Systems Engineering Perspective on Homeostasis and Disease

scientific article published on 9 September 2013

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

scientific article published on 6 November 2018

A mathematical simulation of the inflammatory response to anthrax infection

scientific article published on January 2008

A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury

scientific article

A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration

scientific article published on 17 April 2006

A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation

scientific article published on 3 April 2006

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

scientific article published on 15 December 2020

A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior

scientific article published on 11 October 2008

A three-dimensional mathematical and computational model of necrotizing enterocolitis.

scientific article published on 7 December 2012

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine* ⬇️

scientific article published on April 1, 2012

Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1.

scientific article published in September 2007

Agent-based models in translational systems biology.

scientific article

Agent-based models of inflammation in translational systems biology: A decade later

scientific article published on 01 July 2019

An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients

scientific article published on 01 February 2020

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated with Mortality and Altered TH17 Responses Following Blunt Trauma

scientific article published on 19 September 2017

An agent-based model of inflammation and fibrosis following particulate exposure in the lung ⬇️

scientific article published on March 6, 2011

An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction

scientific article published on 04 May 2008

An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation.

scientific article

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure

scientific article

Association of a Functional Polymorphism in the CHRFAM7A Gene with Inflammatory Response Mediators and Neuropathic Pain after Spinal Cord Injury

scientific article published on 23 May 2019

Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies

scientific journal article

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

scientific article

Automated parameter estimation for biological models using Bayesian statistical model checking

scientific article published on 7 December 2015

Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

scientific article

Biosimulation of acute phonotrauma: An extended model ⬇️

scientific article published on November 1, 2011

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

scientific article

Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice

scientific article

Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap-Mediated Injury in Liver Ischemia Reperfusion

scientific article published on 30 November 2018

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality

scientific article

Computational Modeling of Inflammation and Wound Healing

scientific article

Computational and systems biology in trauma and sepsis: current state and future perspectives ⬇️

scientific article published on January 1, 2012

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

scientific article published on 04 June 2019

Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria

scientific article

Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure

scientific article

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

scientific article published on 01 August 2019

Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock

scientific article

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

scientific article published on 01 May 2019

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma

scientific article published in March 2018

Differential inflammatory networks distinguish responses to bone marrow-derived versus adipose-derived mesenchymal stem cell therapies in vascularized composite allotransplantation.

scientific article published on 27 April 2017

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

scientific article published on 20 November 2019

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients

scientific article

Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators

scientific article published on 25 January 2016

Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage

scientific article published on 20 October 2020

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction

scientific article published on 01 May 2019

Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock

scientific article published in February 2007

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

scientific article

Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma

scientific article published on 03 July 2019

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

scientific article

Equation-Based Models of Dynamic Biological Systems

Equation-based models of dynamic biological systems.

scientific article published on 14 May 2008

Exercise training decreases hepatic injury via changes in immune response to liver ischemia/reperfusion in mice

scientific article published on 14 September 2020

Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress

scientific article published on 15 January 2009

From data patterns to mechanistic models in acute critical illness.

scientific article

Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis

scientific article published on 19 August 2009

Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses

scientific article

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen

scientific article published on 12 April 2019

Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies

scientific article

Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase

scientific article published on 23 April 2010

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.

scientific article

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling

scientific article published on 01 May 2007

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation

scientific article published on 04 November 2005

Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers

scientific article published on 01 July 2019

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions

scientific article published on 01 May 2005

How implementation of systems biology into clinical trials accelerates understanding of diseases.

scientific article

Hybrid Equation/Agent-Based Model of Ischemia-Induced Hyperemia and Pressure Ulcer Formation Predicts Greater Propensity to Ulcerate in Subjects with Spinal Cord Injury ⬇️

scientific article published on May 16, 2013

Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1α in Mouse Hepatocytes ⬇️

scientific article published on August 1, 2011

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies

scientific article published on 25 June 2018

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

scientific article

IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis

scientific article published on 25 November 2020

Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies

scientific article

Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study.

scientific article published on 17 October 2013

Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.

scientific article published in August 2015

In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation.

scientific article

In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice

scientific article

In silico design of clinical trials: a method coming of age.

scientific article published in October 2004

In silico modeling: methods and applications to trauma and sepsis

scientific article

In silico models of acute inflammation in animals.

scientific article published on September 2006

In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

scientific article published on 28 April 2015

In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes

scientific article published on 11 June 2013

Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

scientific article published on 11 July 2016

Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma

scientific article

Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death

scientific article

Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness

scientific article published on 23 August 2018

Inflammatory Mediators Associated With Pressure Ulcer Development in Individuals With Pneumonia After Traumatic Spinal Cord Injury: A Pilot Study

scientific article published on 24 January 2017

Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages

scientific article

Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation

scientific article

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock

scientific article published on January 2009

Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite

scientific article published on 7 July 2005

Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice

scientific article

Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling

scientific article

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury

scientific article published on 01 December 2008

Low levels of mammalian TGF-beta1 are protective against malaria parasite infection, a paradox clarified in the mosquito host

scientific article

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes

scientific article published on 08 November 2019

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks

scientific article published on 4 November 2016

Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity

scientific article

Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation

scientific article

Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem

scientific article published on March 2007

Mathematical models of the acute inflammatory response.

scientific article published in October 2004

Mechanisms of hepatoprotection by nitric oxide

scientific article

Mechanistic simulations of inflammation: current state and future prospects.

scientific article published on 26 August 2008

Modeling and Hemofiltration Treatment of Acute Inflammation

scientific article published on 18 October 2016

Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis ⬇️

scientific article published on December 10, 2012

Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response ⬇️

scientific article published on December 23, 2010

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

scientific article published on 21 December 2021

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus

scientific article published on 6 March 2015

Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS

scientific article published on 01 August 2007

Nitric oxide, a protective molecule in the cardiovascular system

scientific article published on October 2013

Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation

scientific article published in September 2003

One-dimensional elastic continuum model of enterocyte layer migration

scientific article

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism

scientific article published on March 2003

Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture

scientific article published in July 2008

Peroxisomal localization of inducible nitric oxide synthase in hepatocytes

scientific article

Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort.

scientific article

Precision Medicine for Critical Illness and Injury

scientific article published on 01 September 2016

Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans

scientific article published on July 2015

Prehospital plasma is associated with distinct biomarker expression following injury

scientific article published on 31 March 2020

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

scientific article published on 22 December 2020

Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer

scientific article published on 01 June 2018

Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness

scientific article published on 01 March 2020

Racial Disparities and Sex-Based Outcomes Differences after Severe Injury ⬇️

scientific article published on April 21, 2012

Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies

scientific article published on April 2014

Resetting the transcription factor network reverses terminal chronic hepatic failure

scientific article

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide

scientific article published on July 2002

Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury.

scientific article

SPARK: A Framework for Multi-Scale Agent-Based Biomedical Modeling

scientific article

Sepsis: Something old, something new, and a systems view

scientific article published on 27 July 2011

Sepsis: from pattern to mechanism and back.

scientific article published on January 2012

Suppressed networks of inflammatory mediators characterize chronic venous insufficiency

scientific article published on 10 February 2018

Systemic Arginine Depletion After a Murine Model of Surgery or Trauma ⬇️

scientific article published on December 16, 2011

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

scientific article published on 9 October 2007

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4

scientific article published on 04 May 2006

Systemic inflammation and remote organ injury following trauma require HMGB1

scientific article published on 25 July 2007

Systems biology and inflammation

scientific article published on 01 January 2010

TWO AUTOCOVARIANCE-BASED MEASURES OF BALANCE IN PARKINSONIANS AND NORMAL CONTROLS.

scientific article published on January 2010

Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

scientific article

The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury ⬇️

scientific article published on January 1, 2014

The acute inflammatory response in diverse shock states

scientific article published on 01 July 2005

The dynamics of acute inflammation

scientific article

The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

scientific article

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical

scientific article published on 03 February 2022

The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

scientific article published on 04 April 2012

The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support

scientific article

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure

scientific article published on 22 May 2017

The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture

scientific article published in July 2008

The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.

scientific article published on August 2005

The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis

scientific article published in December 2006

Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock

scientific article published in September 2007

Time for trauma immunology

scientific article published on 11 July 2017

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice

scientific article published on 28 November 2017

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock

scientific article published on 18 January 2006

Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure

scientific article published on 21 April 2012

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.

scientific article published on 9 August 2011

Transforming growth factor-beta in critical illness

scientific article

Translational Systems Biology of Inflammation: Potential Applications to Personalized Medicine ⬇️

scientific article published on September 1, 2010

Translational systems approaches to the biology of inflammation and healing

scientific article

Translational systems biology and voice pathophysiology

scientific article

Translational systems biology of inflammation

scientific article

Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient

scientific article published on March 2008

Trauma in silico: Individual-specific mathematical models and virtual clinical populations.

scientific article published in April 2015

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients

scientific article published on 25 February 2020

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

scientific article published on 26 September 2009

Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis

scientific article

What's New in Shock, June 2018?

scientific article published on 01 June 2018

X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

scientific article

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury

scientific article published on 16 November 2018

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