List of works - Hideshi Ihara

2-Oxo-histidine-containing dipeptides are functional oxidation products

scientific article published on 30 November 2018

8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis

scientific article published on 14 May 2015

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

scientific article

8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25.

scientific article published on 29 July 2015

8-Nitro-cGMP attenuates context-dependent fear memory in mice

scientific article published on 14 February 2019

8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells

scientific article published on 20 March 2020

8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage.

scientific article published on 27 May 2017

A novel neurotoxoid vaccine prevents mucosal botulism

scientific article published on 01 February 2005

Alternative polyadenylation sites of human endothelial nitric oxide synthase mRNA

scientific article

Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile

scientific article published on January 2011

Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins

scientific article published on 22 August 2005

Cell signaling mediated by nitrated cyclic guanine nucleotide

scientific article published on 25 June 2010

Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism

scientific article published in October 2002

Characterization of Fusarium oxysporum beta-1,6-galactanase, an enzyme that hydrolyzes larch wood arabinogalactan

scientific article published on 9 March 2007

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

scientific article published on 27 October 2017

Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

scientific article published on 25 December 2007

Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex

scientific article published on 26 December 2006

Effects of low protein intake on the development of the remaining kidney in subtotally nephrectomized immature rats: expression of inducible and endothelial NO synthase ⬇️

scientific article published on August 4, 2010

Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation.

scientific article published on 26 July 2016

Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock

scientific article published on 07 March 2019

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides

scientific article published on 27 August 2020

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

scientific article

Expression of neuronal nitric oxide synthase variant, nNOS-mu, in rat brain

scientific article published on 10 January 2006

Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes

scientific article published on 13 June 2017

Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides

scientific article published on 01 September 2015

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide

scientific article published on 28 April 2013

Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples

scientific article published on 21 November 2020

Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death

scientific article published on 16 October 2009

High Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species

scientific article published on 16 November 2020

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

scientific article

Identification of a GH62 α-L-arabinofuranosidase specific for arabinoxylan produced by Penicillium chrysogenum

scientific article published on 23 December 2010

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.

scientific article

Identification of two GH27 bifunctional proteins with beta-L-arabinopyranosidase/alpha-D-galactopyranosidase activities from Fusarium oxysporum

scientific article

Immunostimulatory activity of polysaccharides isolated from Caulerpa lentillifera on macrophage cells

scientific article

Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera

scientific article

Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes

scientific article published on 7 October 2012

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

scientific article published on 16 December 2017

Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells.

scientific article

Molecular characterization of a Penicillium chrysogenum exo-1,5-alpha-L-arabinanase that is structurally distinct from other arabinan-degrading enzymes

scientific article published in February 2004

Naringin lauroyl ester inhibits lipopolysaccharide-induced activation of nuclear factor κB signaling in macrophages

scientific article published on 11 March 2016

Nitric oxide enhances increase in cytosolic Ca(2+) and promotes nicotine-triggered MAPK pathway in PC12 cells

scientific article

Nitric oxide inhibits depolarization-evoked glutamate release from rat cerebellar granule cells

scientific article published on 14 October 2006

Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells.

scientific article

Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.

scientific article published on June 2008

Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke

scientific article

Nucleotides function as endogenous chemical sensors for oxidative stress signaling.

scientific article published on 28 December 2010

Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo

scientific article published on 10 August 2016

PKC‐dependent inhibition of CA2+‐dependent exocytosis from astrocytes ⬇️

scientific article published on October 21, 2010

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis

scientific article published on 02 January 2019

Potentiation by high potassium of lipopolysaccharide-induced nitric oxide production from cultured astrocytes

scientific article published on 26 September 2005

Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate

scientific article

Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

2022 scholarly article

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

scientific article

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

scientific article

Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.

scientific article published on 21 June 2017

Redox regulation of Ca/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue

scientific article published on 28 October 2018

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

scientific article published in April 2014

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

scientific article published on April 2016

Redox signaling regulated by electrophiles and reactive sulfur species

scientific article

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

scientific article published on January 2012

SNAP-25 S-Guanylation and SNARE Complex Formation

scientific article published on 01 January 2019

Specificity of botulinum protease for human VAMP family proteins.

scientific article

Substrate specificity and gene expression of two Penicillium chrysogenum α-L-arabinofuranosidases (AFQ1 and AFS1) belonging to glycoside hydrolase families 51 and 54.

scientific article published on 14 March 2012

Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation

scientific article

Sulfide catabolism ameliorates hypoxic brain injury

scientific article published on 25 May 2021

Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation

scientific article published on 26 January 2017

Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome

scientific article

The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of Escherichia coli Controls Expression of Anaerobic Respiratory Genes and Antibiotic Tolerance

scientific article published in 2022

The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response

scientific article

Theophylline potentiates lipopolysaccharide-induced NO production in cultured astrocytes.

scientific article

Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation.

scientific article published on 5 November 2015

[Regulatory mechanism of cytotoxicity by reactive sulfur species].

scientific article

p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.

scientific article published on January 2007

List of works by Hideshi Ihara

2-Oxo-histidine-containing dipeptides are functional oxidation products

8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25.

8-Nitro-cGMP attenuates context-dependent fear memory in mice

8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells

8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage.

A novel neurotoxoid vaccine prevents mucosal botulism

Alternative polyadenylation sites of human endothelial nitric oxide synthase mRNA

Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile

Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins

Cell signaling mediated by nitrated cyclic guanine nucleotide

Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism

Characterization of Fusarium oxysporum beta-1,6-galactanase, an enzyme that hydrolyzes larch wood arabinogalactan

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex

Effects of low protein intake on the development of the remaining kidney in subtotally nephrectomized immature rats: expression of inducible and endothelial NO synthase ⬇️

Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation.

Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Expression of neuronal nitric oxide synthase variant, nNOS-mu, in rat brain

Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes

Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide

Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples

Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death

High Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Identification of a GH62 α-L-arabinofuranosidase specific for arabinoxylan produced by Penicillium chrysogenum

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.

Identification of two GH27 bifunctional proteins with beta-L-arabinopyranosidase/alpha-D-galactopyranosidase activities from Fusarium oxysporum

Immunostimulatory activity of polysaccharides isolated from Caulerpa lentillifera on macrophage cells

Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera

Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells.

Molecular characterization of a Penicillium chrysogenum exo-1,5-alpha-L-arabinanase that is structurally distinct from other arabinan-degrading enzymes

Naringin lauroyl ester inhibits lipopolysaccharide-induced activation of nuclear factor κB signaling in macrophages

Nitric oxide enhances increase in cytosolic Ca(2+) and promotes nicotine-triggered MAPK pathway in PC12 cells

Nitric oxide inhibits depolarization-evoked glutamate release from rat cerebellar granule cells

Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells.

Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.

Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke

Nucleotides function as endogenous chemical sensors for oxidative stress signaling.

Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo

PKC‐dependent inhibition of CA2+‐dependent exocytosis from astrocytes ⬇️

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis

Potentiation by high potassium of lipopolysaccharide-induced nitric oxide production from cultured astrocytes

Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate

Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.

Redox regulation of Ca/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

Redox signaling regulated by electrophiles and reactive sulfur species

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

SNAP-25 S-Guanylation and SNARE Complex Formation

Specificity of botulinum protease for human VAMP family proteins.

Substrate specificity and gene expression of two Penicillium chrysogenum α-L-arabinofuranosidases (AFQ1 and AFS1) belonging to glycoside hydrolase families 51 and 54.

Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation

Sulfide catabolism ameliorates hypoxic brain injury

Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation

Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome

The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of Escherichia coli Controls Expression of Anaerobic Respiratory Genes and Antibiotic Tolerance

The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response

Theophylline potentiates lipopolysaccharide-induced NO production in cultured astrocytes.

Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation.

[Regulatory mechanism of cytotoxicity by reactive sulfur species].

p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.