Search filters

List of works by Richard Lewis

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

scientific article

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells

scientific article

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

scientific article published on June 2015

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

scientific article

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

scientific article published in Nature

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.

scientific article

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

scientific article published on 02 July 2008

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

scientific article published on 21 August 2009

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

scientific article

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions

scientific article

Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

scientific article

Store-Operated Calcium Channels

scientific article

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions

scientific article

The molecular choreography of a store-operated calcium channel

scientific article published on March 2007