List of works by Adrian B. McDermott

A Global Immunological Observatory to meet a time of pandemics

scientific article published on 08 June 2020

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization

scientific article published on 17 October 2020

A Multiplex Microsphere-Based Immunoassay Increases the Sensitivity of SIV-Specific Antibody Detection in Serum Samples and Mucosal Specimens Collected from Rhesus Macaques Infected with SIVmac239

scientific article

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus.

scientific article published on 4 August 2015

A dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variation

scientific article published on December 2004

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

scientific article published on 19 March 2018

AIDS vaccines and preexposure prophylaxis: is synergy possible?

scientific article

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals

scientific article

Accumulation of follicular CD8+ T cells in pathogenic SIV infection.

scientific article

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

scientific article published on 23 July 2019

Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.

scientific article published in October 2014

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 30 May 2016

An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

scientific article published in June 2017

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

scientific article published on 14 July 2020

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

scholarly article by Nicole Doria-Rose published in 2021

Antibody reactivity to SARS-CoV-2 in adults from the Vancouver metropolitan area, Canada

scientific article published on 09 October 2020

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag

scientific article

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

scientific article published on 01 January 2019

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 01 June 2019

CD8(+) T cells in preventing HIV infection and disease

scientific article published on June 2012

Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts

scientific article

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

scientific article published on 29 June 2020

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

scientific article

Cytotoxic T-lymphocyte escape does not always explain the transient control of simian immunodeficiency virus SIVmac239 viremia in adenovirus-boosted and DNA-primed Mamu-A*01-positive rhesus macaques

scientific article

DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells

scientific article

Defining B cell immunodominance to viruses

scientific article published on 13 February 2017

Defining the risk of SARS-CoV-2 variants on immune protection

scientific article published on 31 March 2022

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

scientific article published on 26 February 2019

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

scientific article published on 09 November 2020

Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

scientific article published on 15 April 2020

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

scientific article published on 03 December 2020

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

scientific article

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

scientific article

Dynamic Perspectives on the Search for a Universal Influenza Vaccine

scientific article published on 01 April 2019

Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen

scientific article

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Erratum to “A novel technique for the fluorometric assessment of T lymphocyte antigen specific lysis” [J. Immunol. Methods 249 (2001) 99–110]

scholarly article published in Journal of Immunological Methods

Erratum: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 01 October 2016

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

scientific article published on 28 July 2020

Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages.

scientific article published on 05 February 2014

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

scientific article published on January 2017

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

scientific article published on 07 February 2020

H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem.

scientific article published on 15 June 2015

HIV vaccine design: insights from live attenuated SIV vaccines

scientific article

HIV vaccine research and discovery in the nonhuman primates model: a unified theory in acquisition prevention and control of SIV infection

scientific article published on July 2013

Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates

scientific article published on 3 June 2015

Hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines

scientific article published on 14 November 2019

Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1

scientific article

Higher PIK3C2B gene expression of H1N1+ specific B-cells is associated with lower H1N1 immunogenicity after trivalent influenza vaccination in HIV infected children

scientific article published on 21 April 2020

Homologous boosting with adenoviral serotype 5 HIV vaccine (rAd5) vector can boost antibody responses despite preexisting vector-specific immunity in a randomized phase I clinical trial

scientific article

Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature

scientific article published on 01 August 2020

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

scientific article

Immunity to Influenza: Catching a Moving Target To Improve Vaccine Design

scientific article published on 01 January 2019

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells

scientific article published on 09 April 2019

Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody

scientific article published on 30 December 2015

Intranasal live influenza vaccine priming elicits localized B cell responses in mediastinal lymph nodes

scientific article published on 14 February 2018

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem

scientific article

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection

scientific article

Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection

scientific article published on 30 January 2014

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

scientific article

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

scientific article published on 06 October 2008

Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge

scientific article

Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burdens

scientific article published on 27 April 2016

Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses

scientific article published on August 2003

Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach

scientific article published on 31 August 2020

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 11 February 2019

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

scientific article published on 18 June 2019

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

scientific article published on 01 November 2019

Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor

scientific article published on 03 February 2020

Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans

scientific article published on July 2017

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

scientific article published on 01 April 2019

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection

scientific article published on July 2015

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination

scientific article published on 13 December 2017

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

scientific article published on 12 August 2015

Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

scientific article published on 25 January 2021

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

scientific article published on 31 October 2016

Repeated low-dose mucosal simian immunodeficiency virus SIVmac239 challenge results in the same viral and immunological kinetics as high-dose challenge: a model for the evaluation of vaccine efficacy in nonhuman primates

scientific article published on March 2004

Researchers take a measured response. Immunologists compare data and techniques at Measurement of Antigen-Specific Immune Response conference

article

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

scientific article

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

scientific article published on 29 September 2020

Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012)

scientific article

Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

scientific article published on 15 April 2019

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial

scientific article published on 28 August 2019

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

scientific article published on 24 January 2018

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

scientific article published on September 2015

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study

article by Martin R Gaudinski et al published 2 March 2019 in The Lancet

Shaping a universally broad antibody response to influenza amidst a variable immunoglobulin landscape

scientific article published on 04 May 2018

Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy

article

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

scientific article published on 4 March 2015

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

scientific article published in December 2017

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

scientific article

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

scientific article published on 22 April 2020

The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

scientific article published on 23 December 2016

Vaccination induces HIV broadly neutralizing antibody precursors in humans ⬇️

journal article published in 2022

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

scientific article

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239

scientific article

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

scientific article published on 05 December 2018

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection

scientific article

Why are there so few (or so many) circulating coronaviruses?

scientific article published in September 2021

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

scholarly article by Kizzmekia Corbett et al published 20 August 2021 in Nature Immunology

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