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List of works by Geert J.L.H. van Leenders

A Calculator for Prostate Cancer Risk 4 Years After an Initially Negative Screen: Findings from ERSPC Rotterdam

scientific article published on 20 July 2012

A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies

scientific article published on 13 May 2017

A critical analysis of the tumor volume threshold for clinically insignificant prostate cancer using a data set of a randomized screening trial

scientific article

A new and highly prognostic system to discern T1 bladder cancer substage.

scientific article published on 25 October 2011

A new system for substaging pT1 papillary bladder cancer: a prognostic evaluation.

scientific article published in September 2005

Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma

scientific article published on 20 February 2016

Activation of c-MET induces a stem-like phenotype in human prostate cancer

scientific article

Active surveillance for prostate cancers detected in three subsequent rounds of a screening trial: characteristics, PSA doubling times, and outcome

scientific article published on 05 December 2006

Alternative prostate cancer grading systems incorporating percent pattern 4/5 (IQ-Gleason) and cribriform architecture (cGrade) improve prediction of outcome after radical prostatectomy

scientific article published in 2022

An activating mutation in AKT1 in human prostate cancer

scientific article published on 01 December 2008

Androgen receptor profiling predicts prostate cancer outcome

scientific article

Antibody EPR3864 is specific for ERG genomic fusions in prostate cancer: implications for pathological practice.

scientific article published on 15 April 2011

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.

scientific article published on 30 April 2015

Automated detection of cribriform growth patterns in prostate histology images

scientific article published on 10 September 2020

Body mass index as a prognostic marker for biochemical recurrence in Dutch men treated with radical prostatectomy

scientific article published on 11 February 2009

Can non-malignant biopsy features identify men at increased risk of biopsy-detectable prostate cancer at re-screening after 4 years?

scientific article published on 08 October 2007

Cancer Detection and Cancer Characteristics in the European Randomized Study of Screening for Prostate Cancer (ERSPC) – Section Rotterdam

scientific article published on 16 January 2007

Cellular and molecular biology of the prostate: stem cell biology

scientific article published on November 2003

Clinical outcome comparison of Grade Group 1 and Grade Group 2 prostate cancer with and without cribriform architecture at the time of radical prostatectomy

scientific article published on 16 January 2020

Clinicopathological characteristics of glomeruloid architecture in prostate cancer

scientific article published on 20 February 2020

Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer

scientific article

Comparison of RNA extraction kits and histological stains for laser capture microdissected prostate tissue

scientific article

Comparison of Tumor Volume Parameters on Prostate Cancer Biopsies

scientific article published on 06 January 2020

Comparison of incidentally detected prostate cancer with screen-detected prostate cancer treated by prostatectomy

article

Computational imaging modalities for multi-focal whole-slide imaging systems

scientific article published on 01 July 2020

Concordance of PD-L1 expression in matched urothelial bladder cancer specimens

scientific article published on 25 September 2018

Concordance of cribriform architecture in matched prostate cancer biopsy and radical prostatectomy specimens

scientific article published on 02 August 2019

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations.

scientific article published on 2 January 2018

Cribriform architecture in radical prostatectomies predicts oncological outcome in Gleason score 8 prostate cancer patients

scientific article published on 20 July 2020

Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer

scientific article published on 5 September 2014

Cysteine-rich secretory protein 3 and β-microseminoprotein on prostate cancer needle biopsies do not have predictive value for subsequent prostatectomy outcome

scientific article published on 16 March 2011

Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients

scientific article published on 12 March 2020

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

scientific article published on 11 August 2020

Despite extensive efforts, the validation of prognostic tissue markers in prostate cancer has not yet resulted in the widespread implementation of novel diagnostic tests

scientific article published on 01 July 2007

Differences in Treatment and Outcome After Treatment with Curative Intent in the Screening and Control Arms of the ERSPC Rotterdam

scientific article published on 18 October 2014

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

scientific article published on 17 February 2016

Differential diagnosis and mutation stratification of desmoid-type fibromatosis on MRI using radiomics

scientific article published on 08 September 2020

Differential tissue expression of extracellular vesicle-derived proteins in prostate cancer

scientific article published on 24 April 2019

Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging

scientific article published on 27 August 2003

Disease-specific death and metastasis do not occur in patients with Gleason score ≤6 at radical prostatectomy

scientific article published on 07 March 2015

Down-staging (<pT2) of urothelial cancer at cystectomy after the diagnosis of detrusor muscle invasion (pT2) at diagnostic transurethral resection (TUR): is prediction possible? ⬇️

scientific article published on July 10, 2012

EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)

scientific article published on 03 October 2019

Editorial comment on: expression and prognostic relevance of annexin A3 in prostate cancer

Eight Endorsements of the International Society of Urological Pathology from the 2019 Consensus Conference on Grading of Prostatic Carcinoma

scientific article published on 08 September 2020

EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study

scientific article published on 29 September 2016

Epithelial cell differentiation in the human prostate epithelium: implications for the pathogenesis and therapy of prostate cancer

scientific article

Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression

scientific article published on 19 June 2018

Equivocal PI-RADS Three Lesions on Prostate Magnetic Resonance Imaging: Risk Stratification Strategies to Avoid MRI-Targeted Biopsies

scientific article published on 10 December 2020

Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer

scientific article

FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?†

scientific article published on 15 July 2020

False-negative Prostate Needle Biopsies: Frequency, Histopathologic Features, and Follow-up

scientific article published on 01 January 2010

Gene-expression analysis of gleason grade 3 tumor glands embedded in low- and high-risk prostate cancer

scientific article

Genetic Aspects and Molecular Testing in Prostate Cancer: A Report from a Dutch Multidisciplinary Consensus Meeting

scientific article published in 2023

Genito-urinary genomics and emerging biomarkers for immunomodulatory cancer treatment

scientific article published on 11 October 2017

Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists

scientific article

Handling and reporting of pelvic lymphadenectomy specimens in prostate and bladder cancer: a web-based survey by the European Network of Uropathology

scientific article published on 01 April 2019

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases

scientific article published on 23 September 2016

Hyaline fibromatosis of Hoffa's fat pad in a patient with a mild type of hyaline fibromatosis syndrome

scientific article published on 17 October 2013

Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer

scientific article

Identifying Cystogenic Paracrine Signaling Molecules in Cyst Fluid of Patients with Polycystic Kidney Disease

scientific article published on 07 November 2018

Immediate treatment vs. active-surveillance in very-low-risk prostate cancer: the role of patient-, tumour-, and hospital-related factors

scientific article published on 14 November 2018

Immunoglobulin G4-related Prostatitis: A Case-control Study Focusing on Clinical and Pathologic Characteristics

Improved Prostate Cancer Biopsy Grading by Incorporation of Invasive Cribriform and Intraductal Carcinoma in the 2014 Grade Groups

scientific article published on 19 August 2019

Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculator for Initial Prostate Biopsy by Incorporating the 2014 International Society of Urological Pathology Gleason Grading and Cribriform growth

scientific article

Inter-observer variability of cribriform architecture and percent Gleason pattern 4 in prostate cancer: relation to clinical outcome

scientific article published on 20 August 2020

Intermediate cells in normal and malignant prostate epithelium express c-MET: implications for prostate cancer invasion

scientific article published on May 2002

Intraductal carcinoma has minimal impact on Grade Group assignment in prostate cancer biopsy and radical prostatectomy specimens

scientific article published on 15 June 2020

Intraoperative assessment and reporting of radical prostatectomy specimens to guide nerve-sparing surgery in prostate cancer patients (NeuroSAFE)

scientific article published on 18 June 2020

Large cribriform growth pattern identifies ISUP grade 2 prostate cancer at high risk for recurrence and metastasis

article

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

scientific article

Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential

scientific article published on 6 July 2015

MET expression during prostate cancer progression

scientific article published on 18 April 2016

Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer

scientific article published on 05 June 2018

MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma

scientific article published on 23 January 2020

Molecular Grade (FGFR3/MIB-1) and EORTC Risk Scores Are Predictive in Primary Non–Muscle-Invasive Bladder Cancer

scientific article published on 09 June 2010

Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications

scientific article

Morphological and immunohistochemical identification of epithelial-to-mesenchymal transition in clinical prostate cancer.

scientific article published on 19 May 2015

Multi-line fluorescence scanning microscope for multi-focal imaging with unlimited field of view

scientific article published on 18 November 2019

NUT midline carcinoma of the parotid gland with mesenchymal differentiation

scientific article published on 01 August 2009

Nivolumab plus ipilimumab as neoadjuvant treatment in primary advanced renal cell tumors: Cutting edges for cutting-edge surgery

scientific article published on 19 March 2020

Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.

scientific article published on 22 November 2013

Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer

scientific article

Outcomes of a bladder cancer screening program using home hematuria testing and molecular markers.

scientific article published on 4 March 2013

PD-L1 Antibody Comparison in Urothelial Carcinoma

scientific article published on 27 November 2018

PD-L1 testing in urothelial carcinoma: are we there yet?

scientific article published on 01 December 2019

Performance of the prostate cancer antigen 3 (PCA3) gene and prostate-specific antigen in prescreened men: exploring the value of PCA3 for a first-line diagnostic test

scientific article

Pitfalls in plaque characterization by OCT: image artifacts in native coronary arteries

scientific article published on 01 July 2011

Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features

scientific article published on 17 November 2006

Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.

scientific article published on 02 May 2013

Primary Cystic Lesions of the Retrorectal Space: MRI Evaluation and Clinical Assessment

scientific article published on 13 July 2017

Prognostic histopathological and molecular markers on prostate cancer needle-biopsies: a review

scientific article published on 27 August 2014

Prostate Carcinoma Grade and Length But Not Cribriform Architecture at Positive Surgical Margins Are Predictive for Biochemical Recurrence After Radical Prostatectomy

scientific article published on 01 February 2020

Prostate cancer antigen 3: diagnostic outcomes in men presenting with urinary prostate cancer antigen 3 scores ≥100

scientific article published on 01 March 2014

Prostate cancer growth patterns beyond Gleason score: entering a new era of comprehensive tumour grading

scientific article published on 19 July 2020

Prostate cancer upgrading with serial prostate MRI scans and repeat biopsy in men on active surveillance: are confirmatory biopsies still necessary?

scientific article published on 31 March 2020

Prostate-specific antigen-based prostate cancer screening: reduction of prostate cancer mortality after correction for nonattendance and contamination in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer

scientific article published on 11 August 2013

Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics

scientific article

Reducing unnecessary biopsies while detecting clinically significant prostate cancer including cribriform growth with the ERSPC Rotterdam risk calculator and 4Kscore

scientific article published on 07 December 2018

Reduction of MRI-targeted biopsies in men with low-risk prostate cancer on active surveillance by stratifying to PI-RADS and PSA-density, with different thresholds for significant disease.

scientific article published in February 2018

Reduction of serum prostate-specific antigen levels following varicella-zoster infection and valaciclovir treatment in prostate cancer

scientific article published on 28 February 2009

Relocation of inadequate resection margins in the wound bed during oral cavity oncological surgery: A feasibility study

scientific article published on 01 February 2019

Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia

scientific article published on 18 April 2016

Reply to Thomas Gevaert, Markus Eckstein, Rodolfo Montironi, and Antonio Lopez-Beltran's Letter to the Editor re: Maud Rijnders, Astrid A.M. van der Veldt, Tahlita C.M. Zuiverloon, et al. PD-L1 Antibody Comparison in Urothelial Carcinoma. Eur Urol 2

scientific article published on 02 February 2019

Restricting False-positive Magnetic Resonance Imaging Scans to Reduce Overdiagnosis of Prostate Cancer

scientific article published on 05 November 2020

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

scientific article

Should Pathologists Routinely Report Prostate Tumour Volume? The Prognostic Value of Tumour Volume in Prostate Cancer

scientific article published on 29 July 2009

Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients

scientific article

Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.

scientific article

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

scientific article published on 26 May 2020

The 2019 International Society of Urological Pathology Consensus Conference on Prostate Cancer Grading

scientific article published on 23 August 2020

The World Health Organization 1973 classification system for grade is an important prognosticator in T1 non-muscle-invasive bladder cancer

scientific article published on 10 April 2018

The added value of percentage of free to total prostate-specific antigen, PCA3, and a kallikrein panel to the ERSPC risk calculator for prostate cancer in prescreened men.

scientific article published on 26 August 2014

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder

scientific article published on 02 October 2020

The pathologist's mean grade is constant and individualizes the prognostic value of bladder cancer grading.

scientific article published on 11 September 2009

The role of HOXC6 in prostate cancer development

scientific article published on 27 August 2015

The value of EZH2, p27(kip1), BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy.

scientific article

The value of an additional hypoechoic lesion-directed biopsy core for detecting prostate cancer

scientific article published on 01 March 2008

The value of dynamic contrast enhanced power Doppler ultrasound imaging in the localization of prostate cancer

scientific article published on 01 February 2003

Three-dimensional analysis reveals two major architectural subgroups of prostate cancer growth patterns

scientific article published on 08 February 2019

Three-dimensional architecture of common benign and precancerous prostate epithelial lesions

scientific article published on 21 April 2019

Three-dimensional microscopic analysis of clinical prostate specimens.

scientific article published on 29 June 2016

Tissue proteomics outlines AGR2 AND LOX5 as markers for biochemical recurrence of prostate cancer

scientific article published on 23 November 2018

Tubular and interstitial nephrocalcinosis

scientific article published on 20 July 2007

Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer

scientific article

Validation of stem cell markers in clinical prostate cancer: α6-integrin is predictive for non-aggressive disease.

scientific article

Variability in Diagnostic Opinion Among Pathologists for Single Small Atypical Foci in Prostate Biopsies

scientific article published on 01 February 2010

Variation in the Prescription of Androgen Deprivation Therapy in Intermediate- and High-risk Prostate Cancer Patients Treated with Radiotherapy in the Netherlands, and Adherence to European Association of Urology Guidelines: A Population-based Study

scientific article published on 17 November 2019

mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma.

scientific article published on 16 April 2016

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