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List of works by Theoharis C Theoharides

A Timely Multidisciplinary Update on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

scientific article published on 30 March 2019

A probable case report of stress-induced anaphylaxis

scientific article published on 06 August 2013

Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: Interleukin-37 Could Be Beneficial

scientific article published on 31 January 2018

Acute stress induces cardiac mast cell activation and histamine release, effects that are increased in Apolipoprotein E knockout mice

scientific article

Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists

scientific article published in March 2003

Acute stress-induced seizures and loss of consciousness in a ten-year-old boy with cutaneous mastocytosis

scientific article published in April 2002

Advances in therapy with antileukotriene drugs

scientific article

Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine

scientific article published in January 2002

Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells

scientific article published in June 2004

Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome

scientific article

Amyotrophic Lateral Sclerosis, Neuroinflammation, and Cromolyn

scientific article published on 07 February 2020

Antidepressants and risk of cancer: a case of misguided associations and priorities

scientific article published in February 2003

Antihistamines and Mental Status

scientific article published on 11 March 2016

Atopic Conditions in Search of Pathogenesis and Therapy ⬇️

scientific article published on 01 May 2013

Autism spectrum disorders and mastocytosis

scientific article published in October 2009

Autism, gut-blood-brain barrier, and mast cells

scientific article published in October 2008

Autism: an emerging 'neuroimmune disorder' in search of therapy

scientific article

Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells

scientific article

Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells

scientific article

Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine.

scientific article published in January 2002

Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

scientific article (publication date: 2015)

Brain cytokines and neuropsychiatric disorders

scientific article published in December 2004

Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin

scientific article published in April 2014

Brain metastases of mouse mammary adenocarcinoma is increased by acute stress ⬇️

scientific article published on September 29, 2010

Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye? ⬇️

scientific article published on November 1, 2011

COVID-19, microthromboses, inflammation, and platelet activating factor

scientific article published on 09 December 2020

COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

scientific article published on 27 April 2020

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33

scientific article published on 06 December 2018

Chronic fatigue syndrome, mast cells, and tricyclic antidepressants

scientific article published on 01 December 2005

Contribution of stress to asthma worsening through mast cell activation

scientific article published on 22 March 2012

Coronary stents, hypersensitivity reactions, and the Kounis syndrome

scientific article published on October 2007

Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells

scientific article published in April 2003

Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress

scientific article published in December 2002

Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin ⬇️

scientific article published on May 4, 2012

Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells

scientific article published on 23 October 2003

Corticotropin-releasing hormone and the blood-brain-barrier

scientific article published on January 2007

Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process

scholarly article

Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway

scientific article

Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria

scientific article

Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor

scientific article

Critical role of mast cells in inflammatory diseases and the effect of acute stress

scientific article

Danger Signals and Inflammation

scientific article published on 22 April 2016

Decreased Mitochondrial Function and Increased Brain Inflammation in Bipolar Disorder and Other Neuropsychiatric Diseases ⬇️

scientific article published on December 1, 2011

Depressive symptoms in urticaria patients treated with first- or second-generation histamine 1 receptor antagonists

scientific article published on 01 August 2007

Dietary Interventions for Atopic Disorders ⬇️

scientific article published on January 1, 2014

Differential release of mast cell mediators and the pathogenesis of inflammation

scientific article published on June 2007

Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders

scientific article

Editorial: Mast Cells in Itch, Pain and Neuro-Inflammation

scientific article published on 03 December 2019

Effect of IL-33 on de novo synthesized mediators from human mast cells

scientific article published on 01 November 2018

Effect of Stress on Neuroimmune Processes

scientific article published on 22 May 2020

Effect of stress on brain inflammation and multiple sclerosis

scientific article published on 26 March 2013

Effect of stress on learning and motivation-relevance to autism spectrum disorder

scientific article published on 01 January 2019

Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes

scientific article published on 05 June 2018

Effects of an Extract of Salmon Milt on Symptoms and Serum TNF and Substance P in Patients With Fibromyalgia Syndrome

scientific article published on 11 July 2019

Environmental and occupational stress and autoimmunity

scientific article published on 16 January 2008

Exosomes in neurologic and psychiatric disorders

scientific article

Extracellular Mitochondrial ATP, Suramin, and Autism? ⬇️

scientific article published on August 15, 2013

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

scholarly article by Irene Tsilioni & Theoharis C Theoharides published 27 August 2018 in Journal of Neuroinflammation

Fibromyalgia syndrome in need of effective treatments

scientific article

Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1).

scientific article

Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells

scientific article published in August 2005

Focal brain inflammation and autism

scientific article published on 9 April 2013

Genitourinary mast cells and survival

scientific article

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

scientific article

High levels of intrauterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions.

scientific article published in June 2003

High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient

scientific article published on 27 June 2014

Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis ⬇️

scientific article published on March 31, 2011

Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor

scientific article published on June 2005

Human mast cells stimulate activated T cells: implications for multiple sclerosis

scientific article published on 01 November 2008

IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells ⬇️

scientific article published on November 1, 2003

IL-10, an inflammatory/inhibitory cytokine, but not always.

scientific article

IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.

scientific article published on 4 November 2010

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

scientific article

IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin

scientific article published on 26 October 2019

IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin

scientific article published on 07 October 2019

IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder

scientific article published on 29 June 2020

IL-9 Induces VEGF Secretion from Human Mast Cells and IL-9/IL-9 Receptor Genes Are Overexpressed in Atopic Dermatitis ⬇️

scientific article published on March 8, 2012

IgE and macrophages for cancer rescue?

scientific article published on 18 April 2019

Immunomodulators for treatment of interstitial cystitis

scientific article

Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers)

scientific article published on 01 June 2018

Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37.

scientific article published on 29 September 2017

Impact of stress and mast cells on brain metastases

scientific article published on 31 October 2008

In Search of Effective Treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

scientific article published on 25 April 2019

Increased Expression of miR-155p5 in Amygdala of Children With Autism Spectrum Disorder

scientific article published on 10 September 2019

Increased affected skin gene expression and serum levels of thymic stromal lymphopoietin in atopic dermatitis ⬇️

scientific article published on November 1, 2010

Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin

scientific article published in October 2004

Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis ⬇️

scientific article published on February 22, 2012

Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

scientific article published on 21 December 2006

Interleukin 33 and interleukin 4 regulate interleukin 31 gene expression and secretion from human laboratory of allergic diseases 2 mast cells stimulated by substance P and/or immunoglobulin E.

scientific article published in January 2018

Interleukin-16 network in inflammation and allergy.

scientific article published in March 2002

Interleukin-17 and the interleukin-17 family member network

scientific article published on January 2004

Interleukin-6 and mast cells

scientific article published in September 2002

Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis

scientific article published in February 2008

Interstitial cystitis: bladder pain and beyond

article

Intimate Contact Could Be Dangerous for Your Health

scientific article published on 07 May 2019

Irritable bowel syndrome and the elusive mast cells

scientific article published on 01 May 2012

Is a Subtype of Autism an Allergy of the Brain? ⬇️

scientific article published on May 1, 2013

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome

scientific article

Key role of CRF in the skin stress response system

scientific article

Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats

scientific article published on 29 April 2008

Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines

scientific article published on 29 June 2017

Luteolin as a therapeutic option for multiple sclerosis

scientific article

Luteolin inhibits human keratinocyte activation and decreases NF-κB induction that is increased in psoriatic skin

scientific article

Luteolin supplements: All that glitters is not gold

scientific article published on 07 November 2020

Mast Cells May Regulate The Anti-Inflammatory Activity of IL-37

scientific article published on 29 July 2019

Mast Cells Regulate Wound Healing in Diabetes

scientific article published on 08 April 2016

Mast Cells in Allergic and Inflammatory Diseases ⬇️

scientific article published on January 1, 2012

Mast Cells, Mastocytosis, and Related Disorders

scientific article published on July 2015

Mast Cells, Mastocytosis, and Related Disorders

scientific article published on 01 November 2015

Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome

scientific article published on 02 August 2019

Mast Cells, Stress, Fear and Autism Spectrum Disorder

scientific article published on 24 July 2019

Mast cell activation and autism ⬇️

scientific article published on December 28, 2010

Mast cell tryptase: a new biomarker in patients with stable coronary artery disease

scientific article published in February 2005

Mast cells and inflammation

scientific article published on 23 December 2010

Mast cells and mast cell mediators as targets of dietary supplements

scientific article published in August 2004

Mast cells and pancreatic cancer

scientific article published in April 2008

Mast cells and stress--a psychoneuroimmunological perspective.

scientific article

Mast cells as targets of corticotropin-releasing factor and related peptides

scientific article published in November 2004

Mast cells emerge as mediators of atherosclerosis: Special emphasis on IL-37 inhibition

scientific article

Mast cells in irritable bowel syndrome and ulcerative colitis: function not numbers is what makes all the difference

scientific article published on 21 January 2014

Mast cells in meningiomas and brain inflammation

scientific article

Mast cells participate in allograft rejection: can IL-37 play an inhibitory role?

scientific article published on 30 June 2018

Mast cells promote malaria infection?

scientific article published on April 2015

Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity

scientific article published on 07 July 2011

Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis

scientific article published on January 2007

Mast cells, brain inflammation and autism

scientific article published on May 2015

Mast cells: the Jekyll and Hyde of tumor growth

scientific article published on May 2004

Mercury induces inflammatory mediator release from human mast cells

scientific article

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells

scientific article published on 12 April 2017

Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells ⬇️

scientific article published on April 27, 2012

Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children ⬇️

scientific article published on November 17, 2010

Mitochondrial dysfunction in affected skin and increased mitochondrial DNA in serum from patients with psoriasis

scientific article published on 01 January 2019

Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content

scientific article published on 21 October 2009

Mold and Immunity

scientific article published on 30 May 2018

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

scientific article published on 03 August 2018

Nanotube Formation: A Rapid Form of "Alarm Signaling"?

scientific article

Nasal cytology with emphasis on mast cells can improve the diagnosis and treatment of chronic rhinosinusitis

scientific article published on 01 September 2019

Nasal provocation of patients with allergic rhinitis and the hypothalamic-pituitary-adrenal axis

scientific article published in March 2007

Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism ⬇️

scientific article published on November 30, 2011

Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.

scientific article published on June 2007

Neuroendocrinology of mast cells: Challenges and controversies

scientific article published on 17 January 2017

Neuroendocrinology of the skin

scientific article published on 01 September 2016

Neuroimmunoendocrine circuitry of the 'brain-skin connection'.

scientific article

Neuroimmunology of stress: skin takes center stage

scientific article

Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells ⬇️

scientific article published on 13 January 2016

Neurotensin and CRH interactions augment human mast cell activation

scientific article

Neurotensin is increased in serum of young children with autistic disorder

scientific article

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

scientific article published on 23 September 2016

Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model

scientific article

Novel therapeutic targets for autism

scientific article

On the Gut Microbiome-Brain Axis and Altruism

scientific article

Panic disorder, interstitial cystitis, and mast cells

scientific article published on 01 August 2004

Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion.

scientific article

Perifollicular and Perivascular Mouse Skin Mast Cells Express Corticotropin-Releasing Hormone Receptor

Perinatal stress, brain inflammation and risk of autism-Review and proposal ⬇️

scientific article published on July 2, 2012

Post-Lyme Syndrome-Associated Polyneuropathy Treated With Immune Immunoglobulin and a Luteolin-Containing Formulation

scientific article published on 01 June 2016

Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells

scientific article

Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans ⬇️

scientific article published on March 28, 2012

Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

scientific article published on 22 April 2019

Recent insights in primary immunodeficiency diseases: the role of T-lymphocytes and innate immunity.

scientific article published on January 2010

Recent progress on pathophysiology, inflammation and defense mechanism of mast cells against invading microbes: inhibitory effect of IL-37

scientific article published on 01 January 2019

Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin

scientific article published on May 2006

Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells

scientific article published on 01 December 2005

Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure

scientific article published in February 2004

Reply to Fattori et al.: Action of SP and IL-33 on mast cells

scientific article published on 6 November 2017

Response of spinal myoclonus to a combination therapy of autogenic training and biofeedback

scientific article published on 12 October 2007

Role of mast cells in tumor growth.

scientific article published on January 2007

Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor.

scientific article published on 21 September 2013

Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli

scientific article

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors.

scientific article

Secondary anetoderma associated with mastocytosis

scientific article published on 3 October 2006

Serotonin-Selective Reuptake Inhibitors and Nonsteroidal Anti-Inflammatory Drugs-Important Considerations of Adverse Interactions Especially for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ⬇️

scientific article published on 01 August 2011

Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients

scientific article published in August 2002

Skin corticotropin-releasing hormone receptor expression in psoriasis

scientific article published on 01 March 2007

Skin mast cells: are we missing the forest for the trees?

scientific article published on 16 May 2016

Spectrum of mast cell activation disorders

scientific article published on May 2014

Spectrum of mast cell activation disorders

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions ⬇️

scientific article published on December 17, 2012

Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cells.

scientific article

Stress triggers coronary mast cells leading to cardiac events

scientific article

Stress, Inflammation, and Autoimmunity: The 3 Modern Erinyes

scientific article published on 18 April 2020

Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice

scientific article published in August 2003

Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice

scientific article

Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells ⬇️

scientific article published on November 17, 2011

Substance P and Hemokinin 1 in Nasal Lavage Fluid of Patients with Chronic Sinusitis and Nasal Polyposis

scientific article published on 01 July 2019

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin

article published in the Proceedings of the National Academy of Sciences of the United States of America

TNF stimulates IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin

scientific article published on 4 November 2017

Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases

scientific article published on 01 January 2018

The "missing link" in autoimmunity and autism: extracellular mitochondrial components secreted from activated live mast cells

scientific article published on 3 July 2013

The Impact of Psychological Stress on Mast Cells

scientific article published on 17 July 2020

The critical role of mast cells in allergy and inflammation

scientific article

The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma

scientific article

The isoflavone genistein inhibits proliferation and increases histamine content in human leukemic mast cells

scientific article published on September 1, 2003

The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis

scientific article

The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

scientific article

The role of mast cells in migraine pathophysiology

scientific article published on 01 July 2005

Theophylline as 'add-on' therapy to cetirizine in patients with chronic idiopathic urticaria. A randomized, double-blind, placebo-controlled pilot study

scientific article published on 30 January 2006

Tolerability and benefit of a tetramethoxyluteolin-containing skin lotion.

scientific article

Topical Application of a Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing

scientific article published on 27 September 2019

Topical immunopharmacology of ocular allergies

scientific article

Treatment approaches for painful bladder syndrome/interstitial cystitis

scientific article published on January 2007

Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability

scientific article

Unwanted Interactions Among Psychotropic Drugs and Other Treatments for Autism Spectrum Disorders ⬇️

scientific article published on August 1, 2012

Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation

scientific journal article

Use of polyphenols in periodontal inflammation

scientific article published on 31 October 2013

Vitamin D and Atopy

scientific article published on 26 April 2017

When to suspect interstitial cystitis

scientific article published on June 1, 2011

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