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List of works by Peter G. Schultz

2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles

scientific article published on 17 April 2020

A CXCR4-targeted site-specific antibody-drug conjugate

scientific article published on 11 September 2014

A General Strategy for Engineering Noncanonical Amino Acid Dependent Bacterial Growth

scientific article published on 04 October 2019

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

scientific article published on 18 April 2020

A New Functional Suppressor tRNA/Aminoacyl−tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins

scientific article (publication date: May 2000)

A New Strategy to Photoactivate Green Fluorescent Protein

A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening

scientific article

A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure

scientific article published on 04 June 2019

A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure

scientific article published on 02 October 2020

A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer

scientific article published on 13 August 2015

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein ⬇️

scientific article published on September 26, 2011

A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids.

scientific article published on 7 June 2017

A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli ⬇️

scientific article published on February 27, 2013

A bacterial strain with a unique quadruplet codon specifying non-native amino acids.

scientific article

A biochemical screen for GroEL/GroES inhibitors

scientific article published on 02 January 2014

A biosynthetic route to dehydroalanine-containing proteins

scientific article published on 01 January 2007

A catalysis-based selection for peroxidase antibodies with increased activity

scientific article published in March 2004

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

scientific article published on 07 March 2019

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta

scholarly article

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

scientific article published on 8 September 2011

A chemically induced vaccine strategy for prostate cancer.

scientific article published on 21 September 2011

A combinatorial scaffold approach toward kinase-directed heterocycle libraries

scientific article

A comparative analysis of HGSC and Celera human genome assemblies and gene sets

scientific article

A facile system for encoding unnatural amino acids in mammalian cells

scientific article

A functional genomics approach to the mode of action of apratoxin A.

scientific article published on 12 February 2006

A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer

scientific article

A general approach to site-specific antibody drug conjugates

scientific article published on 17 January 2014

A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes

scientific article

A genetically encoded bidentate, metal-binding amino acid

scientific article

A genetically encoded boronate-containing amino acid

scientific article published on January 2008

A genetically encoded diazirine photocrosslinker in Escherichia coli

scientific article

A genetically encoded direct sensor of antibody-antigen interactions

scientific article published on September 2009

A genetically encoded epsilon-N-methyl lysine in mammalian cells

scientific article published on May 2010

A genetically encoded fluorescent amino acid.

scientific article published in July 2006

A genetically encoded fluorescent probe in mammalian cells

scientific article

A genetically encoded infrared probe.

scientific article

A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.

scientific article published on 9 July 2007

A genetically encoded photocaged amino acid

scientific article

A genome-wide overexpression screen in yeast for small-molecule target identification

scientific article

A genomic screen for activators of the antioxidant response element

scientific article

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

scientific article published on 23 September 2009

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

scientific article

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling

scientific article published in Nature

A metalloantibody that irreversibly binds a protein antigen.

scientific article published on 6 July 2007

A method for the generation of glycoprotein mimetics

scientific article

A method to site-specifically introduce methyllysine into proteins in E. coli

scientific article published on 22 June 2010

A new strategy for the site-specific modification of proteins in vivo.

scientific article published on June 2003

A new strategy for the synthesis of glycoproteins.

scientific article

A new strategy to photoactivate green fluorescent protein

scientific article

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction

scientific article published on 14 July 2018

A phage display system with unnatural amino acids

scientific article published in December 2004

A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways

scientific article

A potent and highly selective sulfotransferase inhibitor

scientific article

A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins

scientific article

A regenerative approach to the treatment of multiple sclerosis

scientific article

A role for chemistry in stem cell biology

scientific article published in July 2004

A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis

scientific article

A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression

scientific article

A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

scientific article

A small molecule accelerates neuronal differentiation in the adult rat.

scientific article

A small molecule inhibitor of alpha4 integrin-dependent cell migration

scientific article

A small molecule primes embryonic stem cells for differentiation

scientific article

A small molecule promotes mitochondrial fusion in mammalian cells

scientific article published on 21 August 2012

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

scientific article

A small-molecule agonist of the Wnt signaling pathway

scientific article

A small-molecule antagonist of the hedgehog signaling pathway.

scientific article

A small-molecule inducer of the antioxidant response element

scientific article published on May 2010

A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water

scientific article

A stem cell-based approach to cartilage repair.

scientific article

A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells

scientific article

A tryptophanyl-tRNA synthetase/tRNA pair for unnatural amino acid mutagenesis in E. coli

scientific article published on 2 April 2013

A tumor-targeted immune checkpoint blocker

scientific article published on 22 July 2019

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

scientific article published on 30 October 2017

Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression

scientific article (publication date: 19 August 2003)

Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli

scientific article (publication date: 6 March 2002)

Adding amino acids to the genetic repertoire

scientific article

Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli

scientific article

Addition of an alpha-hydroxy acid to the genetic code of bacteria.

scientific article published in January 2008

Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli

scientific article published in August 2002

Addition of the keto functional group to the genetic code of Escherichia coli.

scientific article

An Antibody with a Variable-Region Coiled-Coil “Knob” Domain

An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold

An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold

scientific article

An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity, ⬇️

scientific article published on March 22, 2011

An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation

scientific article published in January 2010

An antibody CDR3-erythropoietin fusion protein

scientific article published on 14 August 2013

An antibody with a variable-region coiled-coil "knob" domain

scientific article

An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coli

scientific article

An efficient rapid system for profiling the cellular activities of molecular libraries.

scientific article published on 21 February 2006

An efficient system for the evolution of aminoacyl-tRNA synthetase specificity

scientific article published on 16 September 2002

An enhanced system for unnatural amino acid mutagenesis in E. coli

scientific article

An expanded eukaryotic genetic code

scientific article (publication date: 15 August 2003)

An expanded genetic code in mammalian cells with a functional quadruplet codon.

scientific article

An expanded genetic code with a functional quadruplet codon

scientific article

An expanding genetic code

scientific article published on 01 July 2005

An image-based screen identifies a small molecule regulator of megakaryopoiesis

scientific article

An immunosuppressive antibody-drug conjugate

scientific article published on 27 February 2015

An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae.

scientific article published on 22 May 2007

An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli

scientific article published on 28 July 2020

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

scientific article published on 01 August 2020

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells ⬇️

scientific article published on August 5, 2010

At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code

scientific article

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

scientific article (publication date: 23 March 2015)

Bacterial Genome Containing Chimeric DNA-RNA Sequences

scientific article published on 30 August 2018

Beyond the canonical 20 amino acids: expanding the genetic lexicon

scientific article

Biosynthesis of a site-specific DNA cleaving protein

scientific article published on 13 September 2008

Bispecific small molecule-antibody conjugate targeting prostate cancer.

scientific article published on 14 October 2013

CXCR4 expression in prostate cancer progenitor cells

scientific article

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Chemical control of stem cell fate and developmental potential

scientific article published on January 2011

Combination Therapy Targeting Both Tumor-Initiating and Differentiated Cell Populations in Prostate Carcinoma ⬇️

scientific article published on December 1, 2010

Comparative analysis of human genome assemblies reveals genome-level differences

scientific article published in August 2002

Construction and Screening of a Lentiviral Secretome Library

scientific article published on 31 May 2017

Control of protein phosphorylation with a genetically encoded photocaged amino acid

scientific article

Coordinated transcription of key pathways in the mouse by the circadian clock

scientific article (publication date: 3 May 2002)

Corrigendum to “Development of a Genetic Selection for Catalytic Antibodies” [Bioorg. Med. Chem. Lett. 12 (2002) 1691]†

article

Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin

scientific article

Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine

scientific article published in May 2005

DNA-Based Assembly of Gold Nanocrystals

scientific article published on 01 June 1999

Dedifferentiation of lineage-committed cells by a small molecule

scientific article (publication date: 21 January 2004)

Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex

scientific article

Design of Potent and Proteolytically Stable Oxyntomodulin Analogs

scientific article published on 4 January 2016

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

scientific article published on 04 May 2016

Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group

scientific article published in January 2004

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

scientific article

Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia

scientific article published on 27 October 2017

Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases

article

Die Erweiterung des genetischen Codes

Directed embryonic stem cell differentiation with small molecules

scientific article

Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase

scientific article

Directed evolution of the site specificity of Cre recombinase

scientific article

Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS).

scientific article

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates

scientific article published on 8 January 2016

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

scientific article published on 24 July 2020

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Dorsomorphin Promotes Human Embryonic Stem Cell Self‐Renewal ⬇️

scientific article published on 07 March 2011

Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding

scientific article published on 26 April 2016

Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies

scientific article

Efficient expression of tyrosine-sulfated proteins in E. coli using an expanded genetic code

scientific article

Efficient incorporation of unnatural amino acids into proteins in Escherichia coli.

scientific article

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells.

scientific article published on July 2013

Efforts toward Expansion of the Genetic Alphabet:  Structure and Replication of Unnatural Base Pairs

scientific article

Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase

scientific article

Engineering Bifunctional Antibodies with Constant Region Fusion Architectures.

scientific article published on 29 November 2017

Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery

scientific article published on 28 March 2016

Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity

scientific article published on 26 August 2020

Engineering yeast endosymbionts as a step toward the evolution of mitochondria

article published in the Proceedings of the National Academy of Sciences of the United States of America

Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids

scientific article published on 15 November 2018

Enhancing protein stability with extended disulfide bonds

scientific article

Enthalpy arrays

scholarly article

Enzymatic phosphorylation of unnatural nucleosides

scientific article published in December 2002

Essential role of stromally induced hedgehog signaling in B-cell malignancies

scientific article

Eupalinilide E Inhibits Erythropoiesis and Promotes the Expansion of Hematopoietic Progenitor Cells ⬇️

scientific article published on March 15, 2013

Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation

scientific article

Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids

scientific article published on January 2009

Evolution of cyclic peptide protease inhibitors ⬇️

scientific article published on June 20, 2011

Evolution of iron(II)-finger peptides by using a bipyridyl amino acid

scientific article

Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli.

scientific article

Evolution of proteins with genetically encoded "chemical warheads"

scientific article

Expanding the Genetic Code

scientific article published on 01 December 2004

Expanding the genetic code

scientific article (publication date: 2006)

Expanding the genetic code of the human hematopoietic system

scientific article published on 06 April 2020

Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris.

scientific article published in March 2009

Exploring the limits of codon and anticodon size

scientific article

Exploring the potential impact of an expanded genetic code on protein function

scientific article published on 18 May 2015

Functional Antibody CDR3 Fusion Proteins with Enhanced Pharmacological Properties ⬇️

scientific article published on June 21, 2013

Functional Replacement of Histidine in Proteins To Generate Noncanonical Amino Acid Dependent Organisms.

scientific article

Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists

scientific article

Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

scientific article

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

scientific article

Generation of a bacterium with a 21 amino acid genetic code

scientific article published in January 2003

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.

scientific article

Genetic Incorporation of a Metal-Ion Chelating Amino Acid into Proteins as a Biophysical Probe

scientific article

Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins

scientific article published on 15 July 2016

Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones.

scientific article published on 29 April 2015

Genetic incorporation of a small, environmentally sensitive, fluorescent probe into proteins in Saccharomyces cerevisiae.

scientific article

Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase.

scientific article published on 17 March 2014

Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells.

scientific article

Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis

scientific article

Genetic incorporation of unnatural amino acids into proteins in mammalian cells

scientific article published on 25 February 2007

Genetic introduction of a diketone-containing amino acid into proteins

scientific article published on 24 August 2006

Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells.

scientific article published on 31 August 2017

Genetically encoded alkenes in yeast

scientific article published in January 2010

Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria

scientific article

Genome-scale functional profiling of the mammalian AP-1 signaling pathway

scientific article

Genomic effects of polyamide/DNA interactions on mRNA expression

scientific article

Genomically recoded organisms expand biological functions

scientific article

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

scientific article

Homogeneously modified immunoglobulin domains for therapeutic application

scientific article published on 25 June 2015

Identification and Characterization of Small‐Molecule Inducers of Fetal Hemoglobin ⬇️

scientific article published on March 17, 2011

Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation.

scientific article

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

scholarly article

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

scientific article

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

scientific article

Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.

scientific article

Identification of metal ion binding peptides containing unnatural amino acids by phage display ⬇️

scientific article published on March 7, 2013

Identification of p53 regulators by genome-wide functional analysis

scholarly article

Identification of small molecule activators of cryptochrome

scientific article

Identification of small-molecule inducers of pancreatic beta-cell expansion

scientific article

Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis

scientific article

Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling

scientific article

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

scientific article (publication date: 9 December 2011)

Immunochemical termination of self-tolerance

scholarly article

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

scholarly article

In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy

scientific article published on 25 June 2008

In vivo photocrosslinking with unnatural amino Acid mutagenesis

scientific article

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells

scholarly article

Large-scale analysis of the human and mouse transcriptomes

scientific article

Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids

scientific article (publication date: 2 August 2011)

Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

scholarly article

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

scientific article (publication date: 10 March 2009)

Microfluidic device for single-molecule experiments with enhanced photostability

scientific article published on September 2009

Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers

scientific article published on 27 April 2015

Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors

scientific article published on 6 September 2016

Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity ⬇️

scientific article published on June 26, 2013

Neratinib protects pancreatic beta cells in diabetes

scientific article published on 01 November 2019

New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice

scientific article published on 03 April 2020

Nonlinear partial differential equations and applications: Genomic analysis of the host response to hepatitis C virus infection

scientific article

One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases

scientific article

One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines ⬇️

scientific article published on 01 October 2003

Optimization of xenon biosensors for detection of protein interactions

scientific article

Optimized clinical performance of growth hormone with an expanded genetic code ⬇️

scientific article published on May 16, 2011

Oxysterols direct immune cell migration via EBI2 ⬇️

scientific article published on July 27, 2011

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells

scientific article

Photocleavage of the polypeptide backbone by 2-nitrophenylalanine

scientific article published on February 2009

Playing with the molecules of life

scientific article published on 18 January 2018

Polymerase recognition of unnatural base pairs

scientific article published on 01 October 2002

Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by Resonance Raman spectroscopy

scientific article published in December 2004

Probing Protein–Protein Interactions with a Genetically Encoded Photo‐crosslinking Amino Acid ⬇️

scientific article published on June 15, 2011

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry

scientific article

Profiling protein function with small molecule microarrays

scientific article

Progress toward a reduced phage genetic code.

scientific article published on 26 March 2018

Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Reactive Aryl Carbamate Side Chains

scientific article published on 3 April 2017

Protein conjugation with genetically encoded unnatural amino acids ⬇️

scientific article published on May 9, 2013

Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid.

scientific article

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

scientific article published on September 2002

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

scientific article

RETRACTED: Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation ⬇️

scientific article published on February 25, 2013

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

scientific article

Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones

scientific article published on 05 October 2016

Rational design of CXCR4 specific antibodies with elongated CDRs

scientific article

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

scientific article published on 23 September 2016

Rational design of a humanized glucagon-like peptide-1 receptor agonist antibody

scientific article published on 29 December 2014

Rational design of antibody protease inhibitors

scientific article

Rational design of humanized dual-agonist antibodies

scientific article published on 24 December 2014

Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids

scientific article

Recombinant expression of selectively sulfated proteins in Escherichia coli

scientific article published on 29 October 2006

Recombinant thiopeptides containing noncanonical amino acids

scientific article published on 14 March 2016

Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

scientific article

Redirection of genetically engineered CAR-T cells using bifunctional small molecules

scientific article published on 24 February 2015

Regenerative phenotype in mice with a point mutation in transforming growth factor β type I receptor ( TGFBR1 ) ⬇️

scientific article published on August 12, 2011

Replacement of 2'-Deoxycytidine by 2'-Deoxycytidine Analogues in the E. coli Genome

scientific article published on 20 October 2016

Replacement of Thymidine by a Modified Base in the Escherichia coli Genome

scientific article

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

scientific article published on 15 May 2009

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Reshaping Antibody Diversity

scientific article

Reshaping Antibody Diversity

Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines

scientific article

Retraction

Retraction of "Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity".

scientific article

Reversine increases the plasticity of lineage-committed mammalian cells

scientific article

Ribosomal route to small-molecule diversity ⬇️

scientific article

Role of tRNA orthogonality in an expanded genetic code

scientific article

Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency

scientific article

Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes

scientific article

Selecting folded proteins from a library of secondary structural elements.

scientific article

Selective Formation of Covalent Protein Heterodimers with an Unnatural Amino Acid ⬇️

scientific article published on March 25, 2011

Selective Staudinger modification of proteins containing p-azidophenylalanine

scientific article published in December 2005

Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

scientific article

Self-renewal of embryonic stem cells by a small molecule

scientific article

Semi-synthesis of a Bacterium with Non-Canonical Cell Wall Crosslinks

scientific article published on 08 June 2020

Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay

scientific article

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery ⬇️

scientific article published on 05 September 2013

Site-Specific Incorporation of a Dithiolane Containing Amino Acid into Proteins

scientific article published on 23 July 2019

Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins

scientific article published on 23 January 2018

Site-directed spin labeling of a genetically encoded unnatural amino acid

scientific article

Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR.

scientific article published on 15 February 2012

Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids

scientific article

Site-specific incorporation of a redox-active amino acid into proteins

scientific article

Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins

scientific article published in January 2008

Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli

scientific article published in December 2004

Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli.

scientific article

Site-specific incorporation of ε-N-crotonyllysine into histones

scientific article published on 11 June 2012

Site-specific labeling of proteins with NMR-active unnatural amino acids

scientific article published on 09 August 2009

Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex

scientific article published on 10 January 2006

Small Molecule Mediated Proliferation of Primary Retinal Pigment Epithelial Cells ⬇️

scientific article published on May 8, 2013

Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.

scientific article

Small molecule selectively suppresses MYC transcription in cancer cells

scientific article published on 14 March 2017

Small molecule-based approaches to adult stem cell therapies

scientific article

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis

scientific article published on 17 April 2017

Small molecules that induce cardiomyogenesis in embryonic stem cells

scientific article published in February 2004

Small-Molecule Stimulators of NRF1 Transcriptional Activity

scientific article published on 09 October 2019

Small-molecule inducer of β cell proliferation identified by high-throughput screening.

scientific article published on 25 January 2013

Small-molecule regulators of human stem cell self-renewal

scientific article published on 04 March 2011

Small-molecule switches for zinc finger transcription factors

scientific article

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

scientific article

Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator

scientific article published on September 2016

Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models

scientific article published on 23 March 2018

Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells ⬇️

scientific article published on November 18, 2011

Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases

scientific article

Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase

scientific article published in November 2005

Structural evidence for substrate strain in antibody catalysis

scientific article

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline

scientific article

Structural plasticity and the evolution of antibody affinity and specificity

scientific article published in July 2003

Structural plasticity of an aminoacyl-tRNA synthetase active site

scholarly article

Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)

scientific article published on 14 August 2018

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

scientific article published on 12 January 2016

Synthesis at the interface of chemistry and biology

scientific article published on September 2009

Synthesis of bispecific antibodies using genetically encoded unnatural amino acids.

scientific article

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids ⬇️

scientific article published on September 17, 2012

Synthetase polyspecificity as a tool to modulate protein function ⬇️

scientific article published on 08 October 2011

Synthetic small molecules that control stem cell fate

scientific article

Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate

scientific article

Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate

scientific article published on 12 October 2016

Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.

scientific article

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

scientific article

Targeting human C-type lectin-like molecule-1 (CLL1) with a bispecific antibody for immunotherapy of acute myeloid leukemia

scientific article

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

scientific journal article

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

article published in the Proceedings of the National Academy of Sciences of the United States of America

The chemistry of the antibody molecule

scientific article published in December 2002

The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs

scientific article

The effects of antibodies on stilbene excited-state energetics

scientific article published on 01 November 2006

The genetic incorporation of a distance probe into proteins in Escherichia coli.

scientific article

The genetic incorporation of p-azidomethyl-l-phenylalanine into proteins in yeast

scientific article published on 22 March 2018

The incorporation of a photoisomerizable amino acid into proteins in E. coli

scientific article published in January 2006

The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication

scientific article published in February 2006

The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

scientific article

The selective incorporation of alkenes into proteins in Escherichia coli

scientific article published in August 2002

The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination

scientific article published on 19 September 2004

Therapeutic applications of an expanded genetic code

scientific article

Toward a Synthetic Yeast Endosymbiont with a Minimal Genome

scientific article published on 26 August 2019

Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues

scientific article

Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1)

scientific article published on 01 February 2002

Transition states. Trapping a transition state in a computationally designed protein bottle

scientific article

Two-Dimensional IR Spectroscopy of Protein Dynamics Using Two Vibrational Labels: A Site-Specific Genetically Encoded Unnatural Amino Acid and an Active Site Ligand ⬇️

scientific article published on August 31, 2011

Unnatural amino acid mutagenesis of fluorescent proteins

scientific article published on 5 September 2012

Unnatural amino acid mutagenesis of green fluorescent protein

scientific article

Using unnatural amino acid mutagenesis to probe the regulation of PRMT1.

scientific article published on 06 January 2014

Versatile strategy for controlling the specificity and activity of engineered T cells

scientific article

Visualization of the delivery and release of small RNAs using genetic code expansion and unnatural RNA-binding proteins

scientific article published on 13 November 2018

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

scientific article

siRNA in human cells selectively localizes to target RNA sites

scientific article (publication date: 16 May 2006)

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