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List of works by Shinji Takai

A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury

scientific article published in February 2003

A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters

scientific article published in April 2003

A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins

scientific article published in April 2004

A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters

scientific article published on 11 February 2004

A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters

scientific article

An antiarrhythmic effect of a chymase inhibitor after myocardial infarction

scientific article

Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

scientific article published on 27 August 2009

Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters

scientific article

Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction

scientific article published in June 2002

Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1–Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells ⬇️

scientific article published on October 2, 2003

Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats

scientific article published on 25 November 2010

Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function

scientific journal article

Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery

scientific article published in May 2002

Chymase as a novel target for the prevention of vascular diseases

scientific article published in October 2004

Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters

scientific article published on 7 July 2010

Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

scientific article published in August 2014

Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes

scientific article published in August 2009

Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet

scientific article published on 30 March 2010

Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice.

scientific article published on 26 May 2009

Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo

scientific article

Chymase-derived angiotensin II and arrhythmias after myocardial infarction

scientific article published in August 2004

Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats

scientific article published on 3 June 2010

Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model

scientific article

Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs

scientific article published on 2 March 2005

Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice

scientific article

Effects of mitomycin C on the expression of chymase and mast cells in the conjunctival scar of a monkey trabeculectomy model

scientific article published on 13 October 2009

Enteric Pathogens and Coinfections in Foals with and without Diarrhea

scientific article published on 27 December 2016

First Microbiological and Molecular Identification of Rhodococcus equi in Feces of Nondiarrheic Cats

scientific article published on 09 July 2019

Human chymase degrades human fibronectin

scientific article

Impact of chymase inhibitor on cardiac function and survival after myocardial infarction ⬇️

scientific article published on November 1, 2003

Increased local angiotensin II formation in aneurysmal aorta

scientific article published in September 2002

Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model

scientific article

Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice.

scientific article published on 25 June 2009

Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins

scientific article published in September 2002

Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis

scientific article published on 7 February 2009

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage ⬇️

scientific article published on July 27, 2010

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

scientific article

Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models

scientific article published on 11 July 2006

Possible roles of mast cell-derived chymase for skin rejuvenation

scientific article

Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats ⬇️

scientific article published on November 29, 2012

Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model

scientific article

Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats

scientific article published on 7 August 2009

Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice

scientific article published on 4 October 2013

Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors

scientific article published in March 2004

Targets of chymase inhibitors

scientific article published on 04 February 2011

The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet

scientific article

The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer

scientific article published in October 2005

Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis

scientific article published in October 2004

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