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List of works by John M Pascal

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

scientific article published on October 2006

A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation

scientific article

Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases

scientific article published on 19 December 2011

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response

scientific article published on 22 July 2015

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

scientific article published on 16 December 2020

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

scientific article published on February 2012

Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin

scientific article published on 01 November 2020

CARM1 regulates replication fork speed and stress response by stimulating PARP1

scientific article published on 30 December 2020

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

scientific article published on 05 September 2020

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

scientific article

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein

scientific article

DNA and RNA ligases: structural variations and shared mechanisms

scientific article

DNA ligases: structure, reaction mechanism, and function

scientific article

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity

scientific article published on 24 May 2019

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

scientific article

Dual roles of PARP-1 promote cancer growth and progression

scientific article published on 19 September 2012

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation

scientific article published on 03 November 2020

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

scientific article published on 01 February 2021

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

scientific article published on 16 August 2016

Human DNA ligase I completely encircles and partially unwinds nicked DNA

scientific article

Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes

scientific article

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS

scientific article published on 11 June 2018

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

scientific article

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

scientific article published on 27 February 2018

New players to the field of ADP-ribosylation make the final cut

scientific article published on 9 April 2013

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

scientific article published on 24 November 2018

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

scientific article published on 24 November 2015

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

scientific article published on 16 January 2013

PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

scientific article

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

scientific article published on 23 December 2015

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

scientific article published on 18 August 2021

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

scientific article published on 21 November 2019

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

scientific article published on 04 July 2019

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

scientific article published on 7 July 2017

Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis

scientific article published in January 2017

Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis

scientific article published on January 1, 2011

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

scientific article published on 19 February 2015

RNA ligase does the AMP shuffle

scientific article published on 01 November 2006

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

scientific article published on 26 October 2011

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

scientific article published on 10 August 2014

Signal-induced PARP1-Erk synergism mediates IEG expression

scholarly article in Signal transduction and targeted therapy, vol. 4 no. 1, 2019

Structural Basis for Calmodulin as a Dynamic Calcium Sensor ⬇️

scientific article published on May 9, 2012

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1 ⬇️

scientific article published on May 11, 2012

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.

scientific article published on 24 November 2015

Structural Implications for Selective Targeting of PARPs

scientific article published on 20 December 2013

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

scientific article published on 28 February 2020

Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase

scientific article published on 02 August 2019

Structural basis for allosteric PARP-1 retention on DNA breaks

scientific article

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

scientific article published on 28 February 2013

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

scientific article

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling

scientific article

Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification

scientific article

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer

scientific article

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1

scientific article published on 11 June 2009

The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine

scientific article published on 07 December 2020

The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction

scientific article

The comings and goings of PARP-1 in response to DNA damage

scientific article published on 23 August 2018

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage

scientific article

The rise and fall of poly(ADP-ribose): An enzymatic perspective

scientific article published on May 2015

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

scientific article published on 01 July 2020

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy

scientific article published on 5 January 2017

Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation

scientific article

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