List of works - Christoph Wülfing

A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse

scientific article

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

scientific article published on 10 January 2022

Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics

scientific article

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

scientific article

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

scientific article published on 4 March 2013

Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function ⬇️

scientific article published on July 27, 2010

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

scientific article

Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance

scientific article

Itk controls the spatiotemporal organization of T cell activation

scientific article published on October 2011

Mechanism and function of Vav1 localisation in TCR signalling.

scientific article published on 6 September 2012

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

scientific article (publication date: 2015)

New TACTICS for finding Numb

scientific article

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor

scientific article published on 15 September 2020

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

scientific article published on 23 January 2017

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization ⬇️

scientific article published on November 11, 2011

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions

scientific journal article

Spatiotemporal patterning during T cell activation is highly diverse

scientific article

Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization

scientific article

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing

scientific article

Systems Imaging of the Immune Synapse

scientific article

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

scientific article

T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice

scientific article

Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy ⬇️

scientific article published on November 1, 2010

The CD3 ζ Subunit Contains a Phosphoinositide-Binding Motif That Is Required for the Stable Accumulation of TCR–CD3 Complex at the Immunological Synapse ⬇️

scientific article published on May 4, 2011

The actin-driven spatiotemporal organization of T-cell signaling at the system scale

scientific article

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions

scientific article

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

scientific journal article

Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42

scientific article

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

scientific article published on 30 October 2019

List of works by Christoph Wülfing

A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function ⬇️

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance

Itk controls the spatiotemporal organization of T cell activation

Mechanism and function of Vav1 localisation in TCR signalling.

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

New TACTICS for finding Numb

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization ⬇️

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions

Spatiotemporal patterning during T cell activation is highly diverse

Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing

Systems Imaging of the Immune Synapse

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice

Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy ⬇️

The CD3 ζ Subunit Contains a Phosphoinositide-Binding Motif That Is Required for the Stable Accumulation of TCR–CD3 Complex at the Immunological Synapse ⬇️

The actin-driven spatiotemporal organization of T-cell signaling at the system scale

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion