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List of works by Yali Dou

ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes

scientific article published on 28 February 2013

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

scientific article published on July 2010

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma

scientific article

Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

scientific article published on 27 April 2017

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

scientific article published on 05 December 2019

Developmental ROS individualizes organismal stress resistance and lifespan

scientific article published on 04 December 2019

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

scientific article published on 14 May 2020

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

scientific article

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

scientific article published on 14 May 2021

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

scientific article published on 27 April 2016

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

scientific article published on 06 February 2020

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

scientific article published on 26 October 2015

H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

scientific article published on 08 June 2020

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

scientific article published on 16 June 2020

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

scientific article

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

scientific article

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

scientific article published on 24 June 2020

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

scientific article

MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

scientific article published on 01 November 2019

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

scientific article published on 01 February 2020

Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches

scientific article published on 25 April 2019

PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

scientific article published on 12 April 2016

Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

scientific article published on 27 February 2020

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

scientific article

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

scientific article published on 21 March 2018

Structural basis for activity regulation of MLL family methyltransferases

scientific article

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

scientific article published on 16 February 2017

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts.

scientific article published on 11 October 2016

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation

scientific article

The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma.

scientific article

Two mammalian MOF complexes regulate transcription activation by distinct mechanisms

scientific article published on October 2009

p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells

scientific article published on 01 January 2020

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