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List of works by Owen Patrick McGuinness

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

scientific article published on 01 May 2020

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

scientific article published on 15 September 2013

A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo

scientific article published on 16 July 2013

Alterations in hepatic gluconeogenic amino acid uptake and gluconeogenesis in the endotoxin treated conscious dog ⬇️

scientific article published on 01 April 1998

Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in Mice ⬇️

scientific article published on July 1, 2011

Automated quantification of microvascular perfusion

scientific article published on 15 July 2018

Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward

scientific article published on 26 July 2018

Cholesteryl ester transfer protein protects against insulin resistance in obese female mice.

scientific article published on 02 September 2013

Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity

scientific article published on 01 September 1990

Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.

scientific article

Circadian disruption leads to insulin resistance and obesity

scientific article published on 21 February 2013

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

scientific article

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

scientific article published in February 2006

Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization ⬇️

scientific article published on October 12, 2010

Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice

scientific article published on 2 December 2004

Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice

scientific article

Dapagliflozin does not directly affect human α or β cells

scientific article published on 19 May 2020

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon

scientific article published on 5 October 2006

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

scientific journal article

Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia ⬇️

scientific article published on January 20, 2012

Eating breakfast and avoiding late-evening snacking sustains lipid oxidation

scientific article published on 27 February 2020

Effect of acute glucagon removal on metabolic response to infection in conscious dog

scientific article published on 01 January 1995

Effects of G6pc2 deletion on body weight and cholesterol in mice

scientific article published on 25 January 2017

Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism

scientific article published on 01 January 1993

Effects of fructose on hepatic glucose metabolism

scientific article

Enhanced Glucose Transport, but not Phosphorylation Capacity, Ameliorates Lipopolysaccharide-Induced Impairments in Insulin-Stimulated Muscle Glucose Uptake.

scientific article published on 14 December 2015

Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance ⬇️

scientific article published on September 10, 2012

Factors Which Regulate Net Hepatic Glucose Uptake In Vivo ⬇️

scientific article published on May 1, 1991

G6PC2 Confers Protection Against Hypoglycemia Upon Ketogenic Diet Feeding and Prolonged Fasting

scientific article published on 19 June 2020

G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress

scientific article published on 14 June 2016

G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance

scientific article published on 21 September 2016

G6PC2: a negative regulator of basal glucose-stimulated insulin secretion

scientific article published on 28 December 2012

Glucagon chronically impairs hepatic and muscle glucose disposal

scientific article published on 28 November 2006

Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability

scientific article published on 10 February 2009

Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia

scientific article published on 31 January 2006

Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output

scientific article published on 01 April 1987

Hepatic Gi signaling regulates whole-body glucose homeostasis.

scientific article published on 16 January 2018

Hepatic and muscle glucose metabolism during total parenteral nutrition: impact of infection

scientific article published on 01 November 1998

Hepatic glucose metabolism during intraduodenal glucose infusion: impact of infection

scientific article published on 01 July 2000

Hepatic production and intestinal uptake of IGF-I: response to infection

scientific article published on 01 December 1998

Hyperglucagonemia and hepatic glucose metabolism during infection in the conscious dog

scientific article published on 01 April 1996

Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN

scientific article published on 01 August 2000

Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice

scientific article published on 16 November 2011

Impact of acute epinephrine removal on hepatic glucose metabolism during stress hormone infusion

scientific article published on 01 July 1999

Impact of chronic fructose infusion on hepatic metabolism during TPN administration

scientific article published in December 2002

Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog

scientific article published on 01 August 1993

Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake

scientific article

Impact of enteral and parenteral nutrition on hepatic and muscle glucose metabolism

scientific article published in September 2000

Impact of infection on glucose-dependent liver glucose uptake during TPN: interaction with insulin ⬇️

scientific article published on October 7, 2003

Impact of infection on hepatic disposal of a peripheral glucose infusion in the conscious dog ⬇️

scientific article published on August 1, 1995

Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection

scientific article published in March 2002

Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice

scientific article published on 5 July 2006

Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency

scientific article published on 14 May 2019

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

scientific article

Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?

scientific article

Infection impairs insulin-dependent hepatic glucose uptake during total parenteral nutrition

scientific article published on 19 November 2002

Insulin secretion in the conscious mouse is biphasic and pulsatile

scientific article

Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas.

scientific article

Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration

scientific article published in March 1991

Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog.

scientific article

Liver but not adipose tissue is responsive to the pattern of enteral feeding

scientific article published on 25 February 2014

Liver, but not muscle, has an entrainable metabolic memory

scientific article published on 23 January 2014

Lost in translation

scientific article published on 01 September 2009

Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity

scientific article published on 19 June 2007

Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6.

scientific article

Microfluidic glucose stimulation reveals limited coordination of intracellular Ca2+ activity oscillations in pancreatic islets

scholarly article

NF-κB-dependent airway inflammation triggers systemic insulin resistance

scientific article

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse

scientific article published on 28 July 2009

Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity

scientific article

Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose

scientific article published on 01 May 2020

Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo

scientific article published on 17 September 2019

Physiological consequences of phasic insulin release in the normal animal

scientific article

Potential positive and negative consequences of ZnT8 inhibition

scientific article published on 01 June 2020

Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.

scientific article published on February 2004

Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis

scientific article published on 12 March 2019

Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice

scientific article

Regulation of glucose production by NEFA and gluconeogenic precursors during chronic glucagon infusion ⬇️

scientific article published on 01 September 1998

Reply to Letter to the Editor: Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo

scientific article published on 01 March 2020

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis

scientific article published on 21 May 2020

Role of cortisol in the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 May 1996

Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog ⬇️

scientific article published on 01 October 1997

Role of glucagon in the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 March 1994

Route-dependent effect of nutritional support on liver glucose uptake

scientific article published on 30 June 2005

Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo

scientific article published on 12 June 2009

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

scientific article published on 16 August 2010

Systemic bile acids induce insulin resistance in a TGR5-independent manner

scientific article published on 19 February 2019

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice

scientific article

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background ⬇️

scientific article published on July 19, 2012

The effect of acute glucagon removal on the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 October 1994

Time course of the hepatic adaptation to TPN: interaction with glycogen depletion

scientific article published on 31 August 2004

Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

scientific article published on 20 May 2015

Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.

scientific article published on 24 July 2013

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