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List of works by Hergen Spits

A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia

scientific article published on 07 May 2019

A common solution to group 2 influenza virus neutralization

scientific article

A new edge to immune surveillance by the neural system

scientific article published on 16 September 2016

A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice

scientific article

A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.

scientific article

A novel mouse model for stable engraftment of a human immune system and human hepatocytes

scientific article

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation

scientific article published on 13 May 2020

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

scientific article

AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses

scientific article published on 23 October 2017

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

scientific article published on 14 June 2019

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice

scientific article published on 02 April 2019

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

scientific article published on 22 May 2014

Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5

scientific article (publication date: 15 April 2011)

Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

scientific article published on 01 January 2020

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice

scientific article

BOB.1 controls memory B-cell fate in the germinal center reaction

scientific article published on 30 April 2019

Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity

scientific article

CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn's disease

scientific article published on 06 October 2021

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.

scientific article published on 21 March 2014

Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture

scientific article published on August 2006

Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3

scientific article published on 06 August 2019

Corrigendum: Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

scientific article published in December 2016

Corrigendum: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

scientific article published on 01 October 2016

Critical assessment of human antibody generation in humanized mouse models

scientific article

Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance

scientific article published on 21 February 2019

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

scientific article published on 27 April 2020

Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.

scientific article

Development and activation of regulatory T cells in the human fetus

scientific article published in February 2005

Development of alphabeta T cells in the human thymus

scientific article

Development of human lymphoid cells

scientific article

Developmental origin of pre-DC2.

scientific article

Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis

scientific article published on 13 February 2003

Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies

scientific article published on 8 September 2015

Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection

scientific article

Erratum to: 'Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance' (J Hepatol 2019; 71(1): 14-24)

scientific article published on 01 August 2020

Erratum: Corrigendum: Evidence of innate lymphoid cell redundancy in humans

article

Erratum: Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

scholarly article published in Nature Immunology

Evidence of innate lymphoid cell redundancy in humans

scientific article published on 12 September 2016

Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice

scientific article published on 01 January 2008

Experimental models to study development and function of the human immune system in vivo

scientific article

Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation

scientific article published in March 2007

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

scientific article

Functional Differences between Human NKp44− and NKp44+ RORC+ Innate Lymphoid Cells ⬇️

scientific article published on April 9, 2012

Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors

scientific article

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

scientific article (publication date: 2011)

Generation and characterization of anti-citrullinated protein antibody-producing B-cell clones from rheumatoid arthritis patients

scientific article published on 02 February 2019

Generation and maintenance of cloned human T cell lines

scientific article published in May 2002

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice

scientific article (publication date: 4 October 2010)

Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer

scientific article published on 01 December 2002

Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming

scientific article

Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire

scientific article published on 15 July 2013

Group 2 innate lymphoid cells show up in the skin ⬇️

scientific article published on June 4, 2013

Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance

scientific article

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

scientific article published on 22 December 2014

High-throughput identification of antigen-specific TCRs by TCR gene capture

scientific article

Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2.

scientific article published on 31 August 2017

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

scientific article published on 11 September 2011

Human ILC1: To Be or Not to Be.

scientific article published on May 2017

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

scientific article published on 8 February 2010

Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft-versus-host disease

scientific article published on 01 November 2019

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells

scientific article published on 23 November 2008

Human innate lymphoid cells

scientific article published on 28 April 2014

Human innate lymphoid cells

scientific article published on 24 September 2016

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

scientific article published on March 2004

Human thymus regeneration and T cell reconstitution

scientific article published on October 2007

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

scientific article published on 20 January 2013

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

scientific article published on July 2009

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

scientific article published on 22 December 2008

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell–dependent antibody responses in vivo ⬇️

scientific article published on March 28, 2011

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

scientific article published on 14 May 2019

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

scientific article published on 25 April 2016

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter

scientific article

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis

scientific article published on 22 February 2008

IL-22-producing CD4+ T cells: middle-men between the immune system and its environment

scientific article published on September 2010

IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells

scientific article

IL-7 Enhances Thymic Human T Cell Development in "Human Immune System" Rag2-/-IL-2R c-/- Mice without Affecting Peripheral T Cell Homeostasis

article

IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells

scientific article published on 01 August 2007

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.

scientific article

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells

scientific article

Identification of human cytotoxic ILC3s

scientific article published on 09 December 2020

Immunogenicity, Including Vitiligo, and Feasibility of Vaccination With AutologousGM-CSF–Transduced Tumor Cells in Metastatic Melanoma Patients

scientific article published on 31 October 2005

In Vivo Modulation of Gene Expression by Lentiviral Transduction in “Human Immune System” Rag2−/−γc −/− Mice

article

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation-Strain-Promoted (4 + 2) Cycloaddition

scientific article published on 6 March 2017

Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis

scientific article published on 11 December 2017

Innate Lymphoid Cells: 10 Years On

scientific article published on 01 August 2018

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function ⬇️

scientific article published on January 6, 2012

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases.

scientific article

Innate lymphoid cells in inflammation and immunity

scientific article

Innate lymphoid cells: from helper to killer

scientific article published on 21 September 2020

Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

scientific article published on 14 July 2015

Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?

scientific article published in April 2009

Interleukin-33 improves local immunity during gram-negative pneumonia by a combined effect on neutrophils and inflammatory monocytes

scientific article published on 11 December 2020

Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants

scientific article published on 24 April 2003

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo

article

Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells

scientific article published on January 2010

Isolation of Human Innate Lymphoid Cells

scientific article published on 29 June 2018

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3

scientific article published on 14 June 2019

Lymphocyte development

scientific article published on 3 April 2013

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens

scientific article published on 01 January 2018

Modeling human lung infections in mice

scientific article published on 01 October 2019

Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2.

scientific article published on 22 October 2013

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells

scientific article

Multiplex flow cytometry-based assay to study the breadth of antibody responses against E1E2 glycoproteins of hepatitis C virus

scientific article published on 27 August 2017

Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit

scientific article published on 30 December 2013

NK cells and type 1 innate lymphoid cells: partners in host defense

scientific article published on June 2016

Natural killer or dendritic: what's in a name?

scientific article published on January 2007

Neoantigen landscape dynamics during human melanoma-T cell interactions

scientific article published on 27 June 2016

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

scientific article published on February 2017

New insights into the function, development, and plasticity of type 2 innate lymphoid cells

article

New models of human immunity

scientific article published in April 2014

Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins

scientific article (publication date: 2013)

Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice

scientific article published on 18 August 2017

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

scientific article published on 01 November 2020

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

scientific article

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

scientific article

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

scientific article published on 5 October 2009

Plasticity of innate lymphoid cell subsets

scientific article published on 27 February 2020

Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1

scientific article published on 03 September 2013

Preclinical test of a lentivirus-mediated RNAi gene therapy against HIV-AIDS in the humanized mouse model.

scientific article published on 3 October 2011

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation

scientific article published on 03 August 2018

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

scientific article published on 31 December 2013

Quantitative events determine the differentiation and function of helper T cells

scientific article published in April 2011

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

scientific article published on 24 April 2006

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2

scientific article published on 04 November 2010

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice

scientific article published on 28 August 2009

Role of human innate lymphoid cells in IMID.

scientific article published on 28 November 2012

STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.

scientific article published on April 2008

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

scientific article published on 13 February 2005

SnapShot: innate lymphoid cells

scientific article published on 5 September 2013

Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression

scientific article published on 13 June 2008

Stable long-term cultures of self-renewing B cells and their applications

scientific article

Stem Cell Factor Consistently Improves Thymopoiesis after Experimental Transplantation of Murine or Human Hematopoietic Stem Cells in Immunodeficient Mice ⬇️

scientific article published on August 22, 2011

Stimulated plasmacytoid dendritic cells impair human T-cell development

scientific article published on 17 August 2006

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article

Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development

scientific article published on 10 May 2010

T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells

scientific article published on 11 August 2008

TOX sets the stage for innate lymphoid cells

scientific article published on 01 June 2015

Telomerase levels control the lifespan of human T lymphocytes

scientific article published on 10 April 2003

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

scientific article published on 10 May 2012

Th1- and Th2-like subsets of innate lymphoid cells

scientific article published on March 2013

The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development

scientific article

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model

article

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation

scientific article published on December 2016

The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut

scientific article published on 01 January 2012

The biology of innate lymphoid cells

scientific article

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.

scientific article

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

scientific article

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

scientific article published on 21 April 2013

The role of Bob1 in rheumatoid arthritis: potential implications for autoimmunity

scholarly article by Nataliya Yeremenko et al published 2012 in Journal of Translational Medicine

The role of ILC2 in pathology of type 2 inflammatory diseases

scientific article published on 30 October 2014

The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells

scientific article

The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development

scientific article

Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation

scientific article published in April 2010

Transcriptional control of innate lymphoid cells

scientific article

Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice

scientific article published on 02 March 2006

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

scientific article published on 01 August 2020

Type 2 innate lymphoid cells–new members of the “type 2 franchise” that mediate allergic airway inflammation ⬇️

scientific article published on 01 May 2012

Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection

scientific article published on 21 February 2007

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

scientific article published on 01 July 2019

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