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List of works by Rajendra Prasad

A New Endogenous Overexpression System of Multidrug Transporters of Candida albicans Suitable for Structural and Functional Studies.

scientific article published on 3 March 2016

A detailed lipidomic study of human pathogenic fungi Candida auris

scientific article published on 05 August 2020

A genome-wide steroid response study of the major human fungal pathogen Candida albicans

scientific article published on 16 June 2007

A homologous overexpression system to study roles of drug transporters in Candida glabrata

scientific article published on 03 June 2020

A key structural domain of the Candida albicans Mdr1 protein.

scientific article

A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans

scientific article published on 2 May 2008

ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

scientific article published on 16 July 2019

ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry

scientific article published in October 2004

ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance

scientific article published on 05 June 2015

ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis

scientific article published in PLoS ONE

Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans

scientific article published on 06 December 2011

Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux.

scientific article published on 3 June 2005

All about Candida Drug Resistance CDRs: Past, Present and Future

scientific article published on 29 October 2018

Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans

scientific article published on 17 November 2006

An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans

scientific article

Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans

scientific article published on 10 August 2010

Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans

scientific article published on 13 June 2011

Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans

scientific article

Antifungals: Mechanism of Action and Drug Resistance

scientific article published on January 2016

Assessment of antifungal resistance and associated molecular mechanism in Candida albicans isolates from different cohorts of patients in North Indian state of Haryana

scientific article published on 26 March 2020

Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.

scientific article

Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.

scientific article published on 20 November 2017

Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans

scientific article

Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.

scientific article published on January 2016

Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system.

scientific article published on 9 October 2007

Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps

scientific article published on 14 November 2019

Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.

scientific article published in February 2006

Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

scientific article published on 5 August 2015

Chimeras of the ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide-binding domains, but transmembrane segment 12 is replaceable with the corresponding homologous region of the non-drug transporter C

scientific article published on 01 May 2006

Comparative Lipidomics in Clinical Isolates of Candida albicans Reveal Crosstalk between Mitochondria, Cell Wall Integrity and Azole Resistance ⬇️

scientific article published on June 27, 2012

Comparative Lipidomics of Azole Sensitive and Resistant Clinical Isolates of Candida albicans Reveals Unexpected Diversity in Molecular Lipid Imprints ⬇️

scientific article published on April 29, 2011

Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans

scientific article published on 01 January 2005

Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis

scientific article published on December 2006

Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump ⬇️

scientific article published on October 24, 2003

Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals

scientific article published on 26 May 2009

Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans

scientific article published on 21 October 2013

Differential dynamics of membrane proteins in yeast.

scientific article published on 16 July 2009

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

scientific article

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable

scientific article

Dosage-dependent functions of fatty acid desaturase Ole1p in growth and morphogenesis of Candida albicans

scientific article published in June 2004

Drug susceptibilities of yeast cells are affected by membrane lipid composition

scientific article published on December 2002

Emerging Mechanisms of Drug Resistance in Candida albicans

scientific article published on 01 January 2019

Employing information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in Mdr1p of Candida albicans

scientific article

Epidemiology and molecular typing of Candida isolates from burn patients

scientific article published in November 2004

Erratum: Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.

scientific article

Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters.

scientific article published on 20 January 2017

Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element.

scientific article

FK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates of Candida albicans

scientific article

Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans.

scientific article

Functional characterization of Candida albicans ABC transporter Cdr1p.

scientific article published on December 2003

Functional characterization of N-terminal nucleotide binding domain (NBD-1) of a major ABC drug transporter Cdr1p of Candida albicans: uncommon but conserved Trp326 of Walker B is important for ATP binding.

scientific article published in May 2005

Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans ⬇️

scientific article published on April 27, 2011

Genome-wide expression profile of steroid response in Saccharomyces cerevisiae

scientific article published in April 2004

Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses

scientific article published on 12 August 2020

Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans.

scientific article published on January 2004

Identification of genome-wide binding sites of heat shock factor 1, Hsf1, under basal conditions in the human pathogenic yeast, Candida albicans

scientific article published on 16 July 2018

In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains

scientific article published on 20 December 2019

In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.

scientific article published on 17 October 2011

In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry

scientific article published on April 2002

Information theoretic measures and mutagenesis identify a novel linchpin residue involved in substrate selection within the nucleotide-binding domain of an ABCG family exporter Cdr1p

scientific article published on 14 January 2019

Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.

scientific article published on 3 July 2013

Interactions between bacteria and Candida in the burn wound

scientific article published on 01 May 2005

Inventory of ABC proteins and their putative role in salt and drug tolerance in Debaryomyces hansenii

scientific article published on 17 July 2018

Iron deprivation inducesEFG1-mediated hyphal development inCandida albicanswithout affecting biofilm formation

article

Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

scientific article published on 01 December 2014

Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model

scientific article published on 16 April 2017

Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis ⬇️

scientific article published on January 1, 2012

Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species

scientific article published on 01 January 2019

Lipidomics andin VitroAzole Resistance inCandida albicans ⬇️

scientific article published on February 1, 2013

Lipids of Candida albicans and their role in multidrug resistance

scientific article published on 24 August 2013

MFS transporters of Candida species and their role in clinical drug resistance.

scientific article published on May 2016

MFS transportome of the human pathogenic yeast Candida albicans

scientific article

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans

scientific article published on 25 July 2018

Mechanism of action of novel synthetic dodecapeptides against Candida albicans

scientific article published on 20 July 2013

Membrane homoeostasis and multidrug resistance in yeast

scientific article published on August 2008

Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans

scientific article published on May 2004

Modulators of the Efflux Pump Cdr1p of Candida albicans: Mechanisms of Action and Chemical Features.

scientific article published on 22 May 2017

Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter.

scientific article published on 13 January 2018

Molecular determinants of transient and reversible induced up-regulation of CaCDR1 in azole susceptible clinical isolates of Candida albicans

scientific article published on 01 February 2011

Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans

scientific article

Molecular studies of NAD- and NADP-glutamate dehydrogenases decipher the conundrum of yeast-hypha dimorphism in zygomycete Benjaminiella poitrasii

scientific article published on 01 December 2019

Molecular typing and in vitro fluconazole susceptibility of Candida species isolated from diabetic and nondiabetic women with vulvovaginal candidiasis in India ⬇️

scientific article published on January 18, 2011

Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans

scientific article published on 29 May 2010

Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.

scientific article

Multidrug resistance in yeast Candida

scientific article

Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts

scientific article published on 3 December 2007

Multidrug transporters of Candida species in clinical azole resistance

scientific article published on 11 July 2019

Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.

scientific article published on 8 June 2015

Ncb2 Is Involved in Activated Transcription of CDR1 in Azole-Resistant Clinical Isolates of Candida albicans ⬇️

scientific article published on August 19, 2011

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

scientific article published on 2 June 2016

Non-heat shock responsive roles of HSF1 in Candida albicans are essential under iron deprivation and drug defense.

scientific article

Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans

article

Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps.

scientific article published on 4 May 2016

Overcoming the heterologous bias: an in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

scientific article published on 4 December 2010

Overexpression of the CORVET complex alleviates the fungicidal effects of fludioxonil on the yeast Saccharomyces cerevisiae expressing hybrid histidine kinase 3

scientific article published on 16 November 2018

PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans

scientific article published on 12 November 2009

PDR-like ABC systems in pathogenic fungi

scientific article published on 25 September 2019

Pathogenicity and drug resistance in Candida albicans and other yeast species. A review

scientific article published on September 2007

Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells

scientific article published on 29 May 2018

Phospholipidome of Candida: each species of Candida has distinctive phospholipid molecular species

scientific article

Phylogenetic and conservation analyses of MFS transporters

scholarly article by Poonam Vishwakarma et al published November 2018 in 3 Biotech

Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.

scientific article published on 29 March 2016

Protonophore FCCP provides fitness advantage to PDR-deficient yeast cells

scientific article published on 17 August 2020

Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis

scientific article

Quorum sensing: A less known mode of communication among fungi.

scientific article published on 21 March 2018

RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans ⬇️

scientific article published on August 16, 2012

Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach

scientific article

Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

scientific article published on 16 April 2013

Resistance to antifungal therapies

scientific article published on February 2017

Response of pathogenic and non-pathogenic yeasts to steroids.

scientific article

Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks

scientific article

SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter

scientific article published in February 2004

Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans

scientific article published on 21 April 2005

Structural heterogeneity in RNA recognition motif 2 (RRM2) of TAR DNA-binding protein 43 (TDP-43): clue to amyotrophic lateral sclerosis

scientific article published on 22 January 2020

Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/H+ transport

scientific article published on 5 January 2007

Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.

scientific article

Susceptibility pattern and molecular type of species-specific Candida in oropharyngeal lesions of Indian human immunodeficiency virus-positive patients

scientific article published on March 2004

Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis

scientific article published on 23 April 2010

The ABCs of Candida albicans Multidrug Transporter Cdr1

scientific article

The E-helix is a central core in a conserved helical bundle involved in nucleotide binding and transmembrane domain intercalation in the ABC transporter superfamily

scientific article published on 09 January 2019

The Quorum-Sensing Molecule Farnesol Is a Modulator of Drug Efflux Mediated by ABC Multidrug Transporters and Synergizes with Drugs in Candida albicans ⬇️

scientific article published on July 18, 2011

The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport

scientific article

The global regulator Ncb2 escapes from the core promoter and impacts transcription in response to drug stress in Candida albicans.

scientific article published on 06 April 2017

The glyoxylate cycle enzyme activities in the pathogenic isolates of Candida albicans obtained from HIV/AIDS, diabetic and burn patients

scientific article published in March 2006

The mechanism of overcoming multidrug resistance (MDR) of fungi by amphotericin B and its derivatives

scientific article published on 01 July 2007

The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance

scientific article

Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans

scientific article published on 11 February 2008

Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells

scientific article published on 5 September 2006

Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast

scientific article published on 26 February 2019

Voriconazole and multidrug resistance in Candida albicans

scientific article published on 01 March 2007

W1038 near D-loop of NBD2 is a focal point for inter-domain communication in multidrug transporter Cdr1 of Candida albicans

scientific article published on 30 January 2018

Withdrawal: Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

scientific article published on 01 March 2020

Yeast ABC transporters in lipid trafficking

scientific article published on 31 May 2016

pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport.

scientific article published on 18 July 2016

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