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List of works by Alison P Klein

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

scientific article

A histomorphologic comparison of familial and sporadic pancreatic cancers

scientific article published on 23 April 2015

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

scientific article published on 01 February 2021

A multimodality test to guide the management of patients with a pancreatic cyst

scientific article published on 01 July 2019

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

scientific article published on 30 August 2019

ATM mutations in patients with hereditary pancreatic cancer

scientific article published on 29 December 2011

Absence of deleterious palladin mutations in patients with familial pancreatic cancer.

scientific article

Absence of germline BRCA1 mutations in familial pancreatic cancer patients

scientific article published on January 2009

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

scientific article published on 12 December 2018

Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery

scientific article

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

scientific article published on 25 January 2017

Altered telomeres in tumors with ATRX and DAXX mutations

scientific article

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population

scientific article published on 13 September 2013

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study

scientific article published on 23 April 2019

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

scientific article published on 03 July 2020

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study ⬇️

scientific article published on 23 February 2017

Associations between genetically predicted blood protein biomarkers and pancreatic cancer risk

scientific article published on 21 May 2020

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study

scientific article published on 20 November 2014

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors

scientific article

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

scientific article published on 5 September 2017

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

scientific article published on 22 June 2015

Copy-number variants in patients with a strong family history of pancreatic cancer

article

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

scientific article

DETECTION OF CIRCULATING TUMOR DNA IN PATIENTS WITH PANCREATIC CANCER USING DIGITAL NEXT-GENERATION SEQUENCING

scientific article published on 20 March 2020

DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease

scientific article published on 01 January 2006

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

scientific article published on 10 April 2009

Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma

scientific article published on 02 August 2017

Detectable clonal mosaicism and its relationship to aging and cancer

journal article published in 2012

Detection and localization of surgically resectable cancers with a multi-analyte blood test.

scientific article published on 18 January 2018

Elevated cancer mortality in the relatives of patients with pancreatic cancer

scientific article

Erratum: Corrigendum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article published in Nature

Exome-Wide Association Study of Pancreatic Cancer Risk

scientific article published on 23 October 2017

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

scientific article

Familial and sporadic pancreatic cancer share the same molecular pathogenesis

scientific article

Familial pancreatic cancer: from genes to improved patient care

scientific article published on October 2007

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

scientific article published on 28 April 2020

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

journal article published in 2016

Frequent detection of pancreatic lesions in asymptomatic high-risk individuals.

scientific article

Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer

scientific article published on 30 October 2019

Genetic and Circulating Biomarker Data Improve Risk Prediction for Pancreatic Cancer in the General Population

scientific article published on 22 April 2020

Genetic and epigenetic alterations of familial pancreatic cancers

scientific article published on December 2008

Genetic mutations associated with cigarette smoking in pancreatic cancer

scientific article

Genome-Wide Somatic Copy Number Alterations in Low-Grade PanINs and IPMNs from Individuals with a Family History of Pancreatic Cancer ⬇️

scientific article published on June 21, 2012

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk

scientific article published on 08 July 2020

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

scientific article

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

scientific article

Genome-wide gene-diabetes and gene-obesity interaction scan in 8,255 cases and 11,900 controls from the PanScan and PanC4 Consortia

scientific article published on 16 June 2020

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

scientific article published on 8 February 2018

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

scientific article published in Nature Communications

Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis.

scientific article published on 31 January 2014

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

scientific article published on 08 July 2019

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients

scientific article published on December 2009

Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation

scientific article

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

scientific article published on 7 February 2017

Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

scientific article published on 3 August 2017

Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk

scientific article published on 23 September 2020

Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms

scientific article published on 22 July 2020

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.

scientific article published on September 2006

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.

scientific article published on 18 April 2018

Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells

scientific article

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report

scientific article published on September 2016

Pancreatic cancer genetic epidemiology consortium

scientific article published on April 2006

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.

scientific article

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer

scientific article

Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

scientific article published on 01 January 2007

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer ⬇️

scientific article published on December 6, 2010

Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas

scientific article published on April 2013

Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds

scientific article published on 01 April 2004

Recent progress in pancreatic cancer

scientific article

Recent trends in the incidence and survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results analysis

scientific article published on 20 January 2020

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development

scientific article

Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance

scientific article published on 24 May 2018

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

scientific article

Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement

scientific article published on 4 January 2012

Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer

scientific article published on 13 June 2019

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article

The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?

scientific article

The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go

scientific article published on 23 July 2020

The prevalence of BRCA2 mutations in familial pancreatic cancer

scientific article published on 01 February 2007

Transflip mutations produce deletions in pancreatic cancer

scientific article published on 29 May 2015

Treatment of familial pancreatic cancer and its precursors

scientific article published on 01 October 2005

Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer

scientific article published on 9 July 2007

Update on Familial Pancreatic Cancer ⬇️

scientific article published on 01 January 2010

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

scientific article published on 9 December 2015

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

scientific article published on 8 December 2011

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

scientific article (publication date: December 2016)

Winners curse correction and variable thresholding improve performance of polygenic risk modeling based on summary-level data from genome-wide association studies

scientific article published on 10 January 2016

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