Search filters

List of works by James E Polli

A substrate pharmacophore for the human organic cation/carnitine transporter identifies compounds associated with rhabdomyolysis

scientific article published on 28 February 2012

A substrate pharmacophore for the human sodium taurocholate co-transporting polypeptide

scientific article published on 13 November 2014

Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target

scientific article

Attenuated Accumulation of Novel Fluorine (F)-Labeled Bile Acid Analogues in Gallbladders of Fibroblast Growth Factor-15 (FGF15)-Deficient Mice

scientific article published on 03 October 2018

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Acetylsalicylic Acid ⬇️

scientific article published on June 6, 2012

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Efavirenz ⬇️

scientific article published on November 22, 2012

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Primaquine Phosphate ⬇️

scientific article published on December 8, 2011

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Quinine Sulfate ⬇️

scientific article published on November 11, 2011

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Zidovudine (Azidothymidine) ⬇️

scientific article published on June 10, 2013

Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride

scientific article

Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen.

scientific article

Characterization of Dexloxiglumide in vitro Biopharmaceutical Properties and Active Transport ⬇️

scientific article published on October 1, 2003

Characterization of Grades of HPMCAS Spray Dried Dispersions of Itraconazole Based on Supersaturation Kinetics and Molecular Interactions Impacting Formulation Performance

scientific article published on 10 September 2020

Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers

scientific article

Computational models for drug inhibition of the human apical sodium-dependent bile acid transporter

scientific article published on September 2009

Considerations for a Pediatric Biopharmaceutics Classification System (BCS): application to five drugs

scientific article

Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity

scientific article published on 15 January 2013

Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging

scientific article

Effect of Common Excipients on Caco-2 Transport of Low-Permeability Drugs ⬇️

scientific article published on November 1, 2001

Effect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects

scientific article published on 29 January 2016

Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells

scientific article published on 26 May 2010

Evaluation of direct curve comparison metrics applied to pharmacokinetic profiles and relative bioavailability and bioequivalence

scientific article published on 01 October 1997

Human drug absorption kinetics and comparison to Caco-2 monolayer permeabilities

scientific article published on 01 January 1998

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

scientific article published on 07 January 2020

Identification of inhibitor concentrations to efficiently screen and measure inhibition Ki values against solute carrier transporters

scientific article

Identification of novel nonsteroidal compounds as substrates or inhibitors of hASBT.

scientific article

Impact of impurity on kinetic estimates from transport and inhibition studies

scientific article

In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice

scientific article

In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transport

scientific article

Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter

scientific article published on May 2006

Inhibition requirements of the human apical sodium-dependent bile acid transporter (hASBT) using aminopiperidine conjugates of glutamyl-bile acids

scientific article

Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): influence of steroidal hydroxylation pattern and C-24 conjugation

scientific article

Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2)

scientific article published on 25 October 2018

Ischemia/Reperfusion-inducible protein modulates the function of organic cation transporter 1 and multidrug and toxin extrusion 1.

scientific article published on 03 June 2013

Lack of Association of Generic Brittle Status with Genetics and Physiologic Measures in Patients with Epilepsy

scientific article published on 26 February 2020

Mechanistic interpretation of conventional Michaelis-Menten parameters in a transporter system

scientific article

Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

scientific article

Method to screen substrates of apical sodium-dependent bile acid transporter

scientific article published on 16 December 2008

Molecular switch controlling the binding of anionic bile acid conjugates to human apical sodium-dependent bile acid transporter.

scientific article

Novel inhibitors of human organic cation/carnitine transporter (hOCTN2) via computational modeling and in vitro testing

scientific article

Phrygian Cap Appearance of a Mouse Gallbladder on Magnetic Resonance Imaging

scientific article published on March 2013

Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system ⬇️

scientific article published on January 1, 1999

Quality-by-design III: application of near-infrared spectroscopy to monitor roller compaction in-process and product quality attributes of immediate release tablets

scientific article

Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition

scientific article

Quantitative structure activity relationship for inhibition of human organic cation/carnitine transporter

scientific article

Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach.

scientific article

Reliability of inhibition models to correctly identify type of inhibition

scientific article

Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids

scientific article

Snapshots of Iron Speciation: Tracking the Fate of Iron Nanoparticle Drugs via a Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Approach

scientific article published on 14 February 2019

Statistics on BCS classification of generic drug products approved between 2000 and 2011 in the USA.

scientific article

Structural determinants for transport across the intestinal bile acid transporter using C-24 bile acid conjugates.

scientific article

Structural requirements of bile acid transporters: C-3 and C-7 modifications of steroidal hydroxyl groups

scientific article published on 3 March 2012

Structural requirements of the human sodium-dependent bile acid transporter (hASBT): role of 3- and 7-OH moieties on binding and translocation of bile acids

scientific article

Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP)

scientific article published on 12 February 2013

Synthesis and Evaluation of Bile Acid-Ribavirin Conjugates as Prodrugs to Target the Liver

scientific article published on 2 February 2015

Synthesis and In Vitro Evaluation of Gabapentin Prodrugs that Target the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT) ⬇️

scientific article published on September 16, 2010

Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2 ⬇️

scientific article published on March 31, 2011

Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver

scientific article

Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT

scientific article

The solute carrier family 10 (SLC10): beyond bile acid transport

scientific article published on April 2013

The use of BDDCS in classifying the permeability of marketed drugs

scientific article published on 31 January 2008

Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.

scientific article

Uptake of pramipexole by human organic cation transporters

scientific article

Why we should be vigilant: drug cytotoxicity observed with in vitro transporter inhibition studies

scientific article

in Vitro-in Vivo Relationships of Several “Immediate” Release Tablets Containing a Low Permeability Drug ⬇️

scientific article published on January 1, 1997

Paulina is supported by:

About Paulina

Help