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List of works by Jerry W Shay

2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state

scientific article published on 28 February 2019

A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer ⬇️

scientific article published on March 11, 2013

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies

scientific article

A method for measuring the distribution of the shortest telomeres in cells and tissues

scientific article published on 7 November 2017

A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation

scientific article

A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis

scientific article

A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells

scientific article

A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells ⬇️

scientific article published on April 15, 2003

A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro

scientific article

A role for both RB and p53 in the regulation of human cellular senescence

scientific article published on 01 September 1991

A three-dimensional model of differentiation of immortalized human bronchial epithelial cells

scientific article

A transcriptionally active DNA-binding site for human p53 protein complexes

scientific article published on June 1992

Abstract A15: Snail upregulation of SPARC leads to increased invasion in models of both early-and late-stage NSCLC

scientific article published on 13 March 2013

Aging. When do telomeres matter?

scientific article published on 01 February 2001

Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

scientific article

Altered states of telomere deprotection and the two-stage mechanism of replicative aging

scientific article published on 17 February 2009

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

scientific article published on 31 July 2017

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

scientific article

Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a

scientific article

Alternative splicing regulation of telomerase: a new paradigm?

scientific article

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

scientific article

Analysis of mammalian telomere position effect

scientific article

Analysis of telomeres and telomerase

scientific article published on November 2003

Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation ⬇️

scientific article published on August 13, 2012

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells ⬇️

scientific article published on September 15, 2003

Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase

scientific article published on February 2007

Antitumor activity of a novel antisense oligonucleotide against Akt1.

scientific article

Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes

scholarly article

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

scientific article

Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels

scientific article published on June 1999

Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture

scientific article

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

scientific article published in January 2003

CDDO-Me Protects against Space Radiation-Induced Transformation of Human Colon Epithelial Cells ⬇️

scientific article published on July 1, 2010

CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation

scientific article

Cancer. Cancer and telomeres--an ALTernative to telomerase.

scientific article

Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs)

scientific article published on 11 June 2019

Cell biology of disease: Telomeropathies: an emerging spectrum disorder

scientific article

Cell-type-specific responses to chemotherapeutics in breast cancer

scientific article published on June 2004

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

scientific article published on 8 June 2007

Characterisation of telomerase immortalised normal human oesophageal squamous cells

scientific article published on March 2003

Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial Cells ⬇️

scientific article published on April 1, 2011

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

scientific article published on January 2001

Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line.

scientific article published on February 2005

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

scientific article published on December 1998

Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells

scientific article

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

scientific article published on 06 June 2019

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination ⬇️

scientific article published on June 1, 2011

Comparison of DNA Quantification Methods for Next Generation Sequencing.

scientific article

Comparison of telomere length measurement methods

scientific article published in March 2018

Concepts and challenges in cancer risk prediction for the space radiation environment

journal article published in 2015

Correlating telomerase activity levels with human neuroblastoma outcomes ⬇️

scientific article published on 01 March 1995

DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle

scientific article

Decellularized mice colons as models to study the contribution of the extracellular matrix to cell behavior and colon cancer progression

scientific article published on 25 September 2019

Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening

scientific article

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC)

scientific article published on 09 May 2019

Development of Methods for Quantitative Comparison of Pooled shRNAs by Mass Sequencing ⬇️

scientific article published on September 28, 2011

Developmental differences in the immortalization of lung fibroblasts by telomerase

scientific article published on October 2003

Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

scientific article published on June 2004

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions

scientific article published on 01 August 2004

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

scientific article

Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma

scientific article

Does a sentinel or a subset of short telomeres determine replicative senescence?

scientific article published on 04 June 2004

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

scientific article published on 15 June 2020

EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells

scientific article published on 28 June 2007

Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

scientific article

Effect of penclomedine (NSC-338720) on telomere fusions, chromatin blebbing, and cell viability with and without telomerase activity and abrogated p53 function

scientific article published on 01 February 1997

Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer

scientific article published on December 2005

Endoplasmic reticulum stress activates telomerase

scientific article

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized

scientific article

Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway

scientific article published on 6 June 2014

Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population

scientific article

Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy

scientific article

Evidence of epithelial to mesenchymal transition associated with increased tumorigenic potential in an immortalized normal prostate epithelial cell line ⬇️

scientific article published on October 13, 2010

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

scientific article

Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis

scientific article

Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids

scientific article published in April 1996

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma

scientific article published on 26 April 2018

Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

scientific article published on May 2007

Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance.

scientific article published on November 2005

Extension of life-span by introduction of telomerase into normal human cells

scientific article

Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?

scientific article published on 14 August 2013

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

scientific article published on 27 July 2016

Fine-tuning the chromosome ends: the last base of human telomeres

scientific article

From Mice and Men to Earth and Space: Joint NASA–NCI Workshop on Lung Cancer Risk Resulting from Space and Terrestrial Radiation ⬇️

scientific article published on September 7, 2011

Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells

scientific article published on September 2005

Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth

scientific article published on 28 April 2011

Functional requirement of p23 and Hsp90 in telomerase complexes

scientific journal article

GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus

scientific article published on 29 March 2007

Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.

scientific article

Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity

scientific article published on 01 June 2016

H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents

scientific article

Hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and their receptors in human breast cells and tissues: alternative receptors

scientific article published on January 1994

Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase

scientific article

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor

scientific article published in December 2005

Histone Modifications and DNA Double-Strand Break Repair after Exposure to Ionizing Radiations ⬇️

scientific article published on February 1, 2013

Historical claims and current interpretations of replicative aging

scientific article

Homologous recombination in human telomerase‐positive and ALT cells occurs with the same frequency ⬇️

scientific article published on November 14, 2003

Human Ku70/80 associates physically with telomerase through interaction with hTERT

scientific journal article

Human diseases of telomerase dysfunction: insights into tissue aging

scientific article

Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations

scientific article published on 28 February 2013

Human telomerase and its regulation

scientific article

Human telomerase can immortalize Indian muntjac cells

scientific article published on November 2002

Human telomeres have different overhang sizes at leading versus lagging strands

scientific article published on February 2006

Human telomeres maintain their overhang length at senescence

scientific article

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

scientific article published on July 2004

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

scientific article published on July 2005

Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer

scientific article published on 21 July 2012

Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton

scientific article published on 27 March 2013

Immortalization of epithelial progenitor cells mediated by resveratrol

scientific article

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

scientific article

Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro

scientific article

Immortalized normal human lung epithelial cell models for studying lung cancer biology

scientific article published on 22 June 2020

Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency

scientific article

Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p.

scientific article published on May 2000

In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies

scientific article published on 01 October 1998

In vivo and in vitro effects of a HIF-1alpha inhibitor, RX-0047.

scientific article published on June 2008

In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor

scientific article published on September 2005

Inducing rapid telomere irreparable damage in telomerase-expressing cancers

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

scientific article published on 17 October 2019

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

scientific article published on 21 March 2018

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine

scientific article

Inexpensive low-oxygen incubators

scientific article published in January 2006

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

scientific article published on December 1999

Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation

scientific article published on 11 February 2014

Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization

scientific article published on 01 May 2008

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

scientific article

KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer

scientific article

Lack of cell cycle regulation of telomerase activity in human cells ⬇️

scientific article published on September 30, 1997

Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro

scientific article published on 01 June 2005

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest

scientific article

Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

scientific article published on 01 August 2005

Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD).

scientific article

Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function

scientific article published on 03 May 2018

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

scientific article published on 01 August 2019

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

scientific article published on 03 December 2020

MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells

scientific article

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

scientific article published on 15 August 2019

Mechanism-based combination telomerase inhibition therapy

scientific article published on 01 January 2005

Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells

scientific article published on 6 August 2013

Mitochondrial genomes in intraspecies mammalian cell hybrids display codominant or dominant/recessive behavior

scientific article published on 01 September 1987

Modification of subtelomeric DNA

scientific article published on May 2004

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

scientific article published on September 1995

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

scientific article

Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

scientific article published in February 2006

Multipotent capacity of immortalized human bronchial epithelial cells

scientific article

Mutant dyskerin ends relationship with telomerase

scientific article published on 01 December 1999

Mutations, Cancer and the Telomere Length Paradox

scientific article

Myofibroblast Differentiation of Normal Human Keratocytes and hTERT, Extended-Life Human Corneal Fibroblasts ⬇️

scientific article published on May 1, 2003

NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells

scientific article published on 19 December 2018

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

scientific article published in Nature Communications

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

scientific article published on 29 December 2016

Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation

scientific article

Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol

scientific article published on 01 January 2006

Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase ⬇️

scientific article published on May 1, 2003

Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors

scientific article published on 01 January 2002

Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent

scientific article published on January 2007

Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells

scientific article published on 19 August 2016

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

scientific article published on 23 June 2005

Pancreatic cancer stem cells: fact or fiction?

scientific article published on 21 February 2009

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

scientific article published on 8 June 2015

Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening.

scientific article

Perifosine as a potential novel anti-telomerase therapy

scientific article

Phospho‐mTOR is not upregulated in metastatic SDHB paragangliomas ⬇️

scientific article published on July 26, 2013

Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers

scientific article (publication date: April 2007)

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

scientific article published on 11 July 2011

Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions ⬇️

scientific article published on May 6, 2011

Progenitor Cell Line (hPheo1) Derived from a Human Pheochromocytoma Tumor ⬇️

scientific article published on June 13, 2013

Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma

scientific article published on April 1999

Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings

scientific article published on 22 November 2019

Prostate tumor-initiating cells: a new target for telomerase inhibition therapy?

scientific article published on 02 March 2009

Proton radiation-induced cancer progression

scientific article published on 18 August 2018

Purkinje cell-specific males absent on the first ( mMof ) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice ⬇️

scientific article published on February 14, 2011

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

scientific article

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells ⬇️

scientific article published on December 1, 2001

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution

scientific article published on 23 September 2019

Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution

scientific article

Quantitative telomeric overhang determination using a double-strand specific nuclease

scientific article

RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion ⬇️

scientific article published on October 9, 2012

Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses

scientific article published on 19 October 2015

Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer

scientific article published on 31 January 2014

Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways

scientific article

Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells.

scientific article published on 20 July 2017

Reflections on telomere dynamics and ageing-related diseases in humans.

scientific article published in March 2018

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy ⬇️

scientific article published on April 4, 2013

Regulation of human telomerase splicing by RNA:RNA pairing

scientific article published on 28 February 2014

Regulation of telomerase activity in immortal cell lines

scientific article published on June 1996

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer

scientific article

Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice

scientific article published on 31 October 2015

Replica plating of mammalian cells using low melt agarose

scientific article published on 6 July 2007

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

scientific article published on July 1989

Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer.

scientific article published in March 2014

Role of telomeres and telomerase in cancer

scientific article

SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport

scientific article

SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy

scientific article published on 10 September 2015

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

scientific article published on October 2016

Senescence and immortalization: role of telomeres and telomerase

scientific article published on 7 October 2004

Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging

scientific article

Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells

scientific article

Silencing the Snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells

scientific article published on 5 February 2018

Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells

scientific article published on 18 April 2020

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs

scientific journal article

Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model

scientific article published in March 2006

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer ⬇️

scientific article published on December 23, 1994

Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient

scientific article

Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome

scientific article published on January 1995

Spontaneous reactivation of a silent telomeric transgene in a human cell line

scientific article published on 20 January 2004

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice ⬇️

scientific article published on February 5, 2013

T-loops Refold after Telomerase Extension and Unfold Again at Late S/G2 for C-strand Fill-in

scientific article published on 10 December 2019

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions

scientific article

TRA-1-60-positive/CD45low cells found in the peripheral blood of prostate cancer patients with metastatic disease - A proof-of-concept study

scientific article published on 24 January 2020

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation ⬇️

scientific article published on October 8, 2012

Targeting telomerase-expressing cancer cells ⬇️

scientific article published on July 1, 2011

Telomerase Activity for the Preoperative Diagnosis of Pancreatic Cancer ⬇️

scientific article published on 01 November 1997

Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers ⬇️

scientific article published on June 21, 1995

Telomerase activity concentrates in the mitotically active segments of human hair follicles

scientific article published on 01 January 1997

Telomerase activity in human breast tumors

scientific article published on 01 January 1996

Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour? ⬇️

scientific article published on 01 October 1997

Telomerase activity in ordinary meningiomas predicts poor outcome

scientific article published on 01 April 1997

Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

scientific article

Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer

scientific article published on May 2010

Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier

scientific article published on 16 March 2006

Telomerase immortalization of human myometrial cells

scientific article published on August 2002

Telomerase in cancer and aging

scientific article

Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner

scientific article published on 12 May 2016

Telomerase regulation: not just flipping the switch ⬇️

scientific article published on February 1, 2002

Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells

scientific article published on May 2008

Telomerase therapeutics for cancer: challenges and new directions

scientific article published on 9 June 2006

Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

scientific article published on 6 July 2018

Telomerase: a target for cancer therapeutics

scientific article

Telomere Biology and Cellular Aging in Nonhuman Primate Cells ⬇️

scientific article published on January 15, 2002

Telomere G-Rich Overhang Length Measurement: DSN Method

scientific article published in January 2017

Telomere G-overhang length measurement method 1: the DSN method

scientific article published on January 2011

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

scientific article published on 10 June 2020

Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In

scientific article published in January 2017

Telomere biology in Metazoa

scientific article

Telomere biology in aging and cancer

scientific article published in September 2005

Telomere clustering drives ALT

scientific article published on 13 October 2019

Telomere dynamics in macaques and humans

scientific article published on 01 April 2007

Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells

scientific article published on August 2009

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

scientific article published on 28 November 2018

Telomere length regulates ISG15 expression in human cells

scientific article

Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy ⬇️

scientific article published on 05 May 2013

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

scientific article

Telomere positional effects and the regulation of cellular senescence

scientific article published on 01 June 1992

Telomere terminal G/C strand synthesis: measuring telomerase action and C-rich fill-in

scientific article published on January 2011

Telomere-binding factors and general DNA repair

scientific article published on 01 February 2005

Telomere-end processing the terminal nucleotides of human chromosomes

scientific article published on 01 April 2005

Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas

scientific article

Telomeres and telomerase in normal and cancer stem cells

scientific article

Telomeres and telomerase: three decades of progress

scientific article published on 01 May 2019

Telomeres are double-strand DNA breaks hidden from DNA damage responses

scientific article published on May 2004

Telomeres in dyskeratosis congenita

scientific article

Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

scientific article published on May 2004

The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo

scientific article

The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation

scientific article published on 28 July 2017

The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells

scientific article

The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth ⬇️

scientific article published on February 1, 2013

The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines ⬇️

scientific article published on November 9, 2010

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

The effects of telomerase inhibition on prostate tumor-initiating cells

scientific article

The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway

scientific article published on 4 March 2004

The frequency of homologous recombination in human ALT cells

scientific article published on 10 May 2004

The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway

scientific article

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

scientific journal article

The longevity gender gap: are telomeres the explanation?

scientific article

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

scientific article

Therapeutic targeting truncated adenomatous polyposis coli (APC) proteins for the selective killing of colorectal cancer cells

Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

scientific article

Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

scientific article published on 01 September 2016

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

scientific article published on 01 August 1995

Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies

scientific article published on August 2007

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

scientific article published on 31 May 2019

Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation

scientific article published on 15 August 2018

Tumor suppression by chromosome 11 is not due to cellular senescence

scientific article published on 01 January 1991

Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro

scientific article

Two- and three-dimensional models for risk assessment of radiation-enhanced colorectal tumorigenesis

scientific article published on January 2009

Use of telomerase to create bioengineered tissues

scientific article

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

scientific article

ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity

scientific article published on 01 January 2018

hTERT associates with human telomeres and enhances genomic stability and DNA repair

scientific article published on 01 January 2003

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor

scientific article published on 20 June 2016

hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing ⬇️

scientific article published on October 25, 2010

p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells

scientific article

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