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List of works by Paul P Tak

'MRI-tis' in the early diagnosis of axial SpA: issues and limitations

scientific article published on 05 October 2010

14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

scientific article

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

scholarly article by Daniel Aletaha et al published 10 August 2010 in Arthritis and Rheumatism

2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

scientific article

A Prospective, Randomized, Placebo-Controlled Study to Identify Biomarkers Associated with Active Treatment in Psoriatic Arthritis: Effects of Adalimumab Treatment on Lesional and Nonlesional Skin ⬇️

scientific article published on December 21, 2012

A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis

scientific article

A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis

scientific article published on 24 June 2015

A novel approach for gene therapy: engraftment of fibroblasts containing the artificial chromosome expression system at the site of inflammation

scientific article

A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes.

scientific article published in February 2006

A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

scientific article

Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis

scientific article published on 01 April 2009

Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker

scientific article published on 01 November 2007

Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals

scientific article

Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)

scientific article

Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis.

scientific article published in March 2010

Adherence to Treat-to-target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort

scientific article published on 15 September 2019

Advancements in adeno-associated viral gene therapy approaches: exploring a new horizon ⬇️

scientific article published on January 1, 2011

Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis

scientific article published on 14 February 2004

Alefacept treatment in psoriatic arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis

scientific article published on October 2002

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.

scientific article

Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.

scientific article published in August 2006

Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients

scientific article published on 01 November 2008

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis ⬇️

scientific article published on June 22, 2012

Animal models for arthritis: innovative tools for prevention and treatment

scientific article published on 30 May 2011

Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation

scientific article

Anti-TNF treatment blocks the induction of T cell-dependent humoral responses ⬇️

scientific article published on September 11, 2012

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

scientific article published on December 2016

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for and CD39

article

B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis

scientific article published in July 2008

Biodistribution and radiation dosimetry of 99mTc-HMPAO-labeled monocytes in patients with rheumatoid arthritis

scientific article published on 16 July 2008

Body mass index and clinical response to infliximab in rheumatoid arthritis ⬇️

scientific article published on 01 February 2011

Brief Report: A phase IIa, randomized, double‐blind, placebo‐controlled trial of apilimod mesylate, an interleukin‐12/interleukin‐23 inhibitor, in patients with rheumatoid arthritis ⬇️

scientific article published on December 14, 2011

Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At-Risk and Earliest Phases of Rheumatoid Arthritis.

scientific article published on 18 July 2016

Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis.

scientific article

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

scientific article published on 24 April 2014

CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial.

scientific article published on 6 August 2010

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis

scientific article published on 17 January 2015

CD97 in Leukocyte Trafficking ⬇️

scientific article published on January 1, 2010

CD97 neutralisation increases resistance to collagen-induced arthritis in mice

scientific article

Characteristics of synovial inflammation in early arthritis analysed by pixel-by-pixel time-intensity curve shape analysis ⬇️

scientific article published on February 28, 2012

Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!

scientific article published on November 2006

Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine.

scientific article published in October 2014

Collagen-induced arthritis in mice

scientific article published on 01 January 2010

Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

scientific article

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

scientific article published on 14 September 2008

Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging

scientific article published in February 2002

Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment

scientific article published on August 2002

Corrigendum: Synovial tissue research: a state-of-the-art review

scientific article

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 23 August 2016

Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study

scientific article

Decrease in synovial cellularity and cytokine expression after autologous stem cell transplantation in patients with juvenile idiopathic arthritis

scientific article published on 01 April 2002

Deletion of either CD55 or CD97 ameliorates arthritis in mouse models

scientific article

Dendritic cell subsets: their roles in rheumatoid arthritis.

scientific article published on January 2008

Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis

scientific article published on 01 March 2006

Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation

scientific article

Digital image analysis for the evaluation of the inflammatory infiltrate in psoriasis

scientific article published on August 2005

Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman's Disease

scientific article

Disease activity-guided rituximab therapy in rheumatoid arthritis: the effects of re-treatment in initial nonresponders versus initial responders

scientific article published on 01 December 2008

Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis

scientific article published in January 2013

Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

scientific article published in August 2006

Distinct synovial immunopathology in Behçet disease and psoriatic arthritis

scientific article published on 6 February 2009

Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?

scientific article published on 2 September 2015

Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis

scientific article published on 08 August 2017

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Pharmacokinetic Modeling: Initial Experience in Patients With Early Arthritis

scientific article published in March 2016

EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

scientific article published on 2 March 2012

Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

scientific article published on March 2007

Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis

scientific article

Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis

scientific article

Efficacy and safety of adalimumab for the treatment of peripheral arthritis in spondyloarthritis patients without ankylosing spondylitis or psoriatic arthritis ⬇️

scientific article published on 08 November 2012

Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up

scientific article published on 28 March 2013

Efficacy and safety of monotherapy with sirukumab compared with adalimumab monotherapy in biologic-naïve patients with active rheumatoid arthritis (SIRROUND-H): a randomised, double-blind, parallel-group, multinational, 52-week, phase 3 study

scientific article published on 26 February 2018

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

scientific article published on 29 January 2013

Efficacy and safety of sirukumab in patients with active rheumatoid arthritis refractory to anti-TNF therapy (SIRROUND-T): a randomised, double-blind, placebo-controlled, parallel-group, multinational, phase 3 study

scientific article

Empty Capsids and Macrophage Inhibition/Depletion Increase rAAV Transgene Expression in Joints of Both Healthy and Arthritic Mice

scientific article published on 2 November 2016

Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis

scientific article

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 10 October 2016

Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

scientific article published on 24 November 2010

Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?

scientific article published on August 2010

Experiences and needs for work participation in employees with rheumatoid arthritis treated with anti-tumour necrosis factor therapy ⬇️

scientific article published on June 15, 2011

Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment ⬇️

scientific article published on September 24, 2012

FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis

scientific article published on 14 August 2014

Female sex increases risk for rheumatoid arthritis only in individuals encoding low-risk HLA-DRB1 alleles

scientific article published on 01 June 2003

Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.

scientific article

Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

scientific article

Function of histone deacetylase inhibitors in inflammation.

scientific article published on January 2011

Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer

scientific article published on June 2009

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

scientific article

Genetics of rheumatoid arthritis contributes to biology and drug discovery

scientific article

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

scientific article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

scientific article

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients ⬇️

article

Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

scientific article

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

scientific article published on 25 July 2016

Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue

scientific article published on 25 January 2010

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

scientific article published on 27 September 2011

How to perform and analyse synovial biopsies

scientific article published on April 2009

How to perform and analyse synovial biopsies

scientific article published on April 2013

Human Lymph Node Stromal Cells Have the Machinery to Regulate Peripheral Tolerance during Health and Rheumatoid Arthritis

scientific article published on 09 August 2020

Human T-cell memory consists mainly of unexpanded clones.

scientific article published on 16 July 2010

Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity.

scientific article published on April 2016

Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool ⬇️

scientific article published on June 11, 2012

Identification of interleukin-7 as a candidate disease mediator in spondylarthritis

scientific article published on 01 November 2008

Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis

scientific article published in June 2006

Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue

scientific article

Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis

scientific article

Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial

scientific article published on 21 August 2012

Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

scientific article published on 26 February 2018

In vitro spontaneous osteoclastogenesis of human peripheral blood mononuclear cells is not crucially dependent on T lymphocytes.

scientific article

Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis

scientific article published on 01 August 2007

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

scientific article published on December 2014

Inflammatory memories: is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?

scientific article published on 09 April 2011

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

scientific article

Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis

scientific article

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene

scientific article

Interferon beta for rheumatoid arthritis: new clothes for an old kid on the block.

scientific article

Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis

scientific article published on 07 January 2011

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

scientific article published on 01 January 2012

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis ⬇️

scientific article published on April 11, 2012

Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor.

scientific article published on 22 June 2016

Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

scientific article published on March 2009

Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM)

scientific article published on 24 February 2020

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis.

scientific article

Labeling of autologous monocytes with 99mTc-HMPAO at very high specific radioactivity

scientific article published on 21 September 2007

Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis

scientific article published in December 2013

Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis

scientific article published on 24 June 2009

Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis.

scientific article published on 20 September 2016

MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

scientific article published on 01 December 2009

MRI assessment of suppression of structural damage in patients with rheumatoid arthritis receiving rituximab: results from the randomised, placebo-controlled, double-blind RA-SCORE study ⬇️

scientific article

Mediators of structural remodeling in peripheral spondylarthritis

scientific article published on December 2009

Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis

scientific article

Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial

scientific article

Molecular Characterization of Human Lymph Node Stromal Cells During the Earliest Phases of Rheumatoid Arthritis

scientific article published on 20 August 2019

Monitoring the T-cell receptor repertoire at single-clone resolution.

scientific article

Monocyte scintigraphy in rheumatoid arthritis: the dynamics of monocyte migration in immune-mediated inflammatory disease

scientific article

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

scientific article

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?

scientific article published on 28 January 2015

Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire

scientific article published on 19 June 2019

Novel approaches for the treatment of rheumatoid arthritis: lessons from the evaluation of synovial biomarkers in clinical trials

scientific article published on April 2008

Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study

scientific article

OMERACT 10 Sharp Symposium: important findings in examination of imaging methods for measurement of joint damage in rheumatoid arthritis

scientific article published on September 2011

Outcomes and Findings of the International Rheumatoid Arthritis (RA) BIODAM Cohort for Validation of Soluble Biomarkers in RA

scientific article published on 01 September 2019

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.

scientific article

Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?

scientific article published on July 2012

Pathogenesis of spondyloarthritis: insights from synovial membrane studies

scientific article published on August 2006

Patient global assessment in psoriatic arthritis: a multicenter GRAPPA and OMERACT study

scientific article published on 15 February 2011

Peripheral joint inflammation in early onset spondyloarthritis is not specifically related to enthesitis ⬇️

scientific article published on April 25, 2013

Physician’s Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study

scientific article published on 15 June 2018

Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system

scientific article published on 8 December 2006

Possible role of shared epitope status in the relationship between matrix metalloproteinase 3 genotype and radiographic progression of rheumatoid arthritis: comment on the article by Constantin et al

scientific article published on 01 April 2003

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

scientific article published on 24 June 2015

Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

scientific article published on November 2010

Presence and Role of Anti–Citrullinated Protein Antibodies in Experimental Arthritis Models ⬇️

scientific article published on April 1, 2013

Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time? ⬇️

scientific article published on December 20, 2010

Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients

scientific article published on 28 August 2015

Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis.

scientific article published on 11 May 2013

Progression of structural damage is not related to rituximab serum levels in rheumatoid arthritis patients

scientific article published on 24 April 2013

Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients

scientific article published on 01 February 2020

Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes

scientific article published in July 2004

Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment

scientific article published on 19 September 2006

Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy

scientific article published on 13 May 2016

Reduction of proinflammatory cytokine expression in the synovium by targeting IKKbeta in vivo in a rat model

scientific article published on 01 November 2006

Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment

scientific article

Relationship between inflammation, bone destruction, and osteoproliferation in the HLA–B27/human β2‐microglobulin–transgenic rat model of spondylarthritis ⬇️

scientific article published on October 1, 2012

Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients

scientific article

Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis

scientific article

Response to rituximab in patients with rheumatoid arthritis in different compartments of the immune system ⬇️

scientific article published on November 1, 2011

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy

scientific article published on July 2010

Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles

scientific article published on 21 February 2008

Rheumatoid synovial inflammation: pixel-by-pixel dynamic contrast-enhanced MR imaging time-intensity curve shape analysis--a feasibility study

scientific article published on 31 July 2009

Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis ⬇️

scientific article published on November 8, 2011

Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice

scientific article published on 28 May 2010

SAFETY, BIODISTRIBUTION, AND EFFICACY OF AN AAV-5 VECTOR ENCODING HUMAN INTERFERON-BETA (ART-I02) DELIVERED VIA INTRA-ARTICULAR INJECTION IN RHESUS MONKEYS WITH COLLAGEN-INDUCED ARTHRITIS.

scientific article published on 13 May 2015

Sa.17. A Functional Variant of TIR-domain-containing Adaptor Protein (TIRAP) is Not Associated with Spondyloarthritis

Safety with ocrelizumab in rheumatoid arthritis: results from the ocrelizumab phase III program

scientific article published on 03 February 2014

Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well

scientific article published on 27 September 2011

Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals

scientific article published on 15 December 2015

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction

scientific article published on 01 March 2007

Signal Transduction Pathways in Chronic Inflammatory Autoimmune Disease: Small GTPases ⬇️

scientific article published on 07 September 2012

Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy

scientific article

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis

scientific article

Single-joint Assessment for the Evaluation of Intraarticular Treatment: Responsiveness and Discrimination of the Composite Change Index

scientific article published on 15 July 2015

Smelling the Diagnosis: The Electronic Nose as Diagnostic Tool in Inflammatory Arthritis. A Case-Reference Study

scientific article

Smoking and overweight determine the likelihood of developing rheumatoid arthritis

scientific article published on 27 October 2012

Soluble Biomarkers of Cartilage and Bone Metabolism in Early Proof of Concept Trials in Psoriatic Arthritis: Effects of Adalimumab Versus Placebo ⬇️

scientific article published on September 3, 2010

Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10 ⬇️

scientific article published on April 26, 2012

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

scientific article published on 30 October 2015

Spondylarthritis in the absence of B lymphocytes

scientific article published on 01 March 2008

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

scientific article

Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.

scientific article published on 9 August 2017

Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis

scientific article published on 10 June 2012

Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis

scientific article published in November 2010

Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes

scientific article

Synovial and mucosal immunopathology in spondyloarthritis

scientific article published on January 2009

Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype

scientific article

Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers

article

Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes

scientific article

Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis.

scientific article published on September 2011

Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood

scientific article published on 01 June 2010

Synovial tissue research: a state-of-the-art review

scientific article

Synovial tissue research: a state-of-the-art review

scientific article published on 01 September 2017

Synovial tissue response to treatment in rheumatoid arthritis

scientific article published on 30 December 2011

Synovitis in psoriatic arthritis: immunohistochemistry, comparisons with rheumatoid arthritis, and effects of therapy

scientific article published on August 2011

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits

scientific article

Tailored therapy for rheumatic disease within reach

scientific article published on 01 January 2011

Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers

scientific article published on 25 January 2010

Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis

scientific article

Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

scientific article published on 17 October 2008

Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players.

scientific article published on 9 May 2015

The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report

scientific article

The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling

scientific article published on 12 June 2009

The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

scientific article published on 13 August 2009

The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation

scientific article

The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation

scientific article

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.

scientific article published on 2 December 2014

The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis

scientific article

The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants

scientific article published on 14 July 2011

The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)

scientific article published on 13 July 2012

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

scientific article published on May 2009

The features of the synovium in early rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria

scientific article

The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis

scientific article (publication date: 25 June 2010)

The interaction of smoking and the HLA-DRB1 shared epitope in rheumatoid factor-positive rheumatoid arthritis: Comment on the article by Padyukov et al

scientific article published on 01 November 2005

The presence of citrullinated proteins is not specific for rheumatoid synovial tissue

scientific article published in November 2004

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: a prospective study

scientific article published on 01 November 2009

The value of rheumatoid factor and anti-citrullinated protein antibodies as predictors of response to infliximab in rheumatoid arthritis: an exploratory study ⬇️

scientific article published on March 30, 2011

Therapeutic options for targeting inflammatory osteoarthritis pain

scientific article published on 01 June 2019

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype

scientific article published on 3 January 2014

Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials

scientific article published on 31 August 2012

Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment

scientific article

Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

scientific article

Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts

scientific article

Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation

scientific article published in October 2008

Tumor necrosis factor antagonist mechanisms of action: a comprehensive review

scientific article published on 26 October 2007

Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity.

scientific article published on 6 August 2013

Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice

scientific article published on 24 January 2015

Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance.

scientific article published on 28 October 2010

Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis.

scientific article

Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment ⬇️

scientific article published on July 16, 2013

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

scientific article published on 05 July 2016

Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis

scientific article (publication date: 2011)

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