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List of works by Elena Govorkova

A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro

scientific article

A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

scientific article published on 05 November 2019

A pharmacologically immunosuppressed mouse model for assessing influenza B virus pathogenicity and oseltamivir treatment

scientific article published on 31 October 2017

Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice.

scientific article

An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness

scientific article published in March 2018

Antiviral resistance among highly pathogenic influenza A (H5N1) viruses isolated worldwide in 2002-2012 shows need for continued monitoring

scientific article

Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype

scientific article

Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets

scientific article

Author Correction for Jones et al., "Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors"

scholarly article published in mBio

Avian flu: Gain-of-function experiments on H7N9.

scientific article published in August 2013

Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China

scientific article

Characterizing Emerging Canine H3 Influenza Viruses

scientific article published on 14 April 2020

Combination chemotherapy for influenza

scientific article

Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants

scientific article published on 21 February 2006

Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice

scientific article published on 25 May 2016

Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance-Associated Substitutions in Ferrets

scientific article

Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium

scientific article published on 11 February 2015

Competitive fitness of oseltamivir-sensitive and -resistant highly pathogenic H5N1 influenza viruses in a ferret model

scientific article

Competitive transmissibility and fitness of oseltamivirsensitive and resistant pandemic influenza H1N1 viruses in ferrets

scientific article published on May 1, 2011

Consequences of resistance: in vitro fitness, in vivo infectivity, and transmissibility of oseltamivir‐resistant influenza A viruses ⬇️

scientific article published on January 1, 2013

Continuing challenges in influenza.

scientific article

Continuing threat of influenza (H5N1) virus circulation in Egypt.

scientific article published in December 2011

Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus

scientific article published on April 2007

Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia

scientific article

Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate

scientific article

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses

scientific article

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses

Drugs in development for influenza

scientific article

Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets

scientific article (publication date: May 2010)

Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model

scientific article published on 14 March 2005

Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus

scientific article published on 12 February 2007

Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic.

scientific article

Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses

scientific article

Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies

scientific article

Fitness costs for Influenza B viruses carrying neuraminidase inhibitor-resistant substitutions: underscoring the importance of E119A and H274Y.

scientific article published on 24 February 2014

Fitness of neuraminidase inhibitor-resistant influenza A viruses

scientific article

Gain-of-function experiments on H7N9.

scientific article published in August 2013

Generation of high-yielding influenza A viruses in African green monkey kidney (Vero) cells by reverse genetics

scientific article

H5N1 influenza--continuing evolution and spread

scientific article

Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses

scientific article

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

scientific article published on 24 April 2018

Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge.

scientific article

Impaired wound healing predisposes obese mice to severe influenza virus infection

scientific article

Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses

scientific article

In vitro profiling of laninamivir-resistant substitutions in N3 to N9 avian influenza neuraminidase subtypes and their association with in vivo susceptibility

scientific article published on 14 October 2020

Inefficient transmission of H5N1 influenza viruses in a ferret contact model

scientific article

Influenza A (H15N4) virus isolation in Western Siberia, Russia ⬇️

scientific article published on 2 January 2013

Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility

scientific article published on 26 March 2020

Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.

scientific article

Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions

scientific article published on 29 November 2019

Influenza H5 virus escape mutants: immune protection and antibody production in mice.

scientific article

Influenza: emergence and control

scientific article

Interactions of oseltamivir-sensitive and -resistant highly pathogenic H5N1 influenza viruses in a ferret model

scientific article published on May 1, 2011

Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice

scientific article

Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004.

scientific article published in June 2006

Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004.

scientific article

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck

scientific article

Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010-2015.

scientific article published on 11 January 2018

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility

scientific article

Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo.

scientific article

Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells

scientific article

Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance

scientific article

Novel Highly Pathogenic Avian A(H5N2) and A(H5N8) Influenza Viruses of Clade 2.3.4.4 from North America Have Limited Capacity for Replication and Transmission in Mammals

scientific article published on March 2016

Novel genotyping and quantitative analysis of neuraminidase inhibitor resistance-associated mutations in influenza a viruses by single-nucleotide polymorphism analysis

scientific article

Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses

scientific article published on 2 April 2014

Optimizing T-705 (favipiravir) treatment of severe influenza B virus infection in the immunocompromised mouse model

scientific article published on 01 May 2019

Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design

scientific article

Oseltamivir prophylactic regimens prevent H5N1 influenza morbidity and mortality in a ferret model

scientific article published in May 2008

Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer

scientific article

Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets

scientific article

Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice

scientific article published on 25 August 2008

Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection

scientific article published on 4 August 2017

Pathogenicity and vaccine efficacy of different clades of Asian H5N1 avian influenza A viruses in domestic ducks.

scientific article

Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference

scientific article published on 18 November 2017

Prevention of influenza by targeting host receptors using engineered proteins

scientific article

Risk assessment of H2N2 influenza viruses from the avian reservoir

scientific article

Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines

scientific article

Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes

scientific article

Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus

scientific article

Single- and multiple-clade influenza A H5N1 vaccines induce cross protection in ferrets

scientific article published on 09 May 2009

Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants

scientific article published in October 2002

Susceptibility of avian influenza viruses of the N6 subtype to the neuraminidase inhibitor oseltamivir

scientific article published on 10 January 2012

Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model.

scientific article

T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro

scientific article

The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

scientific article published on 19 January 2016

The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses

scientific article published on 13 February 2017

The epidemiological and molecular aspects of influenza H5N1 viruses at the human-animal interface in Egypt

scientific article

The neuraminidase inhibitor oseltamivir is effective against A/Anhui/1/2013 (H7N9) influenza virus in a mouse model of acute respiratory distress syndrome

scientific article published on 16 October 2013

The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks.

scientific article

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04.

scientific article

Therapeutics Against Influenza ⬇️

scientific article published on January 1, 2013

Unique Determinants of Neuraminidase Inhibitor Resistance among N3, N7, and N9 Avian Influenza Viruses

scientific article

Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses

scientific article

Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice.

scientific article

What is the optimal therapy for patients with H5N1 influenza?

scientific article

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