List of works - Janet D Siliciano

A long-term latent reservoir for HIV-1: discovery and clinical implications

scientific article

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

scientific article published on 12 December 2013

A primary CD4(+) T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

scientific article

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

scientific article published on 30 January 2019

A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma

scientific article

AIDS/HIV. Rekindled HIV infection

scientific article

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

scientific article

Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study

scientific article published on 07 July 2020

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

scientific article published on 8 January 2002

Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo

scientific article

Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy

scientific article published on 17 June 2009

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy

scientific article

Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo

scientific article published on 10 December 2020

Assays to Measure Latency, Reservoirs, and Reactivation

scientific article

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

scientific article published on 12 April 2019

Assessing suitability of next-generation viral outgrowth assays as proxies for classic QVOA to measure HIV-1 latent reservoir size

scientific article published on 09 March 2020

Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

scientific article published on 25 November 2020

Biomarkers of HIV replication

scientific article published on November 1, 2010

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

scientific article published on 7 January 2015

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

scientific article

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient

scientific article

Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.

scientific article published on September 2000

Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies

scientific article

Consistent Inhibition of HIV-1 Replication in CD4 + T Cells by Acyclovir without Detection of Human Herpesviruses ⬇️

scientific article published on February 16, 2011

DNA damage induces phosphorylation of the amino terminus of p53 ⬇️

scientific article published on December 15, 1997

Defective proviruses rapidly accumulate during acute HIV-1 infection

scientific article published on 08 August 2016

Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses

scientific article published on 01 January 2020

Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy

scientific article published on 27 February 2020

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

scientific article

Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection

scientific article published on October 2015

Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals

scientific article

Establishment of latent HIV-1 infection of resting CD4(+) T lymphocytes does not require inactivation of Vpr.

scientific article

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.

scientific article published on 30 March 2015

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.

scientific article published on 26 February 2018

Experimental approaches to the study of HIV-1 latency

scientific article published on February 2007

Finding a cure for human immunodeficiency virus-1 infection

scientific article published on 30 September 2014

HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy

scientific article published on 24 January 2012

HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy

scientific article published on July 2001

HIV-1 eradication strategies: design and assessment

scientific article

HIV-1 integration landscape during latent and active infection

scientific article

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

scientific article published on 7 November 2017

HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo

scientific article published on 22 June 2020

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

scientific article

Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.

scientific article published on May 2009

Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques

scientific article published on 29 February 2024

Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model

scientific article published on 23 March 2011

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

scientific article

Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

scientific article published on 20 July 2020

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

scientific article published on 6 December 2006

Isolation of metavinculin from chicken smooth muscle

scientific article published in January 1986

Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells

scientific article published on February 2005

Latency and viral persistence in HIV-1 infection

scientific article published on October 2000

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

scientific article (publication date: May 1999)

Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART

scientific article

Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells

scientific article

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

scientific article published on 18 May 2003

Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy

scientific article published on 19 March 2020

Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

scientific article

Measuring the Frequency of Latent HIV-1 in Resting CD4⁺ T Cells Using a Limiting Dilution Coculture Assay

scientific article published on January 2016

Meta-vinculin--a vinculin-related protein with solubility properties of a membrane protein

scientific article published on 01 December 1982

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

scientific article published on 23 March 2014

No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy

scientific article

Non-structured treatment interruptions are associated with higher HIV reservoir size measured by intact proviral DNA assay in people who inject drugs

scientific article published on 10 October 2020

Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists

scientific article published on 05 October 2020

Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.

scientific article published on February 2004

Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough.

scientific article published in August 2008

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

scientific article published on 24 March 2017

Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2

scientific article

Properties of smooth muscle meta-vinculin

scientific article

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

scientific article

Recent developments in the effort to cure HIV infection: going beyond N = 1.

scientific article published on February 2016

Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.

scientific article published on 26 June 2014

Recent trends in HIV-1 drug resistance

scientific article published on 07 September 2013

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

scientific article published on 07 September 2020

Reduced Frequency of Cells Latently Infected with Replication-Competent HIV-1 in Virally Suppressed Individuals Living in Rakai, Uganda

scientific article published on 23 May 2017

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

scientific article published on 24 October 2013

Reply: To PMID 25117799.

scientific article published on 3 June 2015

Residual Plasma Viraemia and Infectious HIV-1 Recovery from Resting Memory CD4 Cells in Patients on Antiretroviral Therapy: Results from ACTG A5173 ⬇️

scientific article published on February 15, 2013

Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

scientific article

Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes

scientific article

Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors.

scientific article published on 12 December 2007

Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

scientific article published on 21 August 2020

Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.

scientific article published in January 2010

Short telomere syndromes cause a primary T cell immunodeficiency

scientific article published on 22 October 2018

Similar frequency and inducibility of intact HIV-1 proviruses in blood and lymph nodes

scientific article published on 03 December 2020

Stability of the latent reservoir for HIV-1 in patients receiving valproic acid

scientific article published on 30 January 2007

The Effect of early treatment on the latent reservoir of HIV-1.

scientific article

The Itk/Btk/Tec family of protein-tyrosine kinases

scientific article published on 01 January 1994

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

scientific article published on 01 July 2019

The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation

scientific article published on 24 September 2008

The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure

scientific article published on March 2006

The multifactorial nature of HIV-1 latency

scientific article

The role of CD32 during HIV-1 infection.

scientific article

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

scientific article published in October 2017

Vinculin is a component of an extensive network of myofibril-sarcolemma attachment regions in cardiac muscle fibers

scientific article

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2 ⬇️

scientific article published on December 1, 1992

List of works by Janet D Siliciano

A long-term latent reservoir for HIV-1: discovery and clinical implications

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

A primary CD4(+) T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma

AIDS/HIV. Rekindled HIV infection

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo

Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy

Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo

Assays to Measure Latency, Reservoirs, and Reactivation

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

Assessing suitability of next-generation viral outgrowth assays as proxies for classic QVOA to measure HIV-1 latent reservoir size

Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

Biomarkers of HIV replication

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient

Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.

Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies

Consistent Inhibition of HIV-1 Replication in CD4 + T Cells by Acyclovir without Detection of Human Herpesviruses ⬇️

DNA damage induces phosphorylation of the amino terminus of p53 ⬇️

Defective proviruses rapidly accumulate during acute HIV-1 infection

Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses

Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection

Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals

Establishment of latent HIV-1 infection of resting CD4(+) T lymphocytes does not require inactivation of Vpr.

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.

Experimental approaches to the study of HIV-1 latency

Finding a cure for human immunodeficiency virus-1 infection

HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy

HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy

HIV-1 eradication strategies: design and assessment

HIV-1 integration landscape during latent and active infection

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.

Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques

Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

International AIDS Society global scientific strategy: towards an HIV cure 2016.

Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

Isolation of metavinculin from chicken smooth muscle

Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells

Latency and viral persistence in HIV-1 infection

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART

Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy

Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

Measuring the Frequency of Latent HIV-1 in Resting CD4⁺ T Cells Using a Limiting Dilution Coculture Assay

Meta-vinculin--a vinculin-related protein with solubility properties of a membrane protein

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy

Non-structured treatment interruptions are associated with higher HIV reservoir size measured by intact proviral DNA assay in people who inject drugs

Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists

Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.

Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough.

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2

Properties of smooth muscle meta-vinculin

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

Recent developments in the effort to cure HIV infection: going beyond N = 1.

Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.

Recent trends in HIV-1 drug resistance

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

Reduced Frequency of Cells Latently Infected with Replication-Competent HIV-1 in Virally Suppressed Individuals Living in Rakai, Uganda

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Reply: To PMID 25117799.