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List of works by Yoshihiko Hirohashi

A gene encoding human gastric signet ring cell carcinoma antigen recognized by HLA-A31-restricted cytotoxic T lymphocytes

scientific article

A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis

scientific article published on October 2005

A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

scientific article

A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins.

scientific article published on February 2005

A screening assistance system for cervical cytology of squamous cell atypia based on a two-step combined CNN algorithm with label smoothing

scientific article published on 28 November 2021

ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD.

scientific article published on 13 May 2019

ALDH1-High Ovarian Cancer Stem-Like Cells Can Be Isolated from Serous and Clear Cell Adenocarcinoma Cells, and ALDH1 High Expression Is Associated with Poor Prognosis ⬇️

scientific article published on June 6, 2013

Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer

scientific article

Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer.

scientific article published on February 2005

Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma-unique pathological features of the primary specimen: A case report

scientific article published on 03 January 2020

Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma

scientific article published on 12 June 2020

An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin.

scientific article published in June 2002

Analysis of a Shared Pancreatic Cancer Antigen Recognized by an HLA-A*2601-Restricted Cytotoxic T-Lymphocyte Clone ⬇️

scientific article published on May 1, 2003

Association between cancer immunity and treatment results in uterine cervical cancer patients treated with radiotherapy

scientific article published on 01 October 2020

Association between radiotherapy-induced alteration of programmed death ligand 1 and survival in patients with uterine cervical cancer undergoing preoperative radiotherapy

scientific article published on 17 January 2020

Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma ⬇️

scientific article published on July 31, 2010

Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma

scientific article published on 01 August 2020

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy

scientific article

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy

scientific article published on 03 February 2016

Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding

scientific article

Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level

scientific article published on 21 April 2016

Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer

scientific article

Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine

scholarly article by Hiroaki Shima et al published 1 August 2018 in Cancer Immunology, Immunotherapy

Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of HSF1.

scientific article published on 8 January 2018

Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma.

scientific article published in June 2009

Characterization of Su48, a centrosome protein essential for cell division

scientific article

Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer

scientific article published on 14 June 2017

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

scientific article published in 2022

Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer

scientific article published on 10 May 2008

Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma

scientific article published on 30 November 2018

Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma

scientific article

Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients

scientific article published on 06 January 2009

Comparison of speedy PCR-ssp method and serological typing of HLA-A24 for Japanese cancer patients ⬇️

scientific article published on January 1, 2011

Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues

scientific article published on 27 October 2017

Constitutive expression and activation of stress response genes in cancer stem-like cells/tumour initiating cells: Potent targets for cancer stem cell therapy ⬇️

scientific article published on August 1, 2013

CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation

scientific article published on 30 June 2015

Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells ⬇️

scientific article published on April 1, 2011

Cytotoxic T Lymphocytes: The Future of Cancer Stem Cell Eradication? ⬇️

scientific article published on June 1, 2013

Cytotoxic T lymphocytes: Sniping cancer stem cells ⬇️

scientific article published on January 1, 2012

DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription

scientific article

DNA methyltransferase 1 is essential for initiation of the colon cancers

scientific article

Dendritic cell and cancer immune checkpoint

scientific article published on January 2016

Depletion of Tregs in vivo : a promising approach to enhance antitumor immunity without autoimmunity ⬇️

scientific article published on 01 November 2012

Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma

scientific article

Detection of autoantibodies to livin and survivin in Sera from lung cancer patients

scientific article published on 08 January 2005

Development of a TCR multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells

article

Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8

scientific article published on 05 August 2020

Development of next-generation peptide vaccination therapy

scientific article published on 01 February 2017

Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma

scientific article published on 25 September 2018

Disruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum

scientific article published on February 2008

Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response

scientific article published on 11 January 2016

ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells ⬇️

scientific article published on March 12, 2012

Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells

scientific article

Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus calmette-guerin immunotherapy for bladder cancer

scientific article published on 01 August 2006

Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population ⬇️

scientific article published on October 2, 2011

Efficient cross-presentation by heat shock protein 90-peptide complex-loaded dendritic cells via an endosomal pathway

scientific article published on August 2007

Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma

scientific article published on 24 August 2017

Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology

scientific article

Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480

scientific article

Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues

scientific article published on 16 March 2012

Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells

scientific article published on 8 October 2009

Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy

scientific article published on 25 April 2006

Expression and function of FERMT genes in colon carcinoma cells

scientific article published on January 1, 2013

Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells ⬇️

scientific article published on August 1, 2013

Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy

scientific article published on 01 January 2015

Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients

scientific article published on 01 July 2007

Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma

scientific article published on 07 July 2020

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

scientific article

Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramer

scientific article published on 24 April 2002

GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis

scientific article

Gene Expression Profiles of Prostate Cancer Stem Cells Isolated by Aldehyde Dehydrogenase Activity Assay ⬇️

scientific article published on May 16, 2012

HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer

scientific article published on 23 March 2015

HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses

scientific article published on 16 February 2017

HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.

scientific article published on 2 May 2012

Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes

scientific article

Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells

scientific article published on 15 December 2014

Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells

scientific article

High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis ⬇️

scientific article published on August 16, 2012

Histone deacetylation, but not hypermethylation, modifies class II transactivator and MHC class II gene expression in squamous cell carcinomas

scientific article published on May 2003

Histopathology of the pancreas in fulminant type 1 diabetes after 23‐year follow‐up: a case report ⬇️

scientific article published on 01 December 2012

Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer: its association with clinical characteristics and survival after cystectomy

scientific article published on 27 August 2009

Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells

scientific article published on 26 September 2016

Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma

scientific article published on 30 January 2014

Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells

scientific article published on 17 February 2017

Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance

scientific article published on 8 June 2016

Identification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from the lung carcinoma antigen, Lengsin ⬇️

scientific article published on June 17, 2011

Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma

scientific article

Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.

scientific article

Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy

scientific article

Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease

scientific article published in January 2002

Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor

scientific article published in August 2004

Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells

scientific article published on March 2010

Immune responses to human cancer stem-like cells/cancer-initiating cells

scientific article

Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients

scientific article published on 24 April 2011

Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series

scientific article published on 11 July 2019

Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients

scientific article published on 16 December 2012

Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.

scientific article published on 12 July 2017

Improved generation of HLA class I/peptide tetramers

scientific article

Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma

scientific article published in September 2017

Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma

scientific article published on 21 September 2018

Interferon gamma assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration

scientific article published on 15 May 2007

LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells

scientific article published on 23 February 2017

Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer

scientific article published on 14 May 2020

Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein

scientific article

Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition

scientific article published on 3 January 2017

LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.

scientific article

MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation

scientific article published on 08 March 2016

Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer

scientific article published on 08 April 2016

Mechanism of immune escape of cancer and its regulation.

scientific article published on May 2009

MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma

scientific article

Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells

scientific article published on 29 December 2015

Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon

scientific article published in March 2017

Molecular pathological approaches to human tumor immunology

scientific article published on April 2009

Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells

scientific article published on August 2002

Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer

scientific article

Non-bacterial cystitis with increased expression of programmed death-ligand 1 in the urothelium: An unusual immune-related adverse event during treatment with pembrolizumab for lung adenocarcinoma

scientific article published on 12 August 2020

Non-neoplastic Fallopian Tube Epithelium Carrying Gene Mutations of a Novel SOX2 Repressor Region is Soil of High-grade Serous Ovarian Cancer

scientific article published on 10 July 2016

Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses

scientific article published on 15 October 2011

Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4.

scientific article

Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma ⬇️

scientific article published on November 20, 2012

Occult Thyroid Follicular Carcinoma Diagnosed as Metastasis to the Chest Wall

scientific article published on August 2017

Occult ovarian clear-cell carcinoma diagnosed as primary adenocarcinoma of the lung: A case report of a diagnostic pitfall for clinicians and pathologists

Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy

scientific article published on 9 February 2016

Osteosarcoma-initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B

scientific article published on 29 November 2019

Ovarian Cancer Stem Cells Are Enriched in Side Population and Aldehyde Dehydrogenase Bright Overlapping Population ⬇️

scientific article published on August 13, 2013

P4-006　　Natural peptidome presented by HLA-A24 of cancer and cancer stem cells

scientific article

Peptide vaccination therapy: Towards the next generation

scientific article

Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma

scientific article published on 18 December 2019

Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer

scientific article published on 18 March 2009

Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer

scientific article

Phase I clinical trial of survivin‐derived peptide vaccine therapy for patients with advanced or recurrent oral cancer ⬇️

scientific article published on December 10, 2010

Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.

scientific article published on 18 March 2017

Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.

scientific article published on 13 July 2016

PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice

scientific article published on 23 August 2014

Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer--results from phase I clinical trials

scientific article

Production of multiple CTL epitopes from multiple tumor-associated antigens

scientific article published on 01 January 2014

Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer

scientific article published on 16 October 2014

Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract ⬇️

scientific article published on August 17, 2012

Prostate cancer stem‐like cells/cancer‐initiating cells have an autocrine system of hepatocyte growth factor ⬇️

scientific article published on February 17, 2013

Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma

scientific article published on 23 July 2019

Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line

scientific article

SOX2 and ALDH1 as Predictors of Operable Breast Cancer

scientific article published on June 2016

SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity ⬇️

scientific article published on September 19, 2011

ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway

scientific article published on 8 November 2017

Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report

scholarly article by Osamu Honjo et al published 3 April 2019 in Journal for Immunotherapy of Cancer

Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication ⬇️

scientific article published on August 2, 2013

Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal

scientific article published on 13 August 2013

Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma

scientific article published on 15 November 2020

Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy

scientific article published on 3 November 2014

Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells

scientific article published on December 2005

Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen-regulated protein 150-peptide complexes

scientific article

The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer

scientific article published on 25 January 2018

The centrosome in normal and transformed cells

scientific article published in August 2004

The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma

scientific article published on 13 October 2010

The functioning antigens: beyond just as the immunological targets

scientific article published on May 2009

The future of immunotherapy for sarcoma

scientific article published on 9 May 2016

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

scientific article published on 05 February 2015

Tumor-Associated Dendritic Cells: Molecular Mechanisms to Suppress Antitumor Immunity ⬇️

scientific article published on 01 August 2011

Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity ⬇️

scientific article published on February 21, 2011

Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses

scientific article published on 01 April 2019

Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor ⬇️

scientific article published on January 3, 2013

Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism

scientific article published on 29 March 2016

[Breast cancer stem cells]

scientific article published on 01 September 2012

[PD-L1-Mediated Immune Escape Mechanism of Cancer Stem-Like Cells]

scientific article published on 01 May 2019

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