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List of works by Jan H M Schellens

"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

scientific article

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

scientific article published on 19 June 2019

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors

scientific article published on 10 August 2017

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

scientific article published on 01 May 2004

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

scientific article

A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer

scientific article published on 31 March 2017

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

scientific article published on 09 October 2019

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

scientific article published on 11 December 2018

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.

scientific article published on 20 January 2016

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

scientific article published on 11 October 2017

A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors.

scientific article published on 3 November 2017

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

scientific article published on 24 November 2020

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

scientific article

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

scientific article

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

scientific article

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

scientific article

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protoc

scientific article published on 21 June 2016

A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers

scientific article published on 11 November 2014

A phase I safety and pharmacologic study of a twice weekly dosing regimen of the oral taxane BMS-275183

scientific article published on 01 July 2007

A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours

scientific article

A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours

scientific article published on 26 December 2018

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors ⬇️

scientific article published on September 28, 2011

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

scientific article published on 01 June 2007

A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma

scientific article published on 07 May 2019

A phosphotyrosine switch regulates organic cation transporters ⬇️

scientific article published on 16 March 2016

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors

scientific article published in February 2006

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

scientific article published in September 2006

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma

scientific article published on 12 November 2010

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

scientific article published on 10 May 2008

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

scientific article published on 31 August 2011

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

scientific article published in January 2006

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues ⬇️

scientific article published on March 5, 2013

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

scientific article published on August 2010

Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).

scientific article

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

scientific article published on 20 March 2006

Acute poisoning after oral intake of a toluene-containing paint thinner

scientific article published on 16 April 2002

Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei

scientific article published on 29 March 2006

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

scientific article published on 01 April 2019

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

scientific article

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma

scientific article

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

scientific article published in September 2002

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

scientific article

Angiotensin II-Receptor Inhibition With Candesartan to Prevent Trastuzumab-Related Cardiotoxic Effects in Patients With Early Breast Cancer: A Randomized Clinical Trial.

scientific article published on 23 June 2016

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

scientific article

Application of PET/CT in the development of novel anticancer drugs

scientific article published on January 2008

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

scientific article published on 24 April 2009

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

scientific article published on 20 August 2008

BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies

scientific article published on 2 June 2017

BRAF-mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

scientific article published on 11 February 2020

Baclofen overdose treated with continuous venovenous hemofiltration

scientific article published on 9 January 2015

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

scientific article published in April 2004

Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report

scientific article published in May 2002

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

scientific article

Bevacizumab

scientific article published on 5 August 2010

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study

scientific article published on 11 March 2016

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

scientific article published on 20 March 2019

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology ⬇️

scientific article published on December 1, 2011

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology

scientific article published on 27 November 2019

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

scientific article

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

scientific article published on 19 August 2018

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies

scientific article published on January 2009

Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.

scientific article

CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES.

scientific article published on 6 November 2017

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity

scientific article published on 01 May 2007

Cannulation of the jugular vein in mice

scientific article published on 01 January 2005

Capecitabine induces severe angina-like chest pain

scientific article published in March 2004

Capecitabine-based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency.

scientific article published on 20 September 2017

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

scientific article

Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review

scientific article published on May 2014

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor

scientific article published on 13 March 2010

Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine

scientific article

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases

scientific article published on 06 January 2020

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials ⬇️

scientific article published on May 17, 2011

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

scientific article published on 20 November 2017

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing

scientific article

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.

scientific article

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function

scientific article published on 01 October 2006

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

scientific article

Clinical experience with aurora kinase inhibitors: a review

scientific article published on 14 August 2009

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar

scientific article published on 18 November 2016

Clinical pharmacokinetics of therapeutic monoclonal antibodies

scientific article published on August 2010

Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518

scientific article published on 25 October 2002

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study

scientific article

Clinical proteomics in breast cancer: a review

scientific article

Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry

scientific article published on 4 April 2006

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

scientific article

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

scientific article published on 8 September 2017

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

scientific article

Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer

scientific article published on 5 February 2018

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

scientific article published on 14 April 2008

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

scientific article

Comparison of toxicity and effectiveness between fixed-dose and body surface area-based dose capecitabine

article

Concise Drug Review: Azacitidine and Decitabine ⬇️

scientific article published on May 13, 2013

Concise Drug Review: Pazopanib and Axitinib ⬇️

scientific article published on June 25, 2012

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

scientific article published on August 2007

Concomitant use of proton pump inhibitors and systemic corticosteroids

scientific article published on January 1, 2013

Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination ⬇️

scientific article published on January 15, 2013

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

scientific article published on 30 March 2015

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression

scientific article

Crizotinib-induced fatal fulminant liver failure

scientific article published on 30 December 2015

Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

scientific article

Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines

scientific article published on 19 March 2004

DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin

scientific article published on January 2003

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

scientific article published on 19 October 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how? - Authors' reply

scientific article published on 01 February 2019

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study ⬇️

scientific article published on March 1, 2012

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

scientific article published on April 2011

Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

scientific article published on 30 August 2014

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error

scientific article published on 02 May 2014

Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk

scientific article

Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population

scientific article

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection

scientific article

Determination of Platinum Originating from Carboplatin in Human Urine and Canine Excretion Products by Inductively Coupled Plasma Mass Spectrometry ⬇️

scientific article published on April 1, 2011

Determination of Sunitinib and Its Active Metabolite N-Desethylsunitinib in Sweat of a Patient ⬇️

scientific article published on 01 October 2011

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography

scientific article

Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry ⬇️

scientific article published on September 17, 2010

Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry

scientific article published on 01 January 2007

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS

scientific article published on 10 December 2015

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

scientific article published on 22 January 2019

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma

scientific article

Development and validation of a quantitative method for thymidine phosphorylase activity in peripheral blood mononuclear cells

article

Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma

scientific article

Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

scientific article published on 22 May 2009

Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients

scientific article

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer

scientific article published on 24 November 2015

Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

scientific article published on 20 March 2013

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

scientific article published on 10 March 2015

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

scientific article

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

scientific article

Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel

scientific article published on 17 October 2012

Development of farnesyl transferase inhibitors: a review

scientific article

Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-meth

article

Dexrazoxane in anthracycline induced cardiotoxicity and extravasation

scientific article

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants

article

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.

scientific article

Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors ⬇️

scientific article published on August 22, 2012

Dose-Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study

article

Dose-finding phase I clinical and pharmacokinetic study of orally administered irinotecan in patients with advanced solid tumors

scientific article published in June 2006

Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate.

scientific article published on February 2012

Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study

scientific article published on 01 December 2015

Drug interactions in oncology

scientific article published in August 2004

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis

scientific article published in April 2004

E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer

scientific article

Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities ⬇️

scientific article published on February 19, 2013

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice

scientific article published in August 2008

Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.

scientific article

Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: results from a phase II randomized, factorial, double-blind study of Cediranib in patients with advanced solid tumors

scientific article published on 9 November 2009

Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis

scientific article published on 04 January 2019

Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours

scientific article

Efficacy of BGJ398, a Fibroblast Growth Factor Receptor 1–3 Inhibitor, in Patients with Previously Treated Advanced Urothelial Carcinoma with FGFR3 Alterations

scientific article published on 30 May 2018

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice

scientific article

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

scientific article published on 7 August 2009

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

scientific article published on 30 September 2019

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOqui

scientific article published in January 2008

Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry

scientific article published on 6 December 2017

Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma

scientific article published on 01 May 2007

Enzyme linked immunosorbent assay for the quantification of nivolumab and pembrolizumab in human serum and cerebrospinal fluid

scientific article published on 17 October 2018

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

scientific article published on 30 November 2017

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

scientific article published on 12 November 2015

Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis

scientific article published on 12 December 2019

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansi

scientific article published on 21 November 2016

Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokinetic-pharmacodynamic simulation study

scientific article published in September 2012

Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer

scientific article published on 01 January 2010

Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

scientific article

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

scientific article published on 17 April 2003

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

scientific article published on 31 December 2015

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors

scientific article published on 7 October 2015

Expression of the breast cancer resistance protein in breast cancer.

scientific article published on April 2002

Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice

scientific article published on 19 May 2008

Facile small scale synthesis of nucleoside 5'-phosphate mixtures

scientific article published in January 2010

Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring

scientific article published on 01 April 2017

Fast and straightforward method for the quantification of pazopanib in human plasma using LC-MS/MS.

scientific article published on 18 December 2017

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

scientific article

First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors

scientific article

Fixed Dosing of Monoclonal Antibodies in Oncology

scientific article published on 28 July 2017

Flat dosing of carboplatin is justified in adult patients with normal renal function

scientific article published in November 2006

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

scientific article published on 25 September 2018

Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material

scientific article published on October 2002

Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer

scientific article

Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first‐line platinum‐gemcitabine chemotherapy ⬇️

scientific article published on September 28, 2011

Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

scientific article

Herb-drug interactions in oncology: focus on mechanisms of induction

scientific article

High-Tech Drugs in Creaky Formulations

scientific article published on 30 May 2017

High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma

scientific article

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature

scientific article

Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons

scientific article published in April 2004

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

scientific article

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

scientific article published in February 2017

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

scientific article published in August 2005

Hyperglycaemia during treatment with everolimus

scientific article published in January 2014

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry

scientific article published in July 2010

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry

scientific article published in March 2006

Identification of two new serum protein profiles for renal cell carcinoma.

scientific article

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study

scientific article published on 07 January 2019

Impact of age on exposure to oral antiandrogen therapies in clinical practice

scientific article published on 02 October 2018

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.

scientific article published on 23 September 2016

Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials

scientific article published on 14 November 2017

Improved pharmacodynamic assay for dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

scientific article published on 01 January 2015

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

scientific article

Improving the solubility of nilotinib through novel spray-dried solid dispersions.

scientific article published on 6 July 2017

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

scientific article published on August 2004

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug

scientific article published in January 2006

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

scientific article published on February 2007

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

scientific article published on October 2005

Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study

scientific article published in October 2014

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

scientific article

Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.

scientific article published on 18 July 2015

Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review

scientific article

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients

scientific article published on 28 July 2016

Inducing synthetic lethality using PARP inhibitors

scientific article published on August 2010

Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).

scientific article

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer

scientific article published on 01 June 2008

Inhibitors of mTOR.

scientific article published on 08 December 2010

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

scientific article published on May 2015

Inter- and intratumoral disposition of platinum in solid tumors after administration of cisplatin

scientific article published on 01 September 2002

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides

scientific article published on 16 February 2018

Is fluorouracil-induced severe toxicity in DPYD*2A individuals related to sex or to treatment regimen?

scientific article published on 22 September 2008

Is rectal administration an alternative route for imatinib?

scientific article published on 08 February 2007

Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells

scientific article published in November 2002

Lapatinib for advanced or metastatic breast cancer

scientific article published on 3 April 2012

Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011;16:1197-1202).

scientific article published on 17 April 2012

Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde

scientific article

Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.

scientific article published in January 2004

Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma

scientific article

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma

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Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

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Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma

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Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma

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Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates ⬇️

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Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite

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Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma

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Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma

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Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate.

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Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma

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Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma

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Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes

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Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

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Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma

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Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

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Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma

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Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.

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Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.

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Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma

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Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction

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Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

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Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction

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Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasm

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Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium

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Liquid chromatography-tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma.

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Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum

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Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma ⬇️

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Liquid chromatography–tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma ⬇️

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Liquid chromatography–tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma ⬇️

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Long-term platinum retention after treatment with cisplatin and oxaliplatin

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Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.

scientific article published on 16 July 2015

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir

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Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

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Management of Hot Flashes in Patients Who Have Breast Cancer With Venlafaxine and Clonidine: A Randomized, Double-Blind, Placebo-Controlled Trial ⬇️

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Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors ⬇️

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Mass balance studies, with a focus on anticancer drugs.

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Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs

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Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma

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Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

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Metabolism of docetaxel in mice

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Metabolism of paclitaxel in mice

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Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer

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Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine ⬇️

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Metabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients

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Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

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Methylnaltrexone

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Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

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Milk Thistle’s Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction ⬇️

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Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab

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Model‐based treatment optimization of a novel VEGFR inhibitor ⬇️

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Molecular Imaging of ABCB1/ABCG2 Inhibition at the Human Blood Brain Barrier using Elacridar and 11C-Erlotinib PET.

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Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

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Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer

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Moving towards dose individualization of tyrosine kinase inhibitors ⬇️

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Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD-1 Expression Levels and PD-1 Receptor Occupancy by Nivolumab and Pembrolizumab

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NT-23PHASE 1/2A STUDY OF GLUTATHIONE PEGYLATED LIPOSOMAL DOXORUBICIN (2B3-101) IN BREAST CANCER PATIENTS WITH BRAIN METASTASES (BCBM) OR RECURRENT HIGH GRADE GLIOMAS (HGG)

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Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort

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New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

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No pharmacokinetic drug-drug interaction between nevirapine and paclitaxel

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No relation between docetaxel administration route and high-grade diarrhea incidence

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Optimizing drug development of anti‐cancer drugs in children using modelling and simulation ⬇️

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Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study

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Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

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Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

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PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer

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Part 1: background, methodology, and clinical adoption of pharmacogenetics

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Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism ⬇️

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Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism ⬇️

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Part 4: Pharmacogenetic Variability in Anticancer Pharmacodynamic Drug Effects ⬇️

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Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines

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Pembrolizumab After Two or More Lines of Previous Therapy in Patients With Recurrent or Metastatic SCLC: Results From the KEYNOTE-028 and KEYNOTE-158 Studies

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Pembrolizumab for the treatment of programmed death-ligand 1-positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE-028 study

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Pemetrexed pathway-associated germline polymorphisms: a useful tool for treatment individualization?

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Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses ⬇️

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Persistent neuropathy after treatment with cisplatin and oxaliplatin

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Personalized medicine in oncology: a personal view with myths and facts

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Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel

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Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells ⬇️

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Pharmacodynamic biomarkers in model-based drug development in oncology

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Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

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Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

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Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

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Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

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Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.

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Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial

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Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol

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Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet

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Pharmacokinetics and Excretion of 14C-Bendamustine in Patients with Relapsed or Refractory Malignancy ⬇️

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Pharmacokinetics and Safety of Olaparib in Patients with Advanced Solid Tumours and Renal Impairment

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Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas

scientific article published on 8 November 2014

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors

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Pharmacokinetics and safety of olaparib in patients with advanced solid tumours and mild or moderate hepatic impairment

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Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

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Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

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Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin ⬇️

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Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature

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Phase 1 and pharmacological study of olaparib in combination with high-dose radiotherapy with and without concurrent cisplatin for non-small cell lung cancer

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Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

scientific article published on 09 March 2020

Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction

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Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors

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Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer

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Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

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Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies ⬇️

scientific article published on August 2, 2011

Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours

scientific article published on 17 August 2006

Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients

scientific article published on 17 February 2007

Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer.

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Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

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Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

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Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors

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Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors

scientific article published on 16 March 2010

Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors

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Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer

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Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors

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Phase I pharmacological study of continuous chronomodulated capecitabine treatment

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Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors

scientific article published on 13 July 2011

Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours

scientific article published on 16 November 2004

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1)

scientific article published on 30 October 2019

Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies

scientific article published in November 2004

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)

scientific article published on 21 October 2019

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

scientific article published on 09 April 2020

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023 ⬇️

scientific article published on September 29, 2012

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

scientific article published on 25 October 2014

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months

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Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer

scientific article published on 01 May 2014

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity

scientific article published on 9 June 2017

Phase Ib study of BGJ398 in combination with BYL719 in patients (pts) with select advanced solid tumors

Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study

scientific article published on 5 February 2018

Photodynamic therapy in oncology

scientific article published on 01 October 2006

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

scientific article published on 02 June 2010

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care

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Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin

scientific article published on 6 October 2004

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors

scientific article published on 31 January 2020

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

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Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin

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Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology

scientific article published on January 2008

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

scientific article published in January 2007

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

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Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years

scientific article published on 13 January 2013

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer

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Population pharmacokinetic–pharmacodynamic analysis for eribulin mesilate‐associated neutropenia ⬇️

scientific article published on September 1, 2013

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer

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Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

scientific article published in April 2002

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

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Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets

scientific article published on April 2014

Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT)

scientific article published on 01 August 2006

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

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Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

scientific article published in March 2014

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

scientific article published on 20 April 2017

Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency

scientific article published on 01 January 2012

Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review

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Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy

scientific article published on March 2008

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

scientific article published on 10 May 2016

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time.

scientific article published on 21 December 2015

Protein versus DNA as a marker for peripheral blood mononuclear cell counting

scientific article published on 16 August 2009

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel ⬇️

article by Jeroen J M A Hendrikx et al published 14 November 2012 in International Journal of Cancer

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

scientific article published on 5 October 2016

Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors

scientific article published on 01 April 2006

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir

scientific article published on 19 April 2020

Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS

scientific article published on 01 January 2014

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry

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Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry

scientific article published on 01 October 2006

Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection

scientific article published in October 2004

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry

scientific article published in January 2005

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

scientific article published on 22 June 2007

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry

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Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 18 January 2010

Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry

scientific article published on 26 July 2008

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

scientific article published on 30 October 2018

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

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Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry ⬇️

scientific article published on December 7, 2012

Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spe

scientific article published on January 2004

Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors

scientific article published in April 2006

Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts

scientific article published in March 2006

Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer ⬇️

scientific article published on September 1, 2003

Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity

scientific article published on 01 January 2007

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

scientific article published on 6 February 2007

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

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Relationship between cisplatin administration and the development of ototoxicity

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Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer

scientific article published on 15 April 2011

Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.

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Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care

scientific article published on 4 January 2016

Reply to T. Magnes et al.

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Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

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Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method

scientific article published on 10 February 2009

Reviewing the cost-effectiveness of endocrine early breast cancer therapies: influence of differences in modeling methods on outcomes

scientific article published on October 2011

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

scientific article published on 21 August 2015

Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.

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Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity

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Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes

scientific article published on 24 March 2006

Screening for polymorphisms in the PXR gene in a Dutch population

scientific article published on 28 March 2006

Selected new developments in oncology

scientific article published on 01 August 2010

Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial

scientific article published on 19 November 2020

Selective Oral MEK1/2 Inhibitor Pimasertib: A Phase I Trial in Patients with Advanced Solid Tumors

scientific article published on 10 November 2020

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

scientific article

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy

scientific article published on 3 February 2014

Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples

scientific article published in July 2010

Serum degradome markers for the detection of breast cancer

scientific article published on 01 August 2010

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.

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Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer

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Serum β-HCG and CA-125 as Tumor Markers in a Patient with Osteosarcoma: Case Report ⬇️

scientific article published on January 1, 2011

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer

scientific article published on 01 January 2012

Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake

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Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel

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Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

scientific article published on 09 April 2013

Simple high‐performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue ⬇️

scientific article published on October 1, 2003

Simultaneous Integrated Boost–Intensity Modulated Radiation Therapy With Concomitant Capecitabine and Mitomycin C for Locally Advanced Anal Carcinoma: A Phase 1 Study ⬇️

scientific article published on April 1, 2013

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography

scientific article published on 28 August 2009

Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships

scientific article published on 01 August 2018

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

scientific article published in October 2009

Slow dissolution behaviour of amorphous capecitabine ⬇️

scientific article published on 05 December 2012

Solubility and bioavailability improvement of pazopanib hydrochloride

scientific article published on 19 April 2018

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers ⬇️

scientific article published on September 30, 2010

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer

scientific article published on 22 August 2006

Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers

article

Standard-Dose Tegafur Combined With Uracil Is Not Safe Treatment After Severe Toxicity From 5-Fluorouracil or Capecitabine ⬇️

scientific article published on December 7, 2010

Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients ⬇️

scientific article published on January 1, 2013

Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry

scientific article published in June 2005

Symptoms and treatment in cancer therapy-induced early menopause

scientific article published on June 2006

Systematic review of biomarkers to monitor therapeutic response in leishmaniasis

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Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma

scientific article published on 12 December 2003

Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective

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Taxanes: Old drugs, new oral formulations ⬇️

scientific article published on 07 May 2013

The Dutch model for clinical pharmacology: collaboration between physician- and pharmacist--clinical pharmacologists

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The European Medicines Agency review of vemurafenib (Zelboraf®) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: summary of the scientific assessment of the Committee for Medicinal Products fo

scientific article published on 05 March 2013

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients

scientific article published on 26 February 2016

The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients ⬇️

scientific article published on 01 December 2010

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

scientific article published on March 2008

The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS

scientific article published on 26 June 2012

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

scientific article published on 7 May 2009

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

scientific article

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry

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The biological and clinical role of drug transporters at the intestinal barrier

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The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

scientific article published on October 2003

The cloudy crystal ball of cost-effectiveness studies

scientific article published in September 2013

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

scientific article published on 01 April 2005

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel ⬇️

scientific article published on September 1, 2013

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

scientific article published in May 2008

The effect of St John's wort on the pharmacokinetics of docetaxel

scientific article published on 01 January 2014

The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel

scientific article published on 7 January 2014

The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors

scientific article

The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.

scientific article published on 24 July 2013

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate

scientific article published on 16 December 2006

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models

scientific article published on 10 October 2006

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome

scientific article published on 31 August 2013

The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass s

scientific article published in July 2008

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases

scientific article published on 11 February 2018

The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance

scientific article published on January 2014

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

scientific article published on 15 April 2014

The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and men.

scientific article

The use of combinations of monoclonal antibodies in clinical oncology

scientific article published on 30 October 2015

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology

scientific article published on 01 March 2019

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?

scientific article published on 26 September 2018

Thermal stability study of crystalline and novel spray-dried amorphous nilotinib hydrochloride

scientific article published on 12 October 2017

Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration

scientific article published in September 2004

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study

scientific article published on January 2002

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype

scientific article

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

scientific article published on 12 August 2015

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

scientific article published on 05 May 2018

Trastuzumab

scientific article published on 31 May 2011

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study

scientific article published on 8 December 2015

Treatment Individualization in Colorectal Cancer

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Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study

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Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

scientific article published on August 2005

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

scientific article

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152) ⬇️

scientific article published on May 28, 2011

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

scientific article published on 16 November 2015

Urinary and fecal excretion of topotecan in patients with malignant solid tumours

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Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

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Utility and Work Productivity Data for Economic Evaluation of Breast Cancer Therapies in the Netherlands and Sweden ⬇️

scientific article published on March 28, 2013

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry

scientific article published on 01 January 2007

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tan

scientific article

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations

scientific article published in February 2007

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

scientific article published on 23 April 2016

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular‐signal‐regulated kinase and DNA in circulating tumor cells ⬇️

scientific article published on April 12, 2012

Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 15 March 2010

Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo

scientific article published on 21 June 2005

Variability in bioavailability of small molecular tyrosine kinase inhibitors

scientific article published on 20 March 2015

Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study

scientific article published on 03 March 2020

[Demethylating medication in myelodysplastic syndrome]

scientific article published on 01 January 2012

[Drug research in oncology; advances in the genome era]

scientific article published in January 2014

[Threshold value for reimbursement of costs of new drugs: cost-effectiveness research and modelling are essential links]

scientific article published on 01 January 2015

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