Search filters

List of works by René Hen

(Radio)active neurogenesis in the human hippocampus.

scientific article

3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221.

scientific article published in June 2005

4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning.

scientific article

5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice

scientific article published on 5 March 2003

5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses

scientific article published in January 2002

5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice

scientific article published in May 2002

5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants

scientific article published on January 2010

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

scientific article published on 21 September 2015

5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice

scientific article

A Distributed Neural Code in the Dentate Gyrus and in CA1

scientific article published on 04 June 2020

A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors

scientific article published on 29 June 2016

A Novel Method for Chronic Social Defeat Stress in Female Mice

scientific article published in November 2017

A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment.

scientific article published on 26 September 2013

A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor

scientific article published on 18 August 2012

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

scientific article published on September 2009

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

scientific article

Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.

scientific article published on 3 November 2017

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

scientific article published on 14 December 2015

Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins

scientific article published in February 2009

Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP.

scientific article published in February 2004

Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse

scientific article published in August 2006

Add neurons, subtract anxiety.

scientific article published on July 2014

Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood

scientific article published on 4 May 2017

Adult hippocampal neurogenesis as target for the treatment of depression.

scientific article published on June 2007

Adult hippocampal neurogenesis in depression

scientific article published on September 2007

Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression

scientific article published on 01 December 2020

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus?

scientific article

Adult neurogenesis modifies excitability of the dentate gyrus

scientific article published on 26 December 2013

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

scientific article published on 09 May 2019

Adult-born hippocampal neurons promote cognitive flexibility in mice

scientific article published on 19 March 2012

Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice

scientific article published in November 2004

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

scientific article published in November 2003

An exploratory study of combination buspirone and melatonin SR in Major Depressive Disorder (MDD): A possible role for neurogenesis in drug discovery ⬇️

scientific article published on September 19, 2012

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

scholarly article

Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens

scientific article

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice.

scientific article published on 28 May 2013

Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates.

scientific article

Antidepressants increase neural progenitor cells in the human hippocampus

scientific article

Anxiety Cells in a Hippocampal-Hypothalamic Circuit

scientific article published on 30 January 2018

Anxiety as a developmental disorder

scientific article published on 12 September 2007

Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning

scientific article

Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.

scientific article

Autism and increased paternal age related changes in global levels of gene expression regulation

scientific article

Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).

scientific article

Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor

scientific article published on 11 April 2007

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

scientific article published on 08 April 2011

Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders

scientific article

Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.

scientific article

Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments.

scientific article published on 17 February 2011

Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward

scientific article published on 14 March 2007

Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.

scientific article published in February 2008

Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice

scientific article

Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies

scientific article published on 12 December 2015

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

scientific article published on 01 December 2018

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

scientific article published on 13 July 2020

Contributions of adult neurogenesis to dentate gyrus network activity and computations

scientific article published on 01 August 2019

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

scientific article published in July 2006

Cover Image, Volume 28, Issue 7

DISC1 puts the brakes on neurogenesis

scientific article published in September 2007

Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze

scientific article

Dendritic inhibition in the hippocampus supports fear learning

scientific article

Dentate gyrus neurogenesis and depression

scientific article published on January 2007

Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior.

scientific article

Different data from different labs: lessons from studies of gene-environment interaction

scientific article

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus

scientific article

Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity

scientific article published on 16 April 2015

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding

scientific article

Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses.

scientific article published in January 2004

Dorsal vs ventral hippocampal neurogenesis: implications for cognition and mood

scientific article

Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal

scientific article published on 11 April 2008

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

scientific article

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus.

scientific article published on 29 September 2010

Effects of chronic fluoxetine in animal models of anxiety and depression.

scientific article published in July 2004

Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.

scientific article published on 22 February 2018

Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system

scientific article

Experience dictates stem cell fate in the adult hippocampus

scientific article

Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells

scientific article published in August 2015

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin ⬇️

scientific article published on September 4, 2012

Fear erasure in mice requires synergy between antidepressant drugs and extinction training.

scientific article published on December 2011

Feeding disorders in 5-HT4 receptor knockout mice

scientific article

Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system

scientific article

Food for Thought: Linking Caloric Intake to Behavior via Sirtuin Activity ⬇️

scientific article published on December 23, 2011

Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages

scientific article published in May 2013

From psychiatric disorders to animal models: a bidirectional and dimensional approach

scientific article

Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model

scientific article published on 12 February 2019

Functional connectome of the striatal medium spiny neuron.

scientific article

Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus.

scientific article published on 03 August 2015

Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus

scientific article

GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors.

scientific article

Gambling disorder: an integrative review of animal and human studies

scientific article

Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice

scientific article

Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior

scientific article published on 15 December 2016

Genetic and environmental factors interact to influence anxiety

scientific article

Genetic approaches for understanding the role of serotonin receptors in mood and behavior.

scientific article published on 4 February 2013

Genetic approaches to the study of anxiety

scientific article published in January 2004

Genetics of affective and anxiety disorders

scientific article

Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors

scientific article published on 17 January 2014

GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine

scientific article published on 31 May 2016

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.

scientific article

Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression

scientific article

Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression

scientific article

Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.

scientific article

Hippocampal neurogenesis and depression.

scientific article published in January 2008

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

scientific article published in Nature

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment.

scientific article

Hippocampal neurogenesis: regulation by stress and antidepressants

scientific article published on June 2006

Hippocampal subfields and major depressive disorder

scientific article

Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution

scientific article (publication date: 27 April 2001)

Human Adult Neurogenesis: Evidence and Remaining Questions

scientific article published on 18 April 2018

Human Hippocampal Neurogenesis Persists throughout Aging

scientific article published in April 2018

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice

scientific article

Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus

scientific article

Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response

scientific article

Implications of the Functional Integration of Adult-Born Hippocampal Neurons in Anxiety-Depression Disorders ⬇️

scientific article published on October 1, 2010

Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice

scientific article published in May 2002

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor.

scientific article published in January 2006

Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

scientific article

Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress

scientific article

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

scientific article

Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces

scientific article published in December 2004

Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ-A novel tool to manipulate and trace adult neurogenesis

scientific article published on 3 February 2011

Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice.

scientific article published in June 2002

Is there a genomic tone? Implications for understanding development, adaptation and treatment

scientific article published on 17 June 2009

Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation

scientific article published in August 2004

Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

scientific article

Knockout Corner

scientific article

Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis

scientific article

Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications ⬇️

scientific article

Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications

Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment

scientific article published on 14 December 2018

Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes

scientific article published on 10 April 2018

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.

scientific article

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

scientific article

Maternal effects in infant and adult phenotypes of 5HT1A and 5HT1B receptor knockout mice.

scientific article

Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth

scientific journal article

Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.

scientific article

Modeling treatment-resistant depression.

scientific article

Modification of serotonin neuron properties in mice lacking 5-HT1A receptors

scientific article published in January 2002

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits.

scientific article published on 31 August 2016

NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination ⬇️

scientific article published on June 20, 2012

Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates ⬇️

scientific article published on April 15, 2011

Neural circuits and behaviour: developmental and evolutionary perspectives

scientific article published on 3 November 2005

Neuroanatomic Differences Associated With Stress Susceptibility and Resilience

scientific article published on 18 August 2015

Neurodevelopmental origins of depressive disorders

scientific article published on 21 December 2006

Neurogenesis and affective disorders ⬇️

scientific article published on March 1, 2011

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

scientific article published on 27 November 2012

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.

scientific article published on May 2009

Neurogenesis-dependent and independent effects of anti-depressant drugs

scientific article published in October 2009

Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

scientific article

Neuronal plasticity and antidepressant actions

scientific article published on February 2013

Neuroscience. Is more neurogenesis always better?

scientific article published on January 2007

Olfactory Deficits Cause Anxiety-Like Behaviors in Mice ⬇️

scientific article published on May 9, 2012

Optimization of immunolabeling and clearing techniques for indelibly-labeled memory traces

scientific article published on 16 April 2018

Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

scientific article published on 12 December 2017

PM309. Methamphetamine induced changes of monoamine neurotransmission in 5-HT1B KO mice.

scientific article

Paradoxical influence of hippocampal neurogenesis on working memory

scholarly article

Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice

scientific article

Paternal transmission of complex phenotypes in inbred mice.

scientific article

Pattern separation: a common function for new neurons in hippocampus and olfactory bulb

scientific article published on May 2011

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

scientific article published on April 2017

Protective effect of 5-HT1B receptor gene deletion on the age-related decline in spatial learning abilities in mice

scientific article

Putting a KAP on transcription and stress

scientific article published on December 2008

Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus

scientific article published on 23 August 2019

Rapid anxiolytic effects of a 5-HT₄ receptor agonist are mediated by a neurogenesis-independent mechanism

scientific article

Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test

scientific article

Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice

scientific article

Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice.

scientific article

Regulation of hippocampal memory traces by neurogenesis

scientific article published on 17 September 2015

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior ⬇️

scientific article published on June 7, 2013

Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons

scientific article published on 17 January 2019

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

scientific article

Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist

scientific article

Role of adult hippocampal neurogenesis in persistent pain

scientific article

Running rescues a fear-based contextual discrimination deficit in aged mice.

scientific article published on 11 August 2015

S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice.

scientific article

Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.

scientific article

Serotonin receptor expression along the dorsal-ventral axis of mouse hippocampus.

scientific article

Serotonin receptors in depression: from A to B.

scientific article published on 09 February 2017

Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety

scientific article

Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout

scientific article

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

scientific article published in March 2002

Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism

scientific article

Spatial learning in the 5-HT1B receptor knockout mouse: selective facilitation/impairment depending on the cognitive demand

scientific article published on November 2003

State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice.

scientific article published in July 2005

Suppression of adult neurogenesis increases the acute effects of kainic acid

scientific article

Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice.

scientific article published on 23 February 2009

TREKing toward new antidepressants

scientific article published on 01 September 2006

Targeted gene expression in dopamine and serotonin neurons of the mouse brain

scientific article

Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses

scientific article published on 01 June 2018

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

scientific article

The current state of the neurogenic theory of depression and anxiety

scientific article

The developmental origins of anxiety

scientific article published on July 2004

The participation of cortical amygdala in innate, odour-driven behaviour

scientific article

The serotonergic system and anxiety

scientific article published on January 2004

The when and where of BDNF and the antidepressant response

scientific article published on April 2008

The young and the restless: regulation of adult neurogenesis by Wnt signaling

scientific article

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex ⬇️

scientific article published on October 1, 2003

Treatment resistant depression: A multi-scale, systems biology approach

scientific article

Untangling depression and anxiety: clinical challenges

scientific article

Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system

scientific article published in February 2003

Variation in the large-scale organization of gene expression levels in the hippocampus relates to stable epigenetic variability in behavior

scientific article

Young and excitable: the function of new neurons in the adult mammalian brain

scientific article

Paulina is supported by:

About Paulina

Help