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List of works by Carsten J Kirschning

A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages ⬇️

scientific article published on October 15, 2003

Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses

scientific article

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

scientific article

Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes

scientific article published on May 2004

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia

scholarly article by Oliver H Robak et al published 1 August 2018 in Journal of Clinical Investigation

Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms

scientific article published on March 2013

Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B ⬇️

scientific article published on May 25, 2012

Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2

scientific article

CCL17 controls mast cells for the defense against filarial larval entry

scientific article

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

scientific article

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements

scientific article

Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2.

scientific article published on 14 July 2003

Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.

scientific article published on 12 March 2007

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene

scientific article published on 4 April 2007

Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6.

scientific article

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

scientific article

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

scientific article

Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model

scientific article published on November 2003

Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis

scientific article published on July 2009

Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis

scientific article published in October 2002

Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection

scientific article published on 01 September 2002

Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response toSalmonella entericaSerovar Typhimurium andStaphylococcus aureusin Mice ⬇️

scientific article published on October 1, 2003

Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease

scientific article

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

scientific article published on 24 August 2011

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

scientific article

Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways

scientific article

Experimental models of acute infection and Toll-like receptor driven septic shock

scientific article published in January 2009

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.

scientific article published on 28 October 2011

Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori

scientific article

Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation

scientific article

Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.

scientific article published on 14 May 2008

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

scientific article published on 12 February 2002

Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo

scientific article published on October 2004

Hepatitis B virus particles activate B cells through the TLR2-MyD88-mTOR axis

scientific article published on 04 January 2021

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.

scientific article

Human but not murine toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides

scientific article published on September 2004

IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells

scientific article published on 01 November 2007

Induction of experimental cerebral malaria is independent of TLR2/4/9.

scientific article published on August 2007

Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE

scientific article published on 08 December 2008

Induction of nuclear factor- kappa B and c-Jun/activator protein-1 via toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans.

scientific article published on 25 August 2004

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

scientific article

Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.

scientific article published in October 2008

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

scientific article

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

scientific article

Mechanisms of Yersinia enterocolitica evasion of the host innate immune response by V antigen

scientific article published on January 2003

Molecular cloning and characterization of a novel anti-TLR9 intrabody.

scientific article published on 26 July 2013

Murine TLR2 expression analysis and systemic antagonism by usage of specific monoclonal antibodies

scientific article

MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS.

scientific article

MyD88 plays a unique role in host defense but not arthritis development in Lyme disease

scientific article published on 01 August 2004

MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis

scientific article published on 5 March 2007

MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection

scientific article published on 22 July 2008

Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

scientific article published on 01 December 2018

Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.

scientific article

Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum

scientific article

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

scientific article published in December 2009

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease

scientific article published on 13 October 2010

Primary sterile necrotic cells fail to cross-prime CD8(+) T cells

scientific article

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

scientific article published on 28 June 2012

Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.

scientific article

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

scientific article published on 8 September 2016

Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease

scientific article

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

scientific article

Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae

scientific article published on September 2002

Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1↔1)αGlc based lipid A mimetics.

scientific article published on 25 August 2015

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

scientific article

Staphylococcus aureus-derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2.

scientific article

Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

scientific article

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition

scientific article

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

scientific article

TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity

scientific article published on 21 October 2019

TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice

scientific article published on 21 July 2008

TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock

scientific article published on November 2007

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes

scientific article (publication date: 2012)

The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin

scientific article published on May 2003

The IL-1R/TLR signaling pathway is essential for efficient CD8(+) T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model

scientific article

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling

scientific article

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release

scientific article

The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway

scientific article

The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4.

scientific article

The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells

scientific article published in May 2005

Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferi ⬇️

scientific article published on 01 January 2002

Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids

scientific article published on 8 May 2017

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis

scientific article published on 12 September 2019

Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis

scientific article published on January 2003

Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi

scientific article published in January 2002

Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection

scientific article

Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells

scientific article published on 05 July 2006

Toll-like receptors and innate antifungal responses

scientific article published on January 2004

Toll-like receptors as key mediators in innate antifungal immunity

scientific article

Tripalmitoyl-S-glyceryl-cysteine-dependent OspA vaccination of toll-like receptor 2-deficient mice results in effective protection from Borrelia burgdorferi challenge

scientific article

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

scientific article

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