List of works - Sabine Gilch

A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis

scientific article

Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells

scientific article published on 05 January 2007

Aptamers against prion proteins and prions.

scientific article

Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line

scientific article

Autophagy induction by trehalose counteracts cellular prion infection

scientific article

Autophagy pathways in the treatment of prion diseases

scientific article published on 01 February 2019

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection

scientific article published on 4 December 2007

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression

scientific article published on 16 October 2019

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

scientific article

Cholesterol balance in prion diseases and Alzheimer's disease

scientific article

Chronic wasting disease

scientific article published on 01 January 2011

Chronic wasting disease: Emerging prions and their potential risk.

scientific article

Combining autophagy stimulators and cellulose ethers for therapy against prion disease

scientific article from 2019

CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells

scientific article

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

scientific article published on 11 August 2017

Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion

scientific article

Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.

scientific article published on May 2013

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

scientific article published on 12 November 2002

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms

scientific article published in December 2017

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.

scientific article published on 6 September 2012

Gene-edited murine cell lines for propagation of chronic wasting disease prions

scientific article published on 01 August 2019

High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population

scientific article published on 28 March 2017

Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

scientific article published on 13 October 2009

Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrPC.

scientific article published on 19 February 2018

Large-scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility

scientific article published on 18 August 2020

Modulation of Host Cell Death by SARS Coronavirus Proteins

scholarly article by Claudia Diemer published in October 2009

Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc

scientific article

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene

scientific article

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

scientific article

Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.

scientific article published on 25 May 2007

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells

scientific article published on 11 March 2003

Preparation and Characterization of Cellulose Ether Liposomes for the Inhibition of Prion Formation in Prion-Infected Cells

scientific article published on 23 March 2019

Prion diseases: from molecular biology to intervention strategies

scientific article published on December 2003

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells

scientific article published on 11 February 2016

Prion infection influences murine endogenous retrovirus expression in neuronal cells

scientific article published on 15 March 2006

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

scientific article

Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells

scientific article published on 11 September 2009

Prion-protein-specific aptamer reduces PrPSc formation

scientific article

Promising developments bringing prion diseases closer to therapy and prophylaxis

scientific article

Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein

scientific article

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

scientific article published on 29 September 2017

Recognition of lumenal prion protein aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP.

scientific article published in April 2004

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain

scientific article

Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.

scientific article

Targeting prion proteins in neurodegenerative disease

scientific article published in July 2008

The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders

scientific article published on 23 September 2020

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

scientific article published on 14 December 2017

The prion protein requires cholesterol for cell surface localization.

scientific article published on 8 November 2005

The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

scientific article published on 9 July 2004

The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.

scientific article published on August 2007

Therapy in prion diseases: from molecular and cellular biology to therapeutic targets

scientific article published in February 2009

Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice

scientific article published on 15 July 2007

Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.

scientific article published on 20 February 2007

List of works by Sabine Gilch

A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis

Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells

Aptamers against prion proteins and prions.

Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line

Autophagy induction by trehalose counteracts cellular prion infection

Autophagy pathways in the treatment of prion diseases

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

Cholesterol balance in prion diseases and Alzheimer's disease

Chronic wasting disease

Chronic wasting disease: Emerging prions and their potential risk.

Combining autophagy stimulators and cellulose ethers for therapy against prion disease

CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion

Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.

Gene-edited murine cell lines for propagation of chronic wasting disease prions

High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population

Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrPC.

Large-scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility

Modulation of Host Cell Death by SARS Coronavirus Proteins

Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells

Preparation and Characterization of Cellulose Ether Liposomes for the Inhibition of Prion Formation in Prion-Infected Cells

Prion diseases: from molecular biology to intervention strategies

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells

Prion infection influences murine endogenous retrovirus expression in neuronal cells

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells

Prion-protein-specific aptamer reduces PrPSc formation

Promising developments bringing prion diseases closer to therapy and prophylaxis

Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Recognition of lumenal prion protein aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP.

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain

Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.

Targeting prion proteins in neurodegenerative disease

The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

The prion protein requires cholesterol for cell surface localization.

The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.

Therapy in prion diseases: from molecular and cellular biology to therapeutic targets

Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice

Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.