List of works - Shelly C Lu

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

scientific article published on April 2004

A morphological method for ammonia detection in liver

scientific article

Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis

scientific article published in January 2004

Abstract 2350: Transarterial radioembolization versus systemic treatment for the management of hepatocellular carcinoma with vascular invasion: Analysis of the US National Cancer Database

scientific article published in 2020

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis ⬇️

scientific article published on November 1, 2010

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

scientific article published on 01 September 2020

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

scientific article published on 01 June 2019

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.

scientific article published on April 2010

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation

scientific article

Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes

scientific article published on December 2008

Chemotherapy-associated liver injury in colorectal cancer

scientific article published on 20 May 2020

Cloning and characterization of the human glutathione synthetase 5'-flanking region

scientific article

Current status of hepatocellular carcinoma detection: screening strategies and novel biomarkers

scientific article published on 06 September 2019

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

scientific article published on 28 January 2022

Deregulated neddylation in liver fibrosis

scientific article

Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells

scientific article published on March 2007

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice

scientific article published on 9 December 2011

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

scientific article published on 14 August 2013

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice

scientific article published on April 2008

FRI-294-Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD

scholarly article

Factors Associated With Detection and Survival of T1 Hepatocellular Carcinoma in the United States: National Cancer Database Analysis

scientific article published on 01 September 2020

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

scientific article

Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals

scientific article

Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice

scientific article

Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine

scholarly article

Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment

scientific article published on 23 September 2020

Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.

scientific article

Homocysteine, the bad thiol

scientific article

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis

scientific journal article

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis

scientific article published on 9 October 2012

Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis

scientific article published on 01 June 2019

Identification of a gene-pathway associated with non-alcoholic steatohepatitis

scientific article published on 30 November 2006

Impaired liver regeneration in mice lacking glycine N-methyltransferase.

scientific article published on August 2009

Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.

scientific article published on 19 March 2004

Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis

scientific article published on 08 October 2020

Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice

scientific article

Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.

scientific article published on 6 October 2003

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

scientific article

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine

scientific article published on 2 April 2004

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

scientific article

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

scientific article published on June 2011

Keratin mutation primes mouse liver to oxidative injury.

scientific article

L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine

scientific article published on 26 March 2003

Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta

scientific article published on February 2008

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

scientific article

Liver cancer-associated changes to the proteome: what deserves clinical focus?

scientific article published on 19 September 2018

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice ⬇️

scientific article published on October 1, 2010

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

scientific article published on April 2008

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

scientific article published on 23 September 2020

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer

scientific article published on 14 May 2013

Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis

scientific journal article

Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer

Metabolic landscape of the mouse liver by quantitative <sup>31</sup> P-NMR analysis of the phosphorome

scientific article published on 07 December 2020

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

scientific article published on 26 January 2017

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts.

scientific article published on 4 May 2018

Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

scientific article published on 25 June 2019

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

scientific article published on December 2011

Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.

scientific article published on 28 June 2013

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.

scientific article published on October 2006

Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy

scientific article

Methionine adenosyltransferases in liver cancer

scientific article published on 01 August 2019

Methionine adenosyltransferases in liver health and diseases

scientific article published on 01 September 2017

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

scientific article published on 19 September 2015

Methionine metabolism and liver disease

scientific article published on January 2008

Methylthioadenosine.

scientific article published in November 2004

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

scientific article published on 20 September 2018

MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease

scientific article published on 23 March 2016

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma

scientific article

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases

scientific article published in April 2006

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

scientific article published in March 2012

NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD

scientific article published on 23 May 2019

Non-alcoholic fatty liver disease proteomics

scientific article

Non-alcoholic steatohepatitis and animal models: understanding the human disease.

scientific article

Nonalcoholic steatohepatitis, animal models, and biomarkers: what is new?

scientific article published on 01 January 2010

Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants

scientific article

Overview of extracellular microvesicles in drug metabolism.

scientific article published on May 2010

PINE: An Automation Tool to Extract & Visualize Protein-Centric Functional Networks

scientific article published on 28 May 2020

PS-034-MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

scholarly article

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells

scientific article published on 27 September 2018

Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes

scientific article published on 29 September 2016

Prohibitin 1 in liver injury and cancer

scientific article published on 20 February 2020

Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells

scientific article published on 16 December 2016

Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine

scientific article published on 16 January 2012

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity

scientific article published on 18 April 2014

RXRα-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity ⬇️

scientific article published on December 1, 2003

Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer

scientific article published on 21 February 2020

Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver

scientific article published in March 2004

Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone

scientific article

Role of Aramchol in steatohepatitis and fibrosis in mice.

scientific article published on 4 October 2017

Role of S-adenosyl-L-methionine in liver health and injury

scientific article published on May 2007

Role of S-adenosylmethionine in two experimental models of pancreatitis

scientific article published in November 2002

Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells

scientific article

Role of methionine adenosyltransferase genes in hepatocarcinogenesis

scientific article published on 24 March 2011

S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver

scholarly article

S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells

scientific article published on 16 April 2009

S-Adenosylmethionine in cell growth, apoptosis and liver cancer

scientific article published on March 2008

S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes.

scientific article published on 18 November 2010

S-Adenosylmethionine: a control switch that regulates liver function.

scientific article

S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers

scientific article

S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).

scientific article published in July 2004

S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.

scientific article published in February 2002

S-adenosylmethionine and proliferation: new pathways, new targets

scientific article

S-adenosylmethionine in Liver Health, Injury, and Cancer ⬇️

scientific article published on October 1, 2012

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model

scientific article

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

scientific article published on May 2008

S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis

scientific article published on 25 September 2008

S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase

scientific article published on 01 July 2006

SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum

scientific article published on 05 October 2020

Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.

scientific article published on 07 June 2002

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

scientific article

Structure and function study of the complex that synthesizesS-adenosylmethionine

scientific article

Sub‐proteome approach to the knowledge of liver ⬇️

scientific article published on 03 February 2010

Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes

scientific article

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

scientific article

Targeting Hepatic Glutaminase 1 Ameliorates Non-Alcoholic Steatohepatitis by Restoring Disrupted Hepatic Very-Low Density Lipoproteins Triglyceride Assembly

scholarly article

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

scientific article published on 21 February 2020

The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: An Adaptation to the Warburg Effect? ⬇️

scientific article published on February 1, 2011

The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.

scientific article published in April 2012

The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers

scientific article published on 06 December 2018

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

scientific article

Transarterial radioembolization versus systemic treatment for the management of hepatocellular carcinoma with vascular invasion: analysis of the US national cancer database

scientific article published in 2020

WITHDRAWN: Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region

retracted scientific article published in December 2004

Where are we in the search for noninvasive nonalcoholic steatohepatitis biomarkers? ⬇️

scientific article published on October 1, 2011

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

scientific article published on 16 August 2019

List of works by Shelly C Lu

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

A morphological method for ammonia detection in liver

Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis

Abstract 2350: Transarterial radioembolization versus systemic treatment for the management of hepatocellular carcinoma with vascular invasion: Analysis of the US National Cancer Database

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis ⬇️

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation

Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes

Chemotherapy-associated liver injury in colorectal cancer

Cloning and characterization of the human glutathione synthetase 5'-flanking region

Current status of hepatocellular carcinoma detection: screening strategies and novel biomarkers

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

Deregulated neddylation in liver fibrosis

Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice

FRI-294-Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD

Factors Associated With Detection and Survival of T1 Hepatocellular Carcinoma in the United States: National Cancer Database Analysis

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals

Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice

Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine

Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment

Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.

Homocysteine, the bad thiol

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis

Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Identification of a gene-pathway associated with non-alcoholic steatohepatitis

Impaired liver regeneration in mice lacking glycine N-methyltransferase.

Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.

Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis

Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice

Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Keratin mutation primes mouse liver to oxidative injury.

L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine

Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

Liver cancer-associated changes to the proteome: what deserves clinical focus?

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice ⬇️

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer

Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis

Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer

Metabolic landscape of the mouse liver by quantitative <sup>31</sup> P-NMR analysis of the phosphorome

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts.

Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.

Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy

Methionine adenosyltransferases in liver cancer

Methionine adenosyltransferases in liver health and diseases

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

Methionine metabolism and liver disease

Methylthioadenosine.

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD

Non-alcoholic fatty liver disease proteomics

Non-alcoholic steatohepatitis and animal models: understanding the human disease.

Nonalcoholic steatohepatitis, animal models, and biomarkers: what is new?

Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants

Overview of extracellular microvesicles in drug metabolism.

PINE: An Automation Tool to Extract & Visualize Protein-Centric Functional Networks

PS-034-MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells