List of works - Kevin O Saunders

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

scientific article published on 30 July 2020

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

scientific article

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

scientific article

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

scientific article published on 3 June 2015

Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

scientific article published on 8 April 2015

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

article

Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans

scientific article published on 16 December 2019

Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

article

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 02 December 2019

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

scientific article published on 01 July 2019

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

scientific article published on 24 January 2020

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

scientific article published on 13 August 2014

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

scientific article published on 2 May 2018

HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces Gp41 Antibody Immunodominance in Rhesus Macaques

scientific article published on 09 August 2017

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

article

Immune checkpoint modulation enhances HIV-1 antibody induction

scientific article published on 19 February 2020

Immunogenicity of NYVAC prime-protein boost HIV-1 envelope vaccination and SHIV challenge of nonhuman primates

scientific article published on 7 February 2018

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

scientific article published on 7 March 2018

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

article

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

scientific article published on 23 November 2017

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

scientific article published on 31 December 2020

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

scientific article published on 28 March 2022

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 17 September 2019

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.

scientific article

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures

scientific article published on 10 November 2020

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Safety and immune responses after a 12-month booster in healthy HIV-uninfected adults in HVTN 100 in South Africa: A randomized double-blind placebo-controlled trial of ALVAC-HIV (vCP2438) and bivalent subtype C gp120/MF59 vaccines

scientific article published on 24 February 2020

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

scientific article published in Nature Communications

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

scientific article published on March 2017

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

scientific article published on 17 June 2019

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates

scientific article published on 04 June 2021

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

scientific article published on 18 March 2015

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

scientific article

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

scientific article published on 08 May 2020

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

scientific article

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

scientific article published in December 2017

List of works by Kevin O Saunders

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans

Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces Gp41 Antibody Immunodominance in Rhesus Macaques

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

Immune checkpoint modulation enhances HIV-1 antibody induction

Immunogenicity of NYVAC prime-protein boost HIV-1 envelope vaccination and SHIV challenge of nonhuman primates

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Safety and immune responses after a 12-month booster in healthy HIV-uninfected adults in HVTN 100 in South Africa: A randomized double-blind placebo-controlled trial of ALVAC-HIV (vCP2438) and bivalent subtype C gp120/MF59 vaccines

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models