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List of works by Heiko Wurdak

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

scientific article published on 07 March 2019

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

scientific article published on 23 September 2009

A small molecule accelerates neuronal differentiation in the adult rat.

scientific article

A small molecule primes embryonic stem cells for differentiation

scientific article

An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation

scientific article published in January 2010

Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion

scientific article published in May 2008

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery. ⬇️

scientific article

CBIO-33INVESTIGATING GLIOMA CELL PHENOTYPES WITH SMALL MOLECULES.

scientific article

Chemical ROCK inhibition induces neurite-like outgrowth and connectivity in undifferentiated glioblastoma cells

scientific article published on 31 January 2018

Chemical control of stem cell fate and developmental potential

scientific article published on January 2011

Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells

scientific article published on 10 October 2019

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

scientific article published on 10 November 2018

Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells

scientific article

DiGeorge syndrome and pharyngeal apparatus development

scientific article published on November 2006

Directed embryonic stem cell differentiation with small molecules

scientific article

Exploring The Cancer Stem Cell Phenotype with High-Throughput Screening Applications ⬇️

scientific article published on June 1, 2012

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma

scientific article published on 16 December 2019

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes

scientific article published on 27 July 2020

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

scientific article

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

scientific article published in January 2018

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice ⬇️

scientific article published on 01 August 2018

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

scientific article published on 07 August 2021

Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases ⬇️

scientific article published on 18 May 2016

Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling

scientific article

OP07. Cytoplasmic TACC3 regulates gene expression in glioblastoma multiforme cells

scientific article

Optimising single cell RNAseq for the analysis of paired primary and recurrent Glioblastoma

scientific article published on 31 January 2018

PDTM-33. FOCUSED ULTRASOUND DISRUPTION OF THE BLOOD BRAIN BARRIER IN THE BRAINSTEM: A FEASIBILITY AND SAFETY STUDY

PP08. SITE-SPECIFIC PHENOTYPES OF CANCER CELLS AND MACROPHAGES IN INTRACRANIAL BREAST CANCER METASTASES.

scientific article published in January 2017

PP17. RHO GTPASE SIGNALLING IN CANCER CELL INVASION AND ANGIOGENESIS IN BRAIN TUMOURS.

scientific article

PP27. ESTABLISHMENT OF A HAEMATOPOIETIC STEM-CELL BASED THERAPY FOR BRAIN TUMOURS IN PRE-CLINICAL MOUSE MODELS.

scientific article published in January 2017

Polyelectrolyte complex templated synthesis of monodisperse, sub-100 nm porous silica nanoparticles for cancer targeted and stimuli-responsive drug delivery

scientific article published on 03 November 2020

Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

scientific article

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells. ⬇️

scientific article

Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules

scientific article

Rho GTPase signaling and role of the Rac1 exchange factor DOCK4 in GBM invasion and vascular growth

scientific article published on 31 January 2018

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

scientific article published on 23 June 2021

Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion ⬇️

scientific article published on 15 March 2018

TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7.

scientific article

TMOD-24. PATIENT-DERIVED BRAIN TUMOUR IPSCS: MODELS FOR INVESTIGATING GLIOMA STEMNESS AND DRUG DISCOVERY

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

scientific article published on 18 October 2017

Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord

scientific article published on 23 December 2006

shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

scientific article published on 27 December 2018

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