List of works - Małgorzata Sierant

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

scientific article

Chlorambucil labelled with the phenosafranin scaffold as a new chemotherapeutic for imaging and cancer treatment.

scientific article published in September 2017

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.

scientific article published on 19 April 2018

Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.

scientific article

DNA binding and cleavage studies of copper(II) complexes with 2'-deoxyadenosine modified histidine moiety

scientific article

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

scientific article published on 09 September 2008

Escherichia coli tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of S-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNA

scientific article published in 2022

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate

scientific article published on 19 June 2018

Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function

scientific article published in 2022

Evaluation of BACE1 Silencing in Cellular Models

scientific article

Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

scientific article published on 26 August 2016

Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions

scientific article

Longer 19-base pair short interfering RNA duplexes rather than shorter duplexes trigger RNA interference

scientific article published in August 2010

Photosensitive nanocapsules for use in imaging from poly(styrene-co-divinylbenzene) cross-linked with coumarin derivatives.

scientific article published on 17 July 2013

RNA interference in silencing of genes of Alzheimer's disease in cellular and rat brain models.

scientific article published on January 2008

RNAi mediated silencing of cyclin-dependent kinases of G1 phase slows down the cell-cycle progression and reduces apoptosis

scientific article

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

scientific article published on 15 June 2017

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

scientific article (publication date: 15 December 2016)

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

scientific article published on 7 April 2011

List of works by Małgorzata Sierant

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Chlorambucil labelled with the phenosafranin scaffold as a new chemotherapeutic for imaging and cancer treatment.

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.

Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.

DNA binding and cleavage studies of copper(II) complexes with 2'-deoxyadenosine modified histidine moiety

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

Escherichia coli tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of S-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNA

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate

Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function

Evaluation of BACE1 Silencing in Cellular Models

Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions

Longer 19-base pair short interfering RNA duplexes rather than shorter duplexes trigger RNA interference

Photosensitive nanocapsules for use in imaging from poly(styrene-co-divinylbenzene) cross-linked with coumarin derivatives.

RNA interference in silencing of genes of Alzheimer's disease in cellular and rat brain models.

RNAi mediated silencing of cyclin-dependent kinases of G1 phase slows down the cell-cycle progression and reduces apoptosis

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference