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List of works by Leoni Kunz-Schughart

A Complex Scenario and Underestimated Challenge: The Tumor Microenvironment, ER Stress, and Cancer Treatment.

scientific article published on 16 January 2018

A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation

scientific article published in May 2001

A reliable tool to determine cell viability in complex 3-d culture: the acid phosphatase assay

scientific article

Adaptation of an automated selective dissociation procedure to two novel spheroid types

scientific article published on 01 February 1997

Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

scientific article

An ovarian spheroid based tumor model that represents vascularized tumors and enables the investigation of nanomedicine therapeutics

scientific article published on 01 January 2020

Anti-inflammatory and angiostatic therapy in chemorefractory multisystem Langerhans' cell histiocytosis of adults

scientific article

Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization

scientific article

Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells.

scientific article published on 4 November 2015

Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution

scientific article published on 2 January 2016

Basophils enhance immunological memory responses

scientific article published on 30 May 2008

Brave little world: spheroids as an in vitro model to study tumor-immune-cell interactions

scientific article

CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges

scientific article

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116.

scientific article published on March 2010

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116.

scientific article published on 21 August 2009

CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity

scientific article

CD84 expression on human hematopoietic progenitor cells

scientific article (publication date: September 2003)

Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma

scientific article published on 7 October 2015

Cancer stem cells as a predictive factor in radiotherapy

scientific article published on April 2012

Characterization and modulation of fibroblast/endothelial cell co-cultures for the in vitro preformation of three-dimensional tubular networks

scientific article published on 01 November 2011

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability

scientific article published on 28 September 2016

Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma

scientific article published on 20 July 2009

Cytotoxic properties of radionuclide-conjugated Cetuximab without and in combination with external irradiation in head and neck cancer cells in vitro.

scientific article published on 3 April 2014

Defects in N-glycosylation induce apoptosis in yeast

scientific article published in February 2006

Defining high-fat-diet rat models: metabolic and molecular effects of different fat types

scientific article published on 01 June 2006

Differentiation of hematopoietic progenitor cells towards the myeloid and B-lymphoid lineage by hepatocyte growth factor (HGF) and thrombopoietin (TPO) together with early acting cytokines

scientific article published on 01 August 2006

Discovery of the cancer stem cell related determinants of radioresistance.

scientific article published on 03 July 2013

Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells

scientific article published on 23 November 2020

EGFR/JIP-4/JNK2 signaling attenuates cetuximab-mediated radiosensitization of squamous cell carcinoma cells

scientific article

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo

scientific article

Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells.

scientific article published on 2 April 2016

Epstein-Barr virus small RNA (EBER) genes: differential regulation during lytic viral replication

scientific article published on November 1998

Evaluation of membrane physiology following fluorescence activated or magnetic cell separation

scientific article

Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

scientific article

Exposure to continuous bromodeoxyuridine (BrdU) differentially affects cell cycle progression of human breast and bladder cancer cell lines

scientific article published in April 2004

Expression and function of homing-essential molecules and enhanced in vivo homing ability of human peripheral blood-derived hematopoietic progenitor cells after stimulation with stem cell factor

scientific article published on 01 January 2004

Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers, and never-smokers

scientific article published in May 2003

Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma

scientific article

Expression of CD68 in non-myeloid cell types

scientific article

Expression of peroxisome proliferator activated receptor gamma and cyclo-oxygenase 2 in primary and recurrent ovarian carcinoma

scientific article published on 12 May 2006

Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium

scientific article published on 25 March 2014

Fates of genetically engineered haematopoietic and mesenchymal stem cell grafts in normal and injured rat hearts

scientific article

Fibroblastic reaction and vascular maturation in human colon cancers

scientific article published on 01 November 2009

Flow cytometric cell-based assay to preselect antibody constructs for radionuclide conjugation.

scientific article published on 28 August 2012

GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice

scientific article published in January 2003

Genome and transcriptome profiles of CD133-positive colorectal cancer cells.

scientific article

Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro

scientific article

Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells

scientific article

Hepatic progenitor cells from adult human livers for cell transplantation

scientific article

High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer

scientific article published on 01 August 2005

Identification of genes expressed in tumor-associated macrophages

scientific article published in January 2003

Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro

scientific article

Impact of proliferative activity and tumorigenic conversion on mitochondrial function of fibroblasts in 2D and 3D culture

scientific article published in January 2001

Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts

scientific article published on 4 June 2010

In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors

scientific article

Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis

scientific article published on 18 February 2020

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

scientific article

Inhibitory effect of tumor cell-derived lactic acid on human T cells

scientific article published on 25 January 2007

Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells

scientific article

Labeling fibroblasts with biotin-BSA-GdDTPA-FAM for tracking of tumor-associated stroma by fluorescence and MR imaging

scientific article

Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1

scientific article published on 18 May 2007

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

scientific article published on 25 May 2011

Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

scientific article

Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

scientific article published on 15 April 2004

Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study

scientific article published in January 2007

MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity

scientific article published on 01 November 2021

Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE)

scientific article

Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides

scientific article published in May 2005

Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

scientific article

Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts

scientific article

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

scientific article published on 16 November 2010

Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines

scientific article published on 18 June 2020

Mitochondrial function in oncogene-transfected rat fibroblasts isolated from multicellular spheroids.

scientific article published on November 1997

Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology

scientific article published on 01 February 1998

Multicellular tumor spheroids: an underestimated tool is catching up again.

scientific article published on 25 January 2010

Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor

scientific article

Multiple molecular analyses from minimal cell quantities by sequential isolation and preamplification of DNA and RNA.

scientific article

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin

scientific article published on 16 December 2019

Nanoparticles for radiooncology: Mission, vision, challenges.

scientific article published on 14 December 2016

Phosphorous metabolites and steady-state energetics of transformed fibroblasts during three-dimensional growth

scientific article published on October 2002

Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids

scientific article published on 9 March 2010

Potential of a Cetuximab-based radioimmunotherapy combined with external irradiation manifests in a 3-D cell assay.

scientific article published on 11 February 2014

Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro

scientific article published in May 2006

Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture

scientific article

Publisher Correction: Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

scientific article published on 04 August 2020

Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo

scientific article published on 10 September 2012

Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer

scientific article published on 04 January 2021

Relevance of disease- and organ-specific endothelial cells for in vitro research

scientific article published on December 2010

Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells

scientific article published on 01 October 2002

Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.

scientific article

SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC)

scientific article published on 25 May 2020

SCF modulates organ distribution and hematopoietic engraftment of CB-derived pluripotent HPC transplanted in NOD/SCID mice

scientific article

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

scientific article published on 25 July 2013

Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation

scientific article published on 8 August 2011

Sodium-iodide symporter positive cells after intracellular uptake of (99m)Tc versus α-emitter 211At. Reduction of clonogenic survival and characterization of DNA damage

scientific article

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

scientific article published on 04 June 2020

Spheroid-based drug screen: considerations and practical approach

scientific article (publication date: February 2009)

Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis

scientific article published on 01 September 2007

Temozolomide preferentially depletes cancer stem cells in glioblastoma

scientific article

Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas

scientific article published on 15 November 2005

The "classical" macrophage marker CD68 is strongly expressed in primary human fibroblasts

scientific journal article

The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity

scientific article published on 22 January 2019

The fibroblast: sentinel cell and local immune modulator in tumor tissue

scientific article published on January 2004

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model

scientific article published on June 2004

The why and how of amino acid analytics in cancer diagnostics and therapy.

scientific article published on 5 December 2016

Three-dimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation

scientific article published on May 1996

Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation

scientific article published on 14 September 2013

Three-dimensional fibroblast-tumor cell interaction causes downregulation of RACK1 mRNA expression in breast cancer cells in vitro

scientific article published on 01 November 2002

Three-dimensional tissue structure affects sensitivity of fibroblasts to TGF-beta 1

Tumor Necrosis Factor-α Activates NFκB to Inhibit Renin Transcription by Targeting cAMP-responsive Element ⬇️

scientific article published on October 16, 2003

Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?

scientific article

Tumor-associated fibroblasts (part II): Functional impact on tumor tissue

scientific article

Tumor-associated fibroblasts recruit blood monocytes into tumor tissue

scientific article published in May 2003

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

scientific article published on 8 November 2005

Validity of a patient-derived system of tissue-specific human endothelial cells: interleukin-6 as a surrogate marker in the coronary system

scientific article published on 08 June 2007

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

scientific article

[Tumor pathophysiology]

scientific article published on 01 November 2012

mTOR inhibitors and calcineurin inhibitors do not affect adhesion molecule expression of human macro- and microvascular endothelial cells

scientific article published on 4 March 2008

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