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List of works by Zixin Deng

'Streptomyces nanchangensis', a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters

scientific article published in February 2002

A Dual Role Reductase from Phytosterols Catabolism Enables the Efficient Production of Valuable Steroid Precursors

scientific article published on 30 November 2020

A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in var. beijingensis

article published in 2019

A Non-Restricting and Non-Methylating Escherichia coli Strain for DNA Cloning and High-Throughput Conjugation to Streptomyces coelicolor ⬇️

scientific article published on November 22, 2011

A Site-Specific Integrative Plasmid Found in Pseudomonas aeruginosa Clinical Isolate HS87 along with A Plasmid Carrying an Aminoglycoside-Resistant Gene

scientific article

A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

scientific article

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

scientific article published on 29 July 2019

A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery

scientific article published on 01 November 2019

A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in streptomyces

scientific article published on 16 May 2008

A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin ⬇️

scientific article published on May 2003

A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA.

scientific article published on 14 November 2006

A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22

scientific article published on 01 February 2002

A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71.

scientific article published on 20 June 2014

A novel DNA modification by sulfur: DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans

scientific article published on 01 May 2007

A novel DNA modification by sulphur

scientific article published on September 2005

A novel aliphatic 18F-labeled probe for PET imaging of melanoma

scientific article published on 22 August 2013

A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16.

scientific article

A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella

scientific article

A novel method to prepare L-arabinose from xylose mother liquor by yeast-mediated biopurification

scientific article

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

scientific article published on 01 February 2019

A novel streptonigrin type alkaloid from the <i>Streptomyces flocculus</i> CGMCC 4.1223 mutant Δ<i>stnA/Q2</i>

scientific article published on 07 December 2020

A novel target of IscS in Escherichia coli: participating in DNA phosphorothioation

scientific article

A rapid and easy protein N-terminal profiling strategy using (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP) labeling and StageTip.

scientific article published on 9 June 2017

A self-ligation method for PCR-sequencing the telomeres of Streptomyces and Mycobacterium linear replicons ⬇️

scientific article published on April 26, 2012

A small-molecule dye for NIR-II imaging

scientific article published on 23 November 2015

A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.

scientific article published on 15 March 2013

ATPase genes of diverse multidrug-resistant Acinetobacter baumannii isolates frequently harbour integrated DNA.

scientific article published on 19 November 2008

Absolute quantification of proteins in the fatty acid biosynthetic pathway using protein standard absolute quantification

scientific article published on 17 February 2016

Actinoallomurus acanthiterrae sp. nov., an actinomycete isolated from rhizosphere soil of the mangrove plant Acanthus ilicifolius

scientific article published on September 21, 2012

Activation of Natural Products Biosynthetic Pathways via a Protein Modification Level Regulation.

scientific article published on 31 May 2017

Aglycone Polyether Nanchangmycin and Its Homologues Exhibit Apoptotic and Antiproliferative Activities against Cancer Stem Cells

scientific article published on 12 October 2018

Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453.

scientific article published in April 2008

An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin.

scientific article

An Alternative Approach to Synthesizing Galactooligosaccharides by Cell-Surface Display of β-Galactosidase on Yarrowia lipolytica

scientific article

An Fe2+ - and α-Ketoglutarate-Dependent Halogenase Acts on Nucleotide Substrates

scientific article published on 11 March 2020

An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain

scientific article

An Unusual Protector-Protégé Strategy for the Biosynthesis of Purine Nucleoside Antibiotics.

scientific article published on 12 January 2017

An in vitro DNA phosphorothioate modification reaction

scientific article published on 09 December 2019

An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

scientific article published on 14 July 2016

Analysis of Streptomyces coelicolor membrane proteome using two-dimensional native/native and native/sodium dodecyl sulfate gel electrophoresis

scientific article published on 18 August 2014

Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria

scientific article published on 19 July 2007

Analysis of functions in plasmid pHZ1358 influencing its genetic and structural stability in Streptomyces lividans 1326.

scientific article published on 6 December 2008

Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase

scientific article

Antibacterial natural products lobophorin L and M from the marine-derived Streptomyces sp. 4506

scientific article published on 27 July 2020

Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production

scientific article

Assignment of EC numbers to enzymatic reactions with reaction difference fingerprints

scientific article

Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis

scientific article published on 06 September 2019

Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365. ⬇️

scientific article published on 3 March 2017

Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

scientific article published on 26 November 2015

Biosynthesis of Tropolones in Streptomyces spp: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on Tropone Ring ⬇️

scientific article published on 13 April 2018

Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route

scientific article published on 18 November 2019

Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme

scientific article published on 4 May 2017

Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ.

scientific article

Biosynthesis of the β-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941. ⬇️

scientific article

Biotransformation of isoeugenol to vanillin by a newly isolated Bacillus pumilus strain: Identification of major metabolites

scientific article published on 19 May 2007

CRISPR/Cas9-Based Editing of Streptomyces for Discovery, Characterization, and Production of Natural Products

scientific article published on 24 July 2018

CRISPR/dCas9-Mediated Multiplex Gene Repression in Streptomyces

scientific article published on 04 July 2018

Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A

scientific article published on 19 June 2008

Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain

scientific article published on 01 February 2022

Cezomycin is activated by CalC to its ester form for further biosynthesis steps in the production of calcimycin in Streptomyces chartreusis NRRL 3882. ⬇️

scientific article published on 13 April 2018

Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins

scientific article published on 16 May 2016

Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.

scientific article

Characterization of a FAD-dependent halogenase XanH and engineering construction of multifunctional fusion halogenases

scientific article published on 10 July 2020

Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis

scientific article

Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888.

scientific article

Characterization of the Biosynthetic Gene Cluster for Benzoxazole Antibiotics A33853 Reveals Unusual Assembly Logic

scientific article published on October 2015

Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus

scientific article published on 12 February 2019

Characterization of the N-methyltransferase CalM involved in calcimycin biosynthesis by Streptomyces chartreusis NRRL 3882.

scientific article published on 11 April 2013

Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570 ⬇️

scientific article

Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin (A23187) in Streptomyces chartreusis NRRL 3882 ⬇️

scientific article

Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H

scientific article

Characterization of the positive SARP family regulator PieR for improving piericidin A1 production in var. Hangzhouwanensis

Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.

scientific article

Cleavage of Phosphorothioated DNA and Methylated DNA by the Type IV Restriction Endonuclease ScoMcrA ⬇️

scientific article published on December 23, 2010

Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification

scientific article

Cloning, expression and purification of dptC, a DNA phosphorothioate modification related gene from Salmonella enteric serovar Cerro 87

scientific article published in October 2013

Cometabolic degradation of dibenzofuran and dibenzothiophene by a newly isolated carbazole-degrading Sphingomonas sp. strain

scientific article published on 2 March 2007

Comparative Analysis of CRISPR Loci Found in Streptomyces Genome Sequences

scientific article published on 20 July 2018

Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds

scientific article published on 07 January 2020

Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum.

scientific article published in April 2012

Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors

scientific article

Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics.

scientific article published on 19 August 2016

Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes

scientific article

Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes

scientific article published on 30 October 2018

Correction: A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery

scientific article published on 28 November 2019

Correction: sRNAscanner: A Computational Tool for Intergenic Small RNA Detection in Bacterial Genomes.

scientific article

Corrigendum: Identifying the Minimal Enzymes for Unusual Carbon-Sulfur Bond Formation in Thienodolin Biosynthesis

scientific article published on 21 April 2016

Cross-module Enoylreduction in the Azalomycin F Polyketide Synthase

scientific article published on 31 August 2020

Crystal Structure of the Cysteine Desulfurase DndA from Streptomyces lividans Which Is Involved in DNA Phosphorothioation ⬇️

scientific article published on May 3, 2012

Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA

scientific article

DNA Backbone Sulfur-Modification Expands Microbial Growth Range under Multiple Stresses by its anti-oxidation function

scientific article

DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans

scientific article

DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses

scientific article published on 04 July 2020

DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites

scientific article published on 16 April 2007

DNA phosphorothioation in Streptomyces lividans: mutational analysis of the dnd locus

scientific article

De Novo Biosynthesis of β-Valienamine in Engineered Streptomyces hygroscopicus 5008.

scientific article published on 5 October 2015

Deciphering Carbamoylpolyoxamic Acid Biosynthesis Reveals Unusual Acetylation Cycle Associated with Tandem Reduction and Sequential Hydroxylation.

scientific article published on August 2016

Deciphering Piperidine Formation in Polyketide-Derived Indolizidines Reveals a Thioester Reduction, Transamination, and Unusual Imine Reduction Process.

scientific article published on 28 October 2016

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

scientific article published on 22 June 2013

Design of hyperthermophilic lipase chimeras by key motif-directed recombination

scientific article published on 21 December 2014

Deubiquitinase Ubp3 enhances the proteasomal degradation of key enzymes in sterol homeostasis

scientific article published on 29 January 2021

Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma

scientific article published on 18 January 2013

Direct Genetic and Enzymatic Evidence for Oxidative Cyclization in Hygromycin B Biosynthesis

scientific article published on 19 June 2018

Direct evidence that ThiI is an ATP pyrophosphatase for the adenylation of uridine in 4-thiouridine biosynthesis

scientific article published in August 2008

Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway

scientific article (publication date: 2013)

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090 ⬇️

scientific article published in 2018

Disruption of a methyltransferase gene in actinomycin G gene cluster in Streptomyces iakyrus increases the production of phenazinomycin.

scientific article published on 27 January 2014

Dissection of the neocarazostatin: a C4 alkyl side chain biosynthesis by in vitro reconstitution

scientific article published on 13 April 2017

Divergent Biosynthesis of C-Nucleoside Minimycin and Indigoidine in Bacteria

scientific article published on 25 November 2019

Effective elimination of nucleic acids from bacterial protein samples for optimized blue native polyacrylamide gel electrophoresis

scientific article published in July 2009

Efficient biosynthesis of heterodimeric C-aryl pyrroloindoline alkaloids

scientific article published in Nature Communications

Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system

scientific article published on 02 March 2019

Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable blaDHA-1-carrying plasmid by an ST23 strain.

scientific article

Engineered Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters ⬇️

article

Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction.

scientific article

Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics.

scientific article published on 24 March 2012

Engineering the Erythromycin-Producing Strain <i>Saccharopolyspora erythraea</i> HOE107 for the Heterologous Production of Polyketide Antibiotics

scientific article published on 08 December 2020

Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs).

scientific article published on April 2016

Enhanced vanillin production from ferulic acid using adsorbent resin

scientific article published on 23 November 2006

Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster

scientific article

Enhancing Ristomycin A Production by Overexpression of ParB-Like StrR Family Regulators Controlling the Biosynthesis Genes

scientific article published on 10 September 2021

Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes.

scientific article

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

scientific article published on 26 November 2019

Essential Role of the Donor Acyl Carrier Protein in Stereoselective Chain Translocation to a Fully Reducing Module of the Nanchangmycin Polyketide Synthase ⬇️

scientific article published on January 17, 2012

Evaluation and optimization of analytical procedure and sample preparation for polar <i>Streptomyces albus</i> J1074 metabolome profiling

scientific article published on 25 May 2022

Expanding the Bioactive Chemical Space of Anthrabenzoxocinones through Engineering the Highly Promiscuous Biosynthetic Modification Steps.

scientific article published on 11 December 2017

Expansion of the known Klebsiella pneumoniae species gene pool by characterization of novel alien DNA islands integrated into tmRNA gene sites.

scientific article published on 21 December 2010

Exploration of Hygromycin B Biosynthesis Utilizing CRISPR-Cas9-Associated Base Editing

scientific article published on 10 April 2020

Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor

scientific article

Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement

scientific article published on 6 July 2017

Function of transporter genes fscTI and fscTII in the biosynthetic cluster of candicidin/FR-008

scientific article published in December 2012

Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues.

scientific article published on 31 August 2017

Functional Characterization of PyrG, an Unusual Nonribosomal Peptide Synthetase Module from the Pyridomycin Biosynthetic Pathway

scientific article published on 20 May 2016

Functional analysis of spfD gene involved in DNA phosphorothioation in Pseudomonas fluorescens Pf0-1

scientific article published on 24 January 2009

Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.

scientific article

Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes.

scientific article published on 23 April 2009

Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells

scientific article published on 10 April 2018

Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008 ⬇️

scientific article

Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks

scientific article

Genetic manipulation system and genomic library of Streptomyces luteosporeus NRRL 2401

scientific article

Genetically engineered Pichia pastoris yeast for conversion of glucose to xylitol by a single-fermentation process.

scientific article

Genome Engineering and Modification Toward Synthetic Biology for the Production of Antibiotics

scientific article published on 15 March 2017

Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus

scientific article published on 23 January 2021

Genome engineering for microbial natural product discovery

scientific article published on 03 March 2018

Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396.

scientific article

Genome-Wide Mutagenesis Links Multiple Metabolic Pathways with Actinorhodin Production in Streptomyces coelicolor ⬇️

scientific article published on 22 March 2019

Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007 ⬇️

scientific article published on 18 December 2019

Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S

scientific article published on 22 August 2017

H2O2-induced reactive oxygen species regulated gene transcription, enzyme activity and validamycin A biosynthesis by Streptomyces hygroscopicus 5008

article

Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM)

scientific article published on 03 October 2020

Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria

scientific article published on 01 December 2020

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

scientific article published on 24 March 2017

High-Throughput Screening for Streptomyces Antibiotic Biosynthesis Activators ⬇️

scientific article published on April 13, 2012

Highly Efficient Erythritol Recovery from Waste Erythritol Mother Liquor by a Yeast-Mediated Biorefinery Process.

scientific article

Highly Efficient Fructooligosaccharides Production by an Erythritol-Producing Yeast Yarrowia lipolytica Displaying Fructosyltransferase.

scientific article published on 9 May 2016

Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system

scientific article published on 29 August 2015

Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes

scientific article published on 22 January 2016

ICEberg 2.0: an updated database of bacterial integrative and conjugative elements

scientific article published on 01 January 2019

Identification and Characterization of an Antibacterial Type VI Secretion System in the Carbapenem-Resistant Strain Klebsiella pneumoniae HS11286.

scientific article published on 12 October 2017

Identification and characterization of acetyltransferase-type toxin-antitoxin locus in Klebsiella pneumoniae

scientific article published on 20 February 2018

Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488.

scientific article published on 18 August 2016

Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer

scientific article

Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137

scientific article published on 01 January 2015

Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.

scientific article

Identification and engineering of regulation-related genes toward improved kasugamycin production

scientific article published on 31 October 2015

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

scientific article published on 11 May 2015

Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL30471 ⬇️

scientific article

Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis

scientific article published on 01 September 2006

Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue

scientific article published in September 2008

Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.

scientific article published on 14 June 2003

Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2).

scientific article

Identification of genes necessary for jinggangmycin biosynthesis from Streptomyces hygroscopicus 10-22.

scientific article

Identification of the genecluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471 ⬇️

scientific article published on December 23, 2010

Identifying the Minimal Enzymes for Unusual Carbon-Sulfur Bond Formation in Thienodolin Biosynthesis

scientific article published on 21 March 2016

Improving the expression of recombinant proteins in E. coli BL21 (DE3) under acetate stress: an alkaline pH shift approach

scientific article

In Vitro CRISPR/Cas9 System for Efficient Targeted DNA Editing

scientific article

In Vitro Packaging Mediated One-Step Targeted Cloning of Natural Product Pathway

scientific article published on 11 September 2019

In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan

scientific article

In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid

scientific article published on 01 January 2019

Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex

scientific article published in June 2008

Increasing the heterologous production of spinosad in <i>Streptomyces albus</i> J1074 by regulating biosynthesis of its polyketide skeleton

scientific article published on 20 September 2021

Integrated Approach To Producing High-Purity Trehalose from Maltose by the Yeast Yarrowia lipolytica Displaying Trehalose Synthase (TreS) on the Cell Surface

scientific article published on 29 July 2016

Isolation and characterization of Micromonospora phage PhiHAU8 and development into a phasmid

scientific article published on July 2004

Isolation and characterization of a new epsilon-poly-L-lysine-producing strain TUST-2

scientific article published in February 2010

Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy

scientific article published on 13 October 2016

Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis

scientific article

Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology

scientific article published on 29 February 2016

Mapping the resistance-associated mobilome of a carbapenem-resistant Klebsiella pneumoniae strain reveals insights into factors shaping these regions and facilitates generation of a 'resistance-disarmed' model organism.

scientific article

Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain

scientific article

Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin

scientific article published on May 2008

Mechanistic Investigation on ROS Resistance of Phosphorothioated DNA.

scientific article published on 20 February 2017

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968.

scientific article

Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways

scientific article

Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics

scientific article published on 12 May 2015

Methyltransferases of gentamicin biosynthesis

scientific article

Microbial transformation of benzothiophenes, with carbazole as the auxiliary substrate, by Sphingomonas sp. strain XLDN2-5.

scientific article

Micromonospora avicenniae sp. nov., isolated from a root of Avicennia marina

scientific article

Micromonospora sonneratiae sp. nov., isolated from a root of Sonneratia apetala

scientific article

Micromonospora zhanjiangensis sp. nov., isolated from mangrove forest soil

scientific article

Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization ⬇️

scientific article

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure

scientific article

MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands

scientific article published on 30 May 2007

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

scientific article published on 07 December 2020

Multiplex genome editing using a dCas9-cytidine deaminase fusion in Streptomyces

scientific article published on 20 December 2019

Mutagenesis of cysteine residues in dptC from Salmonella enteric serovar Cerro 87 and its effects on DNA phosphorothioate modification

scientific article published in February 2013

Nanopore target sequencing for accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses

scientific article (preprint)

Naphthoquinone-Based Meroterpenoids from Marine-Derived Streptomyces sp. B9173

scientific article published on 15 August 2020

Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

scientific article published on 08 July 2015

Near-Infrared II Dye-Protein Complex for Biomedical Imaging and Imaging-Guided Photothermal Therapy

scientific article published on 26 July 2018

New metabolites in dibenzofuran cometabolic degradation by a biphenyl-cultivated Pseudomonas putida strain B6-2.

scientific article published in November 2009

Nitrilase superfamily aryl acylamidase from the halotolerant mangrove Streptomyces sp. 211726.

scientific article published on 22 April 2014

Nonomuraea nitratireducens sp. nov., a new actinobacterium isolated from Suaeda australis Moq. rhizosphere

scientific article published on 13 August 2020

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery.

scientific article published on 8 January 2018

Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging.

scientific article

Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging

scientific article published on 01 March 2020

Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN

scientific article published on 01 May 2017

Operon for biosynthesis of lipstatin, the Beta-lactone inhibitor of human pancreatic lipase

scientific article

Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola ⬇️

scientific article

Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008 ⬇️

scientific article published on October 13, 2011

Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis ⬇️

scientific article published on June 29, 2011

Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS

scientific article published on 24 July 2019

Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units ⬇️

scientific article

Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14

scientific article

Phosphorothioate DNA as an antioxidant in bacteria ⬇️

scientific article published on July 5, 2012

Phosphorothioated DNA Is Shielded from Oxidative Damage

scientific article published on 04 April 2019

Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions

scientific article

PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi.

scientific article published on 17 November 2009

Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow

scientific article published on 13 December 2018

PreQ0 base, an unusual metabolite with anti-cancer activity from Streptomyces qinglanensis 172205

scientific article published on 01 January 2015

Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis

scientific article published on 30 September 2019

Product-mediated regulation of pentalenolactone biosynthesis in Streptomyces species by the MarR/SlyA family activators PenR and PntR.

scientific article published on 11 January 2013

Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli

scientific article published on 12 September 2019

Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families

scientific article published on 9 January 2015

Proteomic Analysis and NIR-II Imaging of MCM2 Protein in Hepatocellular Carcinoma

scientific article published on 24 May 2018

Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation

scientific article published on 20 August 2019

Puromycin A, B and C, cryptic nucleosides identified from Streptomyces alboniger NRRL B-1832 by PPtase-based activation.

scientific article

Quaternary Ammonium Salt Based NIR-II Probes for in vivo Imaging

scientific article published on 06 May 2019

Rational engineering acyltransferase domain of modular polyketide synthase for expanding substrate specificity

scientific article published on 12 March 2019

Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins

scientific article

Recycling of over-activated acyls by a Type II Thioesterase during Calcimycin biosynthesis in Streptomyces chartreusis NRRL 3882. ⬇️

scientific article published on 13 April 2018

RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4'-Methoxy-2,2'-Bipyrrole-5'-Carbaldehyde

scientific article published on 07 January 2020

Regulation of the biosynthesis of thiopeptide antibiotic cyclothiazomycin by the transcriptional regulator SHJG8833 in Streptomyces hygroscopicus 5008.

scientific article

Regulatory Mechanism of Nicotine Degradation in Pseudomonas putida

scientific article published on 04 June 2019

Revisiting the Mechanism of the Anaerobic Coproporphyrinogen III Oxidase HemN

scientific article published on 01 April 2019

Role of an FtsK-like protein in genetic stability in Streptomyces coelicolor A3(2).

scientific article published on 5 January 2007

SecReT4: a web-based bacterial type IV secretion system resource

scientific article

SecReT6: a web-based resource for type VI secretion systems found in bacteria

scientific article published on July 2015

Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.

scientific article published on 03 October 2008

Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader

scientific article published on 06 June 2019

Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus

scientific article published on 7 June 2016

Specific Small-Molecule NIR-II Fluorescence Imaging of Osteosarcoma and Lung Metastasis

scientific article published on 03 December 2019

Spot 42 RNA regulates putrescine catabolism in Escherichia coli by controlling the expression of puuE at the post-transcription level

scientific article published in 2021

Stabilization of Multimeric Proteins via Intersubunit Cyclization.

scientific article

StnK2 catalysing a Pictet-Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin

scientific article published on 01 December 2018

Strained cyclooctyne as a molecular platform for construction of multimodal imaging probes.

scientific article

Strategies for Enhancing the Yield of the Potent Insecticide Spinosad in Actinomycetes

scientific article published on 05 July 2018

Streptomyces arcticus sp. nov., isolated from the Arctic

scientific article

Streptomyces coelicolor A3(2) lacks a genomic island present in the chromosome of Streptomyces lividans 66.

scientific article published in December 2004

Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation ⬇️

scientific article published on February 2013

Streptomyces polaris sp. nov. and Streptomyces septentrionalis sp. nov., isolated from frozen soil

scientific article published on 24 September 2018

Streptomyces species: Ideal chassis for natural product discovery and overproduction

scientific article published on 28 May 2018

Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System

scientific article published on 28 April 2020

Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.

scientific article published on 14 March 2018

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica ⬇️

scientific article published on March 1, 2012

Structural basis for the biosynthesis of lovastatin

scientific article published on 08 February 2021

Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis

scientific article published on 21 December 2016

Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification ⬇️

scientific article published on April 24, 2012

Structure of the N -glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry

scientific article

Studies towards the synthesis of medermycin via Dötz benzannulation

scientific article published on 17 October 2014

Substitution of a Single Amino Acid Reverses the Regiospecificity of the Baeyer-Villiger Monooxygenase PntE in the Biosynthesis of the Antibiotic Pentalenolactone.

scientific article published on 23 November 2016

Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase

scientific article published on 4 April 2018

Sulfonium-Based Homolytic Substitution Observed for the Radical SAM Enzyme HemN

scientific article published on 17 February 2020

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.

scientific article published on 9 May 2013

Synthetic Genomics: From DNA Synthesis to Genome Design.

scientific article

Systematic research on the pretreatment of peptides for quantitative proteomics using a C₁₈ microcolumn

scientific article published on 9 July 2013

TADB 2.0: an updated database of bacterial type II toxin-antitoxin loci

scientific article published on 2 November 2017

TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea

scientific article

Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis

scientific article published on 09 January 2009

Targeted engineering and scale up of lycopene overproduction in Escherichia coli

scientific article published in 2015

The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility

scientific article published on 11 February 2020

The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN.

scientific article published on 23 January 2017

The N-terminal Nucleophile Serine of Cephalosporin Acylase Executes the Second Autoproteolytic Cleavage and Acylpeptide Hydrolysis ⬇️

scientific article published on May 16, 2011

The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis

scientific article published on 01 August 2006

The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators

scientific article published on 23 November 2011

The defense mechanism of phosphorothioated DNA under peroxynitrite-mediated oxidative stress

scientific article published on 20 August 2020

The enzymology of polyether biosynthesis

scientific article published on January 2009

The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5

scientific article

The mildiomycin biosynthesis: initial steps for sequential generation of 5-hydroxymethylcytidine 5'-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119.

scientific article

The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008. ⬇️

scientific article published on 16 January 2009

The pheV phenylalanine tRNA gene Klebsiella pneumoniae clinical isolates is an integration hotspot for possible niche-adaptation genomic islands

scientific article published in March 2010

The standalone aminopeptidase PepN catalyzes the maturation of blasticidin S from leucylblasticidin S

scientific article

Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA ⬇️

scientific article published on August 28, 2012

Theoretical study on the relationship between Rp-phosphorothioation and base-step in S-DNA: based on energetic and structural analysis

scientific article published on 31 December 2014

Three putative DNA replication/repair elements encoding genes confer self-resistance to distamycin in Streptomyces netropsis

scientific article published on 01 January 2020

Three recently diverging duplicated methyltransferases exhibit substrate-dependent regioselectivity essential for xantholipin biosynthesis

scientific article published on 10 July 2020

Thuricin Z: A Narrow-Spectrum Sactibiotic that Targets the Cell Membrane

scientific article published on 06 November 2019

Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis ⬇️

scientific article published on September 10, 2011

Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus

scientific article published on 26 November 2019

Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex

scientific article published on 01 August 2019

Translational genomics to develop a Salmonella enterica serovar Paratyphi A multiplex polymerase chain reaction assay

scientific article

Two nucleoside receptors from Streptomyces coelicolor: expression of the genes and characterization of the recombinant proteins

scientific article published on 10 February 2015

Two pHZ1358-derivative vectors for efficient gene knockout in streptomyces.

scientific article published in April 2010

Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation

scientific article published on 13 March 2020

Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

scientific article published on 09 September 2020

Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds

scientific article published on 19 March 2015

Unravelling the Biosynthetic Flexibility of UK-2A Enables Enzymatic Synthesis of Its Structural Variants

scientific article published on 25 November 2019

Unveiling the Post-PKS Redox Tailoring Steps in Biosynthesis of the Type II Polyketide Antitumor Antibiotic Xantholipin ⬇️

scientific article published on March 23, 2012

Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

scientific article published on 03 December 2020

Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation

scientific article published on 21 March 2018

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453 ⬇️

scientific article

ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.

scientific article

Vector systems allowing efficient autonomous or integrative gene cloning in Micromonospora sp. strain 40027

scientific article

Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1.

scientific article published on 22 June 2016

Xylitol production from waste xylose mother liquor containing miscellaneous sugars and inhibitors: one-pot biotransformation by Candida tropicalis and recombinant Bacillus subtilis

scientific article published on 16 May 2016

Xylitol production from xylose mother liquor: a novel strategy that combines the use of recombinant Bacillus subtilis and Candida maltosa ⬇️

scientific article published on February 7, 2011

[Aminoglycoside gentamicin research: fundamental progress and new application prospects]

[Baeyer-Villiger monooxygenases in the biosynthesis of microbial secondary metabolites]

scientific article published on 01 March 2019

[Chemical-genetics based screening for furanonaphthoquinone producing endophytic actinomycetes from seeds of Trewia nudiflora]

scientific article published on 01 April 2012

[Function of Streptomyces antibiotic regulatory proteins family transcriptional regulator ctcB in the biosynthetic cluster of chlortetracycline]

scientific article published in September 2016

[Microbial drugs: captured again as S&T spotlight: To the special issue "Innovation & Highly Efficient Production of Microbial Drugs"]

scientific article published in March 2016

[One step production of isomalto-oligosaccharides by engineered Yarrowia lipolytica yeast co-displayed β-amylase and α-transglucosidase]

scientific article published on 01 January 2019

[Progress in developing and applying Streptomyces chassis - A review]

scientific article published in March 2016

[Progress of cell-free protein synthesis system and its applications in pharmaceutical engineering - A review]

scientific article published in March 2016

[Quantitative monitoring targeted proteins and intermediate metabolites in Escherichia coli primary metabolic pathways].

scientific article

[Research progress and prospects of phosphorothioate modification - A review]

scientific article published in December 2016

arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. strain FR-008

scientific article

dndDB: a database focused on phosphorothioation of the DNA backbone

scientific article

industrial strain as cell factory for Ivermectin B1a production

mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes.

scientific article

oriTfinder: a web-based tool for the identification of origin of transfers in DNA sequences of bacterial mobile genetic elements.

scientific article published on 4 May 2018

polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.

scientific article

sRNAscanner: a computational tool for intergenic small RNA detection in bacterial genomes

scientific article

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