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List of works by James M Rae

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

scholarly article by Liang Xu et al published 1 February 2005 in Molecular Cancer Therapeutics

A model citizen? Is tamoxifen more effective than aromatase inhibitors if we pick the right patients?

scientific article published on 29 April 2008

A short-term biomarker modulation study of simvastatin in women at increased risk of a new breast cancer

scientific article published on 11 November 2011

A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival

scientific article

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

scientific article

Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors

scientific article published on April 2006

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

scientific article

An expression signature of estrogen-regulated genes predicts disease-free survival in tamoxifen-treated patients better than progesterone receptor status.

scientific article published on January 2008

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort

scientific article published on 20 January 2009

Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy

scientific article published on 13 October 2015

Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover

scientific article published on 4 November 2015

Attempted replication of SNPs in RANKL and OPG with musculoskeletal adverse events during aromatase inhibitor treatment for breast cancer

scientific article

CYP19A1 polymorphisms and clinical outcomes in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial

scientific article published on 3 May 2015

CYP2D6 Genotype Should Not Be Used for Deciding About Tamoxifen Therapy in Postmenopausal Breast Cancer ⬇️

scientific article published on June 17, 2013

CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients

scientific article published on 6 March 2012

CYP2D6 genotype and tamoxifen response

scientific article

CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial

scientific article published on 6 March 2012

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

scientific article

CYP2D6 testing for breast cancer patients: is there more to the story?

scientific article published in December 2009

Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme

scientific article published on 8 November 2005

Comparative analysis of circulating tumor DNA stability In K3EDTA, Streck, and CellSave blood collection tubes.

scientific article published on 27 April 2016

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients

scientific article published on 15 January 2010

Comprehensive mutation and copy number profiling in archived circulating breast cancer tumor cells documents heterogeneous resistance mechanisms.

scientific article published on 12 December 2017

Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA ⬇️

scientific article published on August 19, 2013

Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium ?Breast Cancer ? the Development and Validation of New Therapeutics?

article

Correction to: Targeted degradation of activating estrogen receptor α ligand-binding domain mutations in human breast cancer

scientific article published on 01 April 2020

Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity

scientific article published on 17 December 2016

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance

scientific article published on September 2008

DNA derived from archival tumor specimens can be used for germline pharmacogenetic analyses

scientific article published on 29 July 2020

Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.

scientific article

EGFR and EGFRvIII expression in primary breast cancer and cell lines.

scientific article published in September 2004

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients

scientific article published on 10 August 2015

ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer

scientific article published on 21 November 2015

ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors

scientific article published on 19 August 2016

Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole

scientific article published on 01 June 2019

Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer

scientific article

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

scientific article published on 11 May 2006

Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors

scientific article published on January 2004

Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines

scientific article published on 22 January 2016

Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion

scientific article published on 12 February 2019

Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines

scientific article

Fulvestrant decreases anastrozole drug concentrations when taken concurrently by patients with metastatic breast cancer treated on SWOG study S0226.

scientific article published on 09 February 2016

Functional Characterization of a Genetic Polymorphism in the Promoter of the ESR2 Gene ⬇️

scientific article published on April 1, 2012

GREB 1 is a critical regulator of hormone dependent breast cancer growth

scientific article published on July 2005

GREB1 is a novel androgen-regulated gene required for prostate cancer growth.

scientific article

Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors

scientific article

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer

scientific article published on 2 April 2013

Genetic variation in Charcot-Marie-Tooth genes contributes to sensitivity to paclitaxel-induced peripheral neuropathy

scientific article published on 23 July 2020

Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy

scientific article published on 10 December 2019

Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses

scientific article

Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples

scientific article published on August 2003

Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study

scientific article published on 06 March 2019

Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients.

scientific article published on 27 March 2017

Heterogeneous estrogen receptor expression in circulating tumor cells suggests diverse mechanisms of fulvestrant resistance

scientific article

Impact of CYP3A5 phenotype on tacrolimus concentrations after sublingual and oral administration in lung transplant

scientific article published on 15 April 2019

Individualized Tamoxifen Dose Escalation-Response

scientific article published on 01 December 2016

Individualized Tamoxifen Dose Escalation: Confirmation of Feasibility, Question of Utility

scientific article published on 24 March 2016

Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome

scientific article published on October 2014

Institutional profile of pharmacogenetics within University of Michigan College of Pharmacy

scientific article published on 26 July 2017

MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research

scientific article published on 27 September 2006

Mechanisms of estrogen-independent breast cancer growth driven by low estrogen concentrations are unique versus complete estrogen deprivation ⬇️

scientific article published on March 29, 2012

Monitoring serial changes in circulating human breast cancer cells in murine xenograft models

scientific article published on July 2008

One step at a time: CYP2D6 guided tamoxifen treatment awaits convincing evidence of clinical validity

scientific article

Osteonecrosis of the Jaw Risk Factors in Bisphosphonate Treated Patients with Metastatic Cancer

scientific article published on 04 December 2020

Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer

scientific article published on 23 March 2016

Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?

scientific article

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

scientific article

Pharmacogenetics of tamoxifen: who should undergo CYP2D6 genetic testing?

scientific article published on February 2009

Pharmacogenomics and Endocrine Therapy in Breast Cancer

scientific article published on 27 December 2019

Re: Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies

scientific article published on 26 March 2015

Response

scientific article published on 03 April 2014

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

scientific article

Targeted degradation of activating estrogen receptor α ligand-binding domain mutations in human breast cancer

scientific article published on 17 February 2020

The CYP17A1 inhibitor abiraterone exhibits estrogen receptor agonist activity in breast cancer

scientific article

The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer

scientific article published on 11 March 2016

The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance

scientific article published on 04 June 2008

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

scientific article

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

scientific article

The role of single nucleotide polymorphisms in breast cancer metastasis

scientific article published on 18 January 2008

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

scientific article

Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients

article published in 2017

What does an orphan G-protein-coupled receptor have to do with estrogen?

scientific article

When will tumor gene expression profiling be incorporated into clinical breast cancer decision making?

scientific article published on January 2006

Whole Genome Amplification of DNA for Genotyping Pharmacogenetics Candidate Genes ⬇️

scientific article published on March 30, 2012

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