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List of works by Eric C Holland

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma

scientific article published on 21 August 2012

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB

scientific article published on 01 June 2018

A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis ⬇️

scientific article published on January 5, 2012

A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle

scientific article

A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle

A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells

scientific article

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

scientific article published on 12 June 2020

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

scientific article published on 26 July 2016

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

scientific article published on 24 October 2009

Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene

scientific article

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

scientific article

An update on mouse brain tumor models in cancer drug discovery.

scientific article

Analysis and visualization of linked molecular and clinical cancer data by using Oncoscape

scientific article published on 01 September 2018

Animal models to study cancer-initiating cells from Glioblastoma ⬇️

scientific article published on June 1, 2011

Anti-PD-L1 antibody direct activation of macrophages contributes to a radiation-induced abscopal response in glioblastoma

scientific article published on 03 December 2019

Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma

scientific article published on 11 July 2019

Astrocyte differentiation states and glioma formation

scientific article

Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.

scientific article

Big data visualization identifies the multidimensional molecular landscape of human gliomas

scientific article

Bioluminescence technology for imaging cell proliferation

scientific article published on 02 November 2005

Brain tumor treatment increases the number of cancer stem-like cells

scientific article published in October 2009

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

scientific article published on 08 March 2021

CBIO-12. GTP METABOLIC SWITCH LEADS TO NUCLEOLAR TRANSFORMATION AND MALIGNANT GROWTH OF GLIOBLASTOMA

scientific article published on 6 November 2017

CS-19PDGF SIGNALING DEPENDENCE IN PRONEURAL GLIOBLASTOMA, THE BEGINNING BUT NOT THE END.

scientific article published in November 2014

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

scientific article

CSIG-17. CHARACTERIZATION OF AN ALTERNATIVELY SPLICED NTRK2 VARIANT IN GLIOMA: EMPLOYING NOVEL REAGENTS TO UNCOVER NOVEL FUNCTIONS

Cancer stem cells and survival pathways

scientific article published on 19 March 2008

Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma

scientific article published on 3 August 2012

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis

scientific article published in March 2005

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis

scientific article published on 16 July 2020

Constitutive activation of Raf-1 induces glioma formation in mice

scientific article published on May 2008

Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9

scientific article published on 01 December 2019

Copy number profiling across glioblastoma populations has implications for clinical trial design.

scientific article

Correction: Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

Corticosteroids compromise survival in glioblastoma

scientific article

Cyclin D1 and Cdk4 Mediate Development of Neurologically Destructive Oligodendroglioma ⬇️

scientific article published on August 15, 2011

DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance

scientific article

DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases

scientific article published on April 2013

DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma

scientific article (publication date: 2012)

Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

article

Developmental neurobiology and the origin of brain tumors

scientific article

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model

scientific article

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

scientific article published on July 2004

Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas

scientific article

EGFR signaling is differentially activated in patient-derived glioblastoma stem cells

scientific article published on January 1, 2010

EPND-09. THE ONCOGENIC EFFECT OF C11ORF95-RELA FUSION MOSTLY DERIVES FROM FACTOR OTHER THAN NF-ΚB ACTIVATION IN SUPRATENTORIAL EPENDYMOMA.

scientific article

Early detection and prognosis of ovarian cancer using serum YKL-40.

scientific article published in August 2004

Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

scientific article published on February 2016

Evidence for and against regional differences in neural stem and progenitor cells of the CNS.

scientific article published on October 2010

Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.

scientific article published on December 2012

Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma

scientific article published in August 2002

Genetic modeling of gliomas in mice: New tools to tackle old problems ⬇️

scientific article published on 08 February 2011

Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses

scientific article published on 01 October 2020

Genetically engineered models have advantages over xenografts for preclinical studies

scientific article

Genetically engineered mouse models of brain cancer and the promise of preclinical testing

scientific article published on January 2009

Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO

scientific article

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

scientific article

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

scientific article

Glioblastoma: molecular analysis and clinical implications.

scientific article published on October 2012

Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay.

scientific article published in December 2015

Glioma formation, cancer stem cells, and akt signaling

scientific article published on September 2008

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

scientific article published on 05 October 2020

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

scientific article published on February 2015

Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner.

scientific article

High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe

scientific article published on 07 May 2016

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

scientific article published on 22 August 2019

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples.

scientific article published on August 2016

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

scientific article published on 01 August 2019

Identification of global alteration of translational regulation in glioma in vivo

scientific article

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift.

scientific article published on 24 March 2014

Incorporating genomic signatures into surgical and medical decision-making for elderly glioblastoma patients

scientific article published on 01 October 2020

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.

scientific article published on 9 April 2018

Inferring transcriptional and microRNA‐mediated regulatory programs in glioblastoma ⬇️

scientific article published on January 1, 2012

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

scientific article published in October 2002

Insulin-like growth factor binding protein 2 promotes glioma development and progression

scholarly article

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

scientific article published on 8 February 2012

Longitudinal prospective study of matrix metalloproteinase-9 as a serum marker in gliomas.

scientific article published on 28 June 2011

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

scientific article published on December 2010

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.

scientific article published on 26 August 2017

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

scientific journal article

MEF promotes stemness in the pathogenesis of gliomas

scientific article published on December 2012

MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials

scientific article published on November 2002

MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo

scientific article published on January 2002

MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas

scientific article published on 19 August 2011

Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma

scientific article

Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules

scientific article published on January 2014

Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors

scientific article published on 22 June 2020

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

article

Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma

scientific article published on 01 November 2019

Modeling Adult Gliomas Using RCAS/t-va Technology

scientific article published on May 2009

Molecular imaging of Akt kinase activity

scientific article published on 12 August 2007

Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

scientific article published in November 2005

Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma

scientific article

Mouse models of brain tumors and their applications in preclinical trials

scientific article

Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery

scientific article

Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma

scientific article published on 04 July 2020

Mutant IDH1 regulates the tumor-associated immune system in gliomas

scientific article published on 2 May 2017

Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma.

scientific article published on 11 June 2017

Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies

scientific article published on 14 May 2018

Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum

scientific article

Notch signaling enhances nestin expression in gliomas

scientific article published on December 2006

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes ⬇️

scientific article published on October 1, 2003

Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.

scientific article published in October 2014

Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.

scientific article published on March 2014

Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice

scientific article

PATH-51. DNA COPY NUMBER PROFILING ACROSS GLIOBLASTOMA POPULATIONS HAS IMPLICATIONS FOR CLINICAL TRIAL DESIGN

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

scientific article

PM-15C11orf95-RELA FUSION ALONE IS SUFFICIENT TO FORM HUMAN SUPRATENTORIAL EPENDYMOMA-LIKE TUMOR IN MICE

scientific article published in November 2014

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

scientific article published on March 2009

PTPS-23A NOVEL ROLE FOR NEUROTROPHIN SIGNALING IN PEDIATRIC ATYPICAL TERATOID RHABDOID TUMORS.

scientific article

Patterns of Failure After Stereotactic Radiosurgery for Recurrent High-Grade Glioma: A Single Institution Experience of 10 Years

scientific article published on 01 August 2019

Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma

scientific article (publication date: 18 January 2011)

Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo

scientific article published on August 2005

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells

scientific article

Personalized medicine for gliomas

scientific article

Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma

scientific article published on 15 April 2020

Phase II trial of an AKT inhibitor (perifosine) for recurrent glioblastoma

scientific article published on 19 July 2019

Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes

scientific article published on 23 November 2020

Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment

scientific article published on January 2007

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

scientific article published on 02 March 2010

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

scientific article

Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion

scientific article published on 31 July 2017

RTHP-27. PATTERNS OF FAILURE AFTER STEREOTACTIC RADIOSURGERY FOR RECURRENT HIGH-GRADE GLIOMA: A SINGLE INSTITUTION EXPERIENCE OF 10 YEARS

Radiation resistance and stem-like cells in brain tumors.

scientific article published in December 2006

Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression

scientific article

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

scientific article published on 01 August 2019

Reply: Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels

scientific article published on 21 December 2016

Rethinking glioma treatment strategy

scientific article published in October 2014

SM-06DEXAMETHASONE USE DURING RADIOTHERAPY IN HIGH-GRADE GLIOMA: AN INSTITUTIONAL REVIEW

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma ⬇️

scientific article published on January 17, 2012

Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas ⬇️

scientific article published on August 10, 2011

Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)

scientific journal article

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

scientific article published on 29 November 2009

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

scientific article published on August 2009

Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma

scientific article

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

scientific article

Stochastic growth pattern of untreated human glioblastomas predicts the survival time for patients

scientific article published on 20 April 2020

Suppression of autophagy impedes glioblastoma development and induces senescence

scientific article published on 15 June 2016

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.

scientific article published on January 2015

TM-15GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO.

scientific article

TMIC-05. ABSCOPAL IMMUNE RESPONSE IN GLIOBLASTOMA ELICITED BY MIR124-ATTENUATED ONCOLYTIC HERPES SIMPLEX VIRUS 1 ARMED WITH UL16 BINDING PROTEIN 3

scientific article published on 5 November 2018

TMIC-13. EFFICACY OF RETINOIC ACID IN REVERSING IMMUNE EVASION IN IDH MUTANT GLIOMAS

scientific article published on 5 November 2018

TMIC-41. LOSS OF HOST-DERIVED OSTEOPONTIN CREATES A GLIOBLASTOMA-PROMOTING MICROENVIRONMENT

TMIC-53. IDENTIFICATION OF MYELOID CELL-DERIVED TRANSCRIPTS IN GLIOBLASTOMA

scientific article published on 5 November 2018

TMOD-30. ANTI-PD-L1 ANTIBODY ENHANCES RADIATION INDUCED ABSCOPAL RESPONSE IN MURINE BRAIN TUMORS

TRRAP and the maintenance of stemness in gliomas

scientific article published in January 2010

Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas

scientific article published on 01 June 2019

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

scientific article published on May 2010

Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

scientific article published on 22 April 2020

The ABCG2 resistance network of glioblastoma

scientific article published on 13 September 2009

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

scientific article

The Probable Cell of Origin of NF1- and PDGF-Driven Glioblastomas ⬇️

scientific article published on September 9, 2011

The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions

scientific article published on 4 June 2014

The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype ⬇️

scientific article published on December 17, 2010

The brain tumor microenvironment.

scientific article published on 28 March 2011

The brain tumor microenvironment.

scientific article published on March 2012

The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.

scientific article

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article

The molecular landscape of adult diffuse gliomas and relevance to clinical trials

scientific article published on 05 March 2019

The perivascular niche microenvironment in brain tumor progression

scientific article published on August 2010

The role of radiotherapy following gross-total resection of atypical meningiomas

scientific article published on 24 August 2012

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

scientific article

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

scientific article published on 7 November 2016

Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma

scientific article published on 14 February 2020

Trapping the mouse genome to hunt human alterations

scholarly article

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization

scientific article published on 8 September 2009

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

scientific article published on 09 March 2020

Validation of a High-Content Screening Assay Using Whole-Well Imaging of Transformed Phenotypes ⬇️

scientific article published on December 23, 2010

Variability in estimated gene expression among commonly used RNA-seq pipelines

scientific article published on 17 February 2020

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

scientific article published on 01 February 2020

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma

scientific article published on 09 March 2011

YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.

scientific article published in October 2006

Yin and yang: cancer-implicated miRNAs that have it both ways.

scientific article

cIMPACT-NOW update 3: recommended diagnostic criteria for "Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV"

scientific article published on 26 September 2018

cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas

scientific article published on 29 January 2020

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

scientific article published on April 2005

miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis

scientific article

p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

scientific article

p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo

scientific article published on 15 April 2010

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