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List of works by Tetsuo Takehara

A case of gastric mixed adenoneuroendocrine carcinoma with difficulty in diagnosis before endoscopic submucosal dissection

scientific article published on January 2016

Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment

scientific article published on 26 February 2009

Adipocytokines and liver disease

scientific article

Adiponectin inhibits murine pancreatic cancer growth

scientific article published on 7 May 2014

Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease

scientific article

Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

scientific article

Alterations in hepatitis B virus nucleotide sequences in a chronic virus carrier from immunotolerant to immunoactive phase

scientific article published on 7 March 2010

Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway.

scientific article

Antiviral therapy for chronic hepatitis C: past, present, and future

scientific article

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

scientific article

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells

scientific article published on December 2009

Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.

scientific article published on 30 January 2017

Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report

scientific article

Characterization of miR-122-independent propagation of HCV.

scientific article

Choroidal and cutaneous metastasis from gastric adenocarcinoma ⬇️

scientific article published on March 7, 2013

Clinical outcomes of direct-acting antiviral treatments for hepatitis C patients after hepatocellular carcinoma are equivalent to interferon treatment

scientific article published on 17 July 2020

Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms: a multicenter retrospective cohort study.

scientific article published on 31 March 2015

Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms

scientific article published on December 2016

Clinical use of molecular targeted agents for primary small bowel adenocarcinoma: A multicenter retrospective cohort study by the Osaka Gut Forum.

scientific article published on June 2017

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice

scientific article published on 25 January 2019

Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan

scientific article published on April 2014

Concanavalin a injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver

scientific article

Concomitant use of romiplostim and chemotherapy for advanced rectal cancer associated with idiopathic thrombocytopenic purpura

scientific article

Cotreatment with lenvatinib and warfarin potassium caused prothrombin time prolongation

scientific article published on 10 July 2019

Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

scientific article

Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice

scientific article

Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohnʼs disease ⬇️

scientific article published on January 12, 2012

Effectiveness of anti-tumor necrosis factor-α therapy in Crohn's disease with abscesses around the sigmoid colon: a case report

scientific article published on January 2015

Endoscopic submucosal dissection in early gastric cancer in elderly patients and comorbid conditions

scientific article

Endoscopic surveillance strategy after endoscopic resection for early gastric cancer.

scientific article

Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.

scientific article published on 28 August 2014

Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings.

scientific article

Evaluation of Endoscopic Ultrasound Image Quality Is Necessary in Endosonographic Assessment of Early Gastric Cancer Invasion Depth ⬇️

scientific article published on September 16, 2012

Evaluation of Fucosylated Haptoglobin and Mac-2 Binding Protein as Serum Biomarkers to Estimate Liver Fibrosis in Patients with Chronic Hepatitis C.

scientific article

Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid

scientific article

Fibroblast growth factor‐2 enhances NK sensitivity of hepatocellular carcinoma cells ⬇️

scientific article published on April 25, 2011

Frequency and role of NKp46 and NKG2A in hepatitis B virus infection.

scientific article

Frequency of, and factors associated with, hepatitis B virus reactivation in hepatitis C patients treated with all-oral direct-acting antivirals: Analysis of a Japanese prospective cohort.

scientific article published on 5 June 2017

Gastric Contraction Imaging System Using a 3-D Endoscope.

scientific article published on 9 January 2014

Gastric ESD under Heparin Replacement at High-Risk Patients of Thromboembolism Is Technically Feasible but Has a High Risk of Delayed Bleeding: Osaka University ESD Study Group

scientific article published on 13 June 2013

Hepatocellular carcinoma occurrence does not differ between interferon-based and interferon-free treatment with liver histological assessment

scientific article published on 08 January 2020

Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma

scientific article published on 01 December 2019

Impact of natural killer cells on chronic hepatitis C and hepatocellular carcinoma

scientific article

Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects

scientific article published on 23 February 2016

Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells

scientific article

Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response

scientific article published on 06 February 2019

Increased FoxM1 expression is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma.

scientific article published on 21 December 2016

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

scientific article published on 11 July 2011

Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation

scientific article

Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy ⬇️

scientific article published on January 7, 2012

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

scientific article

Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma

scientific article published on 18 August 2020

Innate immunity in chronic viral hepatitis

scientific article published on May 1, 2013

Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway.

scientific article

Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

scientific article published on September 2012

Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor

scientific article published on January 2007

Is Obesity a New Risk Factor for Gastritis? ⬇️

scientific article published on January 19, 2012

JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study

scientific article published on 17 February 2020

JSH Guidelines for the Management of Hepatitis C Virus Infection: 2019 Update Protective effect of antiviral therapy against hepatocarcinogenesis

scientific article published on 16 April 2020

Juvenile hepatocellular carcinoma with congestive liver cirrhosis.

scientific article

Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.

scientific article

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

scientific article published on 27 July 2016

Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis

scientific article published on 20 March 2013

Lower Serum Sodium Levels Are Associated with the Therapeutic Effect of Sorafenib on Hepatocellular Carcinoma

scientific article published on 17 June 2020

Lymph node enlargement after definitive chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma

scientific article

Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response

scientific article published on 24 May 2022

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

scientific article published on October 2009

Narrow-band imaging with magnifying endoscopy for Peyer's patches is useful in predicting the recurrence of remissive patients with ulcerative colitis

scientific article

Natural killer cell is a major producer of interferon gamma that is critical for the IL-12-induced anti-tumor effect in mice

scientific article published on 16 September 2009

Natural killer cells in hepatitis C virus infection: from innate immunity to adaptive immunity

scientific article

Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection

scientific article

Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells.

scientific article

Percutaneous endoscopic gastrostomy under steady pressure automatically controlled endoscopy: First clinical series

scientific article published on February 2016

Post-transplant lymphoproliferative disorder of the ileum diagnosed by double-balloon enteroscopy.

scientific article published on 27 November 2013

Predictive factors of anemia during sofosbuvir and ribavirin therapy for genotype 2 chronic hepatitis C patients

scientific article published on 23 May 2019

Renal dysfunction is an independent risk factor for bleeding after gastric ESD

scientific article published on 29 October 2014

Risk of hepatocellular carcinoma after sustained virologic response in hepatitis C virus patients without advanced liver fibrosis

scientific article published on 24 June 2022

Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection

scientific article

Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease

scientific article published on 02 October 2015

S100A8 Production in CXCR2-Expressing CD11b+Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol Diet

scientific article published on 25 November 2015

Serum Fucosylated Haptoglobin as a Novel Diagnostic Biomarker for Predicting Hepatocyte Ballooning and Nonalcoholic Steatohepatitis

scientific article

Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study

scientific article published on 01 October 2020

Solitary fibrous tumor of the liver from development to resection

scientific article

Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9.

scientific article

Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression.

scientific article published on 28 June 2012

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

scientific article published on 28 August 2013

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

scientific article published on October 2010

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. ⬇️

scientific article published on 14 December 2015

The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice.

scientific article published on 13 March 2013

The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells

scientific article

The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin

scientific article published on 30 July 2015

The importance of vitamins D and K for the bone health and immune function in inflammatory bowel disease ⬇️

scientific article published on November 1, 2012

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

scientific article

Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension

scientific article published on 19 June 2020

Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice

scientific article

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy ⬇️

scientific article published on December 15, 2011

Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation.

scientific article published on 24 June 2013

Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study

scientific article published on 25 September 2015

p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.

scientific article published on 12 August 2016

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