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List of works by Donald N Forthal

A High Throughput Protein Microarray Approach to Classify HIV Monoclonal Antibodies and Variant Antigens

scientific article published on 4 May 2015

A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

scientific article

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

scientific article

A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575.

scientific article published in February 2005

Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.

scientific article published in October 2014

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 30 May 2016

Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission

scientific article

Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines

scientific article

Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes

scientific article published on 30 September 2019

Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells

scientific article

Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection

scientific article published on May 2013

Antibody-dependent cellular cytotoxicity in HIV infection

article

Antibody-dependent enhancement and the risk of HIV infection

scientific article published on July 2013

Antiviral antibodies are necessary for control of simian immunodeficiency virus replication

scientific article published on 28 February 2007

Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination ⬇️

scientific article published on August 22, 2012

Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein

scientific article published on 30 July 2015

Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine

scientific article published on 01 January 2020

Authors' Reply to Vrachatis et al. "Pharmaco-Immunomodulatory Therapy in COVID-19"

scientific article published on 03 September 2020

Blocking HIV-1 replication: are Fc-Fcγ receptor interactions required?

article

Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition

scientific article published on 02 September 2016

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

scientific article

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

scientific article

Brucellosis Presenting as Cholecystitis: A Case Report and Literature Review

scientific article published on 15 July 2019

CD8+ T-cell mediated tumor protection by Pseudomonas exotoxin fused to ovalbumin in C57BL/6 mice ⬇️

scientific article published on April 1, 2003

Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits

scientific article

Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge

scientific article published in November 2017

Correction for Kibler et al., "Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC"

scientific article published on 15 October 2019

Correction: The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells.

scientific article

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge

scientific article published on 11 March 2015

Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects

scientific article published on 9 November 2016

Enhanced in vitro transcytosis of simian immunodeficiency virus mediated by vaccine-induced antibody predicts transmitted/founder strain number after rectal challenge

scientific article

Erratum: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 01 October 2016

Evaluation of Heterologous Vaginal SHIV SF162p4 Infection Following Vaccination with a Polyvalent Clade B Virus-Like Particle Vaccine ⬇️

scientific article published on March 21, 2012

Evaluation of passively transferred, nonneutralizing antibody-dependent cellular cytotoxicity-mediating IgG in protection of neonatal rhesus macaques against oral SIVmac251 challenge.

scientific article published on September 2006

Expanded Access Programs, compassionate drug Use, and Emergency Use Authorizations during the COVID-19 pandemic

scientific article published on 27 November 2020

Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques

scientific article published on 28 February 2020

Fc receptor but not complement binding is important in antibody protection against HIV.

scientific article published in September 2007

Fc receptor-mediated antiviral antibodies

scientific article

Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12.

scientific article published on November 2010

FcgammaRIIa genotype predicts progression of HIV infection.

scientific article published in December 2007

Fluconazole combined with flucytosine for treatment of cryptococcal meningitis in patients with AIDS.

scientific article published in October 1994

Functions of Antibodies

scientific article published on August 2014

Functions of Antibodies.

scientific article

Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

scientific article

HIV vaccine candidate activation of hypoxia and the inflammasome in CD14 monocytes is associated with a decreased risk of SIV acquisition

article

HIV-1 specific antibody titers and neutralization among chronically infected patients on long-term suppressive antiretroviral therapy (ART): a cross-sectional study

scientific article published on 15 January 2014

HIV-1-Specific Antibody Response and Function after DNA Prime and Recombinant Adenovirus 5 Boost HIV Vaccine in HIV-Infected Subjects

scientific article

HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and Are Commonly Detected in Plasma From HIV-infected humans

scientific article

Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses

scientific article published on 4 August 2008

High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia

scientific article published on January 2012

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

scientific article

Human immunodeficiency virus replication in AIDS patients with Mycobacterium avium complex bacteremia: a case control study. California Collaborative Treatment Group

scientific article published in March 1998

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis.

scientific article published on 27 December 2017

IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation.

scientific article published in November 2011

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

scientific article published on 9 November 2008

Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques

scientific article published on 28 February 2020

In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds

scientific article

Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

scientific article

Interactions between Natural Killer Cells and Antibody Fc Result in Enhanced Antibody Neutralization of Human Immunodeficiency Virus Type 1

article by Donald N Forthal et al published 1 April 2005 in Journal of Virology

Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1.

scientific article

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

scientific article published on 5 March 2015

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations

scientific article published on 31 December 2015

Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus

scientific article

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

scientific article published on 24 July 2013

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

scientific article published on 20 January 2014

Passive immunization with polyclonal anti-SHIV IgG: partial protection or increased acquisition of heterologous tier 2 SHIV – depending on IgG dose

Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques.

scientific article

Pharmaco-Immunomodulatory Therapy in COVID-19

scientific article published on 21 July 2020

Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection.

scientific article

Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens

scientific article published on 10 February 2016

Priming with a potent HIV-1 DNA vaccine frames the quality of immune responses prior to a poxvirus and protein boost

article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal ⬇️

scientific article published on July 17, 2012

Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group

scientific article published in August 1996

Prophylaxis with weekly versus daily fluconazole for fungal infections in patients with AIDS.

scientific article published in December 1998

Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure

scientific article published on 16 January 2013

Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys

scientific article published on 24 June 2009

Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems

scientific article

Re-Opening Schools Safely: The Case for Collaboration, Constructive Disruption of Pre-COVID Expectations, and Creative Solutions

scientific article published on 20 May 2020

Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate

scientific article

Relationship between Vaccine-Induced Antibody Capture of Infectious Virus and Infection Outcomes following Repeated Low-Dose Rectal Challenges with Simian Immunodeficiency Virus SIVmac251

scientific article published on 20 July 2016

Replication-competent NYVAC-KC yields improved immunogenicity to HIV-1 antigens in rhesus macaques, compared to non-replicating NYVAC

article

Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells

scientific article

Sex-associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines

scientific article

The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells

scientific article

The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis

scientific article published in October 2002

The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients

scientific article published in October 2004

The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV disease. California Collaborative Treatment Group.

scientific article published in February 1995

The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. California Collaborative Treatment Group

scientific article published on June 1999

Vaccine induced antibodies to the first variable loop of human immunodeficiency virus type 1 gp120, mediate antibody-dependent virus inhibition in macaques

scientific article published on 27 October 2011

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

scientific article published on 4 January 2012

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