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List of works by Sheila A Lukehart

A subpopulation of Treponema pallidum is resistant to phagocytosis: possible mechanism of persistence

scientific article published on December 1, 1992

Activation of macrophages by products of lymphocytes from normal and syphilitic rabbits

scientific article

Acyclovir Ointment Does Not Affect the Dark-field Examination in Primary Syphilis ⬇️

scientific article published on 01 October 1983

Advancing the understanding of treponemal disease in the past and present

scientific article published on 19 January 2020

Alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infection

scientific article published on June 1, 1992

An experimental model of early central nervous system syphilis

scientific article published in April 1991

Antibiotic Selection May Contribute to Increases in Macrolide‐ResistantTreponema pallidum

scientific article published on 03 November 2006

Antibody Responses Elicited against theTreponema pallidumRepeat Proteins Differ during Infection with Different Isolates ofTreponema pallidumsubsp.pallidum ⬇️

scientific article published on October 1, 2003

Antigenic cross-reactivity between Treponema pallidum and other pathogenic members of the family Spirochaetaceae

scientific article published on October 1984

Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.

scientific article

Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis

scientific article

Antigenic variation of TprK facilitates development of secondary syphilis

scientific article

Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans

scientific article published on 01 February 1985

Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance

scientific article published on December 2011

Archaeogenetics: What Can Ancient Genomes Tell Us about the Origin of Syphilis?

scientific article published on 01 October 2020

Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004.

scientific article

B-Cell Epitope Mapping of TprC and TprD Variants of <i>Treponema pallidum</i> Subspecies Informs Vaccine Development for Human Treponematoses

scientific article published on 29 March 2022

Barking up the wrong tree? Use of polymerase chain reaction to diagnose syphilitic aortitis

scientific article published on October 2002

Biological basis for syphilis

scientific article

Biomedical Research Priorities for Modern Syphilis Clinical Management, Diagnosis, and Vaccines: Overview and Commentary for Unit 1.

scientific article published on 9 March 2018

CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis

scientific article published on 2 April 2007

CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis

scientific article

Ceftriaxone therapy for asymptomatic neurosyphilis. Case report and Western blot analysis of serum and cerebrospinal fluid IgG response to therapy

scientific article published in July 1986

Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features

scientific article published on 27 January 2004

Cerebrospinal fluid treponemal antibodies in untreated early syphilis

scientific article published on 01 January 1995

Challenges and key research questions for yaws eradication

scientific article

Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens ⬇️

scientific article published on January 1, 1980

Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions ⬇️

scientific article published on 01 January 1980

Characterization of monoclonal antibodies to Treponema pallidum

scientific article published on 01 January 1985

Characterization of the humoral immune response of the rabbit to antigens of Treponema pallidum after experimental infection and therapy

scientific article published on 01 January 1986

Characterization of the serum requirement for macrophage-mediated killing of Treponema pallidum ssp. pallidum: relationship to the development of opsonizing antibodies

scientific article published on 01 April 1993

Chronicity of infection with Treponema paraluis-cuniculi in New Zealand white rabbits

scientific article

Clinical course and treatment of venereal spirochaetosis in New Zealand white rabbits.

scientific article

Comparative Investigation of the Genomic Regions Involved in Antigenic Variation of the TprK Antigen among Treponemal Species, Subspecies, and Strains ⬇️

scientific article published on June 1, 2012

Comparison of methods for the detection of treponema pallidum in lesions of early syphilis

scientific article published in September 1996

Comparison of the diagnostic accuracy of a rapid immunochromatographic test and the rapid plasma reagin test for antenatal syphilis screening in Mozambique

scientific article

Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.

scientific article published on 17 April 2014

Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain.

scientific article published on 26 March 2010

Conservation of the 15-kilodalton lipoprotein among Treponema pallidum subspecies and strains and other pathogenic treponemes: genetic and antigenic analyses

scientific article

Current status of syphilis vaccine development: need, challenges, prospects

scientific article

Demonstration of Treponema pallidum in a cutaneous gumma by indirect immunofluorescence

scientific article published on 01 August 1983

Detection of Treponema pallidum by a fluorescent monoclonal antibody test.

scientific article

Detection of Treponema pallidum by a sensitive reverse transcriptase PCR.

scientific article published on June 1997

Detection of Treponema pallidum in lesion exudate with a pathogen-specific monoclonal antibody

scientific article published on August 1985

Detection of azithromycin resistance in Treponema pallidum by real-time PCR.

scientific article published on 9 July 2007

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.

scientific article published on 27 December 2017

Development of cellular immunity to individual soluble antigens of Treponema pallidum during experimental syphilis

scientific article published in December 1988

Diagnostics for yaws eradication: insights from direct next generation sequencing of cutaneous strains of Treponema pallidum.

scientific article published on 16 October 2017

Effect of cortisone administration on host-parasite relationships in early experimental syphilis

scientific article published on 01 October 1981

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study

scientific article published on 26 October 2017

Efficacy of azithromycin for therapy of active syphilis in the rabbit model

scientific article published on 01 January 1990

Efficacy of aztreonam in treatment of experimental syphilis in rabbits

scientific article published on March 1984

Efficacy of cefmetazole in the treatment of active syphilis in the rabbit model

scientific article

Enhanced Molecular Typing ofTreponema pallidum: Geographical Distribution of Strain Types and Association with Neurosyphilis ⬇️

scientific article published on November 1, 2010

Evaluation of Aqueous Penicillin G and Ceftriaxone for Experimental Neurosyphilis ⬇️

scientific article published on 01 February 1992

Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar

scientific article published on December 2009

Evaluation of cerebrospinal fluid in Southeast Asian refugees with reactive serologic tests for syphilis

scientific article

Excellence in sexually transmitted infection (STI) diagnostics: recognition of past successes and strategies for the future

scientific article published on 29 November 2006

Experimental neonatal syphilis. II. Immunological responses of neonatal rabbits to intradermal inoculation with Treponema pallidum (Nichols strain)

scientific article published on 01 October 1984

Expression of rabbit interleukin-4 and characterization of its biologic activity on T and B-cells

scientific article published on August 2006

Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

scientific article

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen

scientific article

Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase

scientific article

Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection

scientific article published on June 2004

Genital ulceration as a risk factor for human immunodeficiency virus infection

scientific article published on February 1988

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages

article

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages

scientific article published on 22 July 2019

Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis

scientific article published on 24 November 2021

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea

scientific article

Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study.

scientific article

Host response to Treponema pallidum in intradermally-infected rabbits: evidence for persistence of infection at local and distant sites.

scientific article

Identification of Spirochetes Related toTreponema pallidumin Necrotizing Ulcerative Gingivitis and Chronic Periodontitis ⬇️

scientific article published on August 22, 1991

Identification of Treponema pallidum antigens: comparison with a nonpathogenic treponeme.

scientific article published in August 1982

Identification of Treponema pallidum subspecies pallidum in a 200-year-old skeletal specimen.

scientific article published in December 1999

Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue ⬇️

scientific article published on September 15, 1997

Identification of two new antigenic subgroups within the genus Mobiluncus

scientific article published on October 1991

IgG and IgM antibody reactivity to antigens of Treponema pallidum after treatment of syphilis

scientific article published on 01 October 1986

Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model

scientific article

Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment

scientific article published on 01 December 1988

Isolation and laboratory maintenance of Treponema pallidum

scientific article published on 01 November 2007

Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem

scientific article published on 28 July 2016

Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum.

scientific article published on 7 August 2007

Length of guanosine homopolymeric repeats modulates promoter activity of subfamily IItprgenes ofTreponema pallidumssp.pallidum

article published in 2007

Lesions of primary and secondary syphilis contain activated cytolytic T cells

scientific article

Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains

scientific article published on September 2016

Macrolide resistance in Treponema pallidum in the United States and Ireland

scientific article published in July 2004

Macrophage-Mediated Killing of Opsonized Treponema pallidum ⬇️

scientific article published on 01 January 1992

Mass Treatment with Single-Dose Azithromycin for Yaws

scientific article published on 01 September 2016

Mass treatment with single-dose azithromycin for yaws

scientific article

Mechanisms of clearance of Treponema pallidum from the CSF in a nonhuman primate model

scientific article published in October 1998

Modern syphilis--still a shadow on the land.

scientific article

Molecular Typing of Treponema pallidum in Ocular Syphilis

scientific article published on August 2016

Molecular basis of immunological cross-reactivity between Treponema pallidum and Treponema pertenue ⬇️

scientific article published on November 1, 1983

Molecular differentiation of Treponema pallidum subspecies

scientific article

Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema.

scientific article published on 22 August 2006

Molecular studies in Treponema pallidum evolution: toward clarity?

scientific article

Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.

scientific article published on April 2000

Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection

scientific article published on 01 June 1987

Neurosyphilis Increases Human Immunodeficiency Virus (HIV)-associated Central Nervous System Inflammation but Does Not Explain Cognitive Impairment in HIV-infected Individuals With Syphilis

scientific article published on 19 May 2017

New Tools for Syphilis Research

scientific article published on 31 July 2018

Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter?

scientific article published on 16 March 2004

Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis

scientific article published on October 2008

Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92

scientific article published on 13 April 2000

Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes

scientific article

Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis ⬇️

scientific article published on August 1, 1991

Prevention of congenital syphilis

scientific article published on 01 October 1984

Previous Syphilis Alters the Course of Subsequent Episodes of Syphilis

scientific article published on 27 September 2019

Primary Syphilis in the Male Urethra: A Case Report

scientific article published on 01 March 2019

Primary and secondary syphilis lesions contain mRNA for Th1 cytokines

scientific article published in February 1996

Production and characterization of monoclonal antibodies to Mobiluncus species

scientific article published on December 1988

Protection against Syphilis Correlates with Specificity of Antibodies to the Variable Regions ofTreponema pallidumRepeat Protein K ⬇️

scientific article published on October 1, 2003

Quantitation of rabbit cytokine mRNA by real-time RT-PCR.

scientific article published on April 2007

Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis

scientific article

Rapid molecular diagnosis of chronic skin ulcers--authors' reply

scientific article published on 25 June 2014

Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study

scientific article published on 7 February 2018

Rectal mass caused by Treponema pallidum: confirmation by immunofluorescent staining

scientific article published on January 1982

Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis

scientific article published on 9 December 2015

Relative proportions of pathogen-related oral spirochetes (PROS) and Treponema denticola in supragingival and subgingival plaque from patients with periodontitis

scientific article published on 01 February 1992

Resolution of serum and cerebrospinal fluid abnormalities after treatment of neurosyphilis. Influence of concomitant human immunodeficiency virus infection

scientific article published in May 1996

Roxithromycin (RU 965): effective therapy for experimental syphilis infection in rabbits

scientific article published on February 1987

Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture

scientific article published in January 2008

Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection

scientific article published on 01 July 2002

Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains.

scientific article

Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.

scientific article

Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum

scientific article published on August 2003

Serologic testing after therapy for syphilis: is there a test for cure?

scientific article published on 01 June 1991

Serum regulation of in vitro lymphocyte responses in early experimental syphilis

scientific article

Specificity of antibodies from patients with pinta for antigens of Treponema pallidum subspecies pallidum

scientific article published on 01 January 1988

Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity

scientific article published in July 2004

Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.

scientific article

Syphilis

article published in 2009

Syphilis: using modern approaches to understand an old disease ⬇️

scientific article published on December 1, 2011

Syphilis? An Unusual Cause of Surgical Emergency in a Human Immunodeficiency Virus-Infected Man.

scientific article published on 20 June 2015

T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection

scientific article published on September 1999

TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum

scientific article published on 30 April 2009

The Flanking Region Sequences of the 15-kDa Lipoprotein Gene Differentiate Pathogenic Treponemes ⬇️

scientific article published on April 1, 1998

The Response of Symptomatic Neurosyphilis to High-Dose Intravenous Penicillin G in Patients with Human Immunodeficiency Virus Infection

scientific article (publication date: December 1994)

The endemic treponematoses

scientific article published in January 2014

The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles

scientific article

Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.

scientific article published on November 2004

TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain

scientific article published on March 2006

Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat

scientific article published on 23 March 2015

Treponema pallidum Nucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men

scientific article published on 26 July 2019

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

scientific article published on 22 December 2021

Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response.

scientific article

Treponema pallidum strain-specific differences in neuroinvasion and clinical phenotype in a rabbit model

scientific article

Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end.

scientific article

Treponema paraluis-cuniculi infection in a commercial rabbitry: epidemiology and serodiagnosis

scientific article published on 01 December 1983

Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes

scientific article published in October 1996

Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington

scientific article published on December 2012

VDRL antibodies enhance phagocytosis of Treponema pallidum by macrophages

scientific article published on 01 May 1993

When is syphilis not syphilis? Or is it?

scientific article published on September 2014

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