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List of works by Leif W Ellisen

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.

scientific article published on 28 April 2015

A Systematic Comparison of Traditional and Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Genes in More Than 1000 Patients

scientific article published on 21 July 2015

A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity ⬇️

scientific article published on March 1, 2011

A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.

scientific article

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

scientific article

A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

scientific article published on 22 February 2021

ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.

scientific article

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

scientific article published on 29 January 2020

BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma ⬇️

scientific article published on August 31, 2010

Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.

scientific article published on 09 January 2014

Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma

scientific article published on 24 February 2009

Bioprinting the Cancer Microenvironment

scientific article published on 17 June 2016

Circadian function in cancer: regulating the DNA damage response.

scientific article

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

scientific article

Comparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence

scientific article published on 14 September 2015

Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

scientific article published on 30 October 2006

Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

scientific article

FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma

scientific article published on 08 July 2013

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

scientific article

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping ⬇️

scientific article published on December 16, 2011

Growth control under stress: mTOR regulation through the REDD1-TSC pathway

scientific article

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

scientific article

Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cancer

scientific article published on 22 June 2020

Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.

scientific article

Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma

scientific article

Mutational analysis and clinical correlation of metastatic colorectal cancer

scientific article

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

scientific article

Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.

scientific article published on 30 June 2016

PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition

scientific article published on 22 August 2012

Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma

scientific article published on 28 April 2011

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors

scientific article published on 09 April 2020

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

scientific article

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

scientific article published on May 2010

Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.

scientific article published on 21 February 2008

Regulation of gene expression by WT1 in development and tumorigenesis

scientific article

Regulation of mTOR and cell growth in response to energy stress by REDD1.

scientific article

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

scientific article

Standardized decision support in next generation sequencing reports of somatic cancer variants

scientific article published on 04 April 2014

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

scientific article

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

scientific article

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

scientific journal article

The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers

scientific article

The molecular pathogenesis of head and neck squamous cell carcinoma ⬇️

scientific article published on June 1, 2012

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers

scientific article published on 19 April 2007

Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma

scientific article

Women's Health Issues for BRCA Mutation Carriers

scientific article

Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells

scientific article published on 17 July 2014

Young adult daughters of BRCA1/2 positive mothers: what do they know about hereditary cancer and how much do they worry?

scientific article published on 18 February 2013

mTOR Activity Under Hypoxia ⬇️

scientific article published on January 1, 2012

p63 and p73: life and death in squamous cell carcinoma

scientific article published on May 2006

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

scientific article published on January 2006

p63 regulates an adhesion programme and cell survival in epithelial cells

scientific article published on 21 May 2006

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis

scientific article published on 17 March 2016

ΔNp63α represses anti-proliferative genes via H2A.Z deposition.

scientific article

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