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List of works by Roberto Ciccocioppo

3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

scientific article published in March 2007

A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models

scientific article published on 16 April 2016

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam

scientific article published on 6 January 2009

AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology

scientific article

Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S.

scientific article

Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission

scientific article published on 04 November 2019

Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats

scientific article

Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat.

scientific article published on 11 January 2011

Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking

scientific article published on 31 January 2011

Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats

scientific article published on 01 July 2020

Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat

scientific journal article

Acute Elevations in Cortisol Increase the In Vivo Binding of [11C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides

scientific article published on 25 September 2019

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

scholarly article by Laura Micheli et al published May 2015 in European Journal of Pharmacology

Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model

scientific article published on 06 February 2016

Analgesic tolerance to morphine is regulated by PPARγ.

scientific article published in December 2014

Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology

scientific article

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

scientific article published on 18 November 2003

Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments.

scientific article published in January 2002

Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model

scientific article published on April 2015

Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats

scientific article published in November 2002

Brain functional connectivity alterations in a rat model of excessive alcohol drinking: A resting-state network analysis.

scientific article published in July 2017

Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future

scientific article published on 18 May 2019

Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system

scientific article

Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.

scientific article published on 21 June 2017

CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats.

scientific article published on 28 June 2017

Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats.

scientific article

Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats

scientific article published in April 2005

Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors.

scientific article published on 13 November 2017

Chronic THC during adolescence increases the vulnerability to stress-induced relapse to heroin seeking in adult rats

scientific article published on 24 December 2013

Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat

scientific article

Constitutive Increases in Amygdalar Corticotropin-Releasing Factor and Fatty Acid Amide Hydrolase Drive an Anxious Phenotype

scientific article published on 13 January 2017

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

scientific article published on 04 April 2019

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

scientific article

Early life exposure to permethrin: a progressive animal model of Parkinson's disease

scientific article published on 15 October 2016

Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats

scientific article published on 3 May 2005

Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat

scientific journal article

Effect of novel NOP receptor ligands on food intake in rats

scientific article published on 17 February 2006

Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating.

scientific article published on 15 September 2010

Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats

scientific article published in September 2002

Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats

scientific article published on 29 October 2005

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

scientific article

Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study

scientific article published on 27 June 2019

Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics

scientific article

Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition

scientific article

Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects

scientific article published on 4 December 2012

Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption.

scientific article published on 21 September 2015

Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism

scientific article published on 15 February 2018

Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine

scientific article published on 29 November 2018

Further evidence for the involvement of the PPARγ system on alcohol intake and sensitivity in rodents

scientific article published on 16 July 2020

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

scientific article

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.

scientific article published on 3 November 2016

Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.

scientific article published on 26 August 2016

Genetically Selected Alcohol Preferring Rats to Model Human Alcoholism ⬇️

scientific article published on January 1, 2013

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism

scientific article

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects

scientific article

Grand Challenge in Psychopharmacology: Setting Priorities to Shape a Bright Future

scientific article published on 10 February 2017

Hypericum perforatum CO2 Extract and Opioid Receptor Antagonists Act Synergistically to Reduce Ethanol Intake in Alcohol‐Preferring Rats ⬇️

scientific article published on October 1, 2003

Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats

scientific article

Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.

scientific article

Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically-selected Marchigian Sardinian alcohol-preferring rats

scientific article published on 03 November 2020

Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.

scientific article published on 30 April 2008

Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats.

scientific article

Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake.

scientific article published on 26 October 2017

Introduction to Large-Scale Gene Expression Data Analysis

article

Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?

scientific article published on 26 January 2018

MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala.

scientific article published on 18 February 2014

MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats

scientific article

Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors

scientific article published on 15 June 2012

Memory impairment following combined exposure to delta(9)-tetrahydrocannabinol and ethanol in rats

scientific article published in August 2002

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

scientific article

Microarrays in Neuroscience

Microarrays--the challenge of preparing brain tissue samples.

scientific article

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence

scientific article published on 01 July 2019

Modification of anxiety‐like behaviors by nociceptin/orphanin FQ (N/OFQ) and time‐dependent changes in N/OFQ‐NOP gene expression following ethanol withdrawal ⬇️

scientific article published on July 15, 2012

Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain

scientific article published on 16 May 2013

Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain.

scientific article published on 8 June 2016

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

scientific article published on 29 March 2019

NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice

scientific article published on 21 August 2019

NOP receptor antagonism reduces alcohol drinking in male and female rats through mechanisms involving the central amygdala and ventral tegmental area

scientific article published on 03 February 2020

NOP-Related Mechanisms in Substance Use Disorders

scientific article published on 01 January 2019

Neonatal exposure to permethrin pesticide causes lifelong fear and spatial learning deficits and alters hippocampal morphology of synapses

scientific article published on 29 March 2014

Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats.

scientific article

Neuropeptide S differently modulates alcohol-related behaviors in alcohol-preferring and non-preferring rats.

scientific article published on 28 May 2016

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system ⬇️

scientific article published on October 25, 2010

Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats.

scientific article published on 23 October 2009

Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [11C]NOP-1A

scientific article published on 06 May 2019

Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A.

scientific article published on 31 May 2017

Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect

scientific article

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans

scientific article published in November 2017

PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission

scientific article published in March 2015

PPARα/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models

scientific article published on 06 September 2018

PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission

scientific article

Paradoxical response to the sedative effects of diazepam and alcohol in C57BL/6J mice lacking the neuropeptide S receptor

scientific article published on 18 September 2014

Perceived parental care during childhood, ACTH, cortisol and nicotine dependence in the adult

scientific article published on 6 September 2016

Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats.

scientific article published on 18 June 2007

Peroxisome Proliferator-Activated Receptor (PPAR) Agonists as Promising New Medications for Drug Addiction: Preclinical Evidence ⬇️

scientific article published on June 1, 2013

Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system

scientific article published on 25 March 2009

Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats

scientific article published on 30 October 2019

Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats

scientific article published on 20 October 2011

Pharmacological characterisation of [(pX)Phe 4 ]nociceptin(1-13)NH 2 analogues

scholarly article by Anna Rizzi et al published 1 June 2002 in Naunyn-Schmiedeberg's Archives of Pharmacology

Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

scientific article published in January 2002

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.

scientific article published on 28 February 2007

Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists

scientific article published on January 2010

Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents

scientific article

Pioglitazone, a PPARγ agonist, reduces nicotine craving in humans, with marginal effects on abuse potential

scientific article published on 8 October 2017

Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats

scientific article

Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats.

scientific article published on 28 April 2009

Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat.

scientific article published on 2 September 2011

Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.

scientific article

Promising medications for cocaine dependence treatment.

scientific article published on May 2011

Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone

scientific article published on 3 February 2017

Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction ⬇️

scientific article published on December 20, 2012

Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol

scientific article published in March 2007

Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone

scientific article published on 27 March 2003

Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors.

scientific article published on January 2014

Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198.

scientific article

Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats

scientific article

Role of Hypothalamic-Pituitary-Adrenal axis and corticotropin-releasing factor stress system on cue-induced relapse to alcohol seeking

scientific article published on 14 June 2016

Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats

scientific article published on 12 April 2013

Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction

scientific article

Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol

scientific article

Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin

scientific article

Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats

scientific article

Role of the satiety factor oleoylethanolamide in alcoholism

scientific article

Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.

scientific article published on 29 May 2017

Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking

scientific article published on 28 March 2004

Stratified medicine for mental disorders

scientific article published on 04 October 2013

Stress-related neuropeptides and addictive behaviors: beyond the usual suspects

scientific article

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

scientific article

Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study

scientific article published on 30 January 2019

The PPARγ Agonist Pioglitazone Fails to Alter the Abuse Potential of Heroin, But Does Reduce Heroin Craving and Anxiety

scientific article published on 11 September 2018

The anandamide transport inhibitor AM404 reduces ethanol self-administration

scientific article published in July 2007

The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ.

scientific article

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

scientific article

The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking

scientific article

The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.

scientific article published in June 2005

The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users

scientific article

The genetic of alcoholism: learning from 50 years of research

scientific article published on 01 September 2006

The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats

scientific article

The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S

scientific journal article

The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission

scientific article published on 03 October 2012

Translational approach to develop novel medications on alcohol addiction: focus on neuropeptides.

scientific article published on 03 May 2013

Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies

scientific article published on 26 March 2020

Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats.

scientific article published on 8 September 2015

phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats

article

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